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Antigen footprint governs activation of the B cell receptor.
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Bispecific Complement Engagers for Targeted Complement Activation.
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Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement (Journal of Biological Chemistry (2018) 293(17) (6269–6281), (S0021925820397313), (10.1074/jbc.RA117.001179)).
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Differentiating Between Activation via the Lectin or the Classical Complement Pathway in Patients with Systemic Lupus Erythematosus.
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Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation.
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MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes.
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Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants.
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Trypanosoma brucei Invariant Surface gp65 Inhibits the Alternative Pathway of Complement by Accelerating C3b Degradation.
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A low level of naturally occurring antibodies associates with functional antibody deficiency.
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Complement proteins are elevated in patients with axSpA compared with relevant controls with low back pain and axSpA-features without axSpA.. Poster session presented at EULAR 2022, Copenhagen, Denmark.
Laursen, T. L., Bossen, L., Pihl, R., Troldborg, A., Sandahl, T. D., Hansen, A. G., Folserass, T., Vesterhus, M.
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M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis.
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Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome.
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& Loft, A. G. (2022).
POS0059 Complement proteins are elevated in patients with axSpa compared with relevant controls of patients with low back pain and spa-features without axSpa.
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81(Suppl 1), 245-246.
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Potency measurements of the complement system facilitated by antibodies targeting the zymogen form of complement factor D (Adipsin).
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Quantification of the pro-form of human complement component factor D (adipsin).
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Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
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Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
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Effect of dipeptidyl peptidase-4 inhibitors on complement activation.
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, Thiel, S. & de Messias-Reason, I. J. T. (2021).
Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors.
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ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism.
Science Advances,
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, Thiel, S., Beck-Nielsen, H.
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Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study.
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, Hasle, H., Albertsen, BK., Herlin, T. & on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR) (2021).
M-ficolin: a valuable biomarker to identify leukemia from juvenile idiopathic arthritis.
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19(Suppl 1), 24-24. Article P6.
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& Thiel, S. (2021).
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease.
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, Thomas, D. C., Willicombe, M., Palarasah, Y., Botto, M., Pickering, M. C.
& Thiel, S. (2021).
Protease inhibitor plasma concentrations associate with COVID-19 infection.
Oxford open immunology,
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& Rinschen, M. M. (2021).
Proteolysis and inflammation of the kidney glomerulus.
Cell and Tissue Research,
385(2), 489-500.
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Bernth Jensen, J. M., Skeldal, S., Petersen, M. S., Møller, B. K., Hoffmann, S.
, Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2021).
The human natural anti-αGal antibody targets common pathogens by broad-spectrum polyreactivity.
Immunology,
162(4), 434-451.
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Østergaard, J. A., Jansson Sigfrids, F., Forsblom, C., Dahlström, E. H., Thorn, L. M., Harjutsalo, V., Flyvbjerg, A.
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The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes.
Scientific Reports,
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Bernth Jensen, J. M., Petersen, M. S., Ellerman-Eriksen, S., Møller, B. K., Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2020).
Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity.
Scientific Reports,
10(1), Article 4611.
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Pedersen, H., Jensen, R. K., Hansen, A. G., Gadeberg, T. A. F., Thiel, S., Laursen, N. S. & Andersen, G. (2020).
A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system.
The Journal of Biological Chemistry,
295(26), 8746-8758.
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Pedersen, H., Jensen, R. K., Jensen, J. M. B., Fox, R.
, Pedersen, D. V., Olesen, H. G., Hansen, A. G., Christiansen, D.
, Mazarakis, S. M. M., Lojek, N.
, Hansen, P., Gadeberg, T. A. F., Zarantonello, A., Laursen, N. S., Mollnes, T. E., Johnson, M. B., Stevens, B.
, Thiel, S. & Andersen, G. R. (2020).
A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.
Journal of Immunology,
205(8), 2287-2300.
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Weinschutz Mendes, H., Boldt, A. W., Stahlke, E.
, Jensenius, J. C., Thiel, S. & Messias-Reason, I. J. T. (2020).
Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels.
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Zarantonello, A., Presumey, J., Simoni, L., Yalcin, E., Fox, R.
, Hansen, A., Olesen, H. G., Thiel, S., Johnson, M. B., Stevens, B.
, Laursen, N. S., Carroll, M. C.
& Andersen, G. R. (2020).
An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
Journal of Immunology,
205(6), 1678-1694.
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Holt, C. B., Hoffmann-Petersen, I. T., Hansen, T. K., Parving, H.-H.
, Thiel, S., Hovind, P., Tarnow, L., Rossing, P.
& Østergaard, J. A. (2020).
Association between severe diabetic retinopathy and lectin pathway proteins - an 18-year follow-up study with newly diagnosed type 1 diabetes patients.
Immunobiology,
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Jensen, E. G., Jakobsen, T. S., Thiel, S., Askou, A. L. & Corydon, T. J. (2020).
Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration.
International Journal of Molecular Sciences ,
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Sokołowska, A., Świerzko, A. S., Gajek, G., Gołos, A., Michalski, M., Nowicki, M., Szala-Poździej, A., Wolska-Washer, A., Brzezińska, O., Wierzbowska, A., Jamroziak, K., Kowalski, M. L.
, Thiel, S., Matsushita, M.
, Jensenius, J. C. & Cedzyński, M. (2020).
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults.
Scientific Reports,
10(1), Article 10561.
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Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Szala-Poździej, A., Eppa, Ł., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O.
, Thiel, S., Matsushita, M.
, Jensenius, J. C. ... Cedzyński, M. (2020).
Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations.
Frontiers in Immunology,
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LaFon, D. C.
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Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.
Immunity & ageing : I & A,
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Bernth Jensen, J. M., Laursen, N. S., Kjeldsen Jensen, R., Andersen, G. R., Jensenius, J. C., Skov Sørensen, U. B. & Thiel, S. (2020).
Complement activation by human IgG antibodies to galactose-α-1,3-galactose.
Immunology,
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Complement activation in human autoimmune diseases and mouse models; employing a sandwich immunoassay specific for C3dg.
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Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-level in Plasma Samples from Mice and Humans.
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Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Frontiers in Immunology,
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