Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Thomsen, LH & Willig, I 2019, 'Journalism by emoji’s: SoMe editors in the newsroom', Paper presented at Future of Journalism, Cardiff, United Kingdom, 12/09/2019 - 13/09/2019.

Saugel, B, Flick, M, Bendjelid, K, Critchley, LAH, Vistisen, ST & Scheeren, TWL 2019, 'Journal of clinical monitoring and computing end of year summary 2018: hemodynamic monitoring and management', Journal of Clinical Monitoring and Computing, vol. 33, no. 2, pp. 211-222. https://doi.org/10.1007/s10877-019-00297-w

Jakobsen, M, James, O, Moynihan, DP & Nabatchi, T 2019, 'JPART Virtual Issue on Citizen-State Interactions in Public Administration Research', Journal of Public Administration Research and Theory, vol. 29, no. 4, pp. e8-e15. https://doi.org/10.1093/jopart/muw031

Vad, K (ed.) & Grundtvig, NFS 2019, Julesange. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/18485/0#>

Vad, K (ed.) & Grundtvig, NFS 2019, Jule-Sange for Dronning Caroline Amalias Asyl-Børn. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/18488/0#>

Vad, K (ed.) & Grundtvig, NFS 2019, Jule-Sang i Prindsesse Caroline Amalias Asyl. Grundtvigs Værker. <http://www.xn--grundtvigsvrker-7lb.dk/tekstvisning/18475/0#>

Andersen, C 2019, Julian Huxleys biokulturelle menneske og UNESCO. in T kellberg Nielsen, C Andersen, AR Kratschmer & M Clasen (eds), Menneske, kultur evolution, et et biokulturelt perspektiv. Aarhus Universitetsforlag, Aarhus, pp. 259-272.

Terkelsen, O 2019, Jurisdiktion. in Folkeret og menneskerettigheder. Karnov Group, pp. 128-145.

Evald, J 2019, 'Juristen gennem 100 år', Juristen, no. 1, pp. 1-13.

Lippert-Rasmussen, K 2019, 'Just Annexation', Journal of Applied Philosophy, vol. 36, no. 2, pp. 290-297. https://doi.org/10.1111/japp.12308

Iversen, S 2019, '’Just because it isn’t happening here, doesn’t mean it isn’t happening’: narrative, fictionality and reflexivity in humanitarian rhetoric', European Journal of English Studies, vol. 23, no. 2, pp. 190-205. https://doi.org/10.1080/13825577.2019.1640432

Brøcker, KK 2019, 'Justifying the evidential use of intuitive judgements in linguistics'.

Korth, J, Csizmadia, S, Gandolfi, D, Fridlund, M, Pätzold, M, Hirano, T, Livingston, J, Persson, CM, Deeg, HJ, Justesen, AB, Barragán, O, Grziwa, S, Endl, M, Tronsgaard, R, Dai, F, Cochran, WD, Albrecht, S, Alonso, R, Cabrera, J, Cauley, PW, Cusano, F, Eigmüller, P, Erikson, A, Esposito, M, Guenther, EW, Hatzes, AP, Hidalgo, D, Kuzuhara, M, Montañes, P, Napolitano, NR, Narita, N, Niraula, P, Nespral, D, Nowak, G, Palle, E, Petrillo, CE, Redfield, S, Prieto-Arranz, J, Rauer, H, Smith, AMS, Tortora, C, Van Eylen, V & Winn, JN 2019, 'K2-140b and K2-180b - Characterization of a hot Jupiter and a mini-Neptune from the K2 mission', Monthly Notices of the Royal Astronomical Society, vol. 482, no. 2, pp. 1807-1823. https://doi.org/10.1093/mnras/sty2760

Livingston, JH, Dai, F, Hirano, T, Gandolfi, D, Trani, AA, Nowak, G, Cochran, WD, Endl, M, Albrecht, S, Barragan, O, Cabrera, J, Csizmadia, S, de Leon, JP, Deeg, H, Eigmüller, P, Erikson, A, Fridlund, M, Fukui, A, Grziwa, S, Guenther, EW, Hatzes, AP, Korth, J, Kuzuhara, M, Montañes, P, Narita, N, Nespral, D, Palle, E, Pätzold, M, Persson, CM, Prieto-Arranz, J, Rauer, H, Tamura, M, Van Eylen, V & Winn, JN 2019, 'K2-264: A transiting multiplanet system in the Praesepe open cluster', Royal Astronomical Society. Monthly Notices, vol. 484, no. 1, pp. 8-18. https://doi.org/10.1093/mnras/sty3464

Hjorth, M , Justesen, AB, Hirano, T, Albrecht, S, Gandolfi, D, Dai, F, Alonso, R, Barragán, O, Esposito, M, Kuzuhara, M, Lam, KWF, Livingston, JH, Montanes-Rodriguez, P, Narita, N, Nowak, G, Prieto-Arranz, J, Redfield, S, Rodler, F, Van Eylen, V, Winn, JN, Antoniciello, G, Cabrera, J, Cochran, WD, Csizmadia, S, De Leon, J, Deeg, H, Eigmüller, P, Endl, M, Erikson, A, Fridlund, M, Grziwa, S, Guenther, E, Hatzes, AP, Heeren, P, Hidalgo, D, Korth, J, Luque, R, Nespral, D, Palle, E, Pätzold, M, Persson, CM, Rauer, H, Smith, AMS & Trifonov, T 2019, 'K2-290: A warm Jupiter and a mini-Neptune in a triple-star system', Monthly Notices of the Royal Astronomical Society, vol. 484, no. 3, pp. 3522-3536. https://doi.org/10.1093/mnras/stz139

Smith, AMS, Csizmadia, S, Gandolfi, D, Albrecht, S, Alonso, R, Barragan, O, Cabrera, J, Cochran, WD, Dai, F, Deeg, H, Eigmueller, P, Endl, M, Erikson, A, Fridlund, M, Fukui, A, Grziwa, S, Guenther, EW, Hatzes, AP, Hidalgo, D, Hirano, T, Korth, J, Kuzuhara, M, Livingston, J, Narita, N, Nespral, D, Niraula, P, Nowak, G, Palle, E, Paetzold, M, Persson, CM, Prieto-Arranz, J, Rauer, H, Redfield, S, Ribas, I & Van Eylen, V 2019, 'K2-295 b and K2-237 b: Two Transiting Hot Jupiters', Acta Astronomica, vol. 69, no. 2, pp. 135-158. https://doi.org/10.32023/0001-5237/69.2.3

Arboe, T 2019, kælder – kællinge·puse: 48 kc, 3 helsideskort, 6 spaltekort. in Jysk Ordbog. Peter Skautrup Centret for Jysk Dialektforskning, S.l. <http://jyskordbog.dk/jyskordbog/ordbog.html>

Andersen, TR 2019, 'Kære Murakami: Haruki Murakami: Mordet på kommandanten', Litteraturmagasinet Standart, vol. 33, no. 1, pp. 13-15.

Arboe, T 2019, kæreste – kærnemælks·vælling: 43 kc, 2 helsideskort, 1 spaltekort. in Jysk Ordbog. Peter Skautrup Centret for Jysk Dialektforskning, S.l. <http://jyskordbog.dk/jyskordbog/ordbog.html>

Nissen, U 2019, Kærlighedens ansvar: ansatser til samtalens etik. in A Østerlund Nielsen (ed.), Enhed og samarbejde på tværs af moralsk-etiske forskelle. Dansk Missionsråd, Frederiksberg, Ny Mission, vol. 36, pp. 85-101. <https://issuu.com/danishmissioncouncil/docs/ny_mission_36>

Spotti, C 2019, Kähler-Einstein metrics via moduli continuity method. in G Codogni, R Dervan & F Viviani (eds), Springer INdAM Series. Springer, Springer INdAM Series, vol. 31, pp. 141-152. https://doi.org/10.1007/978-3-030-13158-6_7

Boertmann, DM (ed.), Aastrup, P , Asmund, G , Bach, L , Fritt-Rasmussen, J , Gustavson, K , Hansen, V , Johansen, P, Lund, H, Mosbech, A , Riget, FF , Søndergaard, J , Tougaard, J & Wegeberg, S 2019, Kalaallit Nunaanni avatangiisit pisuussutillu uumaatsut. MiljøBiblioteket, vol. 5, Aarhus Universitetsforlag, Aarhus.

Gres, S, Döhler, M, Andersen, P & Mevel, L 2019, 'Kalman filter-based stochastic subspace identification under mixed stochastic and periodic excitation', European Research Network on System Identification- ERNSI 2019, Maastricht, Netherlands, 01/09/2021.

Braga Mattos, AP 2019, 'Kalunga: An Afro-Brazilian Portuguese Variety'. https://doi.org/10.13140/RG.2.2.28864.07687

Thorsteinsson, MM, Strudsholm, F & Vestergaard, M 2019, Kalve i godt huld klarer sig bedre efter indsætning i slagtekalvebesætningen. DLBR. <https://www.landbrugsinfo.dk/kvaeg/koedproduktion/slagtekalve/Sider/Hi-19-5075-Kalve-godt-huld-klarer-bedre-indsaettelse-i-slagtekalvebesaetningen.aspx>

Fibiger, MQ 2019, 'Kāmākhya, den menstruerende gudinde - tantrisme for lægfolk og elite', Religionsvidenskabeligt Tidsskrift, vol. 69, no. 69, pp. 135-147. https://doi.org/10.7146/rt.v0i69.112747

Zickfeld, JH, Schubert, TW, Seibt, B, Blomster, JK, Arriaga, P, Basabe, N, Blaut, A, Caballero, A, Carrera, P, Dalgar, I, Ding, Y, Dumont, K, Gaulhofer, V, Gračanin, A, Gyenis, R, Hu, C-P, Kardum, I, Lazarević, LB, Mathew, L, Mentser, S, Nussinson, R, Onuki, M, Páez, D, Pásztor, A, Peng, K, Petrović, B, Pizarro, JJ, Schönefeld, V, Śmieja, M, Tokaji, A, Vingerhoets, A, Vorster, A, Vuoskoski, J, Zhu, L & Fiske, AP 2019, 'Kama muta: Conceptualizing and measuring the experience often labelled being moved across 19 nations and 15 languages', Emotion (Washington, D.C.), vol. 19, no. 3, pp. 402-424. https://doi.org/10.1037/emo0000450

Hansen, J, Haase, K & Brandt, LØ 2019, 'Kamme og kammageri i middelalderens Odense: nye resultater fra udgravningerne ved Thomas B. Thriges Gade', Odense Bys Museer, vol. 2019, pp. 18-29.

Lagermann, LC 2019, Kampen for inklusion: en ensom affære. in J Hedegaard Hansen & KE Petersen (eds), Inklusion og eksklusion : en grundbog. Hans Reitzels Forlag, København, pp. 405-416.

Egelund, N & Dyssegaard, CB 2019, 'Kampen mod ulighed: Den svenske folkeskoles udvikling gennem de seneste 25 år – og hvad Danmark kan lære af det', Paideia: tidsskrift for professionel pædagogisk praksis, no. 18, pp. 6-14.

Hansen, HR & Henningsen, I 2019, Kampen om evidens i et kritisk perspektiv. in D Dalum Christoffersen & K Stender Petersen (eds), Er der evidens for evidens?. Samfundslitteratur, Frederiksberg, pp. 37-47.

Nielsen, KH 2019, 'Kampen om vores gener', Weekendavisen, vol. Sektion 4 (Ideer), pp. 12.

Bregnballe, T , Holm, TE , Riddervold, M & Rasmussen, LM 2019, 'Kan droner tælle fugle?', Dansk Ornitologisk Forenings Tidsskrift, vol. 113, no. 2, pp. 51-53.

Poulsen, SB & Fenton, RA 2019, 'K+ and the renin-angiotensin-aldosterone system: new insights into their role in blood pressure control and hypertension treatment', The Journal of Physiology, vol. 597, no. 17, pp. 4451-4464. https://doi.org/10.1113/JP276844

Fox, AD & Christensen, TK 2019, 'Kan en faldende andel af hunner blandt ungfugle hos ænder bidrage til en skæv kønsfordeling og medvirke til en samlet bestandsnedgang?', Dansk Ornitologisk Forenings Tidsskrift, vol. 113, pp. 48-49. <https://pub.dof.dk/artikler/313/download/doft-113-2019-41-54-aktuelt-aargang-113-nr-2>

Mortensen, P 2019, 'Kan litteraturen redde planeten, hvis politikerne ikke vil?', Anglo Files, no. 191, pp. 23-28.

Fibiger, MQ 2019, Kan man være buddhist og hindu på en gang?. Religion.dk. <https://www.religion.dk/spoerg-om-religion/kan-man-vaere-buddhist-og-hinduist-samtidig>

Toft, S 2019, Kannibalen. in O Høiris & KA Jensen (eds), Evolutionens menneske - menneskets evolution: Om aben, der blev verdens herre. Aarhus Universitetsforlag, pp. 149-168.

Andersen, FØ 2019, Kan skolen løse to store samfundsproblemer i ét hug? Vi har såkaldte ghetto- og integrationsproblemer og mangler samtidig håndværkere, teknikere og IT-folk. Måske kan p-tech skolemodellen løse begge problemer?. Folkeskolen.dk. <https://www.folkeskolen.dk/659909/kan-skolen-loese-to-store-samfundsproblemer-i-et-hug>

Gundlach, E & Svendsen, GT 2019, 'Kan social tillid skabe økonomisk vækst i fattige lande? Potentielt ja. Det er dog ikke helt let at opnå.', Videnskab.dk. <https://videnskab.dk/kultur-samfund/kan-social-tillid-skabe-oekonomisk-vaekst-i-fattige-lande>

Nielsen, CF 2019, Kant og pædagogik: mellem natur og normativitet. in A von Oettingen (ed.), Pædagogiske tænkere: bidrag til empirisk dannelsforskning. Hans Reitzels Forlag, København, pp. 17-32.

Stenalt, MH , Lassesen, B , Rossen, DS & Bager-Elsborg, A 2019, 'Kan videregående uddannelser mindske frafald ved hjælp af læringsteknologi? Et systematisk review', Dansk Universitetspædagogisk Tidsskrift, vol. 14, no. 26, pp. 82-102. <https://tidsskrift.dk/dut/article/download/108295/161869>

Næser, J 2019, Kap. 29 om EU-forbrugerbeskyttelse. in N Holst-Christensen & M Ellehauge (eds), EU-Karnov. Karnov Group, København.

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Glavind, JG & Pedersen, HH 2019, Kapitel 1 At stille spørgsmål om samfundet. in Gode spørgsmål, rigtige svar. Grundbog i samfundsvidenskabelig metode. 2. edn, Gyldendal, København.

Pedersen, HH & Ulriksen, MS 2019, Kapitel 2 At undersøge vores spørgsmål. in Gode spørgsmål, rigtige svar. Grundbog i samfundsvidenskabelig metode. 2. edn, Gyldendal, København.

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Tahamtani, F , Herskin, MS , Foldager, L, Murrell, J, Sandercock, D & Riber, AB 2019, 'Karakterisering af konventionelle slagtekyllinger med gait score 2 i forhold til mobilitet, adfærd, smerte, morfologi og patologi', No. 2019-760-001056, 7 p., Nov 20, 2019..

Jeppesen, E, Sidman, CF, Ji, G & Martens, K 2019, 'Karl Edward Havens (1957-2019): Obituary', Hydrobiologia, vol. 842, no. 1, pp. 1-3. https://doi.org/10.1007/s10750-019-04062-7

Gregersen, AB 2019, 'Karl Marx' lagen over hovedet: Ronan de Calan & Donatien Mary - Karl Marx' genfærd', Filosofiske Anmeldelser, vol. 7, no. 2, pp. 56-57.

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