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STEFFEN THIEL: Innate Immune system

Steffen Thiel’s research focus is the processes that create inflammation in the body and his group is among the leaders in the field of immune recognition.

Steffen Thiel has been deeply involved in the description of the proteins and processes in the part of the immune system referred to as the complement system.

Recent publications

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Tang, C., Kwiatkowski, D., Garred, P., Madsen, H. O., Svejgaard, A., Michaelsen, T. E., Hibberd, M. L., Sumiya, M., Summerfield, J. A., Booy, R., Levin, M., Van Helden, P., Hoal-van Helden, E., Kuijper, E. J., Fijen, C. A., Dankert, J., Thiel, S., Megyeri, P., Deli, M. A. & Abraham, C. S. (1999). Mannose-binding lectin and meningococcal disease (multiple letters) [3]. Lancet, 354(9175), 336-338. https://doi.org/10.1016/S0140-6736(05)75240-5
Tan, S. M., Chung, M. C., Kon, O. L., Thiel, S., Lee, S. H. & Lu, J. (1996). Improvements on the purification of mannan-binding lectin and demonstration of its Ca(2+)-independent association with a C1s-like serine protease. Biochemical Journal, 319 ( Pt 2), 329-32.
Takahashi, K., Gordon, J., Liu, H., Sastry, K. N., Epstein, J. E., Motwani, M., Laursen, I., Thiel, S., Jensenius, J. C., Carroll, M. & Ezekowitz, R. A. (2002). Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic periotonitis. Microbes and Infections, 4, 773-784.
Takahashi, K., Gordon, J., Liu, H., Sastry, K. N., Epstein, J. E., Motwani, M., Laursen, I., Thiel, S., Jensenius, J. C., Carroll, M. & Ezekowitz, R. A. B. (2002). Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. Microbes and Infection, 4(8), 773-84.
Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Eppa, Ł., Szala-Poździej, A., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O., Thiel, S., Jensenius, J. C., Kasperkiewicz, K. & Cedzyński, M. (2018). The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT). Frontiers in Immunology, 9(SEP), 2153. Article 2153. https://doi.org/10.3389/fimmu.2018.02153