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Marie Curie Fellow

Small Molecule-Donating Artificial Organelles

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, encompassing a spectrum of liver damage. Multiple issues are involved on the cellular level in failing liver often involve enzyme deficiencies, such as reduced biosynthesis of S-adenosylmethionine (SAMe) or antioxidant properties. This project aims to coutneract the accumulation of reactive oxygen species (ROS) and reduced levels of glutathione (GSH). In healthy individuals, GSH is present in high levels in liver cells, playing a key role in removing ROS. In fatty liver cells, the missing antioxidant together with high ROS levels presents a toxic combination further pressuring the injured organ.

Publications

Cell Mimicry as a Bottom‐Up Strategy for Hierarchical Engineering of Nature‐Inspired Entities, Xiaomin Qian, Isabella Nymann Westensee, Edit Brodszkij, Brigitte Städler, WIREs NANOMEDICINE AND NANOBIOTECHNOLOGY, 2021, 13, e1683    

Polymer–Lipid Hybrid Vesicles and Their Interaction with HepG2 Cells, Edit Brodszkij, Isabella N. Westensee, Mathias Bertelsen, Noga Gal, Thomas Boesen, Brigitte Städler, SMALL, 2020, 16, 1906493