Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Qvortrup, L 2019, 'Ja, der er behov for at ændre 7-trinsskalaen', Skolemonitor.

Christensen, TK , Madsen, AB , Madsen, J & Clausen, P 2019, 'Jagttidsrevision for udvalgte arter 2020. Opdatering af det biologiske grundlag for jagttider.', 34 p., Notat fra DCE - Nationalt Center for Miljø og Energi (2011-2019).

Fuji, H, Kanamori, I & Nishigaki, SM 2019, 'Janossy densities for chiral random matrix ensembles and their applications to two-color QCD', Journal of High Energy Physics, vol. 2019, no. 8, 53. https://doi.org/10.1007/JHEP08(2019)053

Sonne, C , Dietz, R , Hansson, SV , Søndergaard, J , Desforges, JP & Alstrup, AKO 2019, 'Japans commercial whaling is a threat to public health', Science of the Total Environment, vol. 680, pp. 10-12. https://doi.org/10.1016/j.scitotenv.2019.05.099

Lindfors, E, Arima, T, Baad-Hansen, L, Bakke, M, De Laat, A, Giannakopoulos, NN, Glaros, A, Guimaraes, AS, Johansson, A, Le Bell, Y, Lobbezoo, F, Michelotti, A, Mueller, F, Ohrbach, R, Wanman, A, Magnusson, T & Ernberg, M 2019, 'Jaw Exercises in the Treatment of Temporomandibular Disorders-An International Modified Delphi Study', Journal of Oral & Facial Pain and Headache, vol. 33, no. 4, 31247061, pp. 389-398. https://doi.org/10.11607/ofph.2359

Christoffersen, EE 2019, 'Jeg er her! En audiowalk om hjemløshed produceret af Aarhus Teater', Peripeti. <http://www.peripeti.dk/2019/10/08/jeg-er-her-audiowalk-aarhus-teater/>

Hansen, HR 2019, Jeg hader, hader skolen. in T Ankerstjerne (ed.), Pædagogik mellem skole og fritid : grundbog til pædagoguddannelsen. Dafolo, Frederikshavn.

Skjerning, HT (ed.) 2019, Jeg har cøliaki - 12 personlige fortællinger om at leve godt med cøliaki. Dansk Cøliaki Forening.

Skaaning Knage, F 2019, 'Jeg vil ikke i skole. Om skolevægring hos børn og unge', Psykolog Nyt.

Descatha, A, Evanoff, BA, Andersen, JH, Fadel, M, Ngabirano, L, Leclerc, A, Dale, AM & Roquelaure, Y 2019, 'JEMINI (Job Exposure Matrix InterNatIonal) Initiative: a Utopian Possibility for Helping Occupational Exposure Assessment All Around the World?', Journal of Occupational and Environmental Medicine, vol. 61, no. 7, pp. e320-e321. https://doi.org/10.1097/JOM.0000000000001631

Paldam, M 2019, Jens Otto Krag. in J Hansen, N Kærgård & JS Thomsen (eds), Med hånden på statskassen: Økonomer i regering. Djøf Forlag, Kbh., pp. 187-208.

Bonde Mørk, A & Søndergaard, L 2019, 'Jernalderfund i Stjær: landsby og gravplads', Annales : Galten Lokalarkivs årsskrift, vol. 29 (2019), pp. 99-105.

Blaabjerg, K, Clausen, TN, Kjærup, RB , Steensgaard, IB & Larsen, PF 2019, Jerntilskud til minkhvalpe dag 3 efter fødsel. in Faglig Årsberetning 2018. Kopenhagen Fur, Aarhus, Faglig årsberetning, pp. 43-50. <https://issuu.com/kopenhagenfur/docs/_rsrapport_2018_final>

Povlsen, KK 2019, J. L. Lund I Friederike Bruns saloner og breve. in AS Vejlby (ed.), Den anden guldalder: Johan Ludvig Lund over alle grænser. Den Hirschsprungske Samling, København, pp. 130-159.

Johnsen, NF, Thomsen, BL, Hansen, JV, Christensen, BS, Rugulies, R & Schlünssen, V 2019, 'Job type and other socio-demographic factors associated with participation in a national, cross-sectional study of Danish employees', BMJ Open, vol. 9, no. 8, e027056. https://doi.org/10.1136/bmjopen-2018-027056

Larsen, KB 2019, 'Johannes' Åbenbaring - Imperiet slår igen', Bibliana, no. 2. <https://readymag.com/u53721909/1670683/7/?fbclid=IwAR2sg4pZqsvC5umxCtbegKE0ZdKdoG6-guu9hVGrYc6nQyJKKkGutW1E6kk>

Uusimäki, E & Asikainen, S 2019, Johdanto. in S Asikainen & E Uusimäki (eds), Sukupuoli Raamatun maailmassa. Suomen eksegeettinen seura, Helsinki, Publications of the Finnish Exegetical Society, vol. 117, pp. 1-18.

Mørch, M , Ahlburg, JV , Saura-Múzquiz, M , Eikeland, AZ & Christensen, M 2019, 'Joined x-ray and neutron powder diffraction refinement of W-type hexaferrites', 53rd International School of Crystallography: Magnetic Crystallography , Erice, Italy, 31/05/2019 - 09/06/2019.

Onuma, Y, Katagiri, Y, Burzotta, F, Holm, NR, Amabile, N, Okamura, T, Mintz, GS, Darremont, O, Lassen, JF, Lefèvre, T, Louvard, Y, Stankovic, G & Serruys, PW 2019, 'Joint consensus on the use of OCT in coronary bifurcation lesions by the European and Japanese bifurcation clubs', EuroIntervention, vol. 14, no. 15, pp. e1568-e1577. https://doi.org/10.4244/EIJ-D-18-00391

Shelmerdine, SC, Gerrard, CY, Rao, P, Lynch, M, Kroll, J, Martin, D, Miller, E, Filograna, L, Martinez, RM, Ukpo, O, Daly, B, Hyodoh, H, Johnson, K, Watt, A, Taranath, A, Brown, S, Perry, D, Boel, LWT, Borowska-Solonynko, A, van Rijn, R, Klein, W, Whitby, E & Arthurs, OJ 2019, 'Joint European Society of Paediatric Radiology (ESPR) and International Society for Forensic Radiology and Imaging (ISFRI) guidelines: paediatric postmortem computed tomography imaging protocol', Pediatric Radiology, vol. 49, no. 5, pp. 694-701. https://doi.org/10.1007/s00247-018-04340-x

Mesbah-Uddin, M , Guldbrandtsen, B , Lund, MS, Boichard, D & Sahana, G 2019, 'Joint imputation of whole-genome sequence variants and large chromosomal deletions in cattle', Journal of Dairy Science, vol. 102, no. 12, pp. 11193-11206. https://doi.org/10.3168/jds.2019-16946

Marand, AJ , Li, HJ & Thorstenson, A 2019, 'Joint inventory control and pricing in a service-inventory system', International Journal of Production Economics, vol. 209, no. March, pp. 78-91. https://doi.org/10.1016/j.ijpe.2017.07.008

Mukherjee, M, Kumar, S, Shojafar, M, Zhang, Q & Mavromoustakis, CX 2019, Joint Task Offloading and Resource Allocation for Delay-Sensitive Fog Networks. in 2019 IEEE International Conference on Communications, ICC 2019 - Proceedings., 8761239, IEEE, IEEE International Conference on Communications, vol. 2019-May, 2019 IEEE International Conference on Communications, ICC 2019, Shanghai, China, 20/05/2019. https://doi.org/10.1109/ICC.2019.8761239

Gjerlevsen, SZ 2019, 'Jokes, Definitions, and the Historical Junctures of Fictionality', Style, vol. 53, no. 4. https://doi.org/10.5325/style.53.4.0426

Tipsmark, KS 2019, 'Jomfruen - en avlshingst i 1600-tallet', Skalk, no. 5, pp. 6-11.

Wamberg, J 2019, 'Jordforbindelsen genoprettet: Antropocænt. I det nøgterne lys, der kastes på kunstnere fra Eckersberg til L. A. Ring, toner naturen frem i et anderledes pågående nærvær på Den Hirschsprungske Samling', Weekendavisen, vol. Sektion 2 (Kultur), pp. 9.

Olesen, JE 2019, 'Jord skal på den politiske dagsorden', LandbrugsAvisen, vol. 3, pp. 15-15. <https://landbrugsavisen.dk/jord-skal-p%C3%A5-den-politiske-dagsorden>

Brorson, M 2019, 'Jørgen K. Bukdahl – Den glemte Aarhus-teolog', Årsskriftet Critique, vol. 9, pp. 117-121. <http://aarsskriftet-critique.dk/2019/10/joergen-k-bukdahl-kierkegaard-brorson-marxisme/>

Fauth, SR & Kristiansen, B 2019, 'Joseph Conrads Metaphysik: Moralischer Nihilismus in The Return und im Frühwerk', Germanisch-Romanische Monatsschrift, vol. 2019, no. 3, pp. 281-310.

Jensen, M 2019, 'Jostabær til maskinhøst', Gartner Tidende, no. 12, pp. 14.

Thomsen, LH & Willig, I 2019, 'Journalism by emoji’s: SoMe editors in the newsroom', Paper presented at Future of Journalism, Cardiff, United Kingdom, 12/09/2019 - 13/09/2019.

Saugel, B, Flick, M, Bendjelid, K, Critchley, LAH, Vistisen, ST & Scheeren, TWL 2019, 'Journal of clinical monitoring and computing end of year summary 2018: hemodynamic monitoring and management', Journal of Clinical Monitoring and Computing, vol. 33, no. 2, pp. 211-222. https://doi.org/10.1007/s10877-019-00297-w

Jakobsen, M, James, O, Moynihan, DP & Nabatchi, T 2019, 'JPART Virtual Issue on Citizen-State Interactions in Public Administration Research', Journal of Public Administration Research and Theory, vol. 29, no. 4, pp. e8-e15. https://doi.org/10.1093/jopart/muw031

Vad, K (ed.) & Grundtvig, NFS 2019, Julesange. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/18485/0#>

Vad, K (ed.) & Grundtvig, NFS 2019, Jule-Sange for Dronning Caroline Amalias Asyl-Børn. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/18488/0#>

Vad, K (ed.) & Grundtvig, NFS 2019, Jule-Sang i Prindsesse Caroline Amalias Asyl. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/18475/0#>

Andersen, C 2019, Julian Huxleys biokulturelle menneske og UNESCO. in T kellberg Nielsen, C Andersen, AR Kratschmer & M Clasen (eds), Menneske, kultur evolution, et et biokulturelt perspektiv. Aarhus Universitetsforlag, Aarhus, pp. 259-272.

Terkelsen, O 2019, Jurisdiktion. in Folkeret og menneskerettigheder. Karnov Group, pp. 128-145.

Evald, J 2019, 'Juristen gennem 100 år', Juristen, no. 1, pp. 1-13.

Lippert-Rasmussen, K 2019, 'Just Annexation', Journal of Applied Philosophy, vol. 36, no. 2, pp. 290-297. https://doi.org/10.1111/japp.12308

Iversen, S 2019, '’Just because it isn’t happening here, doesn’t mean it isn’t happening’: narrative, fictionality and reflexivity in humanitarian rhetoric', European Journal of English Studies, vol. 23, no. 2, pp. 190-205. https://doi.org/10.1080/13825577.2019.1640432

Brøcker, KK 2019, 'Justifying the evidential use of intuitive judgements in linguistics'.

Korth, J, Csizmadia, S, Gandolfi, D, Fridlund, M, Pätzold, M, Hirano, T, Livingston, J, Persson, CM, Deeg, HJ, Justesen, AB, Barragán, O, Grziwa, S, Endl, M, Tronsgaard, R, Dai, F, Cochran, WD, Albrecht, S, Alonso, R, Cabrera, J, Cauley, PW, Cusano, F, Eigmüller, P, Erikson, A, Esposito, M, Guenther, EW, Hatzes, AP, Hidalgo, D, Kuzuhara, M, Montañes, P, Napolitano, NR, Narita, N, Niraula, P, Nespral, D, Nowak, G, Palle, E, Petrillo, CE, Redfield, S, Prieto-Arranz, J, Rauer, H, Smith, AMS, Tortora, C, Van Eylen, V & Winn, JN 2019, 'K2-140b and K2-180b - Characterization of a hot Jupiter and a mini-Neptune from the K2 mission', Monthly Notices of the Royal Astronomical Society, vol. 482, no. 2, pp. 1807-1823. https://doi.org/10.1093/mnras/sty2760

Livingston, JH, Dai, F, Hirano, T, Gandolfi, D, Trani, AA, Nowak, G, Cochran, WD, Endl, M, Albrecht, S, Barragan, O, Cabrera, J, Csizmadia, S, de Leon, JP, Deeg, H, Eigmüller, P, Erikson, A, Fridlund, M, Fukui, A, Grziwa, S, Guenther, EW, Hatzes, AP, Korth, J, Kuzuhara, M, Montañes, P, Narita, N, Nespral, D, Palle, E, Pätzold, M, Persson, CM, Prieto-Arranz, J, Rauer, H, Tamura, M, Van Eylen, V & Winn, JN 2019, 'K2-264: A transiting multiplanet system in the Praesepe open cluster', Royal Astronomical Society. Monthly Notices, vol. 484, no. 1, pp. 8-18. https://doi.org/10.1093/mnras/sty3464

Hjorth, M , Justesen, AB, Hirano, T, Albrecht, S, Gandolfi, D, Dai, F, Alonso, R, Barragán, O, Esposito, M, Kuzuhara, M, Lam, KWF, Livingston, JH, Montanes-Rodriguez, P, Narita, N, Nowak, G, Prieto-Arranz, J, Redfield, S, Rodler, F, Van Eylen, V, Winn, JN, Antoniciello, G, Cabrera, J, Cochran, WD, Csizmadia, S, De Leon, J, Deeg, H, Eigmüller, P, Endl, M, Erikson, A, Fridlund, M, Grziwa, S, Guenther, E, Hatzes, AP, Heeren, P, Hidalgo, D, Korth, J, Luque, R, Nespral, D, Palle, E, Pätzold, M, Persson, CM, Rauer, H, Smith, AMS & Trifonov, T 2019, 'K2-290: A warm Jupiter and a mini-Neptune in a triple-star system', Monthly Notices of the Royal Astronomical Society, vol. 484, no. 3, pp. 3522-3536. https://doi.org/10.1093/mnras/stz139

Smith, AMS, Csizmadia, S, Gandolfi, D, Albrecht, S, Alonso, R, Barragan, O, Cabrera, J, Cochran, WD, Dai, F, Deeg, H, Eigmueller, P, Endl, M, Erikson, A, Fridlund, M, Fukui, A, Grziwa, S, Guenther, EW, Hatzes, AP, Hidalgo, D, Hirano, T, Korth, J, Kuzuhara, M, Livingston, J, Narita, N, Nespral, D, Niraula, P, Nowak, G, Palle, E, Paetzold, M, Persson, CM, Prieto-Arranz, J, Rauer, H, Redfield, S, Ribas, I & Van Eylen, V 2019, 'K2-295 b and K2-237 b: Two Transiting Hot Jupiters', Acta Astronomica, vol. 69, no. 2, pp. 135-158. https://doi.org/10.32023/0001-5237/69.2.3

Arboe, T 2019, kælder – kællinge·puse: 48 kc, 3 helsideskort, 6 spaltekort. in Jysk Ordbog. Peter Skautrup Centret for Jysk Dialektforskning, S.l. <http://jyskordbog.dk/jyskordbog/ordbog.html>

Andersen, TR 2019, 'Kære Murakami: Haruki Murakami: Mordet på kommandanten', Litteraturmagasinet Standart, vol. 33, no. 1, pp. 13-15.

Arboe, T 2019, kæreste – kærnemælks·vælling: 43 kc, 2 helsideskort, 1 spaltekort. in Jysk Ordbog. Peter Skautrup Centret for Jysk Dialektforskning, S.l. <http://jyskordbog.dk/jyskordbog/ordbog.html>

Nissen, U 2019, Kærlighedens ansvar: ansatser til samtalens etik. in A Østerlund Nielsen (ed.), Enhed og samarbejde på tværs af moralsk-etiske forskelle. Dansk Missionsråd, Frederiksberg, Ny Mission, vol. 36, pp. 85-101. <https://issuu.com/danishmissioncouncil/docs/ny_mission_36>

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Lise Refstrup Linnebjerg Pedersen