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David Hasselbach, Research Institute of Molecular Pathology (IMP), Germany

The story of a molecular rope   

It is a little known fact that proteasomes accumulate in most cells in the nucleus. While the mechanisms that lead to this are well established in yeast they are not conserved to animals. Using a CRISPR screen aimed on the degradation of prominent transcription factors we find that a small, little described protein acting as adaptor between the nuclear transport machinery and the proteasome. To understand how it is possible that a tiny 40 kDa protein enables the nuclear transition of a 1.5 MDa we use numerous biophysical techniques including cryo EM.