Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Jäger, G & Turkensteen, M 2026, 'Extending the definition of single and set tolerances', Operations Research Letters, vol. 65, 107407. https://doi.org/10.1016/j.orl.2026.107407

Moskowitz, A, Holmberg, MJ, Kimbrell, J, Granfeldt, A , Andersen, LW, Johnson, N, Semler, MW, DeMasi, SC, Grossestreuer, A, Andrea, L & American Heart Association's Get With The Guidelines®-Resuscitation Investigators 2026, 'External Validation of Rules for Termination of Resuscitation in In-Hospital Cardiac Arrest', Resuscitation, vol. 220, 111019. https://doi.org/10.1016/j.resuscitation.2026.111019

Menaceur Vandenbroucke, C, Unnikrishnan, K, Itak Ita, M, Lassen, UN, Belting, M, Korshoej, AR, Bjarkam, CR & Indira Chandran, V 2026, 'Extracellular vesicles as liquid biopsy tools for personalized therapeutic goals in glioblastoma', Brain : a journal of neurology. https://doi.org/10.1093/brain/awag003

Lafta, MBA, Alhakak, A, Østergaard, L, Bruun, NE, Ruwald, A-C, Le, MV, Philbert, B, Vinther, M, Jørgensen, PG, Havers-Borgersen, E, Jensen, LK, Povlsen, JA , Nielsen, JC, Johansen, JB, Voldstedlund, M, Moser, C, Bundgaard, H, Køber, L & Fosbøl, E 2026, 'Extraction and reimplantation of cardiac implantable electronic devices in patients with non-surgically treated infective endocarditis: a nationwide cohort study', European Heart Journal Open, vol. 6, no. 1, oeag008. https://doi.org/10.1093/ehjopen/oeag008

Wang, L, Meng, F, Liu, W, Zhao, Q, Zhang, J, Xie, Y, Zhang, Y, Duan, S, Li, Y, Cao, L & Fox, AD 2026, 'Extreme drought affects exploratory behaviour and use of agricultural habitat in wintering Greater White-fronted Geese (Anser albifrons)', Ibis. https://doi.org/10.1111/ibi.70033

Dorset, SR 2026, 'Ex vivo gene editing of hematopoietic stem cells for treatment of inborn errors of immunity', PhD, Aarhus University.

Ellemose, J & Elmqvist, N 2026, 'Eye of the Beholder: Towards Measuring Visualization Complexity', IEEE Transactions on Visualization and Computer Graphics, vol. 32, no. 1, pp. 1109-1119. https://doi.org/10.1109/TVCG.2025.3634789

Castenschiold, JHF 2026, 'Eyes in the Sky: Harnessing Drone Technologies and Artificial Intelligence for Researching Seabird Ecology', PhD, Aarhus University.

Luo, Z, Huang, Z, Zhi, D, Qin, T, Yang, J, Wei, Z, Zhou, Y & Yao, B 2026, 'Fabricating tubular Ti₄O₇ ceramic membrane for integrated filtration and electro-oxidation of pesticides in complex water matrices', Separation and Purification Technology, vol. 394, no. Part 2, 137487. https://doi.org/10.1016/j.seppur.2026.137487

Rasmussen, AN , Burau, V , Maindal, HT & Healthy Mind Study Group 2026, 'Facilitating access to mental healthcare for patients with long-term conditions in general practice: a qualitative collective case study', Scandinavian Journal of Primary Health Care, vol. 44, no. 1, pp. 1-13. https://doi.org/10.1080/02813432.2025.2516497

Guldager, R, Sejr Smedegaard, P, Nordentoft, S, Aadal, L, Ingerslev Loft, M & Poulsen, I 2026, 'Facilitators and Barriers of Relatives' Involvement in Care of Patients With Acquired Brain Injury or Malignant Brain Tumour: Scoping Review', Nursing Open, vol. 13, no. 1, e70417. https://doi.org/10.1002/nop2.70417

Leathersich, SJ, García, S, Blockeel, C, Martínez, F, Gosálvez, A, Humaidan, P, Fuente, LDL, Fàbregues, F, Pinborg, A, Stoop, D, Barri, P & Polyzos, NP 2026, 'Factors affecting quality of life in women with diminished ovarian reserve', Fertility and Sterility, vol. 125, no. 1, pp. 160-162. https://doi.org/10.1016/j.fertnstert.2025.08.038

Gude, MF , Nisgaard, LB , Damgaard, D , Iversen, AB , Lisby, M, Diedrichsen, T, Hougaard, KD , Simonsen, CZ & Blauenfeldt, RA 2026, 'Factors associated with missed stroke diagnosis in prehospital triage: a single-center cohort study', BMC Neurology. https://doi.org/10.1186/s12883-026-04688-w

Çavdar, S, Kayhan Koçak, FO, Piotrowicz, K, Okyar Baş, A, Zhu, L, Salis, F, Cotobal Rodeles, S, Holst Andersen, L, Ciccone, AS, Bonnici, M, Kotsani, M, McKeown, W, Ekdahl, A & on behalve of the ECGI group 2026, 'Factors associated with self-perceptions of ageing among geriatric healthcare professionals: a study by the early career geriatricians initiative group of EuGMS', European Geriatric Medicine. https://doi.org/10.1007/s41999-026-01421-1

Christensen, N 2026, 'Fællesmængder. ‘Slægtskaber’ mellem børn og voksne omkring kunst og kultur', Paper presented at Børns møde med den nationale kulturarv, Aarhus, Denmark, 09/03/2026 - 10/03/2026.

Bærndt, MF , Kühle, L, Jensen, SV & Ismail, AM 2026, Fællesskaber på Tværs i Gymnasiet.

Eriksen, C & Pahuus, AMK 2026, Fællesskabets grobund: Løgstrups tænkning om naturlig tillid. Klim, Aarhus.

Nielsen, GB 2026, Fagkritik og studerendes frihed: fra Marxistisk klassekamp til intersektionel kamp for social retfærdighed. in M Agerbo Mørch & S Lægaard (eds), Åndsfrihed, Dannelse, Identitet. Syddansk Universitetsforlag.

Hendriksen, NB 2026, 'Faglig kommentering af forslag fra Kommissionen til ændring af proceduren for godkendelse af lægemidler indeholdende eller bestående af Genetisk Modificerede Organismer', No. 2026-0939901, 5 p., Feb 25, 2026. Rådgivningsnotat fra DCA - Nationalt Center for Fødevarer og Jordbrug.

Shen, C, Zhang, D, Xu, J, Shen, C, Zhang, D, Clausen, J, Song, T & Zhang, C 2026, 'Failure Characteristics of a River Embankment on Soft Ground Improved with Combined Columnar and Grid-Form Deep-Mixed Columns: Three-Dimensional Centrifuge and Numerical Modeling', International Journal of Geomechanics, vol. 26, no. 1, 05025013. https://doi.org/10.1061/IJGNAI.GMENG-11816

Omar, A & Thorsøe, MH 2026, 'Fairer, healthier, and more sustainable? Three contested sociotechnical imaginaries for transforming the European agri-food system', Environment and Planning E: Nature and Space, vol. 9, no. 1, pp. 189-219. https://doi.org/10.1177/25148486251381335

Heß, C 2026, 'Fakten schaffen: Ritualmord und making sense durch antijüdische Ausschreitungen ', Das Mittelalter. Perspektiven mediävistischer Forschung. Beihefte, vol. 22, pp. 121-140. https://doi.org/10.17885/heiup.1552.c24224

Jensen, RT & Rytter, M 2026, 'Falling between two stools: Later-life tactics among older Congolese refugees resettled in Denmark ', Refugee Survey Quarterly.

Adolphsen, C & Naur, E 2026, Familieretshusloven med kommentarer, 2. udgave. 2. edn, Djøf Forlag.

Razavi, AC, Bhatia, HS, Dardari, ZA, Mehta, A, Nasir, K, Blankstein, R, Isiadinso, I, Quyyumi, AA, Vaccarino, V, Fialkow, JA, Khoury, MJ, Coronado, F, Budoff, MJ, Blumenthal, RS, Whelton, SP, Mortensen, MB, Sperling, LS, Matsushita, K, Blaha, MJ & Dzaye, O 2026, 'Family History of Premature Atherosclerotic Cardiovascular Disease and Lipoprotein(a) Levels: A Multi Cohort Analysis', European Journal of Preventive Cardiology, vol. 33, no. 3, pp. 443-445. https://doi.org/10.1093/eurjpc/zwaf392

Tavares, JV, Gloor, E, Silva, TSF, Oliveira, RS, Coelho de Souza, F, Signori-Müller, C, Diniz, FC, Pereira, L, Acosta, M, Gilpin, M, Marca Zevallos, MJ, Salas Yupayccana, CA, Perez-Mullisaca, FM, Jancoski, H, Scalon, MC, Schwantes Marimon, B, Marimon Junior, BH, Malhi, Y, Oliveras Menor, I, Rowland, L, Meir, P, Bittencourt, P, Carlos Lola da Costa, A, Santos, JAR, Teixeira de Oliveira, R, Esquivel-Muelbert, A, Álvarez-Dávila, E, Alexiades, MN, de Oliveira, EA, Andrade, A, Aragão, L, Araujo-Murakami, A, Arroyo, L, Aymard, G, Barroso, JG, Bonal, D, Brienen, R, Céron, C, Camargo, JL, Silva, R, Castro, W, Chave, J, Comiskey, J, Daly, DC, Derroire, G, Disney, M, Dourdain, A, Fauset, S, Feldpausch, T, Flores Llampazo, G, Hérault, B, Hernández, L, Higuchi, N, Honorio Coronado, EN, Jimenez-Rojas, E, Kalamandeen, M, Laurance, S, Laurance, W, Lewis, S, Lima, AS, Monteagudo-Mendoza, A, Morandi, P, NúñezVargas, P, Neill, D, Palacios, W, Parada Gutierrez, A, Pardo-Molina, G, Peñuela-Mora, MC, Pitman, N, Rojas, R, Prieto, A, Réjou-Méchain, M, Ramírez-Angulo, H, Cerruto Ribeiro, S, Ruokolainen, K, Salomão, RP, Serrano, J, Sierra, R, Ruschel, AR, Silveira, M, ter Steege, H, Terborgh, J, Valenzuela Gamarra, L, Vásquez Martinez, R, Vieira, I, Vilanova Torre, E, Vos, VA, Wang, O, Young, K, Muscarella, R, Dexter, KG, Baker, TR, Phillips, OL, Mencuccini, M & Galbraith, D 2026, 'Family imprint reveals basin-wide patterns of Amazon forest embolism resistance', Nature Communications, vol. 17, no. 1, 2073. https://doi.org/10.1038/s41467-026-69892-1

Li, H 2026, 'Farm animal Cell Atlas (FarmCA): exploiting regulatory variants and GWAS loci at single cellular level', PhD, Aarhus University.

Kristiansen, MS 2026, Farms, farmsteads, and farm buildings in medieval Scandinavia. in D Retsö, O Lund, J Myrdal & FC Ljungqvist (eds), Medieval Scandinavia: Contributions to social and economic history. Nordic Academic Press.

Sedgwick, M & Piraino, F 2026, 'Far-Right Politics and the Study of Esotericism: A Response', Aries, vol. 26, no. 1, pp. 129–135. https://doi.org/10.1163/15700593-02601005

Seppäläinen, L, Kubečka, J , Elm, J & Puolamäki, KR 2026, 'Fast and Interpretable Machine Learning Modeling of Atmospheric Molecular Clusters', The journal of physical chemistry. A, vol. 130, no. 4, pp. 902-913. https://doi.org/10.1021/acs.jpca.5c06950

Nevalainen, P, von Ellenrieder, N, Dudley, RWR, Balasubramaniam, N, Beniczky, S, Cacic Hribljan, M, Fabricius, M, Ho, A, Jonsson, H, Meidahl, A, Michaud, E, Nikolic, M, Rasmussen, R, Salli, E, Sidaros, A, Frauscher, B & Gotman, J 2026, 'Fast Ripples Measured From Overnight SEEG Recordings as Markers of the Epileptogenic Zone: A Multicenter Validation Study', Neurology, vol. 106, no. 2, e214511. https://doi.org/10.1212/WNL.0000000000214511

Li, X, Li, A, Bao, B, Zhang, Z, Li, S, Cui, X, Hansen, HCB, Guo, Q & Ekelund, F 2026, 'Fate of dissolved organic matter in the wastewater treatment plant-constructed wetland system', Journal of Environmental Sciences (China), vol. 163, pp. 175-184. https://doi.org/10.1016/j.jes.2025.06.014

Klode, A , Fentz, HN , Nielsen, SA & Trillingsgaard, T 2026, 'Fathers' Childcare Involvement across the First Four Years: The Role of Duration and Share of Parental Leave', Scandinavian Journal of Psychology, vol. 67, no. 2, pp. 368-382. https://doi.org/10.1111/sjop.70030

Ringsmose, JM , Dreyer, P, Ravn Francis, S & Ejlertsen, C 2026, Fathers' experiences of breastfeeding: A scoping review protocol. Center for Open Science. https://doi.org/10.17605/OSF.IO/NCDHY

Machač, M, Papuga, J, Doubrava, K, Barsoum, Z & Yıldırım, HC 2026, 'Fatigue behaviour and thickness effect in thin-walled welded hollow section joints: evaluation using hot-spot stress approach', International Journal of Fatigue, vol. 208, 109565. https://doi.org/10.1016/j.ijfatigue.2026.109565

Majland, M , Jensen, RB , Ettenhuber, P , Shaik, I , Zinner, NT & Christiansen, O 2026, 'Fault-Tolerant Quantum Computations of Vibrational Wave Functions', Journal of Chemical Theory and Computation, vol. 22, no. 1, pp. 30-51. https://doi.org/10.1021/acs.jctc.5c01419

Jønsson, AB , Krogh, S , Severinsen, KE, Aagaard, P, Kasch, H & Nielsen, JF 2026, 'Feasibility and safety of two weeks of blood flow restriction exercise in individuals with spinal cord injury', Journal of Spinal Cord Medicine, vol. 49, no. 1, pp. 58-67. https://doi.org/10.1080/10790268.2024.2408052

Issa, LM, Jørgensen, CC, Madsbad, S, Lindberg-Larsen, M, Varnum, C, Jakobsen, T, Andersen, MR, Bieder, MJ, Overgaard, S, Hansen, TB, Gromov, K & Kehlet, H 2026, 'Feasibility of a prospective multicenter observational study—is diabetes a risk factor in ERAS joint arthroplasty?', Pilot and Feasibility Studies, vol. 12, no. 1, 10. https://doi.org/10.1186/s40814-025-01747-w

Aneggi, E, Nisticò, R, Idriss, H & Jensen, TR 2026, 'Featured Papers in Inorganic Materials 2025', Inorganics, vol. 14, no. 2, 59. https://doi.org/10.3390/inorganics14020059

Hatherley, J, Søgaard, A, Ballantyne, A & Pauwels, R 2026, 'Federation Opacity and the Promise of Federated Learning in Healthcare', American Journal of Bioethics. https://doi.org/10.1080/15265161.2026.2637093

Mirzajani, S & Roohi, M 2026, 'Feedback Long Short-Term Memory: A Long Short-Term MemoryBased Framework for Multivariate Time Series Prediction in Chaotic Systems', Control and Optimization in Applied Mathematics, vol. 11, no. 1, pp. 199-218. https://doi.org/10.30473/coam.2025.72730.1312

Christensen, J 2026, 'Feeding drives intra-annual variation in the field metabolic rate of a coastal Atlantic cod (Gadus morhua) population', Ecology.

Weger, M, Mauvoisin, D, Hoyle, D, Wang, J, Martin, E, Rae, J, Ferguson, C, Klinke, G, Cielesh, M, Macauslane, KL, Larance, M, Quadroni, M, Templeman, I, Walhin, J-P, Karagounis, LG, Betts, JA, Johnston, JD, Durussel, F, Firsov, D, Fournier, S, Müller, O, Schulz, BL, Parton, RG, Weger, BD & Gachon, F 2026, 'Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion', Nature Metabolism, vol. 8, no. 2, pp. 327-349. https://doi.org/10.1038/s42255-026-01453-8

Bhavsar, R, Thuesen, L & Jakobsen, CJ 2026, 'Female Disparity in Referral to Cardiac Diagnostication and Invasive Treatment', Medicina (Lithuania), vol. 62, no. 1, 144. https://doi.org/10.3390/medicina62010144

Ben Messaoud, K, Zaks, N, Licciardi, F, Ramlau-Hansen, CH, Kahn, LG & Janecka, M 2026, 'Female infertility diagnosis and adult-onset psychiatric conditions: a matched cohort study', Human Reproduction, vol. 41, no. 1, pp. 108-115. https://doi.org/10.1093/humrep/deaf202

Gibrael, HS, Linhardt, S, Jangö, H, Toldam, NE, Dreier, S, Thomsen, L, Giraldi, A & Graugaard, C 2026, 'Female sexual health after obstetric anal sphincter injury: a scoping review', Sexual Medicine Reviews, vol. 14, no. 1, qeaf078. https://doi.org/10.1093/sxmrev/qeaf078

Sandager, J 2026, Feminist Organizing and Futures of Women in STEM: Exploring Sparkle, Shimmer and Shadow. Bristol University Press.

Berretta, A & Schwab, C 2026, 'Fermentation-driven interactions of gut microbes with their environment', Essays in Biochemistry. https://doi.org/10.1042/EBC20253057

Hull, SD, Hougaard, KS, Toft, G, Petersen, KKU, Flachs, EM, Lindh, C, Ramlau-Hansen, CH , Wise, LA, Wilcox, A, Liew, Z , Bonde, JP & Tøttenborg, SS 2026, 'Fetal exposure to a mixture of endocrine-disrupting chemicals and biomarkers of male fecundity: A population-based cohort study', Andrology, vol. 14, no. 1, pp. 76-89. https://doi.org/10.1111/andr.70039

Morales-Cano, D, Sharysh, D , Albarrán-Juárez, J, de Molina, A, Labrador-Cantarero, V, Markvard Møller, C, Carramolino, L & Bentzon, JF 2026, 'Fibroblast-like cells accumulate late in human coronary atherosclerosis contributing to necrotic core formation', Cardiovascular Research. https://doi.org/10.1093/cvr/cvag002

Displaying results 1301 to 1350 out of 389648

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen