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STEFFEN THIEL: Innate Immune system

Steffen Thiel’s research focus is the processes that create inflammation in the body and his group is among the leaders in the field of immune recognition.

Steffen Thiel has been deeply involved in the description of the proteins and processes in the part of the immune system referred to as the complement system.

Recent publications

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Super, M., Thiel, S., Lu, J., Levinsky, R. J. & Turner, M. W. (1989). Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet, 2(8674), 1236-9.
Stover, C., Endo, Y., Takahashi, M., Lynch, N. J., Constantinescu, C., Vorup-Jensen, T., Thiel, S., Friedl, H., Hankeln, T., Hall, R., Gregory, S., Fujita, T. & Schwaeble, W. (2001). The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome1p36.2-3. Genes Immun, 2, 119-127.
Stover, C. M., Lynch, N. J., Dahl, M. R., Hanson, S., Takahashi, M., Frankenberger, M., Ziegler-Heitbrock, L., Eperon, I., Thiel, S. & Schwaeble, W. J. (2003). Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single stuctural gene. Genes Immun, 48, 374-384.
Stover, C. M., Thiel, S., Lynch, N. J. & Schwaeble, W. J. (1999). The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement. Journal of Immunology, 163(12), 6848-59.