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Interdisciplinary Nanoscience Center

Biofilm group (Prof. Rikke Louise Meyer)

The group

My research combines microbiology and nanotechnology in pursuit of understanding how biofilms establish, and how they can be controlled.

Investigation of fundamental mechanisms in bacterial adhesion and biofilm formation, particularly the role of extracellular DNA.
Development of new approaches to control biofilms and treat biofilm infections through targeted drug delivery, novel antibiotics and nanobiotics, and non-biocidal biofilm control with e.g. enzymes or salinity oscillation.

2025 highligts

Ajunwa, O. M., Minero, G. A. S., Jensen, S. D. & Meyer, R. L. (2025). Hemin-binding DNA structures on the surface of bacteria promote extracellular electron transfer. Nucleic Acids Research, 53(15), Article gkaf790. https://doi.org/10.1093/nar/gkaf790

Dybtved, M. S., Petersen, M. E., Firdausy, A. F., Johansen, M. I., Faddy, E., Gadeberg, C., Østergaard, L., Jørgensen, N. P., Glud, L. N., Søgaard, A. B., Meyer, R. L. & Zelikin, A. N. (2025). Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. Advanced Healthcare Materials, Article e03932. Advance online publication. https://doi.org/10.1002/adhm.202503932

Evans, D. C. S., Kristensen, M. F., Minero, G. A. S., Palmén, L. G., Knap, I., Tiwari, M. K., Schlafer, S. & Meyer, R. L. (2025). Dental biofilms contain DNase I-resistant Z-DNA and G-quadruplexes but alternative DNase overcomes this resistance. npj Biofilms and Microbiomes, 11(1), Article 80. https://doi.org/10.1038/s41522-025-00694-x

Petersen, M. E., Khamas, A. B., Østergaard, L. J., Jørgensen, N. P. & Meyer, R. L. (2025). Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 69(4), Article e01483-24. https://doi.org/10.1128/aac.01483-24

Del Rey, Y. C., Rikvold, P. D., Lund, M. B., Raittio, E. J., Schramm, A., Meyer, R. L. & Schlafer, S. (2025). Arginine modulates the pH, microbial composition, and matrix architecture of biofilms from caries-active patients. International Journal of Oral Science, 17(1), Article 70. https://doi.org/10.1038/s41368-025-00404-5

Recent publications

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Subbiahdoss, G., Zeng, G., Aslan, H., Ege Friis, J., Iruthayaraj, J., Zelikin, A. N. & Meyer, R. L. (2019). Antifouling properties of layer by layer DNA coatings. Biofouling, 35(1), 75-88. https://doi.org/10.1080/08927014.2019.1568417

Meyer, R. L., Walther, R., Nielsen, S. M., Andersen, P. O., Hansen, L., Vu-Quang, H., Kjems, J. & Zelikin, A. N. (2019). Delivering antibiotics locally to biofilms by targeted drug delivery and prodrug therapy. Abstract from Eurobiofilms 2019, Glasgow, United Kingdom.

Šuláková, M., Pazlarová, J., Meyer, R. L. & Demnerová, K. (2019). Distribution of extracellular DNA in Listeria monocytogenes biofilm. Czech Journal of Food Sciences, 37(6), 409-416. https://doi.org/10.17221/9/2019-CJFS

Shahavi, M. H., Hosseini, M., Jahanshahi, M., Meyer, R. L. & Darzi, G. N. (2019). Evaluation of critical parameters for preparation of stable clove oil nanoemulsion. Arabian Journal of Chemistry, 12(8), 3225-3230. https://doi.org/10.1016/j.arabjc.2015.08.024

Friis, J. E., Subbiahdoss, G., Gerved, G., Holm, A. H., Santos, O., Blichfeld, A. B., Moghaddam, S. Z., Thormann, E., Daasbjerg, K., Iruthayaraj, J. & Meyer, R. L. (2019). Evaluation of Surface-initiated Polymer brush as Anti-scaling Coating for Plate Heat Exchangers. Progress in Organic Coatings, 136, Article 105196. https://doi.org/10.1016/j.porgcoat.2019.06.042

Walther, R., Winther, A., Fruergaard, A. S., Akker, W. V. D., Sørensen, L., Nielsen, S. M., Olesen, M. T. J., Dai, Y., Jeppesen, H. S., Lamagni, P., Savateev, A., Pedersen, S. L., Frich, C. K., Vigier, C. A., Lock, N., Singh, M., Bansal, V., Meyer, R. L. & Zelikin, A. N. (2019). Identification and Directed Development of Non‐Organic Catalysts with Apparent Pan‐Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion. Angewandte Chemie International Edition, 58(1), 278-282. https://doi.org/10.1002/anie.201812668

Meer, M. T., Dillion, R., Nielsen, S. M., Walther, R., Meyer, R. L., Daamen, W. F., Van Den Heuvel, L. P., Van Der Vliet, J. A., Lomme, R. M. L. M., Hoogeveen, Y. L., Schultze Kool, L. J., Schaffer, J. E. & Zelikin, A. N. (2019). Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs. Chemical Communications, 55(4), 443-446. https://doi.org/10.1039/c8cc08737g

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Revised 04.02.2026

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Lise Refstrup Linnebjerg Pedersen