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Plasma mannan-binding lectin levels and activity are increased in allergic patients.
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Erratum: Elevated levels of mannan-binding lectin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL (Clinical and Experimental Immunology (2006) 143, (414-419)).
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Characterization of DNA-protein complexes by nanoparticle tracking analysis and their association with systemic lupus erythematosus.
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Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.
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288(18), 12753-65.
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Pattern Recognition Molecules of the Lectin Pathway-Screening of Patients with Suspected Immunodeficiency.
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POS0059 Complement proteins are elevated in patients with axSpa compared with relevant controls of patients with low back pain and spa-features without axSpa.
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Recombinant mannan-binding lectin (MBL) for therapy.
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M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides.
Virulence,
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A novel nanobody inhibitor of the alternative pathway.
Molecular Immunology,
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A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
Journal of Biological Chemistry,
293(17), 6269-6281.
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Jensen, E. G., Jakobsen, T. S., Thiel, S., Askou, A. L. & Corydon, T. J. (2020).
Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration.
International Journal of Molecular Sciences ,
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Jensen, R. K., Pihl, R., Gadeberg, T. A. F., Jensen, J. K., Andersen, K. R., Thiel, S., Laursen, N. S. & Andersen, G. R. (2023).
Correction: A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement (Journal of Biological Chemistry (2018) 293(17) (6269–6281), (S0021925820397313), (10.1074/jbc.RA117.001179)).
The Journal of Biological Chemistry,
299(2), Article 102951.
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Jensen, M., Eickhoff, M. K., Persson, F., Rossing, P.
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Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort.
Immunobiology,
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, Bech, J. N., Mose, F. H. & Jensen, B. L. (2025).
Pilot Study of Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin Shows Reduced Intrarenal Complement Activation in Patients With Diabetes and CKD.
Kidney International Reports,
10(2), 591-595.
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https://doi.org/10.1016/j.ekir.2024.11.014Jensen, E. G., Jakobsen, T. S., Schnabolk, G., Wilson, K., Rask-Pedersen, M., Jensen, N.
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Nanobody-based gene therapy targeting complement component C3 reduces choroidal neovascularization in mice.
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SGLT-2 inhibitors attenuate pattern recognition molecules collectin kidney 1 and mannose-binding lectin in kidney and liver in mice with diabetes.
American journal of physiology. Renal physiology,
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Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control.
Clinical and Experimental Immunology,
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Diagnostic and Prognostic Value of H-ficolin for Functionally Relevant Coronary Artery Disease.
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, Hejlesen, T. K., Hansen, A. G., Thiel, S. & Mueller, C. (2024).
Diagnostic and prognostic value of mannan-binding lectin associated protein (MAp19) for functionally relevant coronary artery disease.
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Lectin pathway of complement activation and relation with clinical complications in critically ill children.
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The pattern recognition molecule collectin-L1 in critically ill children.
Pediatric Research,
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Use of factorial experimental design to delineate the strong calcium- and pH-dependent changes in binding of human surfactant protein-A to neutral glycosphingolipids--a model for studies of protein-carbohydrate interactions.
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, Skov Sørensen, U. B., Lee, J. C.
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Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Frontiers in Immunology,
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The effect of weight loss on serum mannose-binding lectin levels.
Clinical and Developmental Immunology,
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High mannose-binding lectin early in type 1 diabetes is associated with subsequent development of microalbuminuria in an inception cohort study.
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Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study.
Diabetes,
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Mannan-binding protein and complement dependent opsonization in alcoholic cirrhosis.
Liver International,
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Holt, P., Holmskov, U.
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Purification and characterization of mannan-binding protein from mouse serum.
Scandinavian Journal of Immunology,
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Holt, C. B., Thiel, S., Munk, K., Østergaard, J. A., Bøtker, H. E. & Hansen, T. K. (2014).
Association between endogenous complement inhibitor and myocardial salvage in patients with myocardial infarction.
European Heart Journal: Acute Cardiovascular Care,
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Holt, C. B., Østergaard, J. A., Axelgaard, E., Nielsen, G. K., Endo, Y.
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Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes.
Mediators of Inflammation,
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Holt, C. B., Hoffmann-Petersen, I. T., Hansen, T. K., Parving, H.-H.
, Thiel, S., Hovind, P., Tarnow, L., Rossing, P.
& Østergaard, J. A. (2020).
Association between severe diabetic retinopathy and lectin pathway proteins - an 18-year follow-up study with newly diagnosed type 1 diabetes patients.
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MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes.
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Holers, V. M., Borodovsky, A., Scheinman, R. I., Ho, N., Ramirez, J. R., Dobó, J., Gál, P., Lindenberger, J.
, Hansen, A. G., Desai, D.
, Pihl, R., Thiel, S. & Banda, N. K. (2020).
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D.
Frontiers in Immunology,
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, Thiel, S., Hansen, T. K. & Østergaard, J. A. (2021).
Effect of dipeptidyl peptidase-4 inhibitors on complement activation.
Diabetes/Metabolism Research and Reviews,
37(3), Article e3385.
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Hjelmesæth, J., Ueland, T.
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, Hansen, T. K., Thiel, S., Sagedal, S., Røislien, J. & Hartmann, A. (2006).
Early posttransplant serum osteoprotegerin levels predict long-term (8-yr) patient survival and cardiovascular death in renal transplant patients.
Journal of the American Society of Nephrology,
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Hjelmesaeth, J., Ueland, T.
, Flyvbjerg, A., Bollerslev, J., Leivestad, T., Jenssen, T.
, Hansen, T. K., Thiel, S., Sagedal, S., Røislien, J. & Hartmann, A. (2006).
Early posttransplant serum osteoprotegerin levels predict long-term (8-year) patient survival and cardiovascular death in renal transplant patients.
Journal of the American Society of Nephrology,
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, Hoffmann-Petersen, I. T., Thiel, S., Stehouwer, C. D. A. & Van Greevenbroek, M. M. J. (2016).
Distinct longitudinal associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 with endothelial dysfunction and intima-media thickness.
Arteriosclerosis, Thrombosis, and Vascular Biology,
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, Pedersen, D., Andersen, G. R., Thiel, S., Palarasah, Y. & Hansen, S. W. K. (2022).
Quantification of the pro-form of human complement component factor D (adipsin).
Journal of Immunological Methods,
507, Article 113295.
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, Nielsen, K. R., Steffensen, R., Van Steen, K., Mathieu, C., Giulietti, A., Wouters, P. J., Milants, I., Vanhorebeek, I., Langouche, L., Vermeire, S., Rutgeerts, P.
, Thiel, S., Wilmer, A.
, Hansen, T. K. & Van den Berghe, G. (2009).
Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit.
Critical Care Medicine,
37(1), 192-201, e1-3.
https://doi.org/10.1097/CCM.0b013e31819263d8
