Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Simpson, EL, Bissonnette, R, Deleuran, M, Nakahara, T, Galus, R, de Bruin-Weller, M, Coleman, A, van Spall, M, Chen, Z, Avetisova, E, Bastian, M & Khokhar, FA 2026, 'Dupilumab Treatment Up to 5 Years Shows No Clinically Meaningful Changes in Laboratory Parameters in Adults with Moderate-to-Severe Atopic Dermatitis', Advances in Therapy, vol. 43, no. 3, pp. 1213-1238. https://doi.org/10.1007/s12325-025-03458-3

Vestergård, NF 2026, 'Durable Resistance to Zymoseptoria tritici in Winter Wheat: Integrating Pathogen Diversity, Molecular Markers, and Variety Mixtures’', PhD, Aarhus University.

Ciobotaru, C-G & Le Bars, C 2026 'Dynamical boundaries of affine buildings: C*-simplicity and Poisson boundaries'. <https://arxiv.org/abs/2601.13092>

Salimi, M, Pedersen, AB, Andersen, JEV , Pedersen, HB & Dantan, AR 2026, 'Dynamical measurement of saturation vapor pressures below and above room temperature', Review of Scientific Instruments, vol. 97, no. 3, 035201, pp. 035201. https://doi.org/10.1063/5.0295293

Nicolaisen, PB 2026, 'Dynamic Diversity or Malfunctional Mixing? Challenging the Conventions of Focus Group Composition', International Journal of Qualitative Methods, vol. 25. https://doi.org/10.1177/16094069251411160

Harbo, T & IGOS Consortium 2026, 'Dynamics of Nerve Conduction Studies in Patients With Guillain–Barré Syndrome', Muscle and Nerve. https://doi.org/10.1002/mus.70152

Laugesen, K , Hansen, SB , Bislev, LS , Jørgensen, JOL & Ladefoged, SA 2026, 'Dynamic testing of cortisol in consecutive patients with suspected adrenal disorders: a comparison of Elecsys Cortisol II and LC-MS/MS', Endocrine Connections, vol. 15, no. 1, e250600 . https://doi.org/10.1530/EC-25-0600

Kristensen, M , Wright, TD , Gomes, C , Esterle, L & Larsen, PG 2026, DynSRV: Dynamically Updated Properties for Stream Runtime Verification. in B Könighofer & H Torfah (eds), Runtime Verification - 25th International Conference, RV 2025, Proceedings. Springer, Lecture Notes in Computer Science, vol. 16087, pp. 101-119. https://doi.org/10.1007/978-3-032-05435-7_7

Krogh, MA 2026, 'Dyrebaserede Velfærdsindikatorer - er sensorteknologi en løsning?', No. 2024-0787434, 12 p., Jan 15, 2026. Rådgivningsnotat fra DCA - Nationalt Center for Fødevarer og Jordbrug.

Alstrup, AKO 2026, 'Dyremodeller for Parkinsons og Alzheimers sygdomme', Dyrlægen.

Alstrup, AKO 2026, Dyrevelfærdsorganer. in Dyrevelfærdsorgan. <https://lex.dk/.versionview/2554109?pk_vid=1c041c3d1680688117743449401b5ffc>

Varga, S & Steglich-Petersen, A 2026, 'Dysregulation of Epistemic Emotions in ADHD: Towards an Integrative Model', Review of Philosophy and Psychology. https://doi.org/10.1007/s13164-025-00797-6

Cominetti, E, Simplicio, M, Aranha, DF, Matias, P & Araujo, R 2026, E2Easy: a simple lattice-based in-person end-to-end voting scheme. in B Haslhofer, J Xu, F Victor, M Bartoletti, A Bracciali, K Matsuura, J Nabrzyski, V Estrada-Galiñanes, C Tessone, J Budurushi & K Marky (eds), Financial Cryptography and Data Security. FC 2025 International Workshops - CoDecFin, FinTeAchin, VOTING, 2025, Revised Selected Papers. Springer, pp. 281-296. https://doi.org/10.1007/978-3-032-00495-6_16

Wall, H, Ivarsson, E, Sun, L, Boyner, M, Naghizadeh, M , Dalgaard, TS & Wattrang, E 2026, 'Early access to feed, water and Neurospora intermedia in broiler starter diet (part II)–caecal microbiota, antibody production and blood leukocyte counts', British Poultry Science. https://doi.org/10.1080/00071668.2025.2595642

Rogers, M, Dolidze, K, Mus-Rasmussen, A, Dovigo, F & Doan, L 2026, 'Early childhood educators’ understandings of quality in five countries: similarities and differences to policy', European Early Childhood Education Research Journal (EECERJ), vol. 34, no. 1, pp. 19-35. https://doi.org/10.1080/1350293X.2025.2484241

Beske, RP, Klein, A, Jensen, LO, Eiskjær, H, Mangner, N, Polzin, A, Schulze, PC, Skurk, C, Nordbeck, P, Schrage, B, Panoulas, V, Zimmer, S, Schäfer, A, Hassager, C & Møller, JE 2026, 'Early clinical recovery in STEMI cardiogenic shock: insights from the DanGer shock trial', European heart journal. Acute cardiovascular care. https://doi.org/10.1093/ehjacc/zuag029

Miger, K, Fabricius-Bjerre, A, Olesen, ASO, Nielsen, R, Fredriksen, CA, Pryds, K, Petersen, J & Nielsen, OW 2026, 'Early Detection of Pulmonary Congestion Using Quantitative CT and Lung US in a Porcine Model', Radiology: Cardiothoracic Imaging, vol. 8, no. 1, e240529. https://doi.org/10.1148/ryct.240529

Power, MC, Madsen, M, Bødkergaard, K, Zimmerman, SC, Ackley, SF, Gilsanz, P, Glymour, MM, Henderson, VW , Sørensen, HT & Thomsen, RW 2026, 'Early glycemic control and subsequent risk of incident dementia among new metformin users', American Journal of Medicine, vol. 139, no. 3, pp. 321-332. https://doi.org/10.1016/j.amjmed.2025.10.017

Laue, HE, Kook, D, Khatchikian, C, Coto, SD, Jackson, BP, Palys, TJ, Peacock, JL, Karagas, MR, O'Toole, GA, Hoen, AG & Madan, JC 2026, 'Early-life arsenic exposure modulates the developing microbiome in a rural cohort', Environmental Research, vol. 291, 123588. https://doi.org/10.1016/j.envres.2025.123588

Kubincova, B, Muerner, M, Ma, J, Mueller, J, Šećerović, A, Farshad, M & Grad, S 2026, 'Early markers of mechanical modulation in whole bovine intervertebral discs loaded in a multiaxial bioreactor', European Spine Journal. https://doi.org/10.1007/s00586-025-09676-1

Kristensen, HN , Aarhus, R , Bloch-Nielsen, JR , Maribo, T & Schmidt, AM 2026, 'Early Needs’ Assessment in Patients With Non‐Specific Symptoms of Cancer: An Explorative Study', Physiotherapy Research International, vol. 31, no. 1, e70136. https://doi.org/10.1002/pri.70136

VERITAS Investigators 2026, 'Early Outcomes With a Next-Generation Dual-Seal Left Atrial Appendage Occluder: Results From the VERITAS Study', JACC: Clinical Electrophysiology. https://doi.org/10.1016/j.jacep.2026.01.021

Theilgaard, ZP, Weis, N, Ravn, P, Bernhard, PH, Jørgensen, NP, Knudsen, JA, Öbrink-Hansen, K, Ørsted, I, Schønning, K, Johansen, IS & Lebech, A-M 2026, 'Early shift to oral antibiotic treatment for pyogenic vertebral osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial', Trials, vol. 27, no. 1, 36. https://doi.org/10.1186/s13063-025-09316-5

Krogh, PH, Petersen, CT, Olsen, J & Jørgensen, PR 2026, 'Earthworm Burrows in Glacial Till Soils: Spatial Distribution and Hydrological Function', Ecohydrology, vol. 19, no. 1, e70168, pp. 1-10. https://doi.org/10.1002/eco.70168

Hemme, MS & Munkholm, NV 2026, ECE report on teacher's working time in Denmark.

Trepel, J 2026, 'Ecological Dynamics in a Novel Biosphere: Large Herbivores as Drivers of Vegetation Structure and Plant Diversity', PhD, Aarhus University.

Heikkinen, H, Helms-Lorenz, M, Plauborg, H & Bjerkholt, E 2026, Ecologies of Teacher Induction and Mentoring in Europe: Understanding the Co-existence of Diverse Practices. in Making Sense of European Teacher Induction and Mentoring Practices. Brill, pp. 1-18.

Madsen, M 2026, Economic expertise in education: Modelling as inscription, valuation, and topological contraction. in Palgrave Handbook of Science and Technology Studies in Education. Palgrave.

Bergh, A, Bjørnskov, C & Callais, J 2026, 'Economic globalization and income shares', Journal of Comparative Economics.

Lozano Galindez, JE & Elofsson, K 2026, 'Economic trade-offs of land use change and wildlife values', Natural Resource Modeling, vol. 39, no. 1, e70018. https://doi.org/10.1111/nrm.70018

López-Rodríguez, A, Jeppesen, E , Davidson, TA, Meester, LD, González-Bergonzoni, I, Vidal, N, Sommaruga, R, Özkan, K, Arndt, H, Jürgens, K & Meerhoff, M 2026, 'Ecosystem age drives food web architecture of glacier retreat-formed fishless ponds in Greenland', Oikos, vol. 2026, no. 1, e11415. https://doi.org/10.1002/oik.11415

Shen, DY & Normand, S 2026, 'Ecosystem restoration legislation calls for predicting achievability and forecasting pathways', Restoration Ecology, vol. 34, no. 1, e70249. https://doi.org/10.1111/rec.70249

Christensen, TR, Fauchald, P, Arndal, MF & Christensen, T 2026, 'Editorial: Climate change impacts on arctic ecosystems and associated climate feedbacks', Frontiers in Environmental Science, vol. 14, 1776354. https://doi.org/10.3389/fenvs.2026.1776354

Bangsbo, J, Hostrup, M, Hellsten, Y, Hansen, M, Melin, A & Kjær, M 2026, 'Editorial: Integrating Evidence and Expertise to Advance Elite Athlete Performance', Scandinavian Journal of Medicine and Science in Sports, vol. 36, no. 3, e70238. https://doi.org/10.1111/sms.70238

Zechmeister-Boltenstern, S, Meurer, K, Jarosch, K, Murugan, R, Munkholm, L, Chenu, C & Poeplau, C 2026, 'Editorial for the Second EJP SOIL Special Issue: “Climate-Smart Sustainable Agricultural Soil Management for the Future II”', European Journal of Soil Science, vol. 77, no. 1, e70274. https://doi.org/10.1111/ejss.70274

Collins, JM, Mak, V, Mathios, A, Thøgersen, J & Twigg-Flesner, C 2026, 'Editorial – “New Editorial Board for 2026–2030”', Journal of Consumer Policy, vol. 49, no. 1, 6. https://doi.org/10.1007/s10603-026-09610-y

Mugge, R, Haase, LM, Jaeger-Erben, M, Nhu Laursen, L, Niinimäki , K, Richter, J, Sprecher, B & Watkins, M 2026, 'Editorial: Product lifetimes and the environment: Retaining product value in a circular economy', Resources, Conservation & Recycling, vol. 225, 108617. https://doi.org/10.1016/j.resconrec.2025.108617

Korsgaard, MB 2026, Ed Sheeran. in Ed Sheeran. Lex.dk. <https://lex.dk/Ed_Sheeran>

Acheampong, S, da Silva, AM, Gechev, A, Trebuchon, A, Antal, A, Kamondi, A & Tankisi, H 2026, 'Educational and training needs in clinical neurophysiology among professionals in African countries: results of a survey', Clinical Neurophysiology Practice, vol. 11, pp. 195-196. https://doi.org/10.1016/j.cnp.2026.03.002

Györfi, O, Thammongkolchai, T, Kienitz, R, Shahrizaila, N, Tankisi, H & Kamondi, A 2026, 'Educational needs and training conditions of young clinical neurophysiologists: survey of IFCN-young neurophysiologists network', Clinical Neurophysiology Practice, vol. 11, pp. 93-102. https://doi.org/10.1016/j.cnp.2026.01.009

Laursen, R & Madsen, M 2026, Education and the politics of time. Educational Governance Research, Springer.

Einboden, R, Dawson, L, McCloughen, A & Buus, N 2026, 'Effective equity-oriented work requires a nuanced understanding of power that recognizes the incommensurability of common discourses of ‘empowerment’ and Foucault’s ideas of power', Health. https://doi.org/10.1177/13634593251401504

Andersen, LW , Holmberg, MJ, Krijkamp, E, Stankovic, N , Meilandt, C , Vallentin, MF , Høybye, M, Folke, F, Kunst, N, Dijk, SW, Granfeldt, A & Caulley, L 2026, 'Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes: A Report From the Cardiac Arrest Registry to Enhance Survival', JAMA Internal Medicine, vol. 186, no. 1, pp. 37-43. https://doi.org/10.1001/jamainternmed.2025.6123

Shrestha, R, Paudel, S, Rijal, A , Adhikari, TB, Gradidge, PJ-L, Khatri, B , Neupane, D , Skejø, SD, Vaidya, A, Sanders, T, Lonsdale, C, Subedi, N, Koirala, S, Kallestrup, P & Nielsen, RØ 2026, 'Effectiveness of a female community health volunteer-led physical activity education intervention on accelerometer-derived outcomes in semi-urban Nepal: an open-label, cluster randomised controlled trial', International Journal of Behavioral Nutrition and Physical Activity. https://doi.org/10.1186/s12966-026-01894-0

Fogh, M , Jørgensen, RM , Støvring, H , Toft, G , Maindal, HT , Bruun, JM & Østergaard, JN 2026, 'Effectiveness of a kindergarten-based obesity prevention intervention to reduce risk of overweight at school entry', Obesity Research and Clinical Practice, vol. 20, no. 1, pp. 52-58. https://doi.org/10.1016/j.orcp.2025.12.011

Axelsen, HL, Müller, AG, Fjorback, LO , Goetzsche, K , Nielsen, HB & Juul, L 2026, 'Effectiveness of a one-year teacher training program in delivering school-based mindfulness on schoolteachers' mental health: A nationwide cluster-randomized trial', Social Science & Medicine, vol. 389, 118814. https://doi.org/10.1016/j.socscimed.2025.118814

Pegoraro, S, Veronelli, L, Frisco, F, Brattico, E, Romano, D, Daini, R & Tosi, G 2026, 'Effectiveness of Cognitive Interventions in Healthy Aging: A Systematic Review and Bayesian Meta-analysis', Neuroscience and Biobehavioral Reviews, vol. 183, 106571. https://doi.org/10.1016/j.neubiorev.2026.106571

Jensen, EK, Lichtenstein, MB, Riper, H & Mathiasen, K 2026, 'Effectiveness of Guided Internet-Based Cognitive Behavioral Therapy for Adult Anxiety and Depression in Routine Care: An Observational Study', International Journal of Methods in Psychiatric Research, vol. 35, no. 1, e70058. https://doi.org/10.1002/mpr.70058

Andersen, KS, Hansen, AP, Pedersen, P , Langagergaard, V , Nielsen, CV, Løvschall, C & Pilegaard, MS 2026, 'Effectiveness of multidisciplinary biopsychosocial rehabilitation including workplace interventions for employees on sick leave due to low back pain: A systematic review', Work (Reading, Mass.), pp. 10519815261423506. https://doi.org/10.1177/10519815261423506

Shrestha, R, Paudel, S, Adhikari, TB , Khatri, B, Adhikari, S, Neupane, D, Vaidya, A, Kallestrup, P & Rijal, A 2026, 'Effectiveness of physical activity promotion interventions in low-income and middle-income countries: a systematic review and meta-analysis', British Journal of Sports Medicine, vol. 60, no. 4, pp. 286-299. https://doi.org/10.1136/bjsports-2025-110035

Displaying results 1051 to 1100 out of 389648

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen