Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Ledderer, LK , Nielsen, KH , Skodborg, L & Fage-Butler, A 2026, 'Public trust and mistrust of COVID-19 vaccines: A systematic meta-narrative review', Vaccine, vol. 69, 127947. https://doi.org/10.1016/j.vaccine.2025.127947

Yde, CSZ & Matchkov, VV 2026, 'Pulsatility index: Insights into post-stroke haemodynamics', Neuroscience Insights, vol. 21. https://doi.org/10.1177/26331055261427992

Hesse, M , Andersen, CU, Reitzel, LA, Eriksen, TS & Lindholst, C 2026, 'Purity and adulterants in street heroin in Denmark from 2006 to 2024', Forensic Science International, vol. 380, 112795. https://doi.org/10.1016/j.forsciint.2025.112795

Wojtczuk‐Turek, A, Turek, D, Jurek, P, Edgar, F, Okay-Somerville, B, Podgorodnichenko, N, Fu, N, Järlström, M, Popov, B, Hutchings, P, Sullivan, K, Hafstad, MD, Shkoda, T, Savych, O, Raeder, S, Klein, HJ, Bosak, J, Lupina-Wegener, A, Dvorakova, Z, Gutiérrez-Crocco, F, Kekkonen, A, Leiva, PI, Mynaříková, L, Sánchez-Apellániz, M, Shafique, I, Al-Romeedy, BS, Wee, S, Dunlop, P, Stinglhamber, F, Caesens, G, Caldana, A, Sticca, MG, Vasilev, V, Lauzier, M, Desjardins, G, Zhang, G, Tan, L, Galvez-Sierra, LB, Pérez, ER, Goić, S, Tadić, I, Charvátová, D, Botek, M, Jensen, DH, Rojas, DL, Pazmay-Ramos, SG, Masso, P, Gillet, N, Huyghebaert-Zouaghi, T, Robakidze, M, Martskvishvili, K, Dorrough, AR, Jekel, M, Häffner, C, Sevincer, TA, Kekesi, EK, Agyemang, CB, Apospori, E, Jose, J, Salendu, A, Etikariena, A, Susianto, H, Sjabadhyni, B, Malayeri, S, Seydi, M, Kinahan, M, Lisak, A, Mariani, MG, Salvati, M, Moscatelli, S, Crapolicchio, E, Manzi, C, Shimazu, A, Ikeda, H, Žukauskienė, R, Kaniušonytė, G, Catania, G, Lauri, MA, Madero-Gómez, SM, Fernando, D, Veth, K, Dhakal, S, Lawal, A, Reategui, A, Tristán, OM, Edralin, DM, Schmitz, S, Neto, J, Neto, F, Đorđević, JM, Mihić, V, Kalistova, A, Piterová, I, Mayer, C-H, Charlo Molina, MJ, Ranasinghe, R, Nakchedi-Ooft, T, Sobhie, R, Matteo, M, Chavanovanich, J, Petchthip, N, Karabatı, S, Akbaş, G, Turkoglu, B, Mosanya, M, Pérez de León, P, Labarthe-Carrara, J, Phelps, C & Karamustafa-Köse, G 2026, 'Putting Sustainable Human Resource Management and Workplace Eudaimonic Well-being into Cross-Cultural Context', European Management Journal. https://doi.org/10.1016/j.emj.2026.03.008

Dudina, M, Olesen, SS, Søgaard, KK & Nielsen, HL 2026, 'Pyogenic liver abscess in the North Denmark Region: a population-based cohort study (2010-2022)', European Journal of Clinical Microbiology & Infectious Diseases, vol. 45, no. 1, pp. 287-296. https://doi.org/10.1007/s10096-025-05307-1

Chakraborty, SK, Ray, P, Sousa, FB, Sahoo, C, Prasad, ID, Biswas, S, Nayak, B, Kundu, B, Rojas, R, Jones, AJH , Miwa, JA , Ulstrup, S, Dutta, S, Kumar, S, Malard, LM, Pradhan, GK & Sahoo, PK 2026, 'Quadruple Moiré Pockets in Lateral Heterobilayers: Programmable Phononic Reconfiguration and Anomalous Second Harmonic Generation', Advanced Materials, vol. 38, no. 8, e20008. https://doi.org/10.1002/adma.202520008

Hovgaard, HL 2026, 'Qualifying fluid treatment in thoracic surgery', PhD, Aarhus University.

Uhlenbusch, N, Snijders, RJALM, Mund, M, Janik, MK, Milkiewicz, P, Löwe, B, Kroll, C, Raszeja-Wyszomirska, J, Gerussi, A, Bolis, F, Cristoferi, L, Invernizzi, P, Kovats, P, Papp, M, Grønbæk, L , Grønbæk, H, Tjwa, ETTL, Aamann, L, Ytting, H, Ronca, V, Olsen, K, Oo, YH, van der Meer, AJ, Madaleno, J, Canhão, B, Engel, B, Campos-Murguia, A, Taubert, R, Koc, ÖM, Kramer, M, Willemse, JA, Lohse, AW, Drenth, JPH, Gevers, TJG & Schramm, C 2026, 'Quality of Life in Patients With Variant Syndromes of Autoimmune Liver Diseases: A Cross-Sectional Multicentre Study', Liver International, vol. 46, no. 3, e70526. https://doi.org/10.1111/liv.70526

Beha, GH, Stemmerik, MG, Boer, VO, Van der Ploeg, AT, Van der Beek, NAME, Andersen, H, Marsman, A, Jacobsen, LN, Theunissen, MTM, Petersen, ET & Vissing, J 2026, 'Quantification of muscle glycogen distribution in Pompe disease using 7 Tesla ¹³C NMR spectroscopy', Journal of Neurology, Neurosurgery and Psychiatry, vol. 97, no. 3, jnnp-2025-336628, pp. 201-203. https://doi.org/10.1136/jnnp-2025-336628

Stage, C 2026, Quantified stories of illness and dying on social media. in K Giaxoglou & C Tagg (eds), The Routledge Handbook of Language and Social Media around the World. 1 edn, Routledge, pp. 292-304. https://doi.org/10.4324/9781003360339-24

Wang, Y, Figueroa-Espinoza, B, Torres-Freyermuth, A, Appendini, CM, Chamorro, LP, Rendón-Valdez, C, Quintana-Barranco, R & Tinoco, RO 2026, 'Quantifying Drag on Floating Sargassum Patches Under Combined Air and Water Forcing', Journal of Geophysical Research: Oceans, vol. 131, no. 3, e2025JC023529. https://doi.org/10.1029/2025JC023529

Blake, D & Xydis, G 2026, 'Quantifying local wind farm impacts on land surface temperature: Evidence from airport observations and a preliminary model', Wind Engineering, vol. 50, no. 1, pp. 23-31. https://doi.org/10.1177/0309524X251410691

Morgan, J & Major-Smith, D 2026, 'Quantifying potential selection bias in observational research: simulations and Analyses exploring religion and depression using a prospective UK cohort study (ALSPAC)', Religion, Brain and Behavior, vol. 16, no. 1, pp. 9-23. https://doi.org/10.1080/2153599X.2024.2377545

Valentin, JL 2026, 'Quantifying texture in hexaferrite permanent magnets', PhD.

Parra-Rodas, JF, Arias-Gaviria, J, Larsen, ER & Arango-Aramburo, S 2026, 'Quantifying the 2050 scenarios for Colombia’s electricity sector transition', Renewable Energy, vol. 256, no. Part C, 124040. https://doi.org/10.1016/j.renene.2025.124040

Laustsen, LM , Ejlskov, L , Chen, D , Lasgaard, M, Rod, NH, Gradus, JL, Grønkjær, MS & Plana-Ripoll, O 2026, 'Quantifying the contribution of social disconnection to the mortality gap associated with mental disorders: a decomposition analysis', European Journal of Epidemiology, vol. 41, no. 2, pp. 217-228. https://doi.org/10.1007/s10654-025-01348-0

Kopacz, N, King, HE, Campisi, D, Silfhout, AV, Delen, G & Kate, ILT 2026, 'Quantifying the force regime of pyrene adsorption on anatase', Icarus, vol. 446, 116869, pp. 116869. https://doi.org/10.1016/j.icarus.2025.116869

Herlin, LK , Sommerlund, M, Langan, SM & Schmidt, SAJ 2026, 'Quantifying the increased risk of atopic disorders in patients with ectodermal dysplasias: A nationwide registry-based study', Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2026.03.037

Copic, L 2026, 'Quantitative Results for Multivariate Models', PhD, Aarhus University.

Hafeez, S, Abro, GEM & Marimuthu, M 2026, 'Quantum-Secured AI-Driven Drone Logistics for Real-Time Healthcare Delivery', Arabian Journal for Science and Engineering. https://doi.org/10.1007/s13369-026-11104-5

Hafeez, S, Abro, GEM, Memon, SA, Khan, TA, Memon, I & Nasir, H 2026, 'Quantum-secured routing in drone communication for 6G-enabled smart mobility', Scientific Reports, vol. 16, no. 1, 8626. https://doi.org/10.1038/s41598-026-36297-5

Abrahams, G, Štuhec, A, Spreng, V, Henry, R, Kempf, I, James, J, Sechkar, K, Stacey, S, Trelles-Fernandez, V, Antill, LM, Timmel, CR, Miller, J, Ingaramo, M, York, AG, Tetienne, J-P & Steel, H 2026, 'Quantum spin resonance in engineered proteins for multimodal sensing', Nature, vol. 649, no. 8099, pp. 1172-1179. https://doi.org/10.1038/s41586-025-09971-3

Magris, M , Shabani, M & Iosifidis, A 2026, 'Quasi black-box variational inference for Bayesian learning', Pattern Recognition, vol. 177, 113219. https://doi.org/10.1016/j.patcog.2026.113219

Cioli Puviani, F, Zaffagnini, A, Mazzi, C, Cirillo, DM, Di Gennaro, F, Farkas, FB, Guglielmetti, L, Kherabi, Y, Kunst, H, Sepulcri, C, Wejse, C, Todaro, L & Ursini, T 2026, 'Query into Tuberculosis Infection Screening and Management among Pregnant Migrants, Europe', Emerging Infectious Diseases, vol. 32, no. 3, pp. 469-471. https://doi.org/10.3201/eid3203.251775

Adnew, GA, Schroll, M, Röckmann, T, Keppler, F, Sapper, SE, Jørgensen, CJ, Blunier, T, Laemmel, T, Szidat, S, van der Veen, C & Christiansen, JR 2026, 'Radiocarbon and bulk isotope composition of subglacial methane and carbon dioxide emitted at the western margin of the Greenland ice sheet', Geochimica et Cosmochimica Acta, vol. 414, pp. 328-342. https://doi.org/10.1016/j.gca.2025.12.026

Østergaard, DE, Lundgaard, AY, Rechner, LA, Dejanovic, D, Rose, HK , Hansen, J, Vaalavirta, L, Mokka, M, Aznar, M, Wehner, PS, Hjalgrim, LL & Maraldo, MV 2026, 'Radiotherapy Delivery in Deep Inspiration for Pediatric Patients—Final Results of the Phase II Feasibility Study TEDDI', Pediatric Blood and Cancer, vol. 73, no. 4, e70100. https://doi.org/10.1002/1545-5017.70100

Simpson, E, Biedermann, T, Kircik, L, Chovatiya, R, Figueras, I, Gallo, G, Casillas, M, Ding, Y, Xu, C, Hu, C, Pierce, E, Agell, H & Vestergaard, C 2026, 'Raising the bar of efficacy in Atopic Dermatitis: deep response in week 16 responders treated with lebrikizumab over 2 years', Journal of Dermatological Treatment, vol. 37, no. 1, 2631233. https://doi.org/10.1080/09546634.2026.2631233

Tarbensen, ML 2026, 'Rambling on about sustainability or Eating my way towards interweaving research and practice', Heliotrope. <https://www.heliotropejournal.net/helio/rambling-on-about-sustainability>

Jensen, VV & Hoybye, MT 2026, 'Rammer for forklarlig sundheds-AI', Bibliotek for Læger, pp. 86-95.

Nielsen, CGA , Rasmussen, MB, Rhode, PT, Vibjerg Jensen, R , Jakobsen, L , Støttrup, NB, Veien, KT, Larsen, EN, Charlot, MG & Terkelsen, CJ 2026, 'Randomized comparison of sheath size for coronary intervention: time to hemostasis and risk of radial artery occlusion', Cardiovascular Revascularization Medicine, vol. 83, pp. 59-66. https://doi.org/10.1016/j.carrev.2025.04.042

Kalinichev, AV, Dekina, DI, Pokhvishcheva, NV, Prozherin, IS, Nosov, VG & Peshkova, MA 2026, 'Rapid detection of lead(II) with colorimetric optical sensors: calibration-free analysis demonstrated with semi-quantitative determination of urinary lead', Talanta, vol. 297, no. Part A, 128635. https://doi.org/10.1016/j.talanta.2025.128635

Khatkar, A , Koganti, T , Beucher, AM , Munkholm, LJ & Lamandé, M 2026, 'Rapid non-destructive methods for estimating shear strength of sandy soils', Soil & Tillage Research, vol. 257, 106951. https://doi.org/10.1016/j.still.2025.106951

Ringgaard, D 2026, Rapport.

Demontis, D , Duan, J, Hsu, Y-HH, Pintacuda, G, Grove, J , Nielsen, TT , Thirstrup, J, Martorana, M, Botts, T, Satterstrom, FK, Bybjerg-Grauholm, J, Tsai, JHY , Glerup, S, Hoogman, M, Buitelaar, J, Klein, M, Ziegler, GC, Jacob, C, Grimm, O, Bayas, M, Kobayashi, NF, Kittel-Schneider, S, Lesch, K-P, Franke, B, Reif, A, Agerbo, E, Werge, T, Nordentoft, M, Mors, O , Mortensen, PB, Lage, K, Daly, MJ, Neale, BM & Børglum, AD 2026, 'Rare genetic variants confer a high risk of ADHD and implicate neuronal biology', Nature, vol. 649, no. 8098, pp. 909-917. https://doi.org/10.1038/s41586-025-09702-8

Miranda-Cebrián, H, Cáliz, J, Olesen, JM, González Megías, A, Albacete, S, Martín, F, del Arco, L, Jarne, M, Ortega Casamayor, E, Verdú, M & García, MB 2026, 'Rare plants sustain communities of visitors with similar diversity but different composition across populations of different size', Perspectives in Plant Ecology, Evolution and Systematics, vol. 71, 125930. https://doi.org/10.1016/j.ppees.2026.125930

Zhang, Y, Zhao, F, Qiao, A, Liu, Y & Chen, M 2026, 'Rational Design and Functionalization of Melt Electrowritten 4D Scaffolds for Biomedical Applications', Nano-Micro Letters, vol. 18, no. 1, 144. https://doi.org/10.1007/s40820-025-01986-9

Patabendige, S, Harders, SMW, Bendstrup, E, Durheim, MT, Laursen, CB, Andersen-Ranberg, K, Brockhattingen, KK, Kildegaard, C, Bendixen, M & Davidsen, JR 2026, 'Rationale and design of uLtrasOund applicability in the assessment of patients with fibRosing interstitial lung Disease (LORD): a research protocol of a prospective cohort study', BMJ Open, vol. 16, no. 2, pp. e112171. https://doi.org/10.1136/bmjopen-2025-112171

Klok, FA, Sharp, A, Ahrens, I, Aleksic, M, Ni Ainle, F, Barco, S, Bertoletti, L, Keeling, B, Fengler, K, Helms, J, Jiménez, D, Lang, IM, Lauw, MN, Lorusso, R, Martin-Loeches, I, Meijboom, LJ, Meneveau, N, Montero-Cabezas, J, O'sullivan, G, Pola, R, Pruszczyk, P, Sanchez, O, Schlager, O, Schultz, J, Sinan, UY, Vedovati, MC, Verhamme, P, Zaher, A, Huisman, MV & Konstantinides, SV 2026, 'Rationale for and approach to establishing a multidisciplinary acute pulmonary embolism expert care team', European Heart Journal: Acute Cardiovascular Care, vol. 15, no. 2, pp. 151-161. https://doi.org/10.1093/ehjacc/zuaf141

Sterup, J, Jaatinen, K, Aleksi, M & Bregnballe, T 2026, 'Reactions to a returning predator: How White-tailed Eagles influence Great Cormorant breeding habits', 11th International Conference on Cormorants, Prague, Czech Republic, 03/02/2026 - 06/02/2026.

Ntapanta, SM & Kuppinger , P (ed.) 2026, Ready to Repair: Secondhand Electronics, Repairing, and Waste in Tanzania. in P Kuppinger (ed.), Second-Hand Cultures and Economies of Reuse, Repair, Sharing and Care.. Palgrave Macmillan, Cham, pp. 137-151.

Rønnstad, ATM, Isufi, D, Bunick, CG, Chovatiya, R, Nielsen, ML, Alinaghi, F, Thomsen, SF, Vestergaard, C, Wollenberg, A, Egeberg, A, Thyssen, JP & Loft, N 2026, 'Real-World Evidence of Effectiveness and Safety of Abrocitinib, Baricitinib and Upadacitinib in Atopic Dermatitis: A Systematic Review and Meta-Analysis', American Journal of Clinical Dermatology, vol. 27, no. 1, pp. 49-66. https://doi.org/10.1007/s40257-025-00997-x

Nørgaard, L, Larsen, ML , Deleuran, B , Hermansen, MLF & Troldborg, A 2026, 'Real-world use of anifrolumab in systemic lupus erythematosus: A retrospective study from a Danish tertiary center (2022–2025)', Lupus. https://doi.org/10.1177/09612033261441397

Sølling, AS , Langdahl, BL & Cosman, F 2026, 'Recent Advances in Osteoporosis Therapeutics', Annual Review of Medicine, vol. 77, no. 1, pp. 433-448. https://doi.org/10.1146/annurev-med-050124-040555

Liu, Y-Z , Craig, SBB , Bechsgaard, JS, Dicks, LV, Bruun, HH, Høye, TT , Bilde, T & Thomsen, PF 2026, 'Recent Demographic History Inferred From Allele Frequency Spectra: Evaluation by Simulations and Insights From Pool Sequencing of Wild Bees', Molecular Ecology, vol. 35, no. 1, e70169. https://doi.org/10.1111/mec.70169

Jensen, SS, Jacobsen, GH, Brown, R & Daugaard, LM 2026, 'Reception education for children and young people from Ukraine: Lessons learned from the Danish context', European Educational Research Journal, pp. 1. https://doi.org/10.1177/14749041251409963

Johansen, SL & Schrøder, KC 2026, 'Receptionsanalyse som forskningsparadigme i Danmark', MedieKultur: Journal of media and communication research, vol. 42, no. 80. <https://www.mediekultur.dk/article/view/166464>

Ravn, S , Gotschalck, KA & Nors, J 2026, 'Recidiv efter kurativ kirurgisk behandling af kolorektalcancer', Ugeskrift for Læger, vol. 188, no. 13, V07250620. https://doi.org/10.61409/V07250620

Mink, JW, Adams, HR, Ahrens-Nicklas, R, Andersen, BN, Augustine, E, Boustany, R-M, Cooper, JD, Levin, A, Gissen, P, Laine, M, Mason, HL, Mole, SE, Nickel, M, Ostergaard, JR, Sikorra, L, Treat, L, Whiteman, IT, Williams, R & Schulz, A 2026, 'Recommendations for the diagnosis and management of cln3 disease (batten disease) using the Delphi consensus methodology', Orphanet Journal of Rare Diseases. https://doi.org/10.1186/s13023-026-04298-2

Behar, V 2026, 'Reconfiguring the Experience of Health: Self-Tracking Technologies and the Phenomenology of Medicine', The European Society For Philosophy Of Medicine And Healthcare, Rotterdam, Netherlands, 25/08/2026 - 28/08/2026.

Wilén, C, Ahlqvist, VH, Migueles, JH, Campos-Garzón, P, Dahlén, M, Kosidou, K, Rådholm, K, Henriksson, P & Berglind, D 2026, 'Reconstructing schoolyards with greenery to increase schoolchildren's physical activity and mitigate climate changes in urban areas: study protocol for a stepped-wedge trial', BMC Public Health, vol. 26, no. 1, 708. https://doi.org/10.1186/s12889-026-26609-9

Displaying results 3001 to 3050 out of 390058

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen