JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Gonçalves, N. P., Yan, Y., Ulrichsen, M., Venø, M. T., Poulsen, E. T., Enghild, J. J., Kjems, J. & Vægter, C. B. (2020). Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin. Biomedicines, 8(11), 1-24. Article 450. https://doi.org/10.3390/biomedicines8110450

Yan, Y., Chang, C., Su, J., Venø, M. T. & Kjems, J. (2020). Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs). Biomedicines, 8(10), 1-17. Article 387. https://doi.org/10.3390/biomedicines8100387

Godskesen, L. E., Lassen, T. R., Jespersen, N. R., Siersbæk, M., Yan, Y., Nielsen, M. M., Tjønnfjord, S. K., Grøntved, L., Madsen, G., Kjems, J., Bøtker, H. E., Schmidt, M. R., Krag, A. & Kjeldsen, J. (2020). Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial. Scientific Reports, 10(1), Article 9537. https://doi.org/10.1038/s41598-020-65692-9

Kristensen, L. S., Ebbesen, K. K., Sokol, M., Jakobsen, T., Korsgaard, U., Eriksen, A. C., Hansen, T. B., Kjems, J. & Hager, H. (2020). Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. Nature Communications, 11, Article 4551. https://doi.org/10.1038/s41467-020-18355-2

Thomsen, R. P., Malle, M. G., Okholm, A. H., Krishnan, S., Bohr, S. S. R., Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, N. S. & Kjems, J. (2019). A large size-selective DNA nanopore with sensing applications. Nature Communications, 10(1), Article 5655. https://doi.org/10.1038/s41467-019-13284-1

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Full list of publications

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Revised 08.12.2025

Rikke Ploug Frydenberg