Interdisciplinary Nanoscience Center

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 CellPAT SØREN DEGN: Lymphocyte Biology

SØREN DEGN: Lymphocyte Biology

Søren Degn’s lab focuses on the role of B and T lymphocytes in health and disease, with a particular emphasis on tolerance and autoimmunity. B and T lymphocytes are the main constituents of the adaptive immune system, a branch of the immune system with the remarkable abilities of ‘learning’ and ‘memory’. The lab investigates these phenomena with a combination of molecular techniques, mouse models, flow and imaging cytometry, cell sorting, and advanced imaging techniques, including confocal and two-photon microscopy. This work has implications for the development of treatments for autoimmune diseases, cancer, and infectious diseases, as well as vaccine design.

Recent publications

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Rasmussen, M. Q., Tindbæk, G., Nielsen, M. M., Merrild, C., Steiniche, T., Pedersen, J. S., Moestrup, S. K., Degn, S. E. & Madsen, M. (2023). Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types. Cancers, 15(6), Article 1830. https://doi.org/10.3390/cancers15061830
Rasmussen, M. Q., Bønnelykke-Behrndtz, M. L., Merrild, C., Tvilling, I. K. S., Christensen, J. N., Nielsen, M. M., Georgsen, J. B., Naumann, N., Gudbergsson, J. M., Etzerodt, A., Pedersen, J. S., Jenkins, R. W., Degn, S. E., Moestrup, S. K., Schmidt, H., Steiniche, T. & Madsen, M. (2025). LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling. Pigment Cell & Melanoma Research, 38(5), Article e70053. https://doi.org/10.1111/pcmr.70053
Psianou, K., Panagoulias, I., Papanastasiou, A. D., de Lastic, A.-L., Rodi, M., Spantidea, P. I., Degn, S. E., Georgiou, P. & Mouzaki, A. (2018). Clinical and immunological parameters of Sjögren's syndrome. Autoimmunity Reviews, 17(10), 1053-1064. https://doi.org/10.1016/j.autrev.2018.05.005
Pilati, D., Agyei, E. K., Elkhashab, M., Fuchs, E., Nielsen, I. H., Bjerg, T. W., Anthi, A. K., Jiménez-Reinoso, A., Iversen, M. B., Pohl, L., Narita, R., Frago, S., Jakobsen, M. R., Andersen, J. T., Degn, S. E., Paludan, S. R., Alvarez-Vallina, L. & Howard, K. A. (2025). Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction. Journal of Biological Chemistry, 301(6), Article 108508. https://doi.org/10.1016/j.jbc.2025.108508
Nielsen, I. H., Rovsing, A. B., Janns, J. H., Thomsen, E. A., Ruzo, A., Bøggild, A., Nedergaard, F., Møller, C. T., Boesen, T., Degn, S. E., Shah, J. V. & Mikkelsen, J. G. (2024). Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles. Molecular Therapy Nucleic Acids, 35(4), Article 102318. https://doi.org/10.1016/j.omtn.2024.102318

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Group leader

Revised 08.12.2025
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Anne Færch Nielsen