Ramsay, E., Raviña, M., Sarkhel, S., Hehir, S., Cameron, N. R., Ilmarinen, T., Skottman, H.
, Kjems, J., Urtti, A., Ruponen, M.
& Subrizi, A. (2020).
Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models.
Pharmaceutics,
12(7), Article 667.
https://doi.org/10.3390/pharmaceutics12070667
Xu, W., Tan, Q.
, Yu, M., Sun, Q., Kong, H.
, Lægsgaard, E., Stensgaard, I., Kjems, J., Wang, J., Wang, C.
& Besenbacher, F. (2013).
Atomic-scale structures and interactions between the guanine quartet and potassium.
Chemical Communications,
49(65), 7210-7212.
https://doi.org/10.1039/c3cc43302a
Sun, M., Wang, M., Chen, M., Dagnaes-Hansen, F., Le, D. Q. S., Baatrup, A., Horsman, M. R., Kjems, J. & Bünger, C. (2015).
A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo.
Acta Biomaterialia,
18, 21-29.
https://doi.org/10.1016/j.actbio.2015.02.004
Andersen, P. O., Kring Hansen, B.
, Nielsen, J., Hansen, L., Kjems, J. & Meyer, R. L. (2016).
A targeting ligand for drug delivery to Staphylococcus aureus biofilms. Abstract from Antimicrobial resistance in microbial biofilms and options for treatment, Ghent, Belgium.
Andersen, P. O., Hansen, L., Vu Quang, H., Kjems, J. & Meyer, R. L. (2017).
A Targeting Agent For Drug Delivery To Staphylococcus Aureus Biofilms. 198. Abstract from Eurobiofilms 2017, Amsterdam, Netherlands.
http://www.eurobiofilms.com/wp-content/uploads/2016/06/Eurobiofilms2017-Abstract-book.pdf
Venø, M. T., Reschke, C. R., Morris, G., Connolly, N. M. C.
, Su, J., Yan, Y., Engel, T., Jimenez-Mateos, E. M., Harder, L. M., Pultz, D., Haunsberger, S. J., Pal, A., Heller, J. P., Campbell, A., Langa, E., Brennan, G. P., Conboy, K., Richardson, A., Norwood, B. A. ... Henshall, D. C. (2020).
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Proceedings of the National Academy of Sciences,
117(27), 15977-15988.
https://doi.org/10.1073/pnas.1919313117
Staulund, J.
, Song, P., Qi, H., Thrane, L., Duedahl, P., Weiss, T., Moers, C.
, Keller, A. K., Nørregaard, R., Pedersen, M., Leuvenink, H.
, Kjems, J., Jespersen, B. & Eijken, M. (2022).
Assessing the quality of donor kidneys during normothermic machine perfusion using nanoparticle-based vitality sensors. Abstract from 3rd ECTORS meeting, Rotterdam, Netherlands.
Zou, L., Luo, Y., Chen, M., Wang, G., Ding, M.
, Petersen, C. C., Kang, R., Dagnaes-Hansen, F., Zeng, Y., Lv, N., Ma, Q.
, Le, D. Q. S., Besenbacher, F., Bolund, L., Jensen, T. G., Kjems, J., Pu, W. T.
& Bünger, C. (2013).
A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds.
Scientific Reports,
3, Article 2243.
https://doi.org/10.1038/srep02243
Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D.
, Pedersen, F. S., Birkedal, V., Wagner, R.
, Paludan, S. R. & Kjems, J. (2021).
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Proceedings of the National Academy of Sciences,
118(50), Article e2112942118.
https://doi.org/10.1073/pnas.2112942118
Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J.
, Nielsen, J. S. & Kjems, J. (2019).
A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine.
Theranostics,
9(9), 2662-2677.
https://doi.org/10.7150/thno.32060
Bramsen, J. B., Pakula, M. M., Hansen, T. B., Bus, C., Langkjær, N., Odadzic, D., Smicius, R., Wengel, S. L., Chattopadhyaya, J., Engels, J. W., Herdewijn, P., Wengel, J.
& Kjems, J. (2010).
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Nucleic Acids Research,
38(17), 5761-5773.
https://doi.org/10.1093/nar/gkq341
Hansen, T. B., Venø, M. T., Jensen, T. I., Schaefer, A.
, Damgaard, C. K. & Kjems, J. (2016).
Argonaute-associated short introns are a novel class of gene regulators.
Nature Communications,
7, Article 11538.
https://doi.org/10.1038/ncomms11538
Schaefer, A., Im, H.-I.
, Venø, M. T., Fowler, C. D., Min, A., Intrator, A.
, Kjems, J., Kenny, P. J., O'Carroll, D. & Greengard, P. (2010).
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
Journal of Experimental Medicine,
207(9), 1843-51.
https://doi.org/10.1084/jem.20100451
Ommen, P., Hansen, L., Hansen, B. K., Vu-Quang, H., Kjems, J. & Meyer, R. L. (2022).
Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm.
Frontiers in cellular and infection microbiology,
12, Article 814340.
https://doi.org/10.3389/fcimb.2022.814340
Andersen, P. O., Hansen, B. K., Hansen, L., Nielsen, J., Kjems, J. & Meyer, R. L. (2016).
Aptamers as possible targeting agents for delivery of antibiotics to S. aureus biofilms. Abstract from International Symposium on Staphylococci and Staphylococcus infectionsI, Seoul, Korea, Republic of.
Fang, X., Wang, J., O'Carroll, I. P., Mitchell, M., Zuo, X., Wang, Y., Yu, P., Liu, Y., Rausch, J. W., Dyba, M. A.
, Kjems, J., Schwieters, C. D., Seifert, S., Winans, R. E., Watts, N. R., Stahl, S. J., Wingfield, P. T., Byrd, R. A., Le Grice, S. F. J. ... Wang, Y.-X. (2013).
An unusual topological structure of the HIV-1 Rev response element.
Cell,
155(3), 594-605.
https://doi.org/10.1016/j.cell.2013.10.008
Nielsen, C. K., Kjems, J., Mygind, T., Snabe, T., Schwarz, K., Serfert, Y.
& Meyer, R. L. (2017).
Antimicrobial effect of emulsion-encapsulated isoeugenol against biofilms of food pathogens and spoilage bacteria.
International Journal of Food Microbiology,
242, 7–12.
https://doi.org/10.1016/j.ijfoodmicro.2016.11.002
Ferapontov, A., Omer, M., Baudrexel, I.
, Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S.
, Thiel, S., Vorup-Jensen, T., Jungmann, R.
, Kjems, J. & Degn, S. E. (2023).
Antigen footprint governs activation of the B cell receptor.
Nature Communications,
14(1), Article 976.
https://doi.org/10.1038/s41467-023-36672-0
Nielsen, C. K., Subbiahdoss, G., Zeng, G., Salmi, Z., Kjems, J., Mygind, T., Snabe, T.
& Meyer, R. L. (2018).
Antibacterial isoeugenol coating on stainless steel and polyethylene surfaces prevents biofilm growth.
Journal of Applied Microbiology,
124(1), 179-187.
https://doi.org/10.1111/jam.13634
Høiberg, H. C., Sparvath, S. M., Andersen, V. L., Kjems, J. & Andersen, E. S. (2019).
An RNA origami octahedron with intrinsic siRNAs for potent gene knockdown.
Biotechnology Journal,
14(1), Article 1700634.
https://doi.org/10.1002/biot.201700634
Lützelberger, M., Reinert, L. S., Das, A. T., Berkhout, B.
& Kjems, J. (2006).
A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stability.
Journal of Biological Chemistry,
281(27), 18644-18651.
https://doi.org/10.1074/jbc.M513698200
Wittenborn, T., Nygaard, J. V., Horsman, M. R., Vorup-Jensen, T., Kjems, J., Thim, T., Nielsen, T., Larsen, E. K. U. & Falk, E. (2009).
A Novel in Vivo Angiogenesis Mouse Model.
Arteriosclerosis, Thrombosis, and Vascular Biology, (7).
Daelemans, D., Afonina, E.
, Nilsson, J., Werner, G.
, Kjems, J., Clercq, E., Pavlakis, G. N. & Vandamme, A. (2002).
A novel inhibitor of the CRM-1 mediated pathway.
Proceedings of the National Academy of Sciences,
99, 14440-14445.
Freund, M., Asang, C.
, Kammler, S., Konermann, C.
, Krummheuer, J., Hipp, M., Meyer, I., Gierling, W., Theiss, S., Preuss, T., Schindler, D.
, Kjems, J. & Schaal, H. (2003).
A novel approach to describe a U1 snRNA binding site.
Nucleic Acids Research,
31(23), 6963-6975.
https://doi.org/10.1093/nar/gkg901
Vogt, S., Bobbili, M. R., Stadlmayr, G., Stadlbauer, K.
, Kjems, J., Rüker, F., Grillari, J. & Wozniak-Knopp, G. (2021).
An engineered CD81-based combinatorial library for selecting recombinant binders to cell surface proteins: Laminin binding CD81 enhances cellular uptake of extracellular vesicles.
Journal of Extracellular Vesicles,
10(11), Article e12139.
https://doi.org/10.1002/jev2.12139
Nygaard, J. V., Andersen, M. Ø., Howard, K., Sasov, A.
, Kjems, J. & Besenbacher, F. (2004).
Analysis of Nanoparticles in Scaffolds for Tissue Engineering by use of X-Ray Nano Tomography. Poster session presented at iNANO 4
th annual meeting, Aarhus, Denmark.
Dinesen, A., Andersen, V. L., Elkhashab, M., Pilati, D., Bech, P., Fuchs, E., Samuelsen, T. R., Winther, A., Cai, Y., Märcher, A., Wall, A.
, Omer, M., Nielsen, J. S., Chudasama, V., Baker, J. R.
, Gothelf, K. V., Wengel, J.
, Kjems, J. & Howard, K. A. (2024).
An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.
Bioconjugate Chemistry,
35(2), 214-222.
https://doi.org/10.1021/acs.bioconjchem.3c00491
Fuchs, E., Rudnik-Jansen, I., Dinesen, A., Selnihhin, D., Mandrup, O. A., Thiam, K.
, Kjems, J., Pedersen, F. S. & Howard, K. A. (2022).
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Acta Biomaterialia,
153, 411-418.
https://doi.org/10.1016/j.actbio.2022.09.048
Civit, L., Moradzadeh, N., Jonczyk, A., Neckermann, P., Asbach, B., Peterhoff, D., Wagner, R., Famulok, M., Mayer, G.
, Kjems, J. & Valero, J. (2024).
A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein.
International Journal of Molecular Sciences ,
25(9), Article 4642.
https://doi.org/10.3390/ijms25094642
Knudsen, C. H., ásgrímsdóttir, E. S., Rahimi, K., Gill, K. P., Frandsen, S., Buchholdt, S. H., Chen, M., Kjems, J., Febbraro, F. & Denham, M. (2018).
A modified monomeric red fluorescent protein reporter for assessing CRISPR activity.
Frontiers in Cell and Developmental Biology,
6(MAY), Article 54.
https://doi.org/10.3389/fcell.2018.00054
Rajman, M., Metge, F., Fiore, R., Khudayberdiev, S., Aksoy-Aksel, A., Bicker, S., Reschke, C. R., Raoof, R., Brennan, G. P., Delanty, N., Farrell, M. A., O'Brien, D. F., Bauer, S., Norwood, B.
, Veno, M. T., Krueger, M., Braun, T.
, Kjems, J., Rosenow, F. ... Schratt, G. (2017).
A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses.
E M B O Journal,
36(12), 1770-1787.
https://doi.org/10.15252/embj.201695748
Thomsen, R. P., Malle, M. G.
, Okholm, A. H., Krishnan, S., Bohr, S. S. R.
, Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, N. S.
& Kjems, J. (2019).
A large size-selective DNA nanopore with sensing applications.
Nature Communications,
10(1), Article 5655.
https://doi.org/10.1038/s41467-019-13284-1
Bramsen, J. B., Laursen, M. B., Nielsen, A. F., Hansen, T. B., Bus, C., Langkjær, N., Babu, B. R., Højland, T., Abramov, M., Van Aerschot, A., Odadzic, D., Smicius, R., Haas, J., Andree, C., Barman, J., Wenska, M., Srivastava, P., Zhou, C., Honcharenko, D.
... Kjems, J. (2009).
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Nucleic Acids Research,
37(9), 2867-81.
https://doi.org/10.1093/nar/gkp106
Jakobsen, M. R., Damgaard, C. K., Andersen, E. S., Podhajska, A.
& Kjems, J. (2004).
A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNA.
Nucleic Acids Research,
32(7), e67.
https://doi.org/10.1093/nar/gnh064
Krissanaprasit, A., Mihalko, E., Meinhold, K., Simpson, A., Sollinger, J., Pandit, S.
, Dupont, D. M., Kjems, J., Brown, A. C.
& LaBean, T. H. (Accepted/In press).
A functional RNA-origami as direct thrombin inhibitor with fast-acting and specific single-molecule reversal agents in vivo model.
Molecular Therapy.
https://doi.org/10.1016/j.ymthe.2024.05.002
Nielsen, C., Kjems, J., Sorensen, K. R., Engelholm, L. H. & Behrendt, N. (2014).
Advances in targeted delivery of small interfering RNA using simple bioconjugates.
Expert Opinion on Drug Delivery,
11(5), 791-822.
https://doi.org/10.1517/17425247.2014.896898
Zhang, Z., Olsen, E. M., Kryger, M., Voigt, N. V., Tørring, T., Gültekin, E.
, Nielsen, M., MohammadZadegan, R., Andersen, E. S., Nielsen, M. M., Kjems, J., Birkedal, V. & Gothelf, K. V. (2011).
A DNA tile actuator with eleven discrete states.
Angewandte Chemie International Edition,
50(17), 3983-7.
https://doi.org/10.1002/anie.201007642
Löffler, P. M. G., Ries, O., Rabe, A.
, Okholm, A. H., Thomsen, R. P., Kjems, J. & Vogel, S. (2017).
A DNA-programmed liposome fusion cascade.
Angewandte Chemie International Edition,
56(43), 13228–13231.
https://doi.org/10.1002/anie.201703243
Daniel, C.
, Venø, M. T., Ekdahl, Y.
, Kjems, J. & Öhman, M. (2012).
A distant cis acting intronic element induces site-selective RNA editing.
Nucleic Acids Research,
40(19), 9876-9886.
https://doi.org/10.1093/nar/gks691
Das Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B.
, Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E.
, Kristensen, L. S. & Pivarcsi, A. (2020).
A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.
Scientific Reports,
10, Article 3637.
https://doi.org/10.1038/s41598-020-59660-6