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Nanocarrier stimuli-activated gene delivery.
Small,
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Neonatal Fc Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants.
Molecular Pharmaceutics,
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Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers.
Organic & Biomolecular Chemistry,
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Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography.
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Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity.
ChemBioChem,
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Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model.
Acta Oncologica,
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Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.
Communications Biology,
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Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine.
Vaccine,
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Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles.
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Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.
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Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics,
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Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis.
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Selective cellular removal of miR23b by Rab27a/b-dependent exosome release is linked to acquisition of a metastatic property in bladder cancer. Cancer Research.
Andersen, M. Ø., Nygaard, J. V., Burns, J. S.
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siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.
Molecular Therapy,
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Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding.
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Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
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Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.
Journal of Immunology,
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Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes.
Nano Letters,
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Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors.
Pharmaceutical Research,
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Ebbesen, M. F., Schaffert, D. H., Crowley, M. L., Oupický, D.
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Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications.
Journal of Polymer Science. Part A, Polymer Chemistry,
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Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.
Annals of the Rheumatic Diseases,
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The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular Therapy,
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The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.
Scientific Reports,
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The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing.
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The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.
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Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
iScience,
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Whitehead, B. J., Wu, L.
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Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness.
Journal of Extracellular Vesicles,
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Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells.
Pharmaceutical Research,
32(4), 1462-1474.
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Ultraporous interweaving electrospun microfibers from PCL-PEO binary blends and their inflammatory responses.
Nanoscale,
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Berton, M.
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Uptake of oligonucleotide loaded nanoparticles in prostatic cancer cells and their intracellular localization.
Proceedings of the Controlled Release Society, (24), 669-670.
Dong, M. D., Howard, K. A., Oupicky, D., Bisht, H.
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Visualization of thermally activated nanocarriers using in situ atomic force microscopy: Nanotechnology.
Nanotechnology,
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Hartmann, H., Lakner, U.
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Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. Tissue Engineering. Part A. Tissue Engineering, (3), 718.