JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Seeler, S., Andersen, M. S., Sztanka-Toth, T., Rybiczka-Tešulov, M., van den Munkhof, M. H., Chang, C. C., Maimaitili, M., Venø, M. T., Hansen, T. B., Pasterkamp, R. J., Rybak-Wolf, A., Denham, M., Rajewsky, N., Kristensen, L. S. & Kjems, J. (2023). A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development. Molecular Neurobiology, 60(6), 3239–3260. https://doi.org/10.1007/s12035-023-03253-7

Ferapontov, A., Omer, M., Baudrexel, I., Nielsen, J. S., Dupont, D. M., Juul-Madsen, K., Steen, P., Eklund, A. S., Thiel, S., Vorup-Jensen, T., Jungmann, R., Kjems, J. & Degn, S. E. (2023). Antigen footprint governs activation of the B cell receptor. Nature Communications, 14(1), Article 976. https://doi.org/10.1038/s41467-023-36672-0

Catapano, C., Rahm, J. V., Omer, M., Teodori, L., Kjems, J., Dietz, M. S. & Heilemann, M. (2023). Biased activation of the receptor tyrosine kinase HER2. Cellular and Molecular Life Sciences, 80(6), Article 158. https://doi.org/10.1007/s00018-023-04806-8

Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Kristensen, L. S., Vang, S., Park, S. S., Yeo, G. W., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2023). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. https://doi.org/10.1101/2023.09.14.557527

Tolomeo, D., Traversa, D., Venuto, S., Ebbesen, K., Garcia Rodriguez, J. L., Tamma, G., Ranieri, M., Simonetti, G., Ghetti, M., Paganelli, M., Visci, G., Liso, A., Kok, K., Muscarella, L. A., Fabrizio, F. P., Frassanito, M. A., Lamanuzzi, A., Saltarella, I., Solimando, A. G. ... Storlazzi, C. T. (2023). circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer. Genes, Chromosomes & Cancer, 62(7), 377-391. https://doi.org/10.1002/gcc.23121

Displaying results 36 to 40 out of 432

Full list of publications

Group leader

Group members

Lab website

Revised 08.12.2025

Rikke Ploug Frydenberg