Steffen Thiel

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Petri, C., Thiel, S., Jensenius, J. C. & Herlin, T. (2015). Investigation of Complement-activating Pattern Recognition Molecules and Associated Enzymes as Possible Inflammatory Markers in Oligoarticular and Systemic Juvenile Idiopathic Arthritis. Journal of Rheumatology, 42(7), 1252-8. https://doi.org/10.3899/jrheum.141449

Peterslund, N. A., Koch, C., Jensenius, J. C. & Thiel, S. (2001). Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet, 358(9282), 637-638.

Peterslund, N. A., Koch, C., Jensenius, J. C. & Thiel, S. (2001). Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet, 358(9282), 637-8. https://doi.org/10.1016/S0140-6736(01)05785-3

Petersen, S. V., Thiel, S., Jensen, L., Steffensen, R. & Jensenius, J. C. (2001). An assay for the mannan-binding lectin pathway of complement activation. Journal of Immunological Methods, 257, 107-116.

Petersen, S. V., Thiel, S. & Jensenius, J. C. (2001). The mannan-binding lectin pathway of complement activation: biology and disease association. Molecular Immunology, 38, 133-149.

Petersen, S. V., Thiel, S., Jensen, L., Vorup-Jensen, T., Koch, C. & Jensenius, J. C. (2000). Control of the classical and the MBL pathway of complement activation. Mol. Immunol, 37, 803-11.

Petersen, K. A., Matthiesen, F., Agger, T., Kongerslev, L., Thiel, S., Cornelissen, K. & Axelsen, M. (2006). Phase I safety, tolerability and pharmacokinetic study of recombinant human mannan-binding lectin. Clinical Immunology, 26, 465-475.

Petersen, S. V., Thiel, S., Jensen, L., Vorup-Jensen, T., Koch, C. & Jensenius, J. C. (2000). Control of the classical and the MBL pathway of complement activation. Molecular Immunology, 37(14), 803-11.

Petersen, S. V., Thiel, S. & Jensenius, J. C. (2001). The mannan-binding lectin pathway of complement activation: biology and disease association. Molecular Immunology, 38(2-3), 133-49.

Petersen, T., Møller-Larsen, A., Thiel, S., Brudek, T., Hansen, T. K. & Christensen, T. (2009). Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis. Journal of Neuroimmunology, 215(1-2), 108-116. https://doi.org/10.1016/j.jneuroim.2009.08.015

Petersen, T., Møller-Larsen, A., Thiel, S., Hansen, T. K., Ellermann-Eriksen, S., Brudek, T. & Christensen, T. (2011). Innate and adaptive anti-viral immune responses in MS patients treated with interferon-beta. Retrovirology, 8 (Suppl 1), A214.

Petersen, T., Møller-Larsen, A., Ellermann-Eriksen, S., Thiel, S. & Christensen, T. (2012). Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis. Journal of Neuroimmunology, 249(1-2), 105-108. http://www.ncbi.nlm.nih.gov/pubmed/22608883

Petersen, T., Møller-Larsen, A., Thiel, S., Brudek, T., Hansen, T. K. & Christensen, T. (2011). Immune responses to human endogenous retroviruses are associated with disease activity in multiple sclerosis.. Poster session presented at 14th Annual ESCV Meeting, Madeira, Portugal.

Petersen, K. A., Matthiesen, F., Agger, T., Kongerslev, L., Thiel, S., Cornelissen, K. & Axelsen, M. (2006). Phase I safety, tolerability, and pharmacokinetic study of recombinant human mannan-binding lectin. Journal of Clinical Immunology, 26(5), 465-75. https://doi.org/10.1007/s10875-006-9037-z

Pedersen, D. V., Roumenina, L. T., Jensen, R. K., Gadeberg, T. A., Marinozzi, C., Picard, C., Rybkine, T., Thiel, S., Sørensen, U. B., Stover, C., Fremeaux-Bacchi, V. & Andersen, G. R. (2017). Functional and structural insight into properdin control of complement alternative pathway amplification. EMBO Journal, 36(8), 1084-1099. https://doi.org/10.15252/embj.201696173

Pedersen, D. V., Roumenina, L., Jensen, R. K., Gadeberg, T. A. F., Marinozzi, C., Picard, C., Rybkine, T., Thiele, S., Sorensen, U. B. S., Stover, C., Fremeaux-Bacchi, V. & Andersen, G. R. (2017). Structural and functional studies of human complement factor P. Molecular Immunology, 89(Special issue: EMCHD2017), 197-198. https://doi.org/10.1016/j.molimm.2017.06.206

Pedersen, D. V., Gadeberg, T. A. F., Thomas, C., Joram, N., Jensen, R. K., Mazarakis, S. M. M., Revel, M., El Sissy, C., Petersen, S. V., Lindorff-Larsen, K., Thiel, S., Laursen, N. S., Fremeaux-Bacchi, V. & Andersen, G. R. (2019). Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Frontiers in Immunology, 10, Article 2007. https://doi.org/10.3389/fimmu.2019.02007

Pedersen, H., Jensen, R. K., Hansen, A. G., Gadeberg, T. A. F., Thiel, S., Laursen, N. S. & Andersen, G. (2020). A C3 specific nanobody that blocks all three activation pathways in the human and murine complement system. The Journal of Biological Chemistry, 295(26), 8746-8758. https://doi.org/10.1074/jbc.RA119.012339

Pedersen, D. V., Rösner, T., Hansen, A. G., Andersen, K. R., Thiel, S., Andersen, G. R., Valerius, T. & Laursen, N. S. (2020). Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement. Molecular Immunology, 124, 200-210. https://doi.org/10.1016/j.molimm.2020.06.005

Pedersen, H., Jensen, R. K., Jensen, J. M. B., Fox, R., Pedersen, D. V., Olesen, H. G., Hansen, A. G., Christiansen, D., Mazarakis, S. M. M., Lojek, N., Hansen, P., Gadeberg, T. A. F., Zarantonello, A., Laursen, N. S., Mollnes, T. E., Johnson, M. B., Stevens, B., Thiel, S. & Andersen, G. R. (2020). A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. Journal of Immunology, 205(8), 2287-2300. https://doi.org/10.4049/jimmunol.2000752

Pedersen, H., Jensen, R. K., Hansen, A. G., Petersen, S. V., Thiel, S., Laursen, N. S. & Andersen, G. R. (2022). Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Frontiers in Immunology, 13, Article 872536. https://doi.org/10.3389/fimmu.2022.872536

Pedersen, D. V., Gytz, H., Winkler, M. B. L., Zarantonello, A., Baumann, N., Hansen, A. G., Thiel, S., Andersen, G. R., Valerius, T. & Laursen, N. S. (2023). Bispecific Complement Engagers for Targeted Complement Activation. Journal of Immunology, 211(3), 403-413. https://doi.org/10.4049/jimmunol.2200952

Pedersen, K., Laursen, N. S., Hansen, A. G., Palarasah, Y. & Thiel, S. (2024). Development of an immunoassay for quantification of soluble human CD40L (CD154) in plasma and serum samples. Journal of Immunological Methods, 531, Article 113710. https://doi.org/10.1016/j.jim.2024.113710

Pedersen, K., Hansen, A. G., Palarasah, Y., Troldborg, A. & Thiel, S. (2025). Treat-To-Target: Emergence of Second-Generation CD40L Inhibitors for Treatment of SLE-Identifying Beneficial Patient Candidates for CD40L Inhibitors in a Cross-Sectional SLE Cohort. Scandinavian Journal of Immunology, 102(3), Article e70050. https://doi.org/10.1111/sji.70050

Pedersen, K., Green, K., Kristoffersen, E. L., Schinkel, T., Hansen, A. G., Palarasah, Y., Rovsing, A. B., Andersen, E. S., Valero, J., Civit, L., Laursen, N. S., Troldborg, A., Degn, S. E. & Thiel, S. (2026). Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation. European Journal of Immunology, 56(2), Article e70158. https://doi.org/10.1002/eji.70158

Palarasah, Y., Henriksen, A. S. L., Thiel, S., Henriksen, M. & Hansen, S. W. K. (2022). Potency measurements of the complement system facilitated by antibodies targeting the zymogen form of complement factor D (Adipsin). Molecular Immunology, 146, 46-49. https://doi.org/10.1016/j.molimm.2022.04.002

Ovesen, T., Rickers, J., Jensen, J. M., Thiel, S. & Veirum, J. E. (2011). Immunodeficiencies in children with chronic post tympanic otorrhoea. Danish Medical Bulletin, 58(7), A4282.

Ovesen, T., Kragelund, J. R., Jensen, J. M., Thiel, S. & Veirum, J. E. (2011). Kronisk flåd fra mellemøret hos børn kan skyldes primær immundefekt. Ugeskrift for Læger, 173(34).

Ovesen, T., Kragelund, J. R., Jensen, J. M., Thiel, S. & Veirum, J. E. (2011). Immunodeficiencies in children with chronic post tympanic otorrhoea. Danish Medical Journal, 58(7).

Osthoff, M., Wojtowicz, A., Tissot, F., Jørgensen, C., Thiel, S., Zimmerli, S., Marchetti, O., Khanna, N., Bochud, P.-Y., Trendelenburg, M. & Fungal Infection Network of Switzerland (FUNGINOS) (2016). Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland. Journal of Infection, 72(3), 377-385. https://doi.org/10.1016/j.jinf.2015.12.011

Østergaard, J., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2005). Complement activation and diabetic vascular complications. Clin. Chim. Acta., 361, 10-19.

Østergaard, J., Thiel, S., Gadjeva, M., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2007). Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice. Diabetologia, 50(7), 1541-1549.

Østergaard, J., Thiel, S., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2011). Comment on: Lin et al. (2010) Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes;59: 2247-2252. Diabetes, 60(1), e7-8. https://doi.org/10.2337/db10-1298

Østergaard, J., Thiel, S., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2011). The role of complement C3 in the pathogenesis of diabetic kidney disease in a murine model of type 1 diabetes. Diabetes, e7.

Østergaard, J. A., Bjerre, M., RamachandraRao, S. P., Sharma, A. K., Nyengaard, J. R., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2012). Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model. Experimental Diabetes Research, 2012, 678381. https://doi.org/10.1155/2012/678381

Østergaard, J., Bjerre, M., Dagnaes-Hansen, F., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2013). Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes. Scandinavian Journal of Immunology, 77(3), 187-94. https://doi.org/10.1111/sji.12027

Østergaard, J., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2005). Complement activation and diabetic vascular complications. Clinica Chimica Acta, 361(1-2), 10-9. https://doi.org/10.1016/j.cccn.2005.04.028

Østergaard, J. A., Thiel, S., Hovind, P., Holt, C. B., Parving, H.-H., Flyvbjerg, A., Rossing, P. & Hansen, T. K. (2014). Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study. Diabetologia, 57(10), 2201-7. https://doi.org/10.1007/s00125-014-3332-7

Østergaard, J. A., Thiel, S., Lajer, M., Steffensen, R., Parving, H.-H., Flyvbjerg, A., Rossing, P., Tarnow, L. & Hansen, T. K. (2015). Increased All-Cause Mortality in Patients With Type 1 Diabetes and High-Expression Mannan-Binding Lectin Genotypes: A 12-Year Follow-up Study. Diabetes Care, 38(10), 1898-1903. https://doi.org/10.2337/dc15-0851

Østergaard, J. A., Ruseva, M. M., Malik, T. H., Hoffmann-Petersen, I. T., Pickering, M. C., Thiel, S. & Hansen, T. K. (2016). Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model. Journal of Diabetes Research, 2016, 1825738. Article 1825738. https://doi.org/10.1155/2016/1825738

Østergaard, J. A., Jansson Sigfrids, F., Forsblom, C., Dahlström, E. H., Thorn, L. M., Harjutsalo, V., Flyvbjerg, A., Thiel, S., Hansen, T. K. & Groop, P.-H. (2021). The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes. Scientific Reports, 11(1), 8919. Article 8919. https://doi.org/10.1038/s41598-021-88352-y

Ostergaard, J. A., Thiel, S., Hoffmann-Petersen, I. T., Hovind, P., Parving, H.-H., Tarnow, L., Rossing, P. & Hansen, T. K. (2017). Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes. Diabetes/Metabolism Research and Reviews, 33(5), Article e2895 . https://doi.org/10.1002/dmrr.2895

Oroszlán, G., Dani, R., Szilágyi, A., Závodszky, P., Thiel, S., Gál, P. & Dobó, J. (2017). Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism. Frontiers in Immunology, 8(DEC), 1821. Article 1821. https://doi.org/10.3389/fimmu.2017.01821

Olesen, H. V., Jensenius, J. C., Steffensen, R., Thiel, S. & Schiøtz, P. O. (2006). The mannan-binding lectin pathway and lung disease in cystic fibrosis-disfunction of mannan-binding lectin-asssociated serine protease 2 (MASP-2) may be a major modifier. Clinical Immunology, 121, 324-31.

Olesen, H. V., Jensenius, J. C., Steffensen, R., Thiel, S. & Schiøtz, P. O. (2006). The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier. Clinical Immunology, 121(3), 324-31. https://doi.org/10.1016/j.clim.2006.08.014

Nielsen, RG., Vind, I., Munkholm, P., Jensenius, J. C., Thiel, S. & Husby, S. (2007). Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn's disease. Gut, 56, 311-12.

Nielsen, R. G., Vind, I., Munkholm, P., Jensenius, J. C., Thiel, S., Steffensen, R. & Husby, S. (2007). Genetic polymorphisms of mannan binding lectin (MBL), serum levels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn's disease. Gut, 56(2), 311-2. https://doi.org/10.1136/gut.2006.109504

Nielsen, S. L., Andersen, P. L., Koch, C., Jensenius, J. C. & Thiel, S. (1995). The level of the serum opsonin, mannan-binding protein in HIV-1 antibody-positive patients. Clinical and Experimental Immunology, 100(2), 219-22.

Displaying results 151 to 200 out of 512

Revised 17.04.2023

Anne Færch Nielsen