Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Gillis, C, McIsaac, DI, Santa Mina, D, Chevalier, S, Baldini, G, Carli, F, Scheede-Bergdahl, C, Edgar, L, Smrk, V, Avery, L, Bessissow, A, Coca Martinez, M, Copeland, R, Dalton, SO, Danjoux, G, Denehy, L, Engel, D, Grimmett, C, Grocott, MP, Gill, HL, Jack, S, Jensen, BT, Levett, D, Martinez-Palli, G, Merchant, Z, Moore, J, Pecorelli, N, Randall, I, Riedel, B, Schierbeck, G, Slooter, G, West, M, Fiore, JF & Collaborators 2026, 'Standards for reporting research methods, interventions, and Outcomes in Surgical Prehabilitation studies (SOS-Prehab)', The British journal of surgery, vol. 113, no. 3, znaf302. https://doi.org/10.1093/bjs/znaf302

Bobou, O , Bucci, I & Raja, R 2026, 'Standing on Their Own: A Contextual Analysis of Single and Doule Portraits of Children on Palmyrene Funerary Stelai', Zeitschrift für Orient-Archäologie, vol. 17, pp. 144-220. https://doi.org/10.34780/tv749a59

Gluud, M, Pallesen, EM, Zeng, Z, Namini, MRJ, Vadivel, CK, Gjerdrum, LMR, Yan, L, Ahmad, S, Lindahl, LM, Bzorek, M, Kamstrup, MR, Dey, S, Ostrowski, SR, Sørensen, E, Rantakari, P, Bonefeld, CM, Geisler, C, Woetmann, A, Lahesmaa, R, Iversen, L, Wolf, P, Litman, T, Buus, TB & Ødum, N 2026, 'Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma', Allergy: European Journal of Allergy and Clinical Immunology. https://doi.org/10.1111/all.70292

Jakobsen, NK 2026, State-Based Modelling with a Concept DSL. in M Leuschel & F Ishikawa (eds), Rigorous State-Based Methods - 11th International Conference, ABZ 2025, Proceedings. Springer, Lecture Notes in Computer Science, vol. 15728, pp. 311-321, 11th International Conference on Rigorous State-Based Methods, ABZ 2025, Düsseldorf, Germany, 10/06/2025. https://doi.org/10.1007/978-3-031-94533-5_18

Clausen, T 2026, 'Statens Uddannelsesstøtte 1968-1988. Administration, alternativer, forudsætninger', Historisk Tidsskrift.

Holk, A , Strauch, C & Trottner, L 2026 'Statistical guarantees for denoising reflected diffusion models'.

Pedersen, C 2026, 'Statistical Modeling of Performance in Innovation and the Creative Industries', PhD, Aarhus University, Aarhus.

Geist, J, Hoess, R, Dobler, AH, Deacon, M, Sørensen, F, Tille, M, Kuehn, R & Rasmussen, JJ 2026, 'Status assessment and recovery potential of Denmark´s only freshwater pearl mussel (Margaritifera margaritifera) population in the Varde River system', Global Ecology and Conservation, vol. 66, e04081. https://doi.org/10.1016/j.gecco.2026.e04081

Rosenkilde Laursen, K 2026, 'Stearinlys skaber hygge – men de forurener også den luft, vi indånder: Heldigvis kan man mindske forureningen med enkle tiltag', Videnskab.dk [online]. <https://videnskab.dk/krop-sundhed/stearinlys-skaber-hygge-men-de-forurener-ogsaa-den-luft-vi-indaander/>

Shiri, Y, Lei, J, Amarasinghe, Y, Chen, HT, Chang, CC, Lilly, MP, Addamane, S & Mittleman, DM 2026, 'Steerable terahertz beams using surface waves on an active metasurface', Scientific Reports, vol. 16, no. 1, 3446. https://doi.org/10.1038/s41598-025-33364-1

Rasmussen, KSG 2026, Stemmetilstedevær. Marianne Larsens første værker 1969-1972. in MK Schmidt & JØ Nyboe (eds), På højde med det uafklarede. Marianne Larsens forfatterskab. Forlaget Spring, pp. 22-36.

Kusk, ML 2026, Stemningen i en streg: Tegning som tilgang til at indfange og undersøge stemninger. in J Lykkegård & CM Schou Pallesen (eds), Stemninger. Antropologiske undersøgelser af atmosfære. Aarhus Universitetsforlag, Antropologiske Studier.

Ibsen, DB 2026, 'Steps toward better understanding the role of dietary intake on development of complications in people with type 2 diabetes', American Journal of Clinical Nutrition, vol. 123, no. 1, 101104. https://doi.org/10.1016/j.ajcnut.2025.10.021

Groves, E, Schillinger, S, O'Connor, H, Franke, H, Abashidze, N, Peterson, C, Shen, S, Cox, CMM , Weed, E , Fusaroli, R, Parish-Morris, J, Eigsti, I-M & Grossman, R 2026, 'Stick or Switch? Does Task Success Affect Strategy Use on a Collaborative Task between Autistic and Non-Autistic Teens', INSAR 2026, Prague, Czech Republic, 22/04/2026 - 25/04/2026.

Andersen, FØ , Tidmand, L & Boström, L 2026, 'Stigende pædagogmangel og -frafald i Danmark og Sverige: Forklaringer og løsninger', Kognition & Pædagogik, vol. 36, no. 139, pp. 29-40.

Stubager, R , Langsæther, PE & Hesstvedt, S 2026, 'Still Going Strong? The Social and Political Relevance of Class Identification Over Time in Four Countries', Comparative Political Studies, pp. 1-39. https://doi.org/10.1177/00104140251414034

Møller, SV & Priestley, R 2026, 'Stock Market News and Output Growth', Journal of Money, Credit and Banking. https://doi.org/10.1111/jmcb.70044

Kai, P 2026, 'Storage time of slurry in livestock houses in Denmark', No. 2023-0485325; 2022-0448600, 27 p., Dec 19, 2024..

Poulsen, B & Kristensen, HK 2026, Store Heddinge Kirke og dens bygherre. Jysk Arkæologisk Selskab.

Holm, TE 2026, Stor hornugle, overvågning af ynglefugle. DCE, Teknisk anvisning fra Fagdatacenter for Biodiversitet og Terrestrisk Natur, no. A162, vers. 3, Aarhus University, DCE - Danish Centre for Environment and Energy. <https://ecos.au.dk/fileadmin/ecos/Fagdatacentre/Biodiversitet/TAA162StorHornugleV3.pdf>

Holm, TE & Thorup, O 2026, Stor kobbersneppe, overvågning af ynglefugle. DCE, Teknisk anvisning fra Fagdatacenter for Biodiversitet og Terrestrisk Natur, no. A140, vers. 3, Aarhus University, DCE - Danish Centre for Environment and Energy. <https://ecos.au.dk/fileadmin/ecos/Fagdatacentre/Biodiversitet/TAA140StorKobbersneppe_v3.pdf>

Egendal, WK 2026, 'Stormy seas: COVID-19, Brexit, and informal communication in EU fisheries negotiations', Journal of European Integration, vol. 48, no. 3, pp. 493-512. https://doi.org/10.1080/07036337.2025.2503215

Iversen, S & Ghosal, T 2026, 'Storytelling with Language Models: Narrative Theory meets Generative AI. Introduction to Special Issue', Narrative Inquiry.

AbdulRafiu, A 2026, 'Stranded futures? Quantifying the asset risks of industrial decarbonisation in developed economies', Energy Research and Social Science, vol. 133, 104621. https://doi.org/10.1016/j.erss.2026.104621

Zhang, X, Yang, Y, Rao, Z, Zhao, J, Wu, H, Wu, S, Song, Y & Du, J 2026, 'Strategic application of sludge biochar: achieving optimal pollution treatment and greenhouse gas suppression in constructed wetlands', Bioprocess and Biosystems Engineering. https://doi.org/10.1007/s00449-026-03302-0

Cox, DM, Damasceno, DR, Hagsten, J, Hellesen, C, Hjelmeland, M, Jurasz, J, Kies, A, Lagnelöv, O, Lundberg, M, Lundström, L, McKenna, JTK, Norberg, P, Nøland, JK, Llisterri, AP, Qvist, S, Svanström, S, Såmark-Roth, A, Yang, Y, Hesamzadeh, MR & Tjernberg, LB 2026, 'Strategic capacity expansion planning in hydro-dominated power systems: Insights from the Nordics', Energy, vol. 344, 139771. https://doi.org/10.1016/j.energy.2025.139771

Liu, Y, Guo, C, Qu, F, Zhang, Y, Huang, KW, Xu, C, Guo, J, Xu, Q & Niu, Y 2026, 'Strategic Facet Design of in₂O₃ Catalysts for Enhanced Kinetics and Hydrogen Suppression in Iron–Chromium Flow Batteries', Advanced Science, vol. 13, no. 2, e12148. https://doi.org/10.1002/advs.202512148

Nielsen, KH , Vohnsen, NH & Andersen, C 2026, 'Strategic Skies: Denmark’s Arctic Dilemma and the Danish–Swedish Bifrost Satellite as a Case of Security Science Diplomacy', AU Space Day 2026, Aarhus, Denmark, 22/01/2026.

Groves, E, Franke, H, Peterson, C, Shen, S, Schillinger, S, O'Connor, S, Abashidze, N, Cox, CMM , Weed, E , Fusaroli, R, Parish-Morris, J, Eigsti, I-M & Grossman, R 2026, 'Strategy Matters: Neurotype, Sex, and Initiation Strategy Effects on Collaborative Task Success', INSAR 2026, Prague, Czech Republic, 22/04/2026 - 25/04/2026.

Mejsner, SB , Burau, V & Fehsenfeld, M 2026, 'Strengthening interprofessional collaboration by working with cross-sectoral boundaries: Introducing mental health teams in Denmark', European Journal of Public Health, vol. 36, ckaf236, pp. i3-i7. https://doi.org/10.1093/eurpub/ckaf236

Hvilshøj, R , Hoggan, E & Pakanen, M 2026, 'StressAwear- A multimodal wearable for shared awareness of stress in open plan offices', Design Journal, vol. 29, no. 1, pp. 158-182. https://doi.org/10.1080/14606925.2026.2614658

Christensen, H, Pezzella, FR, Roaldsen, MB, Tomek, A, Wilkie, A, Christensen, L, Dichgans, M, Drummond, A, Laatikainen, T, Molina, CA, Sunnerhagen, KS, Toni, D, Abilleira, S, Aguiar de Sousa, D, Arsovska, A, Audebert, H, Bartolovic, J, Béjot, Y, Biessels, GJ, Bouverie, J, Budincevic, H, Casolla, B, Chabriat, H, Charalambous, M, Dawson, J, Debette, S, de Leeuw, FE, Denes, A, Diomedi, M, Dippel, D, Dirnagl, U, Fischer, U, Flomin, Y, Fonseca, AC, Forchammer, B, Forster, A, Frisullo, G, Galofre, M, Gdovinová, Z, Gumbinger, C, Harbison, J, Hobbs, R, Jatuzis, D, Jurlina, H, Katan, M, Kidd, L, Kiechl, S, Kõrv, J, Kruuse, C, Lang, W, Liesz, A, Lorenzano, S, Luft, A, Lunde, G, Macey, C, Markus, HS, Mead, G, Michel, P, Ozturk, S, Paciaroni, M, Pavlovic, A, Persson, CU, Quinn, TJ, Rothwell, P, Saba, L, Santalucia, P, Santo, G, Simonsen, C, Steiner, T, Stolarz-Skrzypek, K, Tiu, C, Tsiskaridze, A, Tsivgoulis, G, Tuomilehto, J, Ulberg, T, Ursillo, P, Urso, A, van Euler, M, Viigimaa, M, Vivien, D, Wagner, M, Walker, M, Webb, A, Ramos, DW, Zampolini, M, Zedde, M, Ford, G, Kelly, P, Mikulik, R, Norrving, B, Proios, H, Sacco, S, Sandset, E, Wardlaw, J, Vilionskis, A & Caso, V 2026, 'Stroke Action Plan for Europe 2018-2030 (SAP-E): mid-term review and update', European Stroke Journal, vol. 11, no. 1, aakaf026. https://doi.org/10.1093/esj/aakaf026

Gude, MF , Huibers, L, Lock, MK, Pedersen, AF & Blauenfeldt, RA 2026, 'Stroke recognition and early care pathways following telephone triage in out-of-hours primary care: a register-based study from the Central Denmark Region', Scandinavian Journal of Primary Health Care, vol. 44, no. 1, pp. 1-13. https://doi.org/10.1080/02813432.2025.2588126

Bicer, D, Matsuoka, R, Moumbock, AFA, Sukumar, P, Suades, A, Cheruvara, H, Quigley, A, Drew, D, Pardon, E, Steyaert, J, Henderson, PJF, Caffrey, M, Griese, JJ & Nji, E 2026, 'Structural basis of specific lysine transport by Pseudomonas aeruginosa permease LysP', Nature Communications, vol. 17, no. 1, 37. https://doi.org/10.1038/s41467-025-66618-7

Hu, J, Scheidt, T, Thacker, D, Axell, E, Stemme, E, Łapińska, U, Wennmalm, S, Meisl, G, Curk, S, Andreasen, M, Vendruscolo, M, Arosio, P, Šarić, A, Schmit, JD, Knowles, TPJ, Sparr, E, Linse, S, Michaels, TCT & Dear, AJ 2026, 'Structural defects in amyloid-β fibrils drive secondary nucleation', Nature Communications, vol. 17, no. 1, 1933. https://doi.org/10.1038/s41467-026-69377-1

Brunzell, E, Högström, YK, López Hernández, M , Pedersen, JS & Bergström, LM 2026, 'Structural determination of self-assembled aggregates formed by a therapeutic cyclical peptide and an ionic surfactant in aqueous solution', Journal of Colloid and Interface Science, vol. 704, 139373. https://doi.org/10.1016/j.jcis.2025.139373

Cossette-Lefebvre, H & Zala, MI 2026, 'Structural discrimination through ignorance: epistemic injustice, (social) norms, and disability', Synthese, vol. 207, no. 3, 108. https://doi.org/10.1007/s11229-026-05517-w

Correa, Y, Nzekwe, F, Wodaje, T, Brinck, J, Jansen, M, Blanchet, C, Pedersen, JS, Del Giudice, R & Cárdenas, M 2026, 'Structural, functional and biochemical characterisation of apolipoprotein(a)-containing low-density lipoproteins', Journal of Colloid and Interface Science, vol. 701, 138760. https://doi.org/10.1016/j.jcis.2025.138760

Yang, Q, Zhang, HR, Yu, BX, Gao, L, Zhang, T, Tang, BZ, Wang, BY, Wei, S, Liu, XW, Yu, P & Yu, HB 2026, 'Structural pathway of polyamorphous transition in metallic glasses', Materials Futures, vol. 5, no. 2, 025003. https://doi.org/10.1088/2752-5724/ae3f46

Nielsen, MLN 2026, 'Structure–Activity Relationships in Organic Semiconductors for Heterogeneous Photocatalysis', PhD, Aarhus University.

Thomas, SP, Iversen, BB & Grabowsky, S 2026, 'Structure–Function Relationships in Molecular Crystals: A Festschrift to Celebrate Mark A. Spackman', Crystal Growth and Design, vol. 26, no. 5, pp. 1893-1895. https://doi.org/10.1021/acs.cgd.5c00604

Mishra, A , Zubia-Aranburu, J , Zuzic, L , Saeed, K , Nielsen, J, Schio̷tt, B, Dong, M , Otzen, DE & Weidner, T 2026, 'Structure of α-Synuclein Bound to Polystyrene Surfaces Probed by Experimental and Theoretical Sum Frequency Generation Spectroscopy', Langmuir : the ACS journal of surfaces and colloids. https://doi.org/10.1021/acs.langmuir.5c05658

Babizhetskyy, V, Myakush, O, Kotur, B, Smetana, V, Köhler, J, Kremer, RK, Meyer, GH & Mudring, AV 2026, 'Structure-property relationships in cubic Zr₇Ru_6+хGa_17-x (0 ≤ x ≤ 2.0): disorder, electrical transport and bonding', Journal of Alloys and Compounds, vol. 1057, 186704. https://doi.org/10.1016/j.jallcom.2026.186704

Lykkegaard, E, Qvortrup, A & Christensen, JH 2026, 'Student characteristics, wellbeing, and educational vulnerability', Scandinavian Journal of Educational Research. https://doi.org/10.1080/00313831.2026.2642588

Nielsen, GB & Anbert, LC 2026, 'Studenteraktivisme på strømpefødder? Retfærdighed, omsorg og resonans i unges kamp for social retfærdighed i USA og Danmark. ', Økonomi og Politik.

Pedersen, NA, Mikkelsen, GB & Falkenberg, R (eds) 2026, Studia Manichaica: Papers from the Tenth Conference of the International Association of Manichaean Studies Held at Aarhus University, 8-11 August 2022. Corpus Fontium Manichaeorum - Analecta Manichaica, vol. 5, Brepols Publishers, Turnhout.

Thomsen, SH, Van Berkel, A, Van Veen, S, Van Koetsveld, N, Joosten, M, Diderich, KEM, Van den Born, M, Srebniak, MI & Van Opstal, D 2026, 'Studies of post-partum placentas provide insights into the origin of structural chromosomal aberrations', Human Reproduction, vol. 41, no. 2, pp. 168-177. https://doi.org/10.1093/humrep/deaf235

Hjort, PB, Jensen, JE, Jensen, JB & Ernst, A 2026, 'Study of bladder cancer detection in standard white light versus AI-supported endoscopy-01 (RAISE-01): Development and validation of an AI-based support tool', International Journal of Medical Informatics, vol. 213, 106390. https://doi.org/10.1016/j.ijmedinf.2026.106390

Villamil-Alonso, A, Madsen, L, Iburg, TM, Olesen, NJ, Vendramin, N & Cuenca, A 2026, 'Study of Renibacterium salmoninarum infection in rainbow trout (Oncorhynchus mykiss) and the effect of temperature in an in-vivo cohabitation challenge', Aquaculture, vol. 618, 743797. https://doi.org/10.1016/j.aquaculture.2026.743797

Luef, BM, Jensen, NH , Knorr, S , Kristensen, K, Overgaard, M, Stentebjerg, LL, Catalano, PM, Möller, S, Maindal, HT, Jensen, DM & Vinter, CA 2026, 'Study protocol for a 15-year follow-up of a randomized controlled trial on lifestyle intervention in pregnancy: assessing long-term effects on body composition, metabolic traits, and mental health in mothers and offspring', Trials, vol. 27, no. 1, 124. https://doi.org/10.1186/s13063-025-09418-0

Displaying results 3251 to 3300 out of 389736

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen