Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

Sort by: Date | Author | Title

Martin, DG 2019, 'Emociones juiciosas: explorando la dramaturgia de cinco mujeres en Cataluña', Insula, vol. 871-872, no. Julio-Agosto, pp. 37-41.

Anbert, LC 2019, 'Emotional attachments to the national borders: How British military remembrance practices creates a national subject by exclusion', Affects. Borders. Biopolitics, København, Denmark, 21/08/2019 - 23/08/2019.

Vammen, MA, Mikkelsen, S, Forman, JL, Hansen, AM, Bonde, JP, Grynderup, MB, Kolstad, H, Kaerlev, L, Rugulies, R & Thomsen, JF 2019, 'Emotional demands and exhaustion: cross-sectional and longitudinal associations in a cohort of Danish public sector employees', International Archives of Occupational and Environmental Health, vol. 92, no. 5, pp. 639-650. https://doi.org/10.1007/s00420-018-01398-w

Lohse, M & Overgaard, M 2019, 'Emotional priming depends on the degree of conscious experience', Neuropsychologia, vol. 128, pp. 96-102. https://doi.org/10.1016/j.neuropsychologia.2017.10.028

Mikkelsen, MB , O'Toole, MS , Lyby, MS, Wallot, S & Mehlsen, MY 2019, 'Emotional reactivity and interoceptive sensitivity: Exploring the role of age', Psychonomic Bulletin & Review, vol. 26, no. 4, pp. 1440-1448. https://doi.org/10.3758/s13423-019-01603-y

Panjwani, AA, OToole, MS, Applebaum, A, Fresco, DM & Mennin, DS 2019, Emotion Regulation Therapy for Cancer Caregivers: Targeting Mechanisms of Distress. in A Applebaum (ed.), Cancer Caregivers. Oxford University Press, New York.

Jakobsen, FB , Musaeus, P , Kirkeby, L , Hansen, TB & Mørcke, AM 2019, 'Emotions and clinical learning in an interprofessional outpatient clinic: A focused ethnographic study', Journal of Interprofessional Care, vol. 33, no. 1, pp. 57-65. https://doi.org/10.1080/13561820.2018.1514372

Novembre, G, Mitsopoulos, Z & Keller, PE 2019, 'Empathic perspective taking promotes interpersonal coordination through music', Scientific Reports, vol. 9, no. 1, 12255. https://doi.org/10.1038/s41598-019-48556-9

Siem, JB 2019, 'Empati mellem medliden og medlidenhed: Anmeldelse af SIGNA 'Det Åbne Hjerte', Aarhus Festuge ', Peripeti - tidsskrift for dramaturgiske studier. <http://www.peripeti.dk/2019/10/09/signa-det-aabne-hjerte-aarhus-amtssygehus/>

Kildegaard, S & Jensen, JB 2019, 'Emphysematous cystitis leading to bladder necrosis and acute cystectomy - report of a rare case with fatal outcome', Scandinavian Journal of Urology, vol. 53, no. 6, pp. 439-440. https://doi.org/10.1080/21681805.2019.1651391

Franza, A & M. Marshall, A 2019, 'Empirical and semi–analytical methods for centrifuge tunnelling–induced ground movements in sands', Tunnelling and Underground Space Technology Journal, vol. 88, pp. 47-62. https://doi.org/10.1016/j.tust.2019.02.016

Dietrich, J 2019, Empiricism or Rationalism in the Hebrew Bible? Some thoughts about ancient foxes and hedgehogs. in A Schellenberg & T Krüger (eds), Sounding Sensory Profiles in the Ancient Near East. SBL Press, Atlanta, Ancient Near East Monographs, vol. 25, pp. 57-68. <https://www.sbl-site.org/publications/Books_ANEmonographs.aspx>

Bondebjerg, A , Jusufbegovic, L , Qvortrup, L & Vestergaard, S 2019, Empirisk dagtilbudsforskning for 0-6-årige i de skandinaviske lande: forskningskortlægning og -vurdering for året 2017 : teknisk rapport fra Dansk Clearinghouse for Uddannelsesforskning . Clearinghouse-forskningsserien, no. 33, vol. 2019, Dansk Clearinghouse for uddannelsesforskning, DPU, Aarhus Universitet, København.

Schmidt, U 2019, Empirisk kirkeforskning som bidrag til praktisk teologi. in NH Gregersen, L Christoffersen & KMS Leth-Nissen (eds), Den praktiske teologi i Danmark: Festskrift til Hans Raun Iversen. Eksistensen Akademisk, pp. 269-280.

Dyring, R 2019, Emplaced at the threshold of life: toward a phenomenological an-archaeology of borders and human bounding. in A Cooper & S Tinning (eds), Debating and defining border: Philosophical and Theoretical Perspectives. Routledge, Abingdon, pp. 97-111. https://doi.org/10.4324/9781351124881

Dwight, T, Scott, JM & Schwartz, JJ 2019, 'Emplacement and Paleozoic and Cretaceous recrystallisation of the Broughton Arm Peridotite in Western Fiordland, New Zealand', New Zealand Journal of Geology and Geophysics, vol. 62, no. 1, pp. 72-86. https://doi.org/10.1080/00288306.2018.1528989

Gode, HE 2019, 'Employee Ideation on Internal Social Media: Addressing Uncertainty through Dialogue Strategies', International Journal of Strategic Communication, vol. 13, no. 5, pp. 385-403. https://doi.org/10.1080/1553118X.2019.1654481

An, S-H, Meier, KJ, Bøllingtoft, A & Andersen, LB 2019, 'Employee Perceived Effect of Leadership Training: Comparing Public and Private Organizations', International Public Management Journal, vol. 22, no. 1, pp. 2-28. https://doi.org/10.1080/10967494.2018.1497739

Andersen, LPS, Hogh, A, Gadegaard, C & Biering, K 2019, 'Employees exposed to work-related threats and violence in human services sectors: Are any employees members particularly exposed to violence and threats and what role do supervisors play?', Work, vol. 63, no. 1, pp. 99-111. https://doi.org/10.3233/WOR-192911

Ledertoug, MM 2019, Empower4u: Fra udsat anbragt til egen tilværelse. DPU/AU, DPU.

Lund, L & Robinson, S 2019, Empowering teachers through reflective educational dialogue: a handout supporting the video material by Lea Lund & Sarah Robinson. .

Agarwala, S 2019, Enabling new possibilities in smart textiles through printed electronics. in 2019 IEEE 9th International Nanoelectronics Conferences, INEC 2019., 8853853, IEEE, 9th IEEE International Nanoelectronics Conferences, INEC 2019, Kuching, Malaysia, 03/07/2019. https://doi.org/10.1109/INEC.2019.8853853

Cozart, SM & Bengtsen, SS 2019, 'Enabling scholarly identity formation through doctoral writing retreats', EATAW 2019, Göteborg, Sweden, 02/07/2019 - 04/07/2019.

Hernandez Marcano, NJ, Lauritsen, JH, Jacobsen, KK & Jacobsen, RH 2019, Enabling Secure Multicast Group Communications in IP Wireless Networks for the Internet of Things. in European Wireless 2019 Conference, EW 2019: 25th European Wireless Conference. VDE Verlag GmbH, pp. 83-89, European Wireless 2019 - 25th European Wireless Conference, Aarhus, Denmark, 02/05/2019. <http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8835944&isnumber=8835929>

Wright, S 2019, Enactment and transformation of the university: conclusion. in S Wright, S Carney, JB Krejsler, GB Nielsen & J Williams Ørberg (eds), Enacting the university: Danish university reform in an ethnographic perspective. Springer, Dordrecht, Higher Education Dynamics, no. 53, pp. 307-329. https://doi.org/10.1007/978-94-024-1921-4_12

Wright, S 2019, Enactment of the university: issues and concepts. in S Wright, S Carney, JB Krejsler, GB Nielsen & J Williams Ørberg (eds), Higher Education Dynamics: Danish University Reform in an Ethnographic Perspective . Springer, Dordrecht, Higher Education Dynamics, no. 53, pp. 25-51. https://doi.org/10.1007/978-94-024-1921-4_2

Herold, MD , Rand, C & Frank, VA 2019, 'Enactments of a “holistic approach” in two Danish welfare institutions accommodating young adults with offending behavior and drug use experiences', Drugs and Alcohol Today, vol. 19, no. 3, pp. 208-219. https://doi.org/10.1108/DAT-12-2018-0071

Leiva, G, Maudet, N, Mackay, W & Beaudouin-Lafon, M 2019, 'Enact: Reducing Designer--Developer Breakdowns When Prototyping Custom Interactions', ACM Transactions on Computer-Human Interaction, vol. 26, no. 3, pp. 19. https://doi.org/10.1145/331027

Hansen, LE 2019, En ægte lapis lazuli: Evaluering af Cecilia Westerbergs Alkymistens Laboratorium – et udstillingssamarbejde mellem fire kunstmuseer. Aarhus University, Aarhus.

Valimana-Traverso, J, Amariei, G, Boltes, K, Angeles Garcia, M & Marina, ML 2019, 'Enantiomer stability and combined toxicity of duloxetine and econazole on Daphnia magna using real concentrations determined by capillary electrophoresis', Science of the Total Environment, vol. 670, pp. 770-778. https://doi.org/10.1016/j.scitotenv.2019.03.208

Kuhlmann, J, Kretschmann, AC, Bester, K , Bollmann, UE, Dalhoff, K & Cedergreen, N 2019, 'Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions', Chemosphere, vol. 225, pp. 166-173. https://doi.org/10.1016/j.chemosphere.2019.03.023

Riisager, E (ed.) & Grundtvig, NFS 2019, En Bede-Psalme. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/19711/0#>

Skyggebjerg, AK 2019, 'En bestået styrkeprøve: Intergalaktisk. Cecilie Eken afslutter sin ambitiøse science fiction-trilogi for unge med et gigantisk opgør mellem planeter og principper', Weekendavisen, vol. Bøger, no. 51, pp. 12-12.

Naghizadeh, M , Dalgaard, TS & Engberg, RM 2019, 'Encapsulated butyrate in the maintenance of broiler gut barrier function applying a dysbacteriosis model', 6th Conference on Poultry Intestinal Health, Rome, Italy, 03/04/2019 - 05/04/2019.

Naum, ME 2019, 'Enchantment of the underground. Touring mines in early modern Sweden', Journal of Tourism History, vol. 11, no. 1, pp. 1-21. https://doi.org/10.1080/1755182X.2019.1592241

Gehrt, TB , Niziurski, JA , Frostholm, L & Berntsen, D 2019, 'Encoding and retrieval biases for health-related scenes in patients with severe health anxiety', Memory, vol. 27, no. 8, pp. 1110-1121. https://doi.org/10.1080/09658211.2019.1626437

Matthiesen, N & Klitmøller, J 2019, 'Encountering the stranger: Hannah Arendt and the shortcomings of empathy as a moral compass ', Theory & Psychology, vol. 29, no. 2, pp. 182-199. https://doi.org/10.1177/0959354319828174

Rattan, S (ed.) 2019, Encyclopedia of Biomedical Gerontology. vol. 1-3, Academic Press, London.

Zynda, HM, Scare, JA, Steuer, AE, Anderson, HP & Nielsen, MK 2019, 'Encysted cyathostomin larval counts: Mucosal digestion revisited', Veterinary Parasitology, vol. 273, pp. 86-89. https://doi.org/10.1016/j.vetpar.2019.08.009

Wilkening, J, Pearson-Prestera, W, Mungi, NA & Bhattacharyya, S 2019, 'Endangered species management and climate change: When habitat conservation becomes a moving target', Wildlife Society Bulletin, vol. 43, no. 1, pp. 11-20. https://doi.org/10.1002/wsb.944

Schou Pallesen, CM 2019, En del af nationen? minoriteter, medborgerskab og kunsten at dele på den rigtige måde. in A Sybrandt Hansen, S Højlund, CM Schou Pallesen & M Rytter (eds), Hvad vi deler: antropologiske perspektiver på deling som socialt fænomen. Aarhus Universitetsforlag, Aarhus , Antropologiske Studier, no. 5, pp. 109-122.

Iversen, OS , Dindler, C & Smith, RC 2019, En Designtilgang til Teknologiforståelse. Dafolo.

Hansen, BB 2019, 'Endnu en oliekrig', Dagbladet Information.

Khan, S, Taverna, F, Rohlenova, K, Treps, L, Geldhof, V, de Rooij, L, Sokol, L, Pircher, A, Conradi, L-C, Kalucka, J, Schoonjans, L, Eelen, G, Dewerchin, M, Karakach, T, Li, X, Goveia, J & Carmeliet, P 2019, 'EndoDB: a database of endothelial cell transcriptomics data', Nucleic Acids Research, vol. 47, no. D1, pp. D736-D744. https://doi.org/10.1093/nar/gky997

Schuurman, B, Lindekilde, L, Malthaner, S, O'Connor, F, Gill, P & Bouhana, N 2019, 'End of the Lone Wolf: The Typology that Should Not Have Been', Studies in Conflict and Terrorism, vol. 42, no. 8, pp. 771-778. https://doi.org/10.1080/1057610X.2017.1419554

Mavroeidi, P, Arvanitaki, F, Karakitsou, A-K, Vetsi, M, Kloukina, I, Zweckstetter, M, Giller, K, Becker, S, Sorrentino, ZA, Giasson, BI, Jensen, PH, Stefanis, L & Xilouri, M 2019, 'Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models', Acta Neuropathologica, vol. 138, no. 3, pp. 415-441. https://doi.org/10.1007/s00401-019-02014-y

Guimarães Marques, MJ, Real, CC, Victorino, DB, Britto, LR, Cavalheiro, EA, Scorza, FA, Ferraz, HB & Scorza, CA 2019, 'Endogenous protection against the 6-OHDA model of Parkinson's disease in the Amazonian rodent Proechimys', Neuroscience Letters, vol. 709, 134381. https://doi.org/10.1016/j.neulet.2019.134381

van der Weijden, VA, Puntar, B, Rudolf Vegas, A, Milojevic, V, Schanzenbach, CI, Kowalewski, MP, Drews, B & Ulbrich, SE 2019, 'Endometrial luminal epithelial cells sense embryo elongation in the roe deer independent of interferon-tau†.', Biology of Reproduction, vol. 101, no. 5, pp. 882-892. https://doi.org/10.1093/biolre/ioz129

Christensen, LH 2019, En dom om finansiel sikkerhedsstillelse. in T Iversen, S Karstoft & LHG Madsen (eds), Festskrift til Bent Iversen. Djøf Forlag, Kbh., pp. 67-79.

Mahmood, Z , Steenberg, T , Mahmood, K , Labouriau, R & Kristensen, M 2019, 'Endophytic Beauveria bassiana in maize affects survival and fecundity of the aphid Sitobion avenae', Biological Control, vol. 137, 104017. https://doi.org/10.1016/j.biocontrol.2019.104017

Displaying results 97151 to 97200 out of 390065

1944

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen