Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Balling-Ansø, F, Krogh, JL, Lassen, EE & Nielsen, AEB 2026, 'Identification and properties of topological states in the bulk of quasicrystals', Physical Review B, vol. 113, 075134. https://doi.org/10.1103/56vs-zwr8

Bari, EJ, Hansen, S, Sandin, P, Ernstsson, O, Geale, K, Bossios, A, Lehtimäki, L, Janson, C, Ulrik, C, Kankaanranta, H, Aarli, BB, Von Bülow, A, Viinanen, A, Sverrild, A, Lúdvíksdóttir, D, Backman, H, Schmid, JM, Karjalainen, J, Bjermer, L, Kilpeläinen, M, Hilberg, O, Kauppi, P, Lehmann, S, Sandström, T, Skjold, T, Björnsdóttir, US, Yasinska, V, Backer, V, Altraja, A & Porsbjerg, C 2026, 'Identifying an At-Risk Asthma Phenotype: Allergy and Recurrent Infections Predict Severe Disease', Clinical and Experimental Allergy. https://doi.org/10.1111/cea.70230

Særkjær, LL 2026, 'Identifying Monetary Policy and Uncertainty Shocks: Essays in Empirical Macroeconomics', PhD, Aarhus University, Aarhus.

Hill, TA, West, J, Morling, JR & Crooks, CJ 2026, 'Identifying subjects at risk of liver cirrhosis via a range of thresholds for common fibrosis markers: A Welsh general population-based cohort study', Journal of Internal Medicine, vol. 299, no. 3, pp. 398-413. https://doi.org/10.1111/joim.70064

Sartaj, H, Boudjadar, J , Frasheri, M, Ali, S & Larsen, PG 2026, 'Identifying Uncertainty in Self-Adaptive Robotics With Large Language Models', IEEE Software, vol. 43, no. 1, pp. 89-97. https://doi.org/10.1109/MS.2025.3620578

Bossen, C , Kusk, K & Pedersen, AM 2026, ”I didn’t become a physician to be a glorified secretary”: Controversies in clinical AI implementation and scaling. in IT Gulbrandsen, TE Jensen, SN Just, C Lioma, HF Ratner, A Rehn & L Seabrooke (eds), Controversies of AI Society: Book of abstracts. 1 edn, Aalborg University Open Publishing, pp. 29-30, Controversies of AI Society Conference, Copenhagen, Denmark, 09/04/2026. https://doi.org/10.54337/aau.add.scai.boa

Borowski, M, Butcher, PWS, Jones, SJ, Ritsos, PD, Klokmose, CN & Elmqvist, N 2026, '“I Feel Like Iron Man”: Authoring, Exploring, and Presenting Data Visualizations in Immersive AR', IEEE Transactions on Visualization and Computer Graphics. https://doi.org/10.1109/TVCG.2026.3672314

Canibe, N , Kongsted, H & Damborg, P 2026, Igangværende forskningsaktiviteter på Aarhus Universitet og Københavns Universitet, der omhandler alternativer til antibiotika til grise.

Falkenberg, R 2026, Gospel of Thomas Unnumbered: Reading the Coptic Version as a Continuous Text. in H Lundhaug, RB Sarrazin, S Cook, LL Toft & F Graz (eds), Coptic Apocrypha: New Frontiers - New Perspectives. Mohr Siebeck, Göttingen, Parabiblica: Editiones et Studia.

Zattoni, M, Bontempi, L, Ringgaard, S, Luraghi, G, Benhassen, LL , Johansen, P & Colombo, M 2026, 'In silico modelling of aortic annuloplasty: hemodynamic assessment through in vitro experiments and in vivo MRI', Computer Methods and Programs in Biomedicine, vol. 277, 109246. https://doi.org/10.1016/j.cmpb.2026.109246

De Chiara, I, Feola, A, Della Gala, M, Marasco, R, Nielsen, MS, Porcellini, A, Grieco, M, Gentile, MT & Muscariello, L 2026, 'In vitro antitumor activity of Lactococcus lactis cell-free supernatant on human glioblastoma cell lines', Food Research International, vol. 223, no. Part 1, 117840. https://doi.org/10.1016/j.foodres.2025.117840

Larsen Engholm, E, Laursen, CB , Jensen, PHK , Gehrt, TB & Vaeggemose, U 2026, '"I just needed help": a qualitative study of patients' experiences with a single responder ambulance', Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.

Olsen, TV 2026, 'Ikkeideal teori og kravet om effektive remedier', Politica - Tidsskrift for politisk videnskab, vol. 58, no. 1-2, pp. 164-182.

Svraka, L, Andersen, AS, Touborg, T , Emmanuel, T , GK, U , Kadarmideen, H , Bertelsen, T , Vestergaard, C & Johansen, C 2026, 'IL-17 Cytokines Induce IκBζ in Dermal Fibroblasts to Promote Pro-Inflammatory Gene Expression in Psoriasis', International Journal of Molecular Sciences , vol. 27, no. 3, 1297. https://doi.org/10.3390/ijms27031297

Hao, D, Han, H, Li, D, Sun, Y, Wang, Y, Yan, H, Li, G, Liu, H, Li, B, Li, F & Liu, W 2026, 'Lactobacillus salivarius SNK-6 improves egg quality, yolk nutrient composition, and yolk flavor profile in laying hens via modulation of tissue metabolites and Cecal microbiomes', Poultry Science, vol. 105, no. 5, 106649. https://doi.org/10.1016/j.psj.2026.106649

Najafzadehkhoei, S, Vega Yon, G & Tanaka, K, imaginarycss: Tools for Studying Imaginary Cognitive Social Structure, 2026, Computer programme. https://doi.org/10.32614/CRAN.package.imaginarycss

Glas, E 2026, 'Imagine No Diaspora: Reading Jewish Literature in Greek as Migrant Literature', Mnemosyne.

Pade, M 2026, Imitatio, style and intertextuality in Quattrocento humanist translation. in -. Ciceronianus. Scrittori latini per l'Europa.

Madsen, PB 2026, Immaterialret: Markedsret del 3. 9 edn, Djøf Forlag, København.

Nijveldt, R, Maeng, M, Beijnink, CWH, Piek, JJ, Al-Lamee, RK, Raposo, L, Baptista, SB, Escaned, J, Davies, J, Klem, I, Yosofi, B, van Geuns, R-JM, Frederiksen, CA , Jakobsen, L, El Barzouhi, A, van der Heijden, DJ, Ilhan, M, Rasoul, S, Brinckman, S, Saraber, C, Jones, DA, Petersen, SE, Podlesnikar, T, Bunc, M, Beijk, MAM, Piers, LH, van Rees, JB, Seligman, H, Cole, G, Iglesias, JF, Degrauwe, S, van 't Hof, AWJ, Lipsic, E, Pundziute-do Prado, G, Chattranukulchai, P, Rodríguez-Palomares, JF, Rigger, J, Meuwissen, M, Kleijn, L, Pereira, B, Monti, L, van der Schaaf, RJ, Sanchis, J, Belli, G, Tijssen, JGP, Thim, T, van Royen, N & iMODERN Investigators 2026, 'Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction', The New England Journal of Medicine, vol. 394, no. 10, pp. 958-968. https://doi.org/10.1056/NEJMoa2512918

Torrance, I 2026, Immigration, Classical Antiquity, and Diversity: Envoi. in Irish Migrations and Classical Antiquity. Bloomsbury Academic, London, pp. 326-330.

Özcan, D , Nielsen, PS , Mølby Nielsen, AW , Alsner, J , Thorsen, L , Overgaard, J , Offersen, BV & Tramm, T 2026, 'Immune cell composition and prognosis in a national DBCG cohort of node-positive, irradiated breast cancer patients', Dansk Patologi Selskabs Årsmøde 2026, Kolding, Denmark, 12/03/2026 - 14/03/2026.

Chan, WK, Jabbari Shiadeh, SM, Lenzig, J, Svedin, P, Rasmusson, S, Vigne, O, Veit, V, Chumak, T, Ardalan, M & Mallard, C 2026, 'Immune Synaptopathy and Sex Differences in Recognition Memory from Neonatal Staphylococcus epidermidis Infection', Developmental Neuroscience, pp. 1-25. https://doi.org/10.1159/000548381

Rezahosseini, O, Jensen, JUS, Rahimi, HK, Jensen, NE, Jørgensen, CS, Fischer, TK, Ostrowski, SR, Lundgren, J, Ostergaard, L, Harboe, ZB & ENFORCE Study Group 2026, 'Immunogenicity and Safety of the COVID-19 Messenger RNA Vaccine Coadministered With Influenza and 23-valent Pneumococcal Polysaccharide Vaccines', Clinical Infectious Diseases, vol. 82, no. 2, pp. e343-e351. https://doi.org/10.1093/cid/ciaf455

Larsen, FD , Juhl, AK , Dietz, LL, Nielsen, H, Stærke, NB, Johansen, IS, Wiese, L, Benfield, T, Bodilsen, J, Klastrup, V, Lindvig, SO, Rasmussen, LD, Knudsen, LS, Tolstrup, M , Østergaard, LJ, Lundgren, J, Søgaard, OS , Larsen, CS & ENFORCE Study Group 2026, 'Immunogenicity of SARS-CoV-2 primary vaccination and boosters in patients with immune-mediated inflammatory diseases: Impact of immunosuppressive therapy', Vaccine, vol. 73, 128155. https://doi.org/10.1016/j.vaccine.2025.128155

King, HAD, Angelovich, TA, Moso, MA, Pascoe, RD, Churchill, MJ & Lewin, SR 2026, 'Immunotherapy and impact on tissue reservoirs', Current Opinion in HIV and AIDS, vol. 21, no. 1, pp. 31-39. https://doi.org/10.1097/COH.0000000000000996

Daston, L, Pape Møller, J (Translator) & Ploug, IK (Translator) 2026, Imod naturen. translated by Jeppe Pape Møller, Ida Katinka Ploug, Forlaget Slagmark.

Cappelli, F, Fontana, M, Garcia-Pavia, P, Judge, DP, Obici, L, Masri, A, Vogtländer, K, Ciaccia, A, Zazula, A, Tamby, J-F, Castaño, A, Fox, JC, Poulsen, SH, Damy, T, Januzzi, JL & Gillmore, JD 2026, 'Impact of acoramidis on clinical stability in transthyretin amyloid cardiomyopathy: Observations from ATTRibute-CM', European Journal of Heart Failure. https://doi.org/10.1093/ejhf/xuag048

Fonseca, AS, Liisberg, JB, Nøjgaard, JK, Pleva, F, Jensen, SB, Agathokleous, S, Moreno, T, Kedwell-Simmering, K, Casado, C, Encinas, JÁ, Lehmann, M & Jensen, KA 2026, 'Impact of air purifiers on occupational particle exposure in an enclosed bus workshop', Building and Environment, vol. 287, 113823. https://doi.org/10.1016/j.buildenv.2025.113823

Thomsen, JPS 2026, 'Impact of casein composition and phosphorylation on reconstituted micelles, functionality, and digestibility', PhD, Aarhus University.

Boll Kristensen, M, Crichton, M, Marx, W, Naito, T, Del Fabbro, E, Isenring, E & Marshall, S 2026, 'Impact of COVID-19 on early identification of protein-energy malnutrition in the cancer care setting: a repeated cross-sectional survey of cancer care professionals', Supportive Care in Cancer, vol. 34, no. 2, 117. https://doi.org/10.1007/s00520-026-10338-1

Mogensen, H, Louro, J, Maltesen, T, Kenborg, L, Hasle, H, Holmqvist, AS, Heinävaara, S, Feychting, M, Frederiksen, LE & Erdmann, F 2026, 'Impact of disease burden and educational attainment on health-related unemployment among childhood cancer survivors: A mediation analysis within the Nordic SALiCCS research programme', EJC Paediatric Oncology, vol. 7, 100490. https://doi.org/10.1016/j.ejcped.2026.100490

Karim, SR , Jensen, NM , Holck, EN , Clemmesen, TS , Christiansen, EH , Jakobsen, L, Chen, Z, Sonka, M, Karason, K, Broch, K, Solberg, OG & Eiskjær, H 2026, 'Impact of Evolocumab on Coronary Physiology and Microstructure in De-Novo Heart Transplant Recipients', The Journal of Heart and Lung Transplantation, vol. 45, no. 1, pp. 26-36. https://doi.org/10.1016/j.healun.2025.07.037

Krasniqi, L, Terkelsen, CJ, Nissen, H, Freeman, P, Frederiksen, CA , Vase, H , Hejlesen, K , Fur, CB , Thim, T, Eftekhari, A, Uttenthal, F, Ellert, J, Borg Mogensen, NS, Haujir, A, Christiansen, EH & Dahl, JS 2026, 'Impact of Flow-status on Effective Orifice Area in Transcatheter Heart Valves: a COMPARE-TAVI 1 Substudy', Journal of the American Society of Echocardiography, vol. 39, no. 1, pp. 80-88. https://doi.org/10.1016/j.echo.2025.09.017

Jacobsen, S , Bennetsen, MH , Nielsen, PS , Glavind-Kristensen, M , Jensen, AB , Forman, A , Waldstrøm, M & Bor, P 2026, 'Impact of fractional CO₂ laser therapy on vaginal wall histology in breast cancer survivors.', Lasers in Medical Science, vol. 41, no. 1, 26. https://doi.org/10.1007/s10103-026-04829-0

Uth, M, Verdelin, JK, Buhl, KB, Hjelm, J, Pedersen, SU , Daasbjerg, K & Ravnsbæk, DB 2026, 'Impact of Graphene Oxide Lateral Size on the Long-Term Stability of LiNi_0.5Mn_1.5O₄ Electrodes', Batteries and Supercaps, vol. 9, no. 2, e202500357. https://doi.org/10.1002/batt.202500357

Molina-Vila, MA, Tsourti, Z, Vervita, K, Bertran-Alamillo, J, García-Peláez, B, Kerr, KM, Bubendorf, L, Madsen, LB, Biernat, W, Stenzinger, A, Haberecker, M, Blackhall, F, Pokharel, S, Jordana-Ariza, N, Vives-Usano, M, Vagenknecht, P, Dafni, U, Kammler, R, Finn, SP, Peters, S, Stahel, RA & Rosell, R 2026, 'Impact of TP53, KEAP1 and STK11 mutations in localized-stage NSCLC: A European thoracic oncology platform lungscape project', European Journal of Cancer. https://doi.org/10.1016/j.ejca.2026.116583

Andreas Balle Rubak, J , Naveed, K , Jain, S , Esterle, L , Iosifidis, A & Pauwels, R 2026, 'Impact of Labeling Inaccuracy and Image Noise on Tooth Segmentation in Panoramic Radiographs using Federated, Centralized and Local Learning', Dento maxillo facial radiology. https://doi.org/10.1093/dmfr/twag001

Jørgensen, ME, Pauls, DD , Ibsen, DB & Bruun, JM 2026, 'Impact of Lifestyle Intervention on Long-Term Beverage Intake in Children with Overweight and Obesity: A 3-Year Follow-Up Study', Nutrients, vol. 18, no. 1, 147. https://doi.org/10.3390/nu18010147

Dehn, P, Rasmussen, A, Seibæk, L, Sekse, RJT, Thimm, AM & Olesen, ML 2026, 'Impact of Lymphedema on Women's Lives After Gynaecological Cancer: An Integrative Review', Scandinavian Journal of Caring Sciences, vol. 40, no. 1, e70189. https://doi.org/10.1111/scs.70189

Luef, BM, Stentebjerg, LL, Tanvig, MH, Aalders, J, Möller, S, Ovesen, PG, Christesen, HT, McIntyre, HD, Catalano, PM, Jørgensen, JS, Overgaard, M, Jensen, DM & Vinter, CA 2026, 'Impact of maternal fasting blood glucose in pregnancy on body composition, anthropometric, and metabolic outcomes in newborns and 3-Year-Old offspring: results from the lifestyle in pregnancy and offspring study', BMC Pregnancy and Childbirth, vol. 26, no. 1, 193. https://doi.org/10.1186/s12884-026-08692-3

Mahajan, S, Tyagi, A, Boral, P, Mehala, R, Rellegadla, S, Prajapat, G, Roy, P, Gogoi, S & Agrawal, A 2026, 'Impact of multifunctional biopolymer-silica nanocomposites on viscosity, wettability and reservoir microbiome for enhanced oil recovery', Chemical Engineering Science, vol. 320, no. Part A, 122427. https://doi.org/10.1016/j.ces.2025.122427

Henningsen, JB, Søndergaard, MM, Jørgensen, SH, Søby, JH , Bøttcher, M , Rasmussen, LD , Christiansen, EH , Holck, EN, Jensen, LO, Bouchelouche, K, Pedersen, CT, Kragholm, KH & Eftekhari, A 2026, 'Impact of myocardial perfusion abnormalities on clinical outcomes in patients treated with percutaneous coronary intervention for chronic total occlusions', European Heart Journal. Imaging Methods and Practice, vol. 4, no. 1, qyaf137. https://doi.org/10.1093/ehjimp/qyaf137

Cui, Z, Pan, Y, Li, Z, Liu, J, Ozunu, A, Meng, J, Manevski, K & Shan, S 2026, 'Impact of node restriction on Cd and Zn transportation in wheat plant treated with swine manure and its biochar: a field experiment', Food Chemistry, vol. 511, 148820. https://doi.org/10.1016/j.foodchem.2026.148820

Opoku, SY, Barnes, VR, Plauborg, F, Padi, FK, Amisah, S, Dompreh, D, Afele, JT, Anokye, J, Asante, R, Ansah, EG, Osei, MH, Agbenyega, O, Jorgensen, U, Pedersen, SM & Berg, TR 2026, 'Impact of overhead shade intensity and cocoa variety on the micro-climate and productivity of cocoa farms in two ecological zones of Ghana', Ecological Frontiers. https://doi.org/10.1016/j.ecofro.2026.02.015

Hansen, AH , Poulsen, PR , Kristensen, L , Møller, VV , Sinha, PM , Johansen, JG & Sørensen, BS 2026, 'Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model', Radiotherapy and Oncology, vol. 214, 111277. https://doi.org/10.1016/j.radonc.2025.111277

Frederiksen, KS , Brummer, JE, Karriker-Jaffe, K & Chartier, KG 2026, Impact of parental substance use problems on children's risk of becoming NEET. in Supporting Families Affected by Alcohol, Substance use, and Gambling: A Global Approach. Cambridge Scholars Publishing, Newcastle Upon Tyne, UK.

do Canto, LM, Jacobsen, CM , Nissen, PH , Højbjerg, JA, Madsen, JS, Hansen, TF & Andersen, RF 2026, 'Impact of pneumatic tube system transport and blood collection tubes on cell-free DNA analysis of plasma samples', Clinical Chemistry and Laboratory Medicine, vol. 64, no. 2, pp. 332-342. https://doi.org/10.1515/cclm-2025-0367

Hjulmand, J, Pries-Heje, M, Lenz, IT, Carter-Storch, R, Rahman, NSK, Gill, S, Bruun, NE, Povlsen, JA, Christiansen, U, Helweg-Larsen, J, Elming, H, Fosbøl, E, Tønder, N, Moser, C, Iversen, K, Ihlemann, N & Bundgaard, H 2026, 'Impact of Residual Vegetations After Treatment of Left-Sided Infective Endocarditis: A Substudy of the POET Trial', JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2026.01.002

Hada, M, Mizukami, T, Ikeda, K, Munhoz, D, Brouwers, S, Sonck, J, Matsuo, H, Shinke, T, Ando, H, Ko, B, Biscaglia, S, Rivero, F, Engstrøm, T, Arslani, K, Leone, AM, Galante, D, van Nunen, LX, Fearon, WF, Christiansen, EH, Fournier, S, Desta, L, Yong, A, Adjedj, J, Escaned, J, Nakayama, M, Eftekhari, A, Zimmermann, FM, Sakai, K, Storozhenko, T, da Costa, BR, Campo, G, Berry, C, Collison, D, Johnson, T, Amano, T, Perera, D, Jeremias, A, Ali, Z, De Bruyne, B, Barbato, P, Corradetti, S, Stalikas, N, Kechichian, A, Bouisset, F, Kakuta, T, Johnson, NP & Collet, C 2026, 'Impact of Sex on Residual Angina After Percutaneous Coronary Interventions', Catheterization and Cardiovascular Interventions, vol. 107, no. 4, pp. 987-996. https://doi.org/10.1002/ccd.70419

Displaying results 1701 to 1750 out of 389683

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen