Prof. Dr Peter Olinga, Translational Biopharmaceutics, Groningen Research Institute of Pharmacy, The Netherlands

Drug targeting meets liver fibrosis    

Liver fibrogenesis is associated with excessive production of extracellular matrix by myofibroblasts that often leads to cirrhosis and consequently liver dysfunction and death. Novel protein-based antifibrotic drugs show high specificity and efficacy, but their use in the treatment of fibrosis causes a high burden for patients, since repetitive and long-term parenteral administration is required as most proteins and peptides are rapidly cleared from the circulation. Therefore, we developed biodegradable polymeric microspheres for the sustained release of proteinaceous drugs.
  

The lecture is part of the PhD School Nanoscience meets Hepatology, but the lecture is open to all interested.

Host: Associate Professor Brigitte Städler, iNANO & Department of Molecular Biology and Genetics, Aarhus University