SØREN DEGN: Lymphocyte Biology

Søren Degn’s lab focuses on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. B and T lymphocytes are the main constituents of the adaptive immune system, a branch of the immune system with the remarkable abilities of ‘learning’ and ‘memory’. The lab investigates these phenomena with a combination of molecular techniques, mouse models, flow and imaging cytometry, cell sorting, and advanced imaging techniques, including confocal and two-photon microscopy. This work has implications for the development of treatments for autoimmune diseases, cancer, and infectious diseases, as well as vaccine design.

Recent publications

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van der Poel, C. E., Bajic, G., Macaulay, C. W., van den Broek, T., Ellson, C. D., Bouma, G., Victora, G. D., Degn, S. E. & Carroll, M. C. (2019). Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB. Cell Reports, 29(9), 2745-2755.e4. https://doi.org/10.1016/j.celrep.2019.10.086

Thiel, S., Kolev, M., Degn, S. E., Steffensen, R., Hansen, A., Ruseva, M. & Jensenius, J. C. (2009). Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. Journal of Immunology, 182(5), 2939-47. https://doi.org/10.4049/jimmunol.0802053

Thiel, S., Jensen, L., Degn, S. E., Nielsen, H. J., Gál, P., Dobó, J. & Jensenius, J. C. (2012). Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components. Clinical and Experimental Immunology, Supplement, 169(1), 38-48. https://doi.org/10.1111/j.1365-2249.2012.04584.x

Sirinian, C., Papanastasiou, A. D., Degn, S. E., Frantzi, T., Aronis, C., Chaniotis, D., Makatsoris, T., Koutras, A. & Kalofonos, H. P. (2021). Rank-c expression sensitizes er-negative, egfr-positive breast cancer cells to egfr-tyrosine kinase inhibitors (Tkis). Genes, 12(11), Article 1686. https://doi.org/10.3390/genes12111686

Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, M. & Kalofonos, H. P. (2022). Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. NeoPlasia, 33, Article 100836. https://doi.org/10.1016/j.neo.2022.100836

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Revised 08.12.2025

Anne Færch Nielsen