Steffen Thiel

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Troldborg, A., Thiel, S., Trendelenburg, M., Friebus-Kardash, J., Nehring, J., Steffensen, R., Hansen, S. W. K., Laska, M. J., Deleuran, B., Jensenius, J. C., Voss, A. & Stengaard-Pedersen, K. (2018). The Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus. Journal of Rheumatology, 45(8), 1136-1144. https://doi.org/10.3899/jrheum.171033

Troldborg, A., Thiel, S., Mistegaard Jørgensen, C., Stengaard-Pedersen, K. & Loft, A. G. R. (2018). Unique Pattern of Lectin Pathway Complement Protein Levels in Axial Spondyloarthritis.

Troldborg, A., Steffensen, R., Trendelenburg, M., Hauser, T., Winther, K. G., Hansen, A. G., Stengaard-Pedersen, K., Voss, A. & Thiel, S. (2019). Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus. Journal of Clinical Immunology, 39(4), 421-429. https://doi.org/10.1007/s10875-019-00627-2

Troldborg, A., Thiel, S., Elbaek, C. M., Hansen, A., Korsholm, T.-L., Stengaard-Pedersen, K. & Loft, A. G. (2020). Plasma levels of H- and L-ficolin are increased in axial spondyloarthritis: Improvement of disease identification. Clinical and Experimental Immunology, 199(1), 79-87. https://doi.org/10.1111/cei.13374

Troldborg, A., Voss, A., Hansen, S. W. K., Jensenius, J. C., Stengaard-Pedersen, K. & Thiel, S. (2019). Complement Protein CL-K1 at High Concentrations Protects Against the Development of Lupus Nephritis. Arthritis and Rheumatology, 71(suppl.10), Article 2895. https://acrabstracts.org/abstract/complement-protein-cl-k1-at-high-concentrations-protects-against-the-development-of-lupus-nephritis/

Troldborg, A., Halkjær, L., Pedersen, H., Hansen, A., Loft, A. G., Lindegaard, H., Stengaard-Pedersen, K., Graversen, J. H., Palarasah, Y. & Thiel, S. (2020). Complement activation in human autoimmune diseases and mouse models; employing a sandwich immunoassay specific for C3dg. Journal of Immunological Methods, 486, Article 112866. https://doi.org/10.1016/j.jim.2020.112866

Troldborg, A., Godnic-Polai, Z., Cervenak, L., Hansen, A. G., Farkas, H. & Thiel, S. (2024). Inter-α-trypsin inhibitor heavy chain 4 (ITIH4) as a compensatory protease inhibitor in hereditary angioedema. The Journal of Allergy and Clinical Immunology, 154(2), 468-479.e6. https://doi.org/10.1016/j.jaci.2024.03.028

Tizzot, M. R., Lidani, K. C. F., Andrade, F. A., Mendes, H. W., Beltrame, M. H., Reiche, E., Thiel, S., Jensenius, J. C. & de Messias-Reason, I. J. (2018). Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil. Frontiers in Immunology, 9, 2292. Article 2292. https://doi.org/10.3389/fimmu.2018.02292

Thielens, N. M., Cseh, S., Thiel, S., Vorup-Jensen, T., Rossi, V., Jensenius, J. C. & Arlaud, G. J. (2001). Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL. Journal of Immunology, 166, 5068-5077.

Thiel, S., Frederiksen, P. D. & Jensenius, J. C. (2006). Clinical manifestations of mannan-binding lectin deficiency. Molecular Immunology, 43(1-2), 86-96. https://doi.org/10.1016/j.molimm.2005.06.018

Thiel, S., Møller-Kristensen, M., Jensen, L. & Jensenius, J. C. (2002). Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Immunobiology, 205, 446-454.

Thiel, S., Petersen, S. V., Vorup-Jensen, T., Matsushita, M., Fujita, T., Stover, C. M., Schwaeble, W. J. & Jensenius, J. C. (2000). Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. Journal of Immunology, 165, 878-887.

Thiel, S., Jensenius, J. C., Fugger, L. H. & Stengaard-Pedersen, K. (2004). Method for determining predisposition to manifestation of immune system related diseases. (Patent No. PA 2003 00742).

Thiel, S., Vorup-Jensen, T., Stover, C. M., Schwaeble, W., Laursen, S. B., Poulsen, K., Willis, A. C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K. B. & Jensenius, J. C. (1997). A second serine protease associated with mannan-binding lectin that activates complement. Nature, 386, 506-10.

Thiel, S., Steffensen, R. N., Christensen, I. J., Ip, WK., Lau, YL., Reason, IJ., Eiberg, H., Gadjeva, M., Ruseva, M. & Jensenius, J. C. (2007). Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes and Immunity, 8(2), 154-163.

Thiel, S. (2007). Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol. Immunol, 44, 3875-88.

Thiel, S., Kolev, M., Degn, S., Hansen, A., Jensen, L. & Steffensen, R. N. (2007). Characteristics of recombinant mannan-binding lectin associated serine protease 2 (MASP-2) representing natural polymorphisms. Abstract from XIth European Meeting on Cemplement in Human Disease, Cardiff, United Kingdom.

Thiel, S., Kolev, M., Degn, S. E., Steffensen, R., Hansen, A., Ruseva, M. & Jensenius, J. C. (2009). Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. Journal of Immunology, 182(5), 2939-47. https://doi.org/10.4049/jimmunol.0802053

Thiel, S., Bjerke, T., Hansen, D., Poulsen, L. K., Schiøtz, P. O. & Jensenius, J. C. (1995). Ontogeny of human mannan-binding protein, a lectin of the innate immune system. Pediatric Allergy and Immunology, 6(1), 20-3.

Thiel, S. (1992). Mannan-binding protein, a complement activating animal lectin. International Immunopharmacology, 24(2), 91-9.

Thiel, S., Holmskov, U., Hviid, L., Laursen, S. B. & Jensenius, J. C. (1992). The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clinical and Experimental Immunology, 90(1), 31-5.

Thiel, S. & Reid, K. B. (1989). Structures and functions associated with the group of mammalian lectins containing collagen-like sequences. FEBS Letters, 250(1), 78-84.

Thiel, S., Baatrup, G., Friis-Christiansen, P., Svehag, S. E. & Jensenius, J. C. (1987). Characterization of a lectin in human plasma analogous to bovine conglutinin. Scandinavian Journal of Immunology, 26(5), 461-8.

Thiel, S. & Gadjeva, M. (2009). Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins. In U. Kishore (Ed.), Target Pattern Recognition in Innate Immunity (Vol. 653).

Thiel, S., Steffensen, R., Christensen, I. J., Ip, W. K., Lau, Y. L., Reason, I. J. M., Eiberg, H. R. L., Gadjeva, M., Ruseva, M. & Jensenius, J. C. (2007). Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes and Immunity, 8(2), 154-63. https://doi.org/10.1038/sj.gene.6364373

Thiel, S., Vorup-Jensen, T., Stover, C. M., Schwaeble, W., Laursen, S., Poulsen, K., Willis, A. C., Eggleton, P., Hansen, S., Holmskov, U. L., Reid, K. B. & Jensenius, J. C. (1997). A second serine protease associated with mannan-binding lectin that activates complement. Nature, 386(6624), 506-10. https://doi.org/10.1038/386506a0

Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J. & Jensenius, J. C. (2012). Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clinical and Experimental Immunology, Supplement, 169(1), 38-48. https://doi.org/10.1111/j.1365-2249.2012.04584.x

Thiel, S. & Gadjeva, M. (2009). Humoral pattern recognition molecules: mannan-binding lectin and ficolins. Advances in Experimental Medicine and Biology, 653, 58-73.

Thiel, S. (2007). Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Molecular Immunology, 44(16), 3875-88. https://doi.org/10.1016/j.molimm.2007.06.005

Thiel, S. (1998). Plasma mannan-binding lectin kills microorganisms. Biomedicine & Pharmacotherapy, 52(1). https://doi.org/10.1016/S0753-3322(97)86243-9

Teillet, F., Lacroix, M., Thiel, S., Weilguny, D., Agger, T., Arlaud, GJ. & Thielens, NM. (2007). Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55. J. Immunol., 78, 5710-6.

Teillet, F., Lacroix, M., Thiel, S., Weilguny, D., Agger, T., Arlaud, G. J. & Thielens, N. M. (2007). Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55. Journal of Immunology, 178(9), 5710-6.

Tang, C., Kwiatkowski, D., Garred, P., Madsen, H. O., Svejgaard, A., Michaelsen, T. E., Hibberd, M. L., Sumiya, M., Summerfield, J. A., Booy, R., Levin, M., Van Helden, P., Hoal-van Helden, E., Kuijper, E. J., Fijen, C. A., Dankert, J., Thiel, S., Megyeri, P., Deli, M. A. & Abraham, C. S. (1999). Mannose-binding lectin and meningococcal disease (multiple letters) [3]. Lancet, 354(9175), 336-338. https://doi.org/10.1016/S0140-6736(05)75240-5

Tan, S. M., Chung, M. C., Kon, O. L., Thiel, S., Lee, S. H. & Lu, J. (1996). Improvements on the purification of mannan-binding lectin and demonstration of its Ca(2+)-independent association with a C1s-like serine protease. Biochemical Journal, 319 ( Pt 2), 329-32.

Takahashi, K., Gordon, J., Liu, H., Sastry, K. N., Epstein, J. E., Motwani, M., Laursen, I., Thiel, S., Jensenius, J. C., Carroll, M. & Ezekowitz, R. A. (2002). Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic periotonitis. Microbes and Infections, 4, 773-784.

Takahashi, K., Gordon, J., Liu, H., Sastry, K. N., Epstein, J. E., Motwani, M., Laursen, I., Thiel, S., Jensenius, J. C., Carroll, M. & Ezekowitz, R. A. B. (2002). Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. Microbes and Infection, 4(8), 773-84.

Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Eppa, Ł., Szala-Poździej, A., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O., Thiel, S., Jensenius, J. C., Kasperkiewicz, K. & Cedzyński, M. (2018). The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT). Frontiers in Immunology, 9(SEP), 2153. Article 2153. https://doi.org/10.3389/fimmu.2018.02153

Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Szala-Poździej, A., Eppa, Ł., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O., Thiel, S., Matsushita, M., Jensenius, J. C. ... Cedzyński, M. (2020). Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations. Frontiers in Immunology, 10, Article 3097. https://doi.org/10.3389/fimmu.2019.03097

Super, M., Thiel, S., Lu, J., Levinsky, R. J. & Turner, M. W. (1989). Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet, 2(8674), 1236-9.

Stover, C., Endo, Y., Takahashi, M., Lynch, N. J., Constantinescu, C., Vorup-Jensen, T., Thiel, S., Friedl, H., Hankeln, T., Hall, R., Gregory, S., Fujita, T. & Schwaeble, W. (2001). The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome1p36.2-3. Genes and Immunity, 2, 119-127.

Stover, C. M., Lynch, N. J., Dahl, M. R., Hanson, S., Takahashi, M., Frankenberger, M., Ziegler-Heitbrock, L., Eperon, I., Thiel, S. & Schwaeble, W. J. (2003). Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single stuctural gene. Genes and Immunity, 48, 374-384.

Stover, C. M., Thiel, S., Thelen, M., Lynch, N. J., Vorup-Jensen, T., Jensenius, J. C. & Schwaeble, W. J. (1999). Two constituents of the initiation complex of the mannan-binding elctin activation pathway of complement are encoded by a single structural gene. J. Immunol., 162, 3481-90.

Stover, C. M., Thiel, S., Lynch, N. J. & Schwaeble, W. J. (1999). The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement. Journal of Immunology, 163(12), 6848-59.

Stover, C. M., Schwaeble, W. J., Lynch, N. J., Thiel, S. & Speicher, M. R. (1999). Assignment of the gene encoding mannan-binding lectin-associated serine protease 2 (MASP2) to human chromosome 1p36.3-->p36.2 by in situ hybridization and somatic cell hybrid analysis. Cytogenetic and Genome Research, 84(3-4), 148-9.

Stover, C. M., Thiel, S., Thelen, M., Lynch, N. J., Vorup-Jensen, T., Jensenius, J. C. & Schwaeble, W. J. (1999). Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. Journal of Immunology, 162(6), 3481-90.

Stover, C. M., Lynch, N. J., Dahl, M. R., Hanson, S. G., Takahashi, M., Frankenberger, M., Ziegler-Heitbrock, L., Eperon, I., Thiel, S. & Schwaeble, W. J. (2003). Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene. Genes and Immunity, 4(5), 374-84. https://doi.org/10.1038/sj.gene.6363970

Displaying results 51 to 100 out of 512

Revised 17.04.2023

Anne Færch Nielsen