Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Gligorescu, A , Bushi, SN , Lund, MB , Schramm, A, Kristensen, TN & Sørensen, JG 2026, 'Phenotypic plasticity and microbial signal: Unraveling the response of Hermetia illucens to long-term dietary shifts', Journal of Insects as Food and Feed. https://doi.org/10.1163/23524588-bja10362

de Oliveira, JA, dos Santos Lourenço, FM, Martins, JT, Arf, O, Silva, PST, Maltoni, KL & Cassiolato, AMR 2026, 'Phosphate-solubilizing bacteria as biofertilizers for upland rice', Revista Brasileirade Ciencias Agrarias, vol. 21, no. 1, e4441. https://doi.org/10.5039/agraria.v20i1a4441

Florea, A-F, Zak, DH , Petersen, RJ, Dreher, CL, Kappler, A & Hansen, HCB 2026, 'Phosphorus dynamics in acidic and neutral fen soils does vivianite limit phosphorus release?', Geoderma, vol. 466, 117685. https://doi.org/10.1016/j.geoderma.2026.117685

Lynge, FK , Assar, S , Del Rey, YC , Koren, K , Schlafer, S & Kristensen, MF 2026, 'pH-O₂ ratiometry: Correlative imaging of pH and oxygen saturation in dental biofilms', Biofilm. https://doi.org/10.1016/j.bioflm.2026.100348

Guazzetti, D, Aimi, L, Marcantonio, E, Siciliano, GM, Bugatti, K, Dobani, S, Sartori, A, Battistini, L, Zanardi, F & Curti, C 2026, 'Photoinduced, Chemoselective γ-Alkylation of 2-Silyloxyfurans with α-Bromoketones: A Rapid Entry to Chiral ε-Keto-γ-Butenolides', Chemistry - A European Journal, vol. 32, no. 5, e03083. https://doi.org/10.1002/chem.202503083

Hallsteinsdóttir, E 2026, 'Phraseme in der Kommunikation über Nachhaltigkeit: (neue) Formen und Funktionen', Deutsche Gesellschaft für Sprachwissenschaft, Trier, Germany, 25/02/2026 - 27/02/2026.

Long, M , Wielsøe, M & Bonefeld-Jørgensen, EC 2026, 'Phthalates and phthalate alternative in Greenlandic adults: Urinary concentrations and exposure determinants', International Journal of Hygiene and Environmental Health, vol. 271, 114695. https://doi.org/10.1016/j.ijheh.2025.114695

Nielsen, HB, Gupta, N, Andersen, AJ, Dreyer, LW, Flachs, EM, Madsen, IEH, Kolstad, HA, Kromhout, H, Sejbaek, CS & Hougaard, KS 2026, 'Physical work demands and risk of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus. A Danish longitudinal cohort study', Journal of Autoimmunity, vol. 158, 103514. https://doi.org/10.1016/j.jaut.2025.103514

Raj, RK, Verma, RS, Jony, SH, Saini, S & Shreya, S 2026, 'Physics-informed analytical modeling of dzyaloshinskii-moriya interaction gradient-driven magnetic skyrmion', Journal of Magnetism and Magnetic Materials, vol. 648, 174022. https://doi.org/10.1016/j.jmmm.2026.174022

Duvnjak, Z, Michelet, R, Steenholdt, C, Widigson, ESK, Skejø, C, Abrantes, JA, Huisinga, W, Julsgaard, M & Kloft, C 2026, 'Physiologically Motivated Sequential Population Modeling of Albumin Trends and Vedolizumab Pharmacokinetics for Pregnancy Dosing Regimen Optimization', Clinical Pharmacology and Therapeutics, vol. 119, no. 2, pp. 457-469. https://doi.org/10.1002/cpt.70145

Lewko, A, Eggmann, S, Ámundadóttir, ÓR, Astrup, K, Azevedo, VH, Battaglini, D, Meštrović, SB, Dowds, J, Duška, F, Eriksson, F, Hästbacka, J, Hernández-Méndez, B, Hickmann, CE, Ippolito, A, Martí Romeu, JD, Müller, A, Patsaki, I, Rutkauskienė, L, Schanke, CM, Shpata, V, Terzo, D, Tymruk-Skoropad, K, Uba, K, van der Schaaf, M, Zwoliński, T, Nydahl, P & McWilliams, D 2026, 'Physiotherapy provision and practice: A EuropeAn Intensive CarE Unit (ICU) survey (PEAiCE) – A profile of ICU physiotherapy in Europe', Intensive and Critical Care Nursing, vol. 95, 104390. https://doi.org/10.1016/j.iccn.2026.104390

Bakker, P 2026, Pidgins and Creoles. in R Mesthrie (ed.), International Encyclopedia of Language and Linguistics. Elsevier, pp. 1-6. https://doi.org/10.1016/B978-0-323-95504-1.01366-1

Ringgaard, D 2026, Pigen der blev født med anlæg for surrealisme blandt andet. in JØ Nyboe & MK Schimdt (eds), På højde med det uafklarede: Marianne Larsens forfatterskab. Forlaget Spring, Hellerup, pp. 14-21.

Allmendinger, F, Utz, O, Scheuren, PS, Rosner, J, Kramer, JLK & Hubli, M 2026, 'Placebo Effect on Pain-Related Autonomic Responses in a State of Experimentally-Induced Sensitization', European Journal of Pain, vol. 30, no. 4, e70259. https://doi.org/10.1002/ejp.70259

Garval, M , Pedersen, L, Pedersen, LM, Nielsen, AKWDJ, Christiansen, DH , Lange, J & Wagner, S 2026, 'Placement-Dependent Accuracy of a Smartphone-Based Sensor Application Compared to an Accelerometer-Based System for Measuring Physical Activity in Healthy Adults: A Validation Study', Sensors, vol. 26, no. 7, 2033. https://doi.org/10.3390/s26072033

Boot, AM, Ariceta, G, Beck-Nielsen, SS, Brandi, ML, Briot, K, de Lucas Collantes, C, Giannini, S, Haffner, D, Keen, R, Levtchenko, E, Mughal, MZ, Mäkitie, O, Nilsson, O, Schnabel, D, Tripto-Shkolnik, L, Zillikens, MC, Tudor, A & Emma, F 2026, 'Plain language summary of a study looking at the safety of burosumab in children and adolescents with X-linked hypophosphatemia', Future Rare Diseases, vol. 6, no. 1, 2607983. https://doi.org/10.1080/23995270.2025.2607983

Frich, J , Eriksson, E , Jensen, RH, Nilsson, EM, Holmberg, L, Yoo, D, Funk, M & Barendregt, W 2026, Planetary boundaries and data in HCI. in CHI EA '26: Proceedings of the Extended Abstracts of the 2026 CHI Conference on Human Factors in Computing Systems. https://doi.org/10.1145/3772363.3778805

Zhang, G, Yao, F, Lu, Y, Peixoto, L, Zamanian, K, Shi, L, Dippold, M, Zhang, W, Yang, H, Sánchez-Rodríguez, AR, Zhou, J & Li, FM 2026, 'Plant and microbial-derived carbon responses to contrasting tillage practices in a 53-year field experiment', Soil and Tillage Research, vol. 261, 107191. https://doi.org/10.1016/j.still.2026.107191

Hartvig, I, Madsen, IJ, Bünner, MS, Bourbonnais, A, Pedersen, HÆ , Nielsen, LR & Gilbert, MTP 2026, 'Plant conservation hologenomics: integrating population genomics with mycobiome assessments for protected orchid species', Journal for Nature Conservation, vol. 90, 127172. https://doi.org/10.1016/j.jnc.2025.127172

Eriksen, JVN, de Pietri, S, Rathe, M, Hasle, H, Enevold, C, Nielsen, CH, Schmigelow, K, Moser, C, Müller, K & Weischendorff, S 2026, 'Plasma calprotectin to assess susceptibility to bloodstream infections during paediatric acute lymphoblastic leukaemia induction treatment', British Journal of Haematology, vol. 208, no. 4, pp. 1339-1346. https://doi.org/10.1111/bjh.70393

Stensgaard, S, Mehmood, S, Ebert, EBF , Meldgaard, P, Dutta, A & Sorensen, BS 2026, 'Plasma extrachromosomal circular DNA as a biomarker in EGFR-targeted therapy of non-small cell lung cancer', Molecular Oncology, vol. 20, no. 4, pp. 1061-1073. https://doi.org/10.1002/1878-0261.70138

Thomsen, AK, Steffensen, MA, Hinnerskov, JMV, Nielsen, AT, Vorum, H , Honoré, B, Nissen, MH & Sørensen, TL 2026, 'Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration', Aging and Disease, vol. 17, no. 2, pp. 1068-1083. https://doi.org/10.14336/AD.2024.1585

Riishede, I, Rode, L, Lundegaard, PR, Rand, SA, Dyrskjøt, L , Larsen, OH, Ekelund, CK, Pinborg, A, Stender, S & Ghouse, J 2026, 'Plasma proteomic signature of the human menstrual cycle', Nature Medicine. https://doi.org/10.1038/s41591-026-04326-5

Pathak, GS 2026, 'Plastics and Labor: The Case of Disposable Medical Plastics', Medical Anthropology Quarterly. <https://anthrosource.onlinelibrary.wiley.com/doi/10.1111/maq.70063>

Holm, TE & Balsby, TJS 2026, Plettet rørvagtel, overvågning af ynglefugle. DCE, Teknisk anvisning fra Fagdatacenter for Biodiversitet og Terrestrisk Natur, no. A126, vers. 4, Aarhus University, DCE - Danish Centre for Environment and Energy. <https://ecos.au.dk/fileadmin/ecos/Fagdatacentre/Biodiversitet/TAA126_PlettetRoervagtel_v4.pdf>

Kjær, AM 2026, Pockets of Effectiveness. in AM Kjær, M Khisa & XA Ndlovu (eds), Elgar Encyclopedia of African Politics. Edward Elgar Publishing, pp. 329-332.

Knudsen, LED & Sattrup, L 2026, Poetisering af æstetisk resonans. in LED Knudsen & M Rold (eds), Arts-based research. Kunstbaserede forskningsmetoder . Unge Pædagoger.

Vilmar, TW 2026, 'Poetisk natteroderi', Seismograf/DMT. <https://seismograf.org/da/kortkritik/poetisk-natteroderi>

Nielsen, TR 2026, 'Poetisk undersøgelse af den tærskelstilstand, vi alle skal opleve', Peripeti - tidsskrift for dramaturgiske studier, vol. 23, no. 41, pp. 236-241. https://doi.org/10.7146/peri.v23i41.164002

Sattrup, L & Knudsen, LED 2026, Poetizations as an A/R/Tographical Approach: Students’ Engagement as Aesthetic Resonance in Museum Education. in A Lasczik, RL Irwin, A Sinner & V Triggs (eds), International Handbook of A/r/tography. Intellect.

Gul, T , Manevski, K , Arthur, E , Han, E, Zhang, X, Smith, AM & Andersen, MN 2026, 'Point-injection of modified biochar doubles the root penetration rate and enhances nitrogen uptake and growth of wheat in sandy soil', Journal of Soil Science and Plant Nutrition.

Hirsch, C , Lundbye, NN & Otto, M 2026, 'Poisson approximation of large-lifetime cycles', Extremes. https://doi.org/10.1007/s10687-026-00526-x

Ryfisch, S, Başoğlu Acet, D, Benejam, L, Biggs, J, Boissezon, A, Boix, D, Brucet, S, Decrey, M, Dolcerocca, A, Hansen, K, Lago, M, Lemmens, P, Lindoso, D, Llausàs, A, McDonald, H, Meerhoff, M, Mehner, T, Pereira, G, Perrin, JA, Quintana, XD, Rasmussen, M, Ribas, A, Sander Johansson, L, Wijns, R & Blicharska, M 2026, 'Policies and practices impacting the implementation of nature-based solutions: a comparative study of ponds and pondscapes in eight countries', Journal of Environmental Planning and Management, vol. 69, no. 4, pp. 1146-1176. https://doi.org/10.1080/09640568.2024.2418966

Kammersgaard, T, Lloyd, C, Devany, C, Bainbridge, L, Brown, K & Coomber, R 2026, 'Policing and drug market-related violence: Competitive, internal and enforcement-related violence in UK County Lines', International Journal of Drug Policy, vol. 149, 105155. https://doi.org/10.1016/j.drugpo.2026.105155

Brøgger, K & L. Robertson, S 2026, Policing the Academy, Securitizing Knowledge: Unsettling Institutional Autonomy and Academic Freedom in a Changing Geopolitical World. in The Bloomsbury Handbook of Educational Politics and Policy. Bloomsbury.

Fenger, J 2026, 'Policy information and opinion change: panel studies from European Union referendums', Journal of European Public Policy, pp. 1-25. https://doi.org/10.1080/13501763.2026.2654570

Elofsson, K 2026, Policy Instruments for the Efficient Use of Carbon Cascades in Agricultural Products. Fagligt notat fra DCE – Nationalt Center for Miljø og Energi (2020-...), no. 9, vol. 2026, Aarhus University, DCE - Danish Centre for Environment and Energy.

Fenger, J 2026, 'Policy-Specific Information and Voter Competence in Direct Democracy: Panel Evidence from Danish EU Referendums', European Journal of Political Research, pp. 1-12. https://doi.org/10.1017/S1475676526100826

Andersen, D 2026, 'Politisering af embedsværket og demokratisk tilbagegang', Politica.

Hvid, RM 2026, 'Politisk teori som kritisk praksis: om rationel rekonstruktion og Frankfurterskolen', Politica - Tidsskrift for politisk videnskab, vol. 58, no. 1-2.

Nawaz, M, Shabbir, S, Sonne, C & Xiaobo, L 2026, 'Polyamine defense shield of plants against biotic and abiotic stress', Plant Stress, vol. 20, 101253. https://doi.org/10.1016/j.stress.2026.101253

Holmskov, M, Christensen, J, Larsen, MF, Christiansen, AE & Nielsen, RE 2026, 'Polycystic ovary syndrome in women with bipolar affective disorder or epilepsy exposed to valproic acid: a nationwide 16-year cohort study', International Journal of Bipolar Disorders, vol. 14, no. 1, 6. https://doi.org/10.1186/s40345-026-00411-3

Pourhadi, N, Jensen-Dahm, C, Laursen, TM , Gasse, C , Waldemar, G & Janbek, J 2026, 'Polypharmacy in people with dementia: a nationwide Danish study', Alzheimer's Research & Therapy, vol. 18, no. 1, 72. https://doi.org/10.1186/s13195-026-01988-8

Bigi, C, Dürrnagel, M, Klebl, L, Consiglio, A, Pokharel, G, Zonno, M, Bertran, F, Le Fèvre, P, Jaouen, T, Tchouekem, HC, Turban, P, De Vita, A, Miwa, JA, Wells, JW, Oh, D, Comin, R, Thomale, R, Zeljkovic, I, Ortiz, BR, Wilson, SD, Sangiovanni, G, Mazzola, F & Di Sante, D 2026, 'Pomeranchuk instability from electronic correlations in CsTi₃Bi₅ kagome metal', Nature Communications, vol. 17, no. 1, 325. https://doi.org/10.1038/s41467-025-67037-4

Glas, E 2026, 'Pontius Pilatus: wie was hij echt?', Geschiedenis Magazine, vol. 61, no. 2, pp. 32-35.

Wang, X, Aninta, SG, Garcia-Erill, G, Li, Z, Khan, A, Liu, X, Bertola, LD, Dharmayanthi, AB, Yulianto, Yonathan, Rossi, C, Cauble-Sims, R, Rosen, BD, Hagen, DE, Heaton, MP, Smith, TPL, Lenstra, JA, Martins, NFG, Sinding, MHS, Agil, M, Purwantara, B, Hvilsom, C, Semiadi, G & Heller, R 2026, 'Population structure and domestication history of the Javan banteng', Current Biology, vol. 36, no. 2, pp. 458-473.e8. https://doi.org/10.1016/j.cub.2025.11.076

Liu, H, Zak, DH , Rasmussen, JJ, Rezanezhad, F, Fenner, N & Lennartz, B 2026, 'Pore Water Quality in Northern Peatlands: Impacts of Drainage and Rewetting', EGU General Assembly 2026, Vienna, Austria, 03/05/2026 - 08/05/2026. https://doi.org/10.5194/egusphere-egu25-13237

Rasmussen, C , Søndergaard, J & Jørgensen, CJ 2026, 'Portable X-Ray Fluorescence (pXRF) spectrometry and multivariate statistics for geochemical fingerprinting and pollution source determination at a legacy mine site in East Greenland.', Arctic Science Summit Week 2026, Aarhus, Denmark, 25/03/2026 - 01/04/2026.

Martinsen, LK 2026, Portræt af en mønsterbryder. in TL Larsen, LK Martinsen & LB Rønberg (eds), Tråde af tid: Frederiksborgs Gobeliner. Aarhus Universitetsforlag, Aarhus, pp. 48-77.

Donskov, AO, Gaster, T, Hauge, EM , De Thurah, A , Nørgaard, M & Keller, KK 2026, 'Positive predictive value of a register-based method to identify polymyalgia rheumatica in primary and secondary care: a validation study in Denmark', Scandinavian Journal of Rheumatology. https://doi.org/10.1080/03009742.2026.2628455

Displaying results 3101 to 3150 out of 390508

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen