I specialize in Na,K-ATPase research. My work focuses on understanding the mechanisms of ion transport and the impact of mutations on neurological diseases. I have also discovery of a mutation that converts the electrogenic 3Na:2K:1ATP stoichiometry of the Na,K-ATPase to an electroneutral 2Na:2K:1ATP stoichiometry similar to the electroneutral transport mode of the gastric H,K-ATPase. This work provides insight in the molecular basis for the difference in electrogenicity of the two closely related ion pumps.

Working with the Na,K-pump I have discovered a secondary mutation in Na,K-ATPase (“rescue mutation”) that improves Na+ binding and thereby the transport activity in cells of neurological disease mutants. Hence, the rescue mutation represents a new principle for restoring the functional capability of neurological disease mutants that might be exploited in the future to develop pharmaceuticals to treat neurological diseases. 

I teach first-semester medical students in cell biology, where I am responsible for programs covering the transport of ions and uncharged substances across the cell membrane, osmosis and filtration, active and passive transport, and the action potential. Additionally, each semester I have bachelor students writing assignments on the Na,K-ATPase.

My primary work area is the execution of projects from idea to publication. I am involved in all processes, including the practical work in the laboratory.