Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

Sort by: Date | Author | Title

Madsen, LM , Almpanis, A , Storm, F & Pedersen, JB 2026, 'A Hydrogeophysical Survey Utilising the sTEM and sTEMprofiler Systems: Transient Electromagnetic Data and Resistivity Models', Geoscience Data Journal, vol. 13, no. 2, e70067. https://doi.org/10.1002/gdj3.70067

Fu, J, Song, Z, Meng, J, Guo, J, Yang, K, Liu, W & Huan, L 2026, 'AI-augmented electrochemical model for lithium-ion battery: Recent advances and perspectives', Journal of Energy Chemistry, vol. 113, pp. 1056-1080. https://doi.org/10.1016/j.jechem.2025.10.008

Bjerring, JC 2026, 'AI i medicin: et spørgsmål om tillid', Bibliotek for Læger.

Egloffstein, M, Groß, N, Prilop, CN & Mah, D 2026, 'AI Integration, Professional Development, and Instructional Quality in K-12 Education', AERA 2026, Los Angeles, United States, 08/04/2026 - 12/04/2026.

Lammar, D, Horst, M & Müller, R 2026, 'AI in the German Media: Narratives of AI-in-Particular and AI-in-General in German Media Reporting About Artificial Intelligence', Digital Journalism, vol. 14, no. 2, pp. 341-359. https://doi.org/10.1080/21670811.2025.2493759

Johannessen, A, Thorsteinsson, T, Geels, C , Frohn, LM, Clausen, M, Brandt, J, Forsberg, B & Gislason, T 2026, 'Air pollution and childhood asthma in Iceland – Results from a low-pollution area', Environment International, vol. 209, 110170. https://doi.org/10.1016/j.envint.2026.110170

Poulsen, AH, Sørensen, M, Hvidtfeldt, UA, Brandt, J , Ketzel, M & Raaschou-Nielsen, O 2026, 'Air pollution, noise, greenspace and pneumonia, a nation-wide cohort study from Denmark', Environmental Research, vol. 288, no. part 1, 123256. https://doi.org/10.1016/j.envres.2025.123256

Frumer, M , Bruun, MH & Antonsen, CE 2026, 'AI som beslutningsstøtte til fraktur i skadestuen? Billeddiagnostiske teknologier og patientforløb i afprøvningen af fraktur-AI', Tidsskrift for Forskning i Sygdom og Samfund.

Sobrano Fais, R, Comerma Steffensen, SG , Pinilla, E , Matchkov, V, Tostes, RC, Silva Carneiro, F & Simonsen, U 2026, 'A KCa 2.2/2.3 Opener Reverses ET-1-Induced NLRP3 Activation in Hypertensive Mice Corpora Cavernosa', Biomolecules, vol. 16, no. 3, 432. https://doi.org/10.3390/biom16030432

Brandi, U & Sprogøe, J 2026, Aktiv videnskabsteori: En grundbog. Hans Reitzels Forlag, København.

Andersen, SC & Guul, TS 2026, 'A Learning Approach to the Governance of Professionals. Field Experimental Evidence', Journal of Public Administration Research and Theory, vol. 36, no. 1, pp. 51-70. https://doi.org/10.1093/jopart/muaf028

Sedgwick, M 2026, 'Aleksandr Dugin’s Traditionalist Roots', Studies in East European Thought, vol. 78, no. 1-2, pp. 209-224. https://doi.org/10.1007/s11212-025-09708-y

Shyam, S 2026, 'Algorithms and Complexity for Constrained Fair Division, Discrepancy, and Packing', PhD, Aarhus University.

Romio, C , Kofoed, MVW & Møller, HB 2026, 'Alkaline treatment with KOH for enhanced biogas recovery from agricultural feedstock and digested residues', Biomass and Bioenergy, vol. 209, 108913. https://doi.org/10.1016/j.biombioe.2025.108913

Chan, JKN, Li, RCY, Plana-Ripoll, O , Momen, NC, Correll, CU, Solmi, M, Wong, CSM, Ku, KM, Mahboobani, VR, Chung, AKK, Lui, SSY, Sham, PC & Chang, WC 2026, 'All-cause and cause-specific mortality in people with mental disorders: a population-based study on risk evaluation, effect modifiers and excess life-years lost in Hong Kong', European Neuropsychopharmacology, vol. 104, 112742. https://doi.org/10.1016/j.euroneuro.2025.112742

Zhang, H, Windhorst, A, Bornhofen, E, Tulpova, Z, Novak, P, Macas, J, Simkova, H, Nadzieja, M, Kim, JM, Cram, D, Cao, Y, Konkin, DJF, Sass, O, Welna, G, Himmelbach, A, Mascher, M, Link, W, Kwon, S-J, Yang, T-J, Andersen, SU & Jayakodi, M 2026, 'Allelic variation at a single locus distinguishes spring and winter faba beans', Nature Genetics, vol. 58, no. 3, pp. 655-663. https://doi.org/10.1038/s41588-026-02524-y

Petersen, AK 2026, 'All'Inizio il Dono Era', Lares.

Shumilov, E, Ngoya, M, Berning, P, Devillier, R, Forcade, E, Schroeder, T, Kroschinsky, F, Stelljes, M, Valkova, V, Kinsella, F, Chevallier, P, Olesen, G, Mohty, M, de Fontbrune, FS, Wagner-Drouet, E, Zeiser, R, Herling, M, Franke, GN, López-Corral, L, Ayuk, F, Lenz, G, Wulf, G, Sureda, A, Laurence, A, Dreger, P, Bazarbachi, A & Schmitz, N 2026, 'Allogeneic stem cell transplantation for major T-cell lymphoma entities: an analysis of the EBMT-lymphoma working party', Journal of Hematology and Oncology, vol. 19, no. 1, 17. https://doi.org/10.1186/s13045-026-01783-w

Meldgaard, M 2026, 'A logistic analysis of timing of hospital admission and pain relief for childbirth: the Danish Health Literacy in Pregnancy (HeLP) cohort study', Health Literacy and Communication Open. https://doi.org/10.1080/28355245.2026.2635897

Fusaroli, R , Cox, CMM , Weed, E, Szabó, BI, Fein, D & Naigles, L 2026, 'A Longitudinal Investigation of Acoustic Conversational Speech Properties in Autistic and Typically Developing Children', Meeting On Language and Autism, Atlanta, United States, 14/03/2026.

Fusaroli, R , Cox, CMM , Weed, E, Szabó, BI, Fein, D & Naigles, L 2026, 'A Longitudinal Investigation of Acoustic Conversational Speech Properties in Autistic and Typically Developing Children', INSAR 2026, Prague, Czech Republic, 22/04/2026 - 25/04/2026.

Zhang, S, Testani, N, Palosuo, T, Manevski, K , Tanaka, T & Cammarano, D 2026, 'A long-term simulation of organic fertilizer's effects on wheat, barley and potato production', International Symposium Modelling Cropping Systems 2026, Florence, Italy, 02/02/2026 - 04/02/2026.

Kaas, M , Dinesen, SB , Ahlgreen, O , Madsen, P , Mølgaard, S, Dalby, A, Gustafsen, C , Olsen, D , Duan, J , Vilstrup, J , Lende, J, Nordestgaard, S, Zayats, T, Knappskog, PM, Johansson, S, Neckelmann, G, Franke, B, Thirup, S , Børglum, A, Reif, A, Vægter, C , Demontis, D, Haavik, J, Glerup, S & Skeldal, S 2026, 'A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity', Molecular Psychiatry, vol. 31, no. 3, pp. 1311-1324. https://doi.org/10.1038/s41380-025-03242-3

Deng, S, Beale, CM & Thomas, CD 2026, 'Alpha, beta and gamma diversity in relatively natural, mixed and transformed landscape scenarios', Ecography, vol. 2026, no. 2, e08324. https://doi.org/10.1002/ecog.08324

Peña-Aguilera, P, Schmidt, NM, van der Wal, R, Maclean, IMD & Roslin, TV 2026, 'Alpha diversity patterns are unmatched by beta diversity across productivity gradients of the subarctic', Ecosphere, vol. 17, no. 3, e70581, pp. e70581. https://doi.org/10.1002/ecs2.70581

Eghbali, H, Abbasnejad, M, Raoof, M, Zamyad, M, Esmaeili-Mahani, S, Kooshki, R, Mansoori, M & Lobbezoo, F 2026, 'Alpha-pinene modulates feeding behavior and hypothalamic orexin-A expression in a rat model of painful temporomandibular disorder', Journal of Oral and Facial Pain and Headache, vol. 40, no. 2, pp. 43-53. https://doi.org/10.22514/jofph.2026.019

Christensen, KR & Nyvad, AM 2026, Alternativ kongruens? in Grundigt nysgerrig. vol. 56, Dansk Sprognævns skrifter .

Tang, A, Yang, X, Zhou, Y, Li, G, Yu, Z, Yang, H, Li, B, Jeppesen, E & Zhou, Q 2026, 'Altitude, land use and precipitation regimes drive key factors of lake nitrous oxide emission on large geographic scales', Water Research, vol. 291, 125242. https://doi.org/10.1016/j.watres.2025.125242

Eriksson, B 2026, 'Alt liv er her', Litteraturmagasinet Standart.

Fazeli, E , Jan, A, Huber, AK, Jensen, AMG , Fazeli, E, Klein, J, Merchant, K & Andersen, OM 2026, 'A luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity', Journal of Biological Chemistry, vol. 302, no. 2, 111136. https://doi.org/10.1016/j.jbc.2026.111136

Gerber, H , Pedersen, S & Høvring, CM 2026, 'Always On: How Role Work Drives Influencer Marketing Success'.

Ledingham, D, Sathyanarayana, S, Stewart, CB, Iredale, R, Foster, V, Galley, D, Lad, M, Baker, MR & Pavese, N 2026, 'Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α-Synuclein and Mediation of Age Effects', Movement Disorders Clinical Practice. https://doi.org/10.1002/mdc3.70576

Villalva, P & Jordano, P 2026, 'A Machine Learning Application to Camera-Traps: Robust Species Interactions Datasets for Analysis of Mutualistic Networks', Ecology and Evolution, vol. 16, no. 1, e72584. https://doi.org/10.1002/ece3.72584

Aranha, DF , Blatchley Hansen, A , van Baarsen, AN , Nielsen, K & Scholl, P 2026, A Maliciously-Secure Post-Quantum OPRF from Crypto Dark Matter. in IEEE Security & Privacy.

Liebermann, R 2026, “A Man of Pains, Acquainted with Illness": Narrative Medicine and Isaiah’s Suffering Servant (Isa 52:13-53:12). in Biblical Studies and Spiritual Care. Brill.

Graversen, EL , Lønborg, C, Addamo, AM, Costello, MJ & Krause-Jensen, D 2026, 'A marine sediment blue carbon database for European regional seas (EURO-CARBON)', Danish Marine Science Meeting, Elsinore, Denmark, 20/01/2026 - 22/01/2026.

Percy-Smith, VS 2026, 'A material perspective on pupils’ experience during museum education as a space for historical consciousness', History Education Research Journal, vol. 23, no. 1. https://doi.org/10.14324/HERJ.23.1.02

Christiansen, F, Dickeson, S & Sprogis, KR 2026, 'A mechanistic approach to understanding birth timing, calf growth, and residency of southern right whale mother–calf pairs on their calving ground', Ecological Modelling, vol. 514, 111500. https://doi.org/10.1016/j.ecolmodel.2026.111500

Wang, J, Chen, B & Wu, M 2026, 'A mechanistic study of a novel self-healing concpet for cement enabled by large clinker particles: Recovery of transport properties and microstructure characteristics', Construction and Building Materials, vol. 516, 145707. https://doi.org/10.1016/j.conbuildmat.2026.145707

Neil, EQ & Arose, H 2026, 'American Politics, the American Public, and the Protection of Cultural Heritage: An Analysis of the U.S. - Cyprus Cultural Property Agreement', Heritage and Society, vol. 19, no. 1, pp. 242-251. https://doi.org/10.1080/2159032X.2024.2326306

Dicks, L, Roman-Garcia, Y, van Gastelen, S, Maigaard, M, Ingram, P & Schroeder, GF 2026, 'A meta-analysis of the effects of nitrate supplementation on enteric methane emission, production performance, and blood methemoglobin in dairy cattle', Journal of Dairy Science, vol. 109, no. 3, pp. 2444-2457. https://doi.org/10.3168/jds.2025-27514

Christensen, J 2026, 'A metabolic squeeze on marine fish: Does the field metabolic rate limit the geographic distribution of fish populations?', PhD.

Boesen, TJ , Parrott, DJ, Nikolov, IA, Ahrendt, P & Sindbæk, SM 2026, 'Am I your type? Automated similarity search for 3D scanned archaeological artefacts', Digital Applications in Archaeology and Cultural Heritage, vol. 40, e00501. https://doi.org/10.1016/j.daach.2026.e00501

Li, Z, Sun, K, Guan, K, Wang, S, Peng, B, Clarisse, L, Van Damme, M, Coheur, PF, Cady-Pereira, K, Shephard, MW, Zondlo, M & Moore, D 2026, 'Ammonia emissions and depositions over the contiguous United States derived from IASI and CrIS using the directional derivative approach', Atmospheric Chemistry and Physics, vol. 26, no. 1, pp. 703-721. https://doi.org/10.5194/acp-26-703-2026

Gil Arboleda, S, Badyal, A, Miyazawa, A, Larsen, PG & Cavalcanti, A 2026, 'A model-based approach for co-simulation-driven digital twins in robotics', Robotics and Autonomous Systems, vol. 196, 105240, pp. 1-20. https://doi.org/10.1016/j.robot.2025.105240

Xi, X , Zhang, Y, Zhao, D, Chen, F & Howard, KA 2026, 'A modular “Catch-and-Play” platform for rapid T-cell engager target assembly for personalised cancer treatment', Signal Transduction and Targeted Therapy, vol. 11, no. 1, 18. https://doi.org/10.1038/s41392-025-02557-5

Liebermann, R 2026, A More Onerous Citizenship: Reading Pain and Illness in Job and the Individual Psalms of Complaint. in M Chia Mei Tan & E Swai (eds), Positionality in Biblical Studies. Bloomsbury T&T Clark.

Holm, AB 2026, 'Amour-Propre According to Rousseau: On the Shortcomings of the Prevailing Consensus', History of Political Thought, vol. 47, no. 1, pp. 121-142. https://doi.org/10.53765/20512988.47.1.121

Gonçalves, MFM, Gomes, SIL, Scott-Fordsmand, JJ & Amorim, MJB 2026, 'Amputation in Enchytraeus crypticus - a New Approach Methodology (NAM) - assessing the longer-term effects of Cadmium under regeneration stress events', Applied Soil Ecology, vol. 220, 106833. https://doi.org/10.1016/j.apsoil.2026.106833

Leone, CM, di Pietro, G, di Stefano, G, Quesada, C, Salameh, C, Perchet, C, Garcia-Larrea, L, Mouraux, A, Lebrun, L, Gousset, S, Möller-Grell, N, Kostenko, AV, Finnerup, NB, Caspani, O, Jiang, B, Li, T, Rong, C, Genser, B, Treede, RD & Truini, A 2026, 'A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers', Clinical Neurophysiology. https://doi.org/10.1016/j.clinph.2026.2111591

Displaying results 151 to 200 out of 390064

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen