JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Jiang, Y. & Kjems, J. (2025). RNA denaturation underlies circular RNA separation. Nucleic Acids Research, 53(21), Article gkaf1160. https://doi.org/10.1093/nar/gkaf1160

Stenberg, K., Korhonen, S., Seemab, U., Dupont, D. M., Kjems, J., Honkakoski, P. & Subrizi, A. (2025). Selection of locally administered ocular tissue-targeting RNA aptamers using in vivo SELEX. European Journal of Pharmaceutical Sciences, 212, Article 107217. https://doi.org/10.1016/j.ejps.2025.107217

Baindoor, S., Gibriel, H. A. Y., Kool, L., Su, J., Demaegd, K. C., Venø, M. T., Van Den Berg, L. H., Kjems, J., Van Es, M. A. & Prehn, J. H. M. (2025). Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. Advance online publication. https://doi.org/10.1080/21678421.2025.2574690

Bro̷chner, B. V., Zhang, X., Nielsen, J., Kjems, J., Otzen, D. E. & Malle, M. G. (2025). Single-vesicle Tracking of α-Synuclein Oligomers Reveals Pore Formation by a Three-Stage Model. ACS Nano, 19(36), 32108-32122. https://doi.org/10.1021/acsnano.5c04005

Zaheer, S., Baindoor, S., Connolly, N. M. C., Siebenbrodt, K., Bauer, S., Rosenow, F., Andersen, J. S., Venø, M. T., Kjems, J., Henshall, D. C. & Prehn, J. H. M. (2025). Temporal Dynamics of tsRNA Regulation Mark an Abrupt Transition After Epileptogenesis. Journal of Neurochemistry, 169(12), Article e70317. https://doi.org/10.1111/jnc.70317

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Revised 08.12.2025

Rikke Ploug Frydenberg