Pedersen, M. B., Zhou, X., Larsen, E. K. U., Sørensen, U. S., Kjems, J., Nygaard, J. V., Nyengaard, J. R., Meyer, R. L., Boesen, T. & Vorup-Jensen, T. (2010).
Curvature of Synthetic and Natural Surfaces is an Important Target Feature in Classical Pathway Complement Activation.
Journal of Immunology,
184(4), 1931-1945.
https://doi.org/10.4049/jimmunol.0902214
Mollenhauer, J., Stamou, D.
, Flyvbjerg, A., Wengel, J., Gether, U.
, Kjems, J., Bjørnholm, T.
& Besenbacher, F. (2010).
David versus Goliath.
Nanomedicine: Nanotechnology, Biology and Medicine,
6(4), 504-9.
https://doi.org/10.1016/j.nano.2010.04.002Montanini, L., Pazzaglia, L., Spessotto, P.
, Kjems, J., Conti, A., Perris, R., den Boer, M. L. & Benassi, M. S. (2010).
Differential approach to define microRNA expression patterns in osteosarcomas.
Proceedings of the American Association of Cancer Research,
51.
Jepsen, M. DE., Nechyponuk-Zloy, V., Beerens, N., Besenbacher, F., Kjems, J. & Birkedal, V. (2010).
FRET-studies of the HIV-1 genome upon tRNA annealing.
Krüger, A. C., Raarup, M. K., Nielsen, M. M., Kristensen, M., Besenbacher, F., Kjems, J. & Birkedal, V. (2010).
Interaction of hnRNP A1 with telomere DNA G-quadruplex structures studied at the single molecule level.
European Biophysics Journal,
39(9), 1343-1350.
https://doi.org/10.1007/s00249-010-0587-x
Nawroth, I., Alsner, J., Behlke, M. A.
, Besenbacher, F., Overgaard, J., Howard, K. A. & Kjems, J. (2010).
Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis.
Radiotherapy & Oncology,
97(1), 143-8.
https://doi.org/10.1016/j.radonc.2010.09.010
Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Dalsgaard Sørensen, K., Ulhøi, B. P., Borre, M., Kjems, J., Andersen, L. D. & Ørntoft, T. F. (2010).
miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors.
Oncogene,
29(7), 1073.
https://doi.org/10.1038/onc.2009.395
Nielsen, E. J. B., Nielsen, J. M., Becker, D., Karlas, A., Prakash, H.
, Glud, S. Z., Merrison, J., Besenbacher, F., Meyer, T. F.
, Kjems, J. & Howard, K. A. (2010).
Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.
Pharmaceutical Research,
27(12), 2520-7.
https://doi.org/10.1007/s11095-010-0255-y
Madsen, J. B., Dupont, D. M., Andersen, T. B., Nielsen, A. F., Sang, L., Brix, D. M., Jensen, J. K., Broos, T., Hendrickx, M. L. V.
, Christensen, A., Kjems, J. & Andreasen, P. A. (2010).
RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1.
Biochemistry,
49(19), 4103-15.
https://doi.org/10.1021/bi100066j
Dupont, D. M., Madsen, J. B., Hartmann, R. K., Tavitian, B., Ducongé, F.
, Kjems, J. & Andreasen, P. A. (2010).
Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding.
RNA,
16(12), 2360-9.
https://doi.org/10.1261/rna.2338210
Helmig, S. W., Rotaru, A., Arian, D., Kovbasyuk, L.
, Arnbjerg, J., Ogilby, P. R., Kjems, J., Mokhir, A.
, Besenbacher, F. & Gothelf, K. V. (2010).
Single Molecule Atomic Force Microscopy Studies of Photosensitized Singlet Oxygen Behavior on a DNA Origami Template.
A C S Nano,
4(12), 7475-7480.
https://doi.org/10.1021/nn102701f
Voigt, N. V., Tørring, T., Rotaru, A., Jacobsen, M. F., Ravnsbæk, J. B., Subramani, R., Mamdouh, W., Kjems, J., Mokhir, A.
, Besenbacher, F. & Gothelf, K. V. (2010).
Single-molecule chemical reactions on DNA origami.
Nature Nanotechnology,
5(3), 200-203.
https://doi.org/10.1038/nnano.2010.5
Andersen, M. Ø., Nygaard, J. V., Burns, J. S.
, Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J. (2010).
siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.
Molecular Therapy,
18(11), 2018-2027.
https://doi.org/10.1038/mt.2010.166
Xu, W., Wang, J.-G.
, Jacobsen, M. F., Mura, M.
, Yu, M., Kelly, R. E. A., Meng, Q.-Q.
, Lægsgaard, E., Stensgaard, I., Linderoth, T. R., Kjems, J., Kantorovich, L. N.
, Gothelf, K. V. & Besenbacher, F. (2010).
Supramolecular porous network formed by molecular recognition between chemically modified nucleobases guanine and cytosine.
Angewandte Chemie International Edition,
49(49), 9373-7.
https://doi.org/10.1002/anie.201003390
Andersen, M. Ø., Lichawska, A.
, Arpanaei, A., Jensen, S. M. R., Kaur, H., Oupicky, D.
, Besenbacher, F., Kingshott, P., Kjems, J. & Howard, K. A. (2010).
Surface functionalisation of PLGA nanoparticles for gene silencing.
Biomaterials,
31(21), 5671-5677.
https://doi.org/10.1016/j.biomaterials.2010.03.069
Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I. (2010).
Treatment of radiation-induced fibrosis. (Patent No.
WO2010085959A1).
Laursen, M. B., Pakula, M. M., Gao, S., Fluiter, K., Mook, O. R., Baas, F., Langklaer, N., Wengel, S. L., Wengel, J.
, Kjems, J. & Bramsen, J. B. (2010).
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo.
Molecular BioSystems,
6(5), 862-70.
https://doi.org/10.1039/b918869j
Bramsen, J. B., Laursen, M. B., Nielsen, A. F., Hansen, T. B., Bus, C., Langkjær, N., Babu, B. R., Højland, T., Abramov, M., Van Aerschot, A., Odadzic, D., Smicius, R., Haas, J., Andree, C., Barman, J., Wenska, M., Srivastava, P., Zhou, C., Honcharenko, D.
... Kjems, J. (2009).
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Nucleic Acids Research,
37(9), 2867-81.
https://doi.org/10.1093/nar/gkp106
Wittenborn, T., Nygaard, J. V., Horsman, M. R., Vorup-Jensen, T., Kjems, J., Thim, T., Nielsen, T., Larsen, E. K. U. & Falk, E. (2009).
A Novel in Vivo Angiogenesis Mouse Model.
Arteriosclerosis, Thrombosis, and Vascular Biology, (7).
Hartmann, H., Lakner, U.
, Andersen, M. Ø., Kjems, J., Howard, K. A. & Schloßhauer, B. (2009).
Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. Tissue Engineering. Part A. Tissue Engineering, (3), 718.
Mistry, A.
, Glud, S. Z., Kjems, J., Nyengaard, J. R., Howard, K. A., Stolnik, S. & Illum, L. (2009).
Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium.
Journal of Drug Evaluation,
17(7), 543-552.
https://doi.org/10.1080/10611860903055470Molle, D., Segura-Morales, C., Camus, G., Berlloz-Forrent, C.
, Kjems, J., Basyuk, E. & Bertrand, E. (2009).
Endosomal Trafficking of HIV-1 Gag and Genomic RNAs Regulates Viral Egress.
Journal of Biological Chemistry,
284(29), 19727-19743.
https://doi.org/10.1074/jbc.M109.019844Kristensen, T., Christensen, M. S., Jensen, T. H., Kjems, J., Gylling, A. & Scheving, M. (2009).
Experimental Molecular Biology: Laboratory Course Manual.
Andersen, L. D., Ostenfeld, M. S., Bramsen, J. B., Silahtaroglu, A.
, Lamy, P., Ramanathan, R., Fristrup, N., Jensen, J. L., Andersen, C. L., Zieger, K., Kauppinen, S.
, Ulhøi, B. P., Kjems, J., Borre, M. & Ørntoft, T. F. (2009).
Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Research,
69(11), 4851-60.
https://doi.org/10.1158/0008-5472.CAN-08-4043
Krüger, A. C., Nielsen, M. M., Lützelberger, M., Raarup, M. K., Kristensen, M., Kjems, J., Besenbacher, F. & Birkedal, V. (2009).
Interactions between the human telomeric G-quadruplex and hnRNP A1 studied by single-molecule FRET. Poster session presented at X Annual Linz Winter Workshop, Linz, Austria.
Birkedal, V., Krüger, A. C., Nochyporuk-Zloy, V.
, Kjems, J. & Besenbacher, F. (2009).
Methods for single molecule FRET microsocpy data analysis. Poster session presented at 15
th Anniversary International Workshop on "Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences", Berlin, Germany.
Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Ulhøi, B. P., Borre, M., Kjems, J., Dyrskjøt, L. & Ørntoft, T. F. (2009).
miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors.
Oncogene.
https://doi.org/10.1038/onc.2009.395
Glud, S. Z., Bramsen, J. B., Dagnaes-Hansen, F., Wengel, J.
, Howard, K. A., Nyengaard, J. R. & Kjems, J. (2009).
Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.
Oligonucleotides,
19(2), 163-8.
https://doi.org/10.1089/oli.2008.0175
Nygaard, J. V., Andersen, M. Ø., Cloetens, P.
, Foss, M., Kassem, M.
, Kjems, J. & Besenbacher, F. (2009).
Polycaprolactone nanomesh cultured with hMSC evaluated by synchrotron tomography. Poster session presented at Self-assembly: from nature to clinics, Porto, Portugal.
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B., Stark, H.
, Oliveira, C. L. P., Pedersen, J. S., Birkedal, V., Besenbacher, F., Gothelf, K. V. & Kjems, J. (2009).
Self-assembly of a nanoscale DNA box with a controllable lid.
Nature,
459(7243), 73-6.
https://doi.org/10.1038/nature07971
Jahn, K., Nielsen, M. M., Olsen, E. M., Mohammadzadegan, R.
, Andersen, E. S., Gothelf, K. V. & Kjems, J. (2009).
Site-specific labeling of long HIV-1 RNA using DNA templated chemistry. 84-88. Paper presented at 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009, Snowbird, UT, United States.
Larsen, E. K. U., Nielsen, T., Wittenborn, T., Birkedal, H., Vorup-Jensen, T., Jakobsen, M. H.
, Østergaard, L., Horsman, M. R., Besenbacher, F., Howard, K. A. & Kjems, J. (2009).
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
A C S Nano,
3(7), 1947-51.
https://doi.org/10.1021/nn900330m
Gao, S., Dagnæs-Hansen, F., Nielsen, E. J. B., Wengel, J.
, Besenbacher, F., Howard, K. A. & Kjems, J. (2009).
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular Therapy,
17(7), 1225-1233.
https://doi.org/10.1038/mt.2009.91
Damgaard, C. K., Kahns, S., Lykke-Andersen, S., Nielsen, A. L., Jensen, T. H. & Kjems, J. (2008).
A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo.
Molecular Cell,
29(2), 271-278.
https://doi.org/10.1016/j.molcel.2007.11.035,
https://doi.org/10.1016/j.molcel.2007.11.035
Howard, K. A., Paludan, S. R., Behlke, M. A.
, Besenbacher, F., Deleuran, B. W. & Kjems, J. (2008).
Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.
Molecular Therapy,
17(1), 162-168.
https://doi.org/10.1038/mt.2008.220
Torarinsson, E., Yao, Z.
, Wiklund, E. D., Bramsen, J. B., Hansen, C. A.
, Kjems, J., Tommerup, N., Ruzzo, W. L. & Gorodkin, J. (2008).
Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions.
Genome Research,
18(2), 242-251.
https://doi.org/10.1101/gr.6887408Andersen, M. Ø., Howard, K. A., Paludan, S. R., Besenbacher, F. & Kjems, J. (2008).
Delivery of siRNA from lyophilized polymeric surfaces.
Biomaterials,
29(4), 506-512.
https://doi.org/10.1016/j.biomaterials.2007.10.003
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Lind-Thomsen, A.
, Mamdouh, W., Gothelf, K. V., Besenbacher, F. & Kjems, J. (2008).
DNA origami design of dolphin-shaped structures with flexible tails.
A C S Nano,
2(6), 1213-8.
https://doi.org/10.1021/nn800215j
Rahbek, U. L., Howard, K. A., Oupicky, D., Manickam, D. S.
, Dong, M., Nielsen, A. F., Hansen, T. B., Besenbacher, F. & Kjems, J. (2008).
Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides.
Journal of Gene Medicine,
10(1), 81-93.
https://doi.org/10.1002/jgm.1120
Nygaard, J. V., Andersen, M. Ø., Howard, K. A., Foss, M., Bünger, C., Kjems, J. & Besenbacher, F. (2008).
Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnology and Bioengineering (Print),
100(4), 820-9.
https://doi.org/10.1002/bit.21796
Nygaard, J. V., Andersen, M. Ø., Cloetens, P.
, Foss, M., Kassem, M.
, Kjems, J. & Besenbacher, F. (2008).
Nanoscaffolds for Drug Delivery and Tissue Engineering. Poster session presented at iNANO 6
th annual meeting, Aarhus, Denmark.
Astakhova, I., Korshun, V. A.
, Jahn, K., Kjems, J. & Wengel, J. (2008).
Perylene attached to 2'-amino-LNA: synthesis, incorporation into oligonucleotides, and remarkable fluorescence properties in vitro and in cell culture.
Bioconjugate Chemistry,
19(10), 1995-2007.
https://doi.org/10.1021/bc800202v
