Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Strand, J 2026, 'WANTED: Your observations of interactions between wild animals and plastic litter', Det 23. Danske Havforskermøde , Helsingør, Denmark, 20/01/2026 - 22/01/2026.

Dyrlev, EK 2026, 'Warm hands entangled in cold technology? Psychologists’ tinkering expertise in digital psychiatry', Social Science & Medicine, vol. 399, no. 119159, 119159. https://doi.org/10.1016/j.socscimed.2026.119159

Knazovický, M, Rosenqvist, E, N. Akula, N , Lobo, AKM , Hashemi, N , Tsochatzis, E , Lemvig, LK & Ottosen, C-O 2026, 'Water-carbon trade-offs in contrasting Lupinus angustifolius cultivars under combined deficit irrigation, heat stress, and elevated CO2', Plant Stress, vol. 19, 101236. https://doi.org/10.1016/j.stress.2026.101236

Teitelbaum, CS, Prosser, DJ, Ackerman, JT, Ahmed, S, Alam, ABMS, Azmiri, KZ, Batbayar, N, Bêty, J, Blake-Bradshaw, A, Boiko, D, Buitendijk, NH, Buler, JJ, Cabot, D, Casazza, ML, Cohen, B, Davaasuren, B, Farau, S, Feddersen, J, Fieberg, J, Fiedler, W, Glazov, P, Griffin, LR, Guillemain, M, Hagy, H, Hardy, MJ, Highway, C, Hoffman, D, Kang, T, Keever, A, Kilburn, J, Kölzsch, A, Kruckenberg, H, Laaksonen, T, Ladman, BS, Lee, H, Lee, S, Lefebvre, J, Legagneux, P, Linssen, H, Madsen, J, Masto, NM, McWilliams, S, Mezebish Quinn, T, Mitchell, C, Moreau, A, Müskens, G, Newman, S, Nolet, BA, Nuijten, RJM, Osenkowski, J, Overton, CT, Piironen, A, Plaquin, B, Ramey, AM, Rodrigue, J, Rodrigues, D, Schreven, KHT, Si, Y, Sullivan, JD, Takekawa, J, Thomas, PJ, van Toor, M, Waldenström, J, Williams, CK, Wolfson, DW, Xu, F, Brosnan, IG & De La Cruz, SEW 2026, 'Waterfowl Move Less in Heterogeneous and Human-Populated Landscapes, With Implications for Spread of Avian Influenza Viruses', Ecology Letters, vol. 29, no. 1, e70265. https://doi.org/10.1111/ele.70265

Zhang, C, Dong, W, Wang, J, Manevski, K, Timilsina, A & Hu, C 2026, 'Water–Nutrient Co-Limitation Governed Farmland Soil Microbial Community and Enzymatic Responses to Nine-Year Warming', Agronomy, vol. 16, no. 5, 535. https://doi.org/10.3390/agronomy16050535

Warming, JC , Balling, P & Turtos, RM 2026, 'Wavelength-dependent cross section for optically stimulated luminescence in Y2SiO₅:Ce', Radiation Measurements, vol. 191, 107566. https://doi.org/10.1016/j.radmeas.2025.107566

Johansen, M-L , Tutenges, S & Hedlund, A 2026, Ways out of Street Crime: A Comparative Study of Street Crime Desistance in Denmark, Sweden and Norway . VIVE - Det Nationale Forsknings- og Analysecenter for Velfærd, Copenhagen.

Christensen, TD 2026, '"We are juggling many possibilities”: Healthcare professionals’ experiences and perspectives on interpretation of pulmonary embolism signs and symptoms in patients with lung cancer', International Conference on Thrombosis and Hemostasis Issues in Cancer, Bergamo, Italy, 17/04/2026 - 19/04/2026.

Skovgaard, AKP 2026, 'Weaving Prayer: The fabrication of worship in the convent of St Agnes, Emmerich, in the fifteenth century', Textile: The Journal of Cloth and Culture, vol. 24, no. 1, pp. 122-135. https://doi.org/10.1080/14759756.2025.2608375

Birkler, MK, Cornwell, EJ & Rutt , RL 2026, '“We can’t be quiet. We can’t sit back.”: Examining the Indecent Eco-Theology Praxis of Christian Environmentalists in Trump’s America', Dialog. https://doi.org/10.1111/dial.70018

Ana, E-D 2026, 'Welcome to Soylandia: Transnational Farmers in the Brazilian Cerrado by Andrew Ofstehage, Ithaca, NY, Cornell University Press, 2025', Ethnos. <https://www.tandfonline.com/eprint/E4VFZUTDUIYWC8Q66X6T/full?target=10.1080/00141844.2026.2633377>

Nielsen, SS, Alvarez, J, Boklund, A, Dippel, S, Dorea, F, Figuerola, J, Herskin, MS, Michel, V, Miranda Chueca, MA, Nannoni, E, Nonno, R, Stahl, K, Berk, J, Marchewka, J, van Staaveren, N, Balmos, OM, Fabris, C, Mosbach-Schulz, O, Van der Stede, Y, Vitali, M, Rojo Gimeno, C, Velarde, A, Riber, AB & EFSA Panel Animal Health and Animal Welfare (AHAW) 2026, 'Welfare assessment of turkeys (Meleagris gallopavo gallopavo) on farm', EFSA Journal, vol. 24, no. 2, e9851. https://doi.org/10.2903/j.efsa.2026.9851

Kousholt, D & Winther-Lindqvist, DA 2026, '“We need to give our children skills, not fear”: Parents’ perspectives on world-care and upbringing for sustainability', Contemporary Issues in Early Childhood.

Keppeler, FW, Giarrizzo, T, Montaña, CG, Adite, A, Akın, Ş, Angelini, R, Arantes, CC, Benedito, E, Bokhutlo, T, El-Sabaawi, R, Garcia, A, Gonzalez-Bergonzoni, I, Hoeinghaus, D, Hoffman, J, Jensen, OP, Jeppesen, E, Kopf, RK, Layman, CA, Lopez, EO, Maitland, BM, Matsuzaki, SIS, Olin, JA, Paterson, G, Quintana, Y, de Rezende, CE, Trudeau, A, Trindade, PA, Turner, TF, Zandona, E & Winemiller, KO 2026, 'What determines trophic niche breadth? A global analysis of freshwater fishes using isospaces', Reviews in Fish Biology and Fisheries, vol. 36, no. 1, 13. https://doi.org/10.1007/s11160-025-10023-2

Radulescu, RB, Hjortdal, J, Ibáñez, JS, Busin, M, Thuret, G & Ponzin, D 2026, 'What Does Biomicroscopy Mean?', Cornea, vol. 45, no. 1, pp. 1-2. https://doi.org/10.1097/ICO.0000000000004009

De Donà, M 2026, 'What does legitimacy mean within sustainable development? A scoping review', Humanities and social sciences communications, vol. 13, no. 1, 219. https://doi.org/10.1057/s41599-026-06513-8

Ferreira, RT, Reis, MQ, Lange, MHP, da Costa, MWF, Silva, GKM, Lemos, ABO, Dias, DRL, Viana, MDLS, dos Santos, ALO, Fernandes, ABM, Pinheiro, MRB, de Sousa, CW, Duarte, KHA, Fernandes, GVDO, Figueredo, CMDS, Vettore, MV, Araujo, MM, Ritto, FG & Canellas, JVDS 2026, 'What evidence syntheses reveal about PROSPERO, INPLASY, OSF, the Research Registry, and protocols.io: a meta-research study', Frontiers in Research Metrics and Analytics, vol. 11, 1738112. https://doi.org/10.3389/frma.2026.1738112

Bundsgaard, J, Hanghøj, T, Nielsen, BL & Skott, CK 2026, 'What goes on in science, Danish and mathematics teaching? A quantitative Q-method-inspired study of teachers’ and students’ experiences of subject-specific practices', Scandinavian Journal of Educational Research. https://doi.org/10.1080/00313831.2026.2623280

Schillinger, S, O'Connor, H, Franke, H, Peterson, C, Groves, E, Abashidze, N, Shen, S, Prescott, K, Cox, CMM , Weed, E , Fusaroli, R, Grossman, R, Parish-Morris, J & Eigsti, I-M 2026, 'What I say versus what you see: Do self-reported autistic characteristics and camouflaging behaviors predict diagnostic impressions from naive peers?', INSAR 2026, Prague, Czech Republic, 22/04/2026 - 25/04/2026.

Seibt, J & Hakli, R 2026, What is Robophilosophy? in Robophilosophy: Philosophy of, for, and by Social Robotics. MIT Press, Cambridge, MA, pp. 3-73. https://doi.org/10.7551/mitpress/10777.003.0004

Struja, T, Hansen, LH, Matos, J, Gómez, J, Pardo, A, Lourentzou, I, Hejazi, N, Celi, LA & Waschka, AK 2026, 'What is the ideal glucose range for a patient with sepsis in the ICU? A retrospective analysis of MIMIC-IV', BMJ Open, vol. 16, no. 1, e104916. https://doi.org/10.1136/bmjopen-2025-104916

Philippi Rosane, B, Okoren, L, Andersen, BV , Byrne, DV & Bügel, SG 2026, 'What Is the Role of Plant-Based Alternatives to Animal Foods in the Great Food Transformation: A Narrative Review', Journal of Nutrition, vol. 156, no. 2, 101275. https://doi.org/10.1016/j.tjnut.2025.101275

Warner, CD 2026, 'What Makes Love Anti-Political? The Transformative Potentials of Professions of Love to the Dalai Lama and Donald Trump', Paper presented at European Association of Social Anthropology (EASA) 2024 , Barcelona , Spain, 23/07/2024 - 26/07/2024.

Gamst-Jensen, H, Villumsen, BR, Buch, B, Stæhr, JB, Olsen, SW, Egelund Hansen, A, Brix, LD , Viftrup, A, Study Group, WMTY & Nielsen, AH 2026, 'What matters to patients on the day of surgery - a qualitative study', Perioperative Care and Operating Room Management. https://doi.org/10.1016/j.pcorm.2026.100633

Hudson, M, Sovacool, B & AbdulRafiu, A 2026, '“What's the worst that could happen?” Perceptions of physical, financial, reputational, and policy risk in the United Kingdom's low-carbon industrial transition', Energy Strategy Reviews, vol. 64, 102129. https://doi.org/10.1016/j.esr.2026.102129

Augustin, M & Østergaard, SD 2026, 'When Artificial Intelligence Speaks: Psychologically Adverse Effects of the Shift from Text- to Voice-based Chatbots', Acta Neuropsychiatrica, pp. 1-7. https://doi.org/10.1017/neu.2026.10062

Lecchini, D, Krimou, S, Raick, X, Pagli, B, Gache, C, Carpentier, C, Juncker, M, Gautrand, L, Sowinski, J, Sturny, V, Maueau, T, Bambridge, T, Hédouin, L & Bertucci, F 2026, 'When coral dies but fish remain: limits of local restoration under climate pressure (Bora Bora, French Polynesia)', Environmental Biology of Fishes, vol. 109, no. 1, 52. https://doi.org/10.1007/s10641-026-01816-w

Nørregaard, IB 2026, 'When Do People View Discrimination as Morally Acceptable?', Political Behavior, vol. 48, no. 1, 105379, pp. 49-72. https://doi.org/10.1007/s11109-025-10022-w

Evans, VT , Gomes, C & Lucani Rötter, DE 2026, 'When Every Transmission Counts: Event-Trigger Threshold Regulation for STL Properties', IEEE Internet of Things Journal, vol. 13, no. 4, pp. 7040-7051. https://doi.org/10.1109/JIOT.2025.3637893

Komischke, K 2026, 'When grief becomes complicated - Toward a deeper understanding of prolonged grief disorder, its co-occurrence with other complicated grief reactions, and treatment strategies', PhD, Aarhus University.

Øverup, CS, Hald, GM, Rothoff, R & Hald, AN 2026, 'When I Do Not See or Hear So Well: Dyadic Associations Between Sensory Impairment, Communication, and Relationship Satisfaction in Older Age', Psychological Reports. https://doi.org/10.1177/00332941261423089

Artak, CET & Lieberoth, A 2026 'When something goes wrong online: Children’s perceived parental support and family dynamics around screen use (in prep)'.

Kvamme, TL, Monzel, M, Nagai, Y & Silvanto, J 2026, 'When weak imagery is worse than none: Core aphantasia and hypophantasia relate differently to mental health, mediated by subjective interoception', Neuropsychologia, vol. 222, 109368. https://doi.org/10.1016/j.neuropsychologia.2026.109368

Shenderova, S, Morris, J & Comai, G 2026, 'Where is Russian higher education? The spatial imaginaries and realities of internationalization policy', International Journal of Educational Research, vol. 136, 102860. https://doi.org/10.1016/j.ijer.2025.102860

Andersen, TB & Carstensen, JB 2026, 'Where to aim in soccer penalty kicks: Balancing strategy and execution', Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology. https://doi.org/10.1177/17543371261424564

Andersen, LK, Hesse, M & Thylstrup, B 2026, 'Who are the non-participants of prison-based therapeutic communities? Exploring the association with criminal and social capital', European Journal of Criminology.

Losi, L , Fritz , L & Sovacool, B 2026, 'Who cares about carbon dioxide removal? Assessing actors, policy positions, and participation modes within European and United Nations public consultation processes', Climate Policy, vol. 26, no. 1, pp. 104-119. https://doi.org/10.1080/14693062.2025.2485204

Uldbjerg, S 2026, Who is the victim? in C Sand-Iversen (ed.), NEW SKIN. Really Simple Syndication Press, pp. 121-125.

Madsen, JR, Danielsen, PB, Dias, AH , Gormsen, LC , Rodell, AB, Panin, V, Pigg, D, Spottiswoode, B & Munk, OL 2026, 'Whole-body parametric PET/CT imaging of the total distribution volume using a new reversible delayed Logan model', EJNMMI Physics. https://doi.org/10.1186/s40658-026-00853-9

Ringgaard, RL 2026, '“Who said ‘The Emperor’s New Clothes’?”: Crystallizing a public accusation across media platforms', Res Rhetorica, vol. 13, no. 1, pp. 94-114. https://doi.org/10.29107/rr2026.1.5

the RE-STAR team 2026, 'Why do attention-deficit/hyperactive disorder and/or autism traits place adolescents at risk for depression? Protocol for a longitudinal comparison of the mediating role of emotion regulation deficits versus emotional burden', JCPP Advances, vol. 6, no. 1, e70052. https://doi.org/10.1002/jcv2.70052

Seeley, MM, Wiebe, BC, Asner, GP, Abraham, AJ, Cooper, HF, Gehring, CA, Hultine, KR, Allan, GJ, Whitham, TG, Goulden, T & Doughty, CE 2026, 'Why do classification models go wrong? The importance of adaptations and acclimations in driving landscape-level spectral variation in Fremont cottonwood', Remote Sensing of Environment, vol. 334, 115240. https://doi.org/10.1016/j.rse.2026.115240

Madsen, CD 2026, 'Why do some Gifted Children struggle at school? - Children's perspectives on everyday school life', Gifted Child Quarterly.

Recalde-Esnoz, I, Tutenges, S & Del Castillo, H 2026, 'Why do Spanish University Students Flirt in Nightlife Venues?', Archives of Sexual Behavior.

Kalliala, I, Milerad, H, Trope, AEC & Hammer, A 2026, 'Why do the Nordic countries allow colposcopy to be a weak link in the cervical cancer screening chain?', Acta Obstetricia et Gynecologica Scandinavica, vol. 105, no. 3, pp. 392-394. https://doi.org/10.1111/aogs.70166

Møller, J 2026, Why Europe? Aarhus Universitetsforlag.

Berthelsen, UD 2026, Why Humans Dream of Electric Sheep: Philip K. Dick on the Human Condition. in UD Berthelsen, MR Thomsen & M Tannert (eds), Beyond the Turing Test: What science fiction can teach us about artificial intelligence. Routledge - Taylor & Francis.

Aagaard, A 2026, 'Why Industrial Open Innovation Platforms Stall After the Pilot: Governing Value Creation at Scale', California Management Review.

Thomsen, E , Heilmann-Clausen, C & Andreasen, R 2026, 'Why strontium baselines should be based on pristine areas only: The disturbing effect of agricultural lime revisited', Science of the Total Environment, vol. 1010, 181065. https://doi.org/10.1016/j.scitotenv.2025.181065

Grossman, P, Ackland, GL, Allen, AM, Berntson, GG, Booth, LC, Burghardt, GM, Buron, J, Dinets, V, Doody, JS, Dutschmann, M, Farmer, DGS, Fisher, JP, Gourine, AV, Joyner, MJ, Karemaker, JM, Khalsa, SS, Lakatta, EG, Leite, CAC, Macefield, VG, Machado, BH, McAllen, RM, Menuet, C, Mendelowitz, D, Moraes, DJA, Neuhuber, W, Ottaviani, MM, Paterson, DJ, Paton, JF, Pellegrino, PR, Ramchandra, R, Shanks, J, Schwaber, JS, Shivkumar, K, Spyer, KM, Taylor, EW, Taylor, JA, Wang, T, Yao, ST & Zucker, IH 2026, 'WHY THE POLYVAGAL THEORY IS UNTENABLE An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.', Clinical Neuropsychiatry, vol. 23, no. 1, pp. 169-184. https://doi.org/10.36131/cnfioritieditore20260110

Displaying results 3851 to 3900 out of 389740

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen