Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Lieberoth, A & Rasmussen, P 2026, Skærme i skolen: et review af empiriske studier. in Pædagogisk Indblik. Aarhus Universitetsforlag, Pædagogisk Indblik.

Boisen Andersen, D & Hvid, VL 2026, Skal vi gentænke det danske vaccinationsprogram for børn?. Videnskab.dk.

Bregnballe, T & Holm, TE 2026, Skestork, overvågning af ynglefugle. DCE, Teknisk anvisning fra Fagdatacenter for Biodiversitet og Terrestrisk Natur, no. A106, vers. 4, Aarhus University, DCE - Danish Centre for Environment and Energy. <https://ecos.au.dk/fileadmin/ecos/Fagdatacentre/Biodiversitet/TAA106_Skestork_v4.pdf>

Pedersen, AF & Vedsted, P 2026, 'Skill mix in primary care, working hours, time used on management, and burnout among general practitioners', Family Practice, vol. 43, no. 1, cmaf099. https://doi.org/10.1093/fampra/cmaf099

Knage, FS & Schmiegelow, T 2026, Skolefravær: apparater og afprøvninger. in D Kousholt (ed.), Pædagogisk psykologisk rådgivning. Hans Reitzels Forlag.

Christensen, N 2026, 'Skolens hjerte', Skolebiblioteket, vol. 54, no. 1, pp. 4-4.

Vilmar, TW 2026, 'Skønhed i forrådnelse', Seismograf/DMT. <https://seismograf.org/da/kortkritik/skoenhed-i-forraadnelse>

Andersen, FØ 2026, 'Slægtsforskning ved hjælp af Forsvarets 'blå bøger'', Slægtsforskeren, vol. 41, no. 1, pp. 17-18.

Anukam, DC, Nianogo, RA, Arah, OA, Boutros, PC, Rao, J, Fowke, JH & Zhang, ZF 2026, 'Sleep Duration and Prostate Cancer Risk in the Southern Community Cohort Study', Cancer medicine, vol. 15, no. 1, e71466. https://doi.org/10.1002/cam4.71466

Abram, D, Malavolta, G & Roy, L 2026, Slightly Sublinear Trapdoor Hash Functions and PIR from Low-Noise LPN. in B Applebaum & H Lin (eds), Theory of Cryptography - 23rd International Conference, TCC 2025, Proceedings. Springer Science+Business Media, Lecture Notes in Computer Science, vol. 16268 LNCS, pp. 280-300, 23rd International Conference on Theory of Cryptography, TCC 2025, Aarhus, Denmark, 01/12/2025. https://doi.org/10.1007/978-3-032-12287-2_10

Sanderson, H , Costa Moreira Maia, M , Dugasseh, FA , Asiedu, DA & Aagaard, A 2026, 'Small and Medium-Sized Enterprises Climate Accounting Made Easy', Climate, vol. 14, no. 1, 26. https://doi.org/10.3390/cli14010026

Fiałkowska-Filipek, M, Karpavičė, J & Wangwacharakul, P 2026, 'Smart packaging as a digital enabler for circularity in sustainable supply chains', Cleaner Logistics and Supply Chain, vol. 18, 100299. https://doi.org/10.1016/j.clscn.2026.100299

Runge, N & Størup, JO 2026, 'Smooth spaces and jagged edges: Conceptualising a topography of everyday agency and wellbeing in school life', The Nordic Educational Research Association (NERA) Conference 2026 , Aarhus, Denmark, 04/03/2026 - 06/03/2026.

Jeppesen, T 2026 'SMV’ers eksport til USA i en ny handelspolitisk virkelighed' Center for Erhvervsøkonomisk Forskning og Analyse (CEFAU), Aarhus Universitet, Aarhus. <https://econ.au.dk/da/cefau/aktiviteter/vis/artikel/smvers-eksport-til-usa-i-en-ny-handelspolitisk-virkelighed>

Zhao, JW, Benetti, S, Cai, YZ, Pastorello, A, Elias-Rosa, N, Reguitti, A, Valerin, G, Wang, ZY, Cappellaro, E, Feng, GF, Fiore, A, Fitzpatrick, B, Fraser, M, Isern, J, Kankare, E, Kravtsov, T, Kumar, B, Lundqvist, P, Matilainen, K, Mattila, S, Mazzali, PA, Moran, S, Ochner, P, Peng, ZH, Reynolds, TM, Salmaso, I, Srivastav, S, Stritzinger, MD, Taubenberger, S, Tomasella, L, Vinkó, J, Wheeler, JC, Williams, S, Pei, SP, Yang, YP, Liu, XW, Liu, XW & Yang, YP 2026, 'SN 2022ngb: A faint, slowly evolving Type IIb supernova with a low-mass envelope', Astronomy and Astrophysics, vol. 706, A271. https://doi.org/10.1051/0004-6361/202557619

Kangas, T, Charalampopoulos, P, Nagao, T, Yan, L, Stritzinger, M, Schulze, S, Das, K, Elias-Rosa, N, Fremling, C, Perley, D, Sollerman, J, Müller-Bravo, TE, Galbany, L, Groom, SL, Gutiérrez, CP, Kasliwal, MM, Kotak, R, Laher, RR, Lundqvist, P, Mattila, S & Smith, R 2026, 'SN 2023gpw: Exploring the diversity and power sources of hydrogen-rich superluminous supernovae', Astronomy and Astrophysics, vol. 705, A52. https://doi.org/10.1051/0004-6361/202555588

Elklit, J 2026, snap election in Denmark results in a very fragmented parliament. <https://whogoverns.eu/snap-election-in-denmark-a-very-fragmented-parliament/>

Spotti, C & de Borbon, M 2026 'SNC Kähler-Einstein metrics and RCD spaces' ArXiv. https://doi.org/10.48550/arXiv.2601.18741

Ma, X, Räisänen, SE, Wang, K, Harrison, MA, Zimmerman, S & Niu, M 2026, 'Sniffer position in an automated milking system affects the variability, repeatability, and consistent ranking of enteric methane emission measurements of dairy cows', Journal of Dairy Science, vol. 109, no. 3, pp. 2669-2687. https://doi.org/10.3168/jds.2025-27302

Søndergaard, M & Jeppesen, E 2026, 'Søbygård Sø: den lange vej mod bedring', Vand & Jord, vol. 33, no. 1 (feb. 2026), pp. 3-7.

Alsner, KB , Laustsen, LM , Lasgaard, M, Grønkjær, MS & Plana-Ripoll, O 2026, 'Social disconnection and subsequent mental disorders: a population-based cohort study', Social Psychiatry and Psychiatric Epidemiology. https://doi.org/10.1007/s00127-026-03046-y

Madhavan, M, Hornátová, L, Šálek, M, Průchová, A & Linhart, P 2026, 'Social environment affects vocal individuality in a non-learning species', Scientific Reports, vol. 16, no. 1, 51. https://doi.org/10.1038/s41598-025-29387-3

Svendsen, ML , Refsgaard, J, Bredsgaard, M & Maribo, T 2026, 'Social Inequality in the Comprehensive Cardiac Rehabilitation Pathway: A Nationwide Cohort Study Across Hospitals and Primary Health Care Centers', Journal of Cardiopulmonary Rehabilitation and Prevention. https://doi.org/10.1097/HCR.0000000000001019

Bach, JS 2026, 'Social Investment Logics, Potential and Ageing: A Commentary', Nordic Studies on Alcohol and Drugs (NAD), vol. 43, no. 1, pp. 120-122. https://doi.org/10.1177/14550725251415458

Knudsen, NK 2026, Social Ontology and the Indispensability of Experience. in TJ Spiegel (ed.), Social Ontology and Phenomenology . Routledge.

Rasmussen, LG , Nielsen, RO, Hawkins, J, Kallestrup, P, Midtgaard, J & Ryom, K 2026, 'Social prescribing initiatives connecting general practice patients with community-based physical activity: A scoping review with expert interviews', Scandinavian Journal of Public Health, vol. 54, no. 2, pp. 189-209. https://doi.org/10.1177/14034948241299878

Møller, J & Skaaning, S-E 2026, Social Science History: Principles and Procedures for Processing Historical Evidence. Cambridge University Press.

Bjørnskov, C & Svendsen, GT 2026, Social Trust in the Nordic World. Aarhus Universitetsforlag.

Håkansson, KEJ, Ibsen, R, Krogh, NS, Søndergaard, MB, Hansen, S, Bjerrum, AS, von Bülow, A, Hilberg, O, Løkke, A, Bonnesen, B, Kappel, ME, Johansson, SL, Dongo, L, Borup, MB, Vijdea, R, Rasmussen, LM, Schmid, JM, Ulrik, CS & Porsbjerg, C 2026, 'Societal and personal financial burden of severe asthma and impact of biologic therapy: a 19-year nationwide cost analysis', BMJ Open Respiratory Research, vol. 13, no. 1. https://doi.org/10.1136/bmjresp-2025-003867

Mungi, NA, Jhala, YV, Svenning, JC & Qureshi, Q 2026, 'Socioecological risks amplified by rising plant invasions in India', Nature Sustainability, vol. 9, no. 1, pp. 130-141. https://doi.org/10.1038/s41893-025-01690-x

Hjorth, CF , Bakos, I & Cronin-Fenton, D 2026, 'Socioeconomic differences in labour market attachment after breast cancer: a population-based matched cohort study', Supportive Care in Cancer, vol. 34, no. 3, 212. https://doi.org/10.1007/s00520-026-10411-9

Martiny, SK , Schmidt, M , Povlsen, JA , Søgaard, KK , Bøtker, HE & Sørensen, HT 2026, 'Socioeconomic disparities in long-term mortality after infective endocarditis in Denmark: a nationwide cohort study', The Lancet Regional Health - Europe, vol. 62, 101568. https://doi.org/10.1016/j.lanepe.2025.101568

Losi, L 2026, 'Socio-economic status and authority deference: Understanding public (dis)engagement with science in Europe', Public Understanding of Science, vol. 35, no. 3, pp. 313-332. https://doi.org/10.1177/09636625251374514

Hejná, M 2026, Sociolinguistics of voice quality: an interdisciplinary perspective. in A Zabrodskaja (ed.), Research Handbook on Sociolinguistics. Edward Elgar Publishing.

Abraham, AJ, Hempson, GP, le Roux, E , Maré, C, Taylor, LL, Webster, AB, Duvall, ES, Prys-Jones, T, Coppock, J, Ridenour, C, de Jager, P, Augustine, D, Chapman, CA, Fashing, PJ, Harfoot, MBJ, Holdo, RM, Hopcraft, JGC, Johnson, C, van Langevelde, F, Malhi, Y, Morel, A, Nguyen, N, Owen-Smith, N, Potter, AB, Prins, HHT, Rothman, JM, Swedell, L, Svenning, JC, Thomson, ER, van der Plas, F, Veldhuis, MP, Pringle, RM, Clauss, M & Doughty, CE 2026, 'Sodium constraints on megaherbivore communities in Africa', Nature Ecology and Evolution, vol. 10, no. 1, pp. 105-116. https://doi.org/10.1038/s41559-025-02917-y

Duus, CL , Nielsen, SF , Lyksholm, TZ , Mose, FH & Bech, JN 2026, 'Sodium reduction is the key ingredient in dietary treatment of hypertension: a randomized controlled trial on sodium, potassium and nitrate', Journal of Human Hypertension, vol. 40, no. 2, pp. 110-117. https://doi.org/10.1038/s41371-025-01104-7

Ranheim Sveen, T, Madsen, IJ, Gustavsson, E, Cousins, S, Buegger, F, Pritsch, K, Riggi, L, Bengtsson, J, Viketoft, M & Bahram, M 2026, 'Soil-Borne Pathogens Reflect Agricultural Land-Use Legacies', Ecology Letters, vol. 29, no. 2, e70332, pp. e70332. https://doi.org/10.1111/ele.70332

Juelskjær, M 2026, Soil care relations. Remakings at an agricultural plot. in S Bauer, N Sørensen Vaage & D Münster (eds), Liveable Soils Through Technologies of Care: Rethinking Remediation in the Anthropocene.. Amsterdam University Press, pp. 1-19.

Marras, GB, Sulas, F, French, C, Skinner, L, Gustafson, J, Stoddart, S & Parkinson, E 2026, 'Soil development trajectories, valley alluviation, and the rise and fall of bronze age nuragic monuments: a geoarchaeological case study from the basaltic mesa of siddi, sardinia', Catena, vol. 267, 109977. https://doi.org/10.1016/j.catena.2026.109977

Zhang, Y, Sun, S, Zhou, J, van Groenigen, KJ, Delgado-Baquerizo, M, Ma, Y, Moorhead, DL, Hungate, BA, Smith, P, Terrer, C, Liu, J, Sinsabaugh, RL, Guo, L, Ochoa-Hueso, R, Power, SA, Eivind Olesen, J, Luo, Y, Cao, J, Jiang, M, Feng, Z, Luo, M & Chen, J 2026, 'Soil extracellular enzymes drive soil carbon accumulation under elevated CO₂', Functional Ecology, vol. 40, no. 2, pp. 347-359. https://doi.org/10.1111/1365-2435.70249

Webster, AB, Bennett, NC, Clauss, M, Ganswindt, A & Abraham, AJ 2026, 'Soil ingestion: An important contamination pathway for toxic element exposure in wild herbivores', Science of the Total Environment, vol. 1012, 181193. https://doi.org/10.1016/j.scitotenv.2025.181193

Liu, C, Parr, CL, Guénard, B, Cen, X, Chai, H, Li, M, Zhong, Z, Zhao, S, Li, J & He, N 2026, 'Soil Invertebrate Body Size Groups and Effect Magnitude Jointly Influence Global Soil CO₂ Emissions', Global change biology, vol. 32, no. 2, e70770. https://doi.org/10.1111/gcb.70770

Barreras, A, Gutiérrez, S, Vázquez-Lule, A, Gómez-Tagle, A, Delgado, T, Kolb, M, Tarin, T, Torres-Gómez, M, Figueroa, D, Prado, B & Guevara, M 2026, 'Soil moisture decline across the Avocado “Green Gold Belt” in central Mexico', npj Sustainable Agriculture, vol. 4, no. 1, 24. https://doi.org/10.1038/s44264-026-00138-9

McMichael, CNH, Guerra, D, Witteveen, NH, Heijink, BM, Zwarts, A, Zuquim, G, Balslev, H , Ruokolainen, K & Tuomisto, H 2026, 'Soil phytolith assemblages reflect palm community composition in western Amazonia', Review of Palaeobotany and Palynology, vol. 344, 105443. https://doi.org/10.1016/j.revpalbo.2025.105443

Andersen, JE , Sapkota, R , Zervas, A & Winding, A 2026, 'Soil tillage promotes predatory and phototrophic protists over parasitic protists', European Journal of Soil Biology, vol. 128, 103813. https://doi.org/10.1016/j.ejsobi.2026.103813

Selover, M, Leggett-James, MP, Højen, A , Bleses, D & Laursen, B 2026, 'Solitary Screen Time Exacerbates Later Socioemotional Problems in Young Children with Oral Language Difficulties', Research on Child and Adolescent Psychopathology, vol. 54, no. 2, 44. https://doi.org/10.1007/s10802-025-01409-8

Egense, T, Eskildsen, T, Lauridsen, J, O'Brien, B, Jackson, A, Bellony, L, Thøgersen, J & Johnston, VH, SolrWayback, 2026, Computer programme. https://doi.org/10.5281/zenodo.18197486

Lauridsen, EHE , Gantzel, RH, Suarez-Zdunek, MA, Nielsen, MB, Rasmussen, A, Nielsen, SD, Grønbæk, H & Villadsen, GE 2026, 'Soluble CD163 as a Biomarker of Liver Fibrosis and Inflammation in Liver Transplant Recipients', Clinical Transplantation, vol. 40, no. 2, e70468. https://doi.org/10.1111/ctr.70468

Ahrenfeldt, E, Hvid, M , Jurik, AG, Syrbe, U, Poddubnyy, D, Østgård, R , Deleuran, B & Greisen, SR 2026, 'Soluble programmed cell death-1 is increased in axial spondyloarthritis and present at the local site of pathology', Scandinavian Journal of Rheumatology. https://doi.org/10.1080/03009742.2025.2599026

de Waal, MWJ, van der Lee, SJ, Lunding, M, Boonkamp, L, Barrett, N, Monti, G , Jensen, AMG , Vaegter, CB, Raska, J, Cesnarikova, S, Sedmik, J, Trieu, C, Weiss, MM, van Spaendonk, R, Vermunt, L, Ozhegov, G, Tesi, N, Hulsman, M, Januliene, D, Moller, A, Bohaciakova, D, van der Flier, WM, Andersen, OM, Teunissen, CE & Holstege, H 2026, 'Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants', Alzheimer's & Dementia, vol. 22, no. 2, e71042. https://doi.org/10.1002/alz.71042

Displaying results 3151 to 3200 out of 389733

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen