JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Zhang, X., Malle, M. G., Thomsen, R. P., Sørensen, R. S., Sørensen, E. W., Hatzakis, N. S. & Kjems, J. (2024). Deconvoluting the Effect of Cell-Penetrating Peptides for Enhanced and Controlled Insertion of Large-Scale DNA Nanopores. A C S Applied Materials and Interfaces, 16(15), 18422-18433. https://doi.org/10.1021/acsami.3c18636

Baindoor, S., Gibriel, H. A. Y., Venø, M. T., Su, J., Morrissey, E. P., Jirström, E., Woods, I., Kenny, A., Alves, M., Halang, L., Fabbrizio, P., Bilen, M., Engel, T., Hogg, M. C., Bendotti, C., Nardo, G., Slack, R. S., Kjems, J. & Prehn, J. H. M. (2024). Distinct fingerprints of tRNA-derived small non-coding RNA in animal models of neurodegeneration. Disease Models & Mechanisms, 17(11), Article dmm050870. https://doi.org/10.1242/dmm.050870

Smidt, J. M., Märcher, A., Skaanning, M. K., El-Chami, K., Teodori, L., Omer, M., Kjems, J. & Gothelf, K. V. (2024). Dual-Targeting of the HER2 Cancer Receptor with an Antibody-Directed Enzyme and a Nanobody-Guided MMAE Prodrug Scaffold. ChemBioChem, 25(18), Article e202400437. https://doi.org/10.1002/cbic.202400437

Khemka, N., Morris, G., Kazemzadeh, L., Costard, L. S., Neubert, V., Bauer, S., Rosenow, F., Venø, M. T., Kjems, J., Henshall, D. C., Prehn, J. H. M. & Connolly, N. M. C. (2024). Integrative network analysis of miRNA-mRNA expression profiles during epileptogenesis in rats reveals therapeutic targets after emergence of first spontaneous seizure. Scientific Reports, 14(1), Article 15313. https://doi.org/10.1038/s41598-024-66117-7

Teodori, L., Kroer, S., Omer, M., Andersen, V. L., Bech, P., Su, J., Bridoux, J., Nielsen, J. S., Bertelsen, M. B., Hernot, S., Gothelf, K. V. & Kjems, J. (2024). Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imaging. Molecular Therapy - Nucleic Acids, 35(3), Article 102305. https://doi.org/10.1016/j.omtn.2024.102305

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Full list of publications

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Revised 08.12.2025

Rikke Ploug Frydenberg