Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

Sort by: Date | Author | Title

Nørskov, V & Raja, R 2026, 'Communicating classical antiquity. The making of a Museum of Ancient Art', Current World Archaeology, vol. 135, pp. 40.

Ravazzani, S & Maier, CD 2026, Communicating Public Action for Social Change. in The Mediation of Sustainability . Rowman & Littlefield Publishers.

Ahmedzai, HH, Oldervoll, LM, Pilegaard, MS, Stene, GB, Slettvoll, TE & Hauken, MA 2026, 'Community-Based Multidimensional Rehabilitation for Cancer Survivors: A Scoping Review', European Journal of Cancer Care, vol. 2026, no. 1, 3684187. https://doi.org/10.1155/ecc/3684187

Kuhlmann, E, Lotta, G, Burau, V, Correia, T, Falkenbach, M, Ungureanu, M-I, Wallenburg, I, Williams, GA & Lehmann, U 2026, 'Community health workers: a comparative assessment of capacities of a global policy approach in selected European health systems', Health Policy, vol. 165, 105541. https://doi.org/10.1016/j.healthpol.2025.105541

Vestergaard, M, Faergemann Hansen, R, Thomsen, PH, Hoiberg Bentsen, A & Falch-Joergensen, AC 2026, 'Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study', BMC Psychiatry, vol. 26, no. 1, 191. https://doi.org/10.1186/s12888-026-07824-5

Verweij, JW , Nielsen, HM & Buitenhuis, AJ 2026, 'Comparative analysis of genetic diversity in rainbow trout (Oncorhynchus mykiss) populations from Denmark and Finland using SNP data', Aquaculture, vol. 616, 743706. https://doi.org/10.1016/j.aquaculture.2026.743706

Bruun, H, Johnson, C, Raats, T & Vilde Schanke, S 2026, Comparative approaches to public service media in the age of platforms. in Convergence . SAGE Publications.

Thomsen, MR 2026, Comparative Literature in Denmark. in WS Hassan & S Shu-mei (eds), ACLA State of the Discipline Report.

Nielsen, CEB & Clausen, OR 2026, 'Comparative studies of salt pillows in proximity to the Ringkøbing-Fyn High, Denmark', Journal of Structural Geology, vol. 204, 105609. https://doi.org/10.1016/j.jsg.2025.105609

Madsen, PA , Jerez-Bogota, K , Vodolazska, D & Lauridsen, C 2026, 'Comparative Study of Cytokine Measurements in Blood, Plasma and Serum, and Saliva of Juvenile Pigs During Experimentally Induced Acute Inflammation', Veterinary Sciences, vol. 13, no. 1, 68. https://doi.org/10.3390/vetsci13010068

Schjerven, N, Bilotti, G, Kempf, M & Reiter, SS 2026, 'Comparing Connectivity Patterns in Prehistoric Germany by Means of Network Analysis, Artefact and Site Distribution and a Reassessment of Human Mobility (⁸⁷Sr/⁸⁶Sr)', Open Archaeology, vol. 12, no. 1, 20250077. https://doi.org/10.1515/opar-2025-0077

Shen, S, Prescott, K, Peterson, C, Schillinger, S, O'Connor, S, Groves, E, Franke, H, Abashidze, N, Weed, E , Fusaroli, R, Grossman, R, Parish-Morris, J & Eigsti, I-M 2026, 'Comparing Direct and Parent-Report Measures of Expressive Language Abilities in Autistic and Neurotypical Teenagers.', Meeting On Language and Autism, Atlanta, United States, 14/03/2026.

Ferlias, N , Kristjánsdóttir, K, Rotolo, RP, Matzen, LH , Stoustrup, PB & Pedersen, TK 2026, 'Comparing Orofacial Manifestations and Oral Health-Related Quality of Life in Previously Treated Young Adults With Idiopathic Condylar Resorption or Juvenile Arthritis in the Temporomandibular Joint', Orthodontics and Craniofacial Research, vol. 29, no. 2, pp. 309-318. https://doi.org/10.1111/ocr.70076

Agersnap, TN , Lomholt, JJ , Jensen, MB & Thastum, M 2026, 'Comparison of Disorder-Specific Group CBT and Generic Group CBT in Treating Adolescents with Social Anxiety Disorder: A Randomized Controlled Trial', Research on Child and Adolescent Psychopathology, vol. 54, 27. https://doi.org/10.1007/s10802-025-01412-z

Junker, T, Thorlund, MG, Nielsen, TK, Azawi, N, Bach, SW, Belsey, J, Borgbjerg, J & Graumann, O 2026, 'Comparison of health economics in robot-assisted partial nephrectomy and CT-guided cryoablation for the management of T1 renal cell carcinoma: an analysis of a prospective Danish cohort', Cardiovascular and Interventional Radiology, vol. 49, no. 2, pp. 278-288. https://doi.org/10.1007/s00270-025-04224-2

Lim, MH, Chan, HH & Ong, SQ 2026, Comparison of Image Acquisition Devices for YOLO-Based Insect Detection: A Performance Analysis. in J Choudrie, PN Mahalle, T Perumal & A Joshi (eds), ICT for Intelligent Systems - Proceedings of ICTIS 2025. Springer, Lecture Notes in Networks and Systems, vol. 1507, pp. 459-468, 9th International Conference on Information and Communication Technology for Intelligent Systems, ICTIS 2025, Bangkok, Thailand, 04/04/2025. https://doi.org/10.1007/978-981-96-8750-3_37

Žydelis, R, Weihermüller, L, Gomes, LC , Møller, AB, Castaldi, F, Volungevičius, J, Kavaliauskas, A, Koganti, T, Wetterlind, J, Cinkaya, Borůvka, L, van Egmond, F, Higgins, S, Liebisch, F, Povilaitis, V, Kazlauskaitė-Jadzevičė, A, Amalevičiūtė-Volungė, K, Pranaitienė, S & Vaudour, E 2026, 'Comparison of soil property predictions in Lithuanian croplands using UAV, satellite, EMI data and machine learning', Computers and Electronics in Agriculture, vol. 244, 111543. https://doi.org/10.1016/j.compag.2026.111543

van Dijk, LL, Siegmann, S, Field, NL, Sugrue, K, van Reenen, CG, Bokkers, EAM, Sayers, G & Conneely, M 2026, 'Comparison of thoracic ultrasonography (TUS), clinical respiratory scoring (CRS), and blood analysis to evaluate respiratory dysfunction in transported calves', PLoS One, vol. 21, no. 2, e0337418. https://doi.org/10.1371/journal.pone.0337418

McGreevy, PD, Mellor, DJ, Freire, R, Fenner, K, Merkies, K, Warren-Smith, A, Uldahl, M, Starling, M, Lykins, A, McLean, A, Doherty, O, Bradshaw-Wiley, E, Quinn, R, Wilkins, CL, Christensen, JW, Jones, B, Ashton, L, Padalino, B, O’ Brien, C, Copelin, C, Brady, C & Henshall, C 2026, 'COMPASS Guidelines for Conducting Welfare-Focused Research into Behaviour Modification of Animals', Animals, vol. 16, no. 2, 206. https://doi.org/10.3390/ani16020206

Kallestrup-Lamb, M, Marin, AOK & Søgaard, J 2026, 'Competing Demographic Drivers of Hospital Expenditures: Coexistence of the Red Herring and the Steepening Effects', Health Economics. https://doi.org/10.1002/hec.70092

Borowy, I & Heymann, M (eds) 2026, Competing Perspectives of Development: Yearbook for the History of Global Development. De Gruyter, Berlin. https://doi.org/10.1515/9783111635675

Villarruel Hinnerskov, JM, Nielsen, MK, Thomsen, AK, Steffensen, MA, Honoré, B, Vorum, H, Nissen, MH & Sørensen, TL 2026, 'Complement regulatory proteins are associated with progression rate of geographic atrophy secondary to age-related macular degeneration', Immunity and Ageing, vol. 23, no. 1, 11. https://doi.org/10.1186/s12979-026-00562-y

Matousek, C 2026, 'Completing derived representation theory of algebras'.

Andersen, MD & Aagaard, A 2026, 'Comply or collaborate? Paradoxical power shifting in interorganizational sustainability contexts', Paper presented at 41st EGOS Colloquium
, Athens, Greece, 03/07/2025 - 05/07/2025.

Liu, CM, Erikstrup, LT, Edslev, SM, Park, DE, Salazar, JE, Aziz, M, Rendboe, AK, Pham, T, Dinh, KM, Roach, K, Onos, A, Sung, E, Weber, NO, Andersen, PS, Ullum, H, Skov, R, Hungate, BA, Stegger, M, Erikstrup, C & Price, LB 2026, 'Composition and dynamics of the adult nasal microbiome', Microbiome, vol. 14, no. 1, 38. https://doi.org/10.1186/s40168-025-02250-3

Amery, F, Quataert, P, Vandaele, E, Smeets, H, Kristensen, HL, Loades, K, Körner, I & Willekens, K 2026, 'Compost organic matter content varied five-fold and determined compost quality across 107 composts of the North Sea Region', Waste Management, vol. 210, 115259. https://doi.org/10.1016/j.wasman.2025.115259

Folorunso, OA, Kotun, BC, Adeleke, AJ, Egbeagu, UU, Oda, O, Adebayo-Olajide, TC, Ogunbanwo, ST, Stephen, KO, Ajunwa, OM & Itakorode, BO 2026, Comprehensive applications of marine biotoxins resources. in SA Aransiola, S Bhatnagar & NR Maddela (eds), Marine Bioresources: Prospects and Obstacles. Elsevier, pp. 341-367. https://doi.org/10.1016/B978-0-443-36320-7.00005-3

De Witte, NAJ, Best, P, Torous, J, Mulvenna, M, Van Assche, E, Mathiasen, K, Kleiboer, AM, Carlbring, P & Van Daele, T 2026, 'Comprehensive Model for Mental health Access and service use (CoMMA): A process model for technology-enhanced mental healthcare', Internet Interventions, vol. 44, 100927. https://doi.org/10.1016/j.invent.2026.100927

Desita, Z, Tadesse, T, Bohlbro, AS, Sifna, A, Fekadu, H, Bizuneh, S, Sridhar, S, Robert, D, Tadepalli, M, Wejse, C, Schön, T & Rudolf, F 2026, 'Computer-Aided Analysis of Photographed Chest X-Ray Films Performs Well Compared With Trained Radiologists', Mayo Clinic Proceedings: Digital Health, vol. 4, no. 1, 100338. https://doi.org/10.1016/j.mcpdig.2026.100338

Bryld Staunæs, A, Krog Møller, B & Andersen, SR 2026, computer in bed. vol. 6, Forlaget Bandet. <https://www.kk.dk/sites/default/files/agenda/d24a41a0-6f95-4ef8-a741-8c47ccf40567/de9dd985-2d32-4234-9caf-8c54d6713af2-bilag-5.pdf>

Carlsson, MS 2026, 'Conceptions of the relation between well-being and sustainability in social theories, global policy and education research', Health Education, vol. Vol. ahead-of-print .

Gorbahn, K & Otto, M (ed.) 2026, Concepts of Europe from the 19th to the 21st Century: Between Continuity and Change. Brill.

Wunderlich, MF & Møller, A-KL 2026, 'Conceptual and theoretical perspectives on the human resource management-leadership-well-being link: Reviewing 20 years of empirical research', Human Resource Management, vol. 65, no. 2, pp. 407-430. https://doi.org/10.1002/hrm.70029

Grinderslev, JB , Amdisen, MB, Larsen, SR, Trump, BA, Karlsson, M, Zhou, W, Udovic, TJ, Cheng, Y, Tominaga, T, Jensen, TR & Andersson, MS 2026, 'Concomitant Enhancement of the Reorientational Dynamics of the BH₄^–Anions and Mg²⁺Ionic Conductivity in Mg(BH₄)₂·NH₃upon Ligand Incorporation', Journal of Physical Chemistry C, vol. 130, no. 1, pp. 112-123. https://doi.org/10.1021/acs.jpcc.5c07031

Jørgensen, CS, Sørensen, NK, Overvad, L, Dossche, L, Zhai, R, Maternik, M, Raes, A, Hagstrøm, S, Walle, JV, Guo, WJ, Rittig, S & Kamperis, K 2026, 'Conditioning with the enuresis alarm can convert enuresis to nocturia', Journal of Pediatric Urology, vol. 22, no. 1, 105588. https://doi.org/10.1016/j.jpurol.2025.08.038

Frumer, M , Trøllund Rask, M , Frostholm, L, Rønn Christensen, O, Rosendal, M & Bech Risør, M 2026, 'Configuring symptoms: experiences from an internet-based self-help programme for persistent physical symptoms in general practice', Social Science and Medicine, vol. 398, 119158. https://doi.org/10.1016/j.socscimed.2026.119158

Madaki, MY, Ullah, A, Nshing, R, Olasoji, OA, Prishchepov, A, Yin, H & Bavorova, M 2026, 'Conflict and migration as drivers of farmland abandonment in Cameroon', Land Use Policy, vol. 165, 108004. https://doi.org/10.1016/j.landusepol.2026.108004

Edslev, A 2026, 'Conflict over Urban Informality: Meanings of Tax and Renewal in Dar es Salaam's Markets', PhD, Aarhus University, Aarhus. <https://politica.dk/fileadmin/politica/Dokumenter/Afhandlinger/ane_edslev.pdf>

Massyn, L, Wichmann-Hansen, G & Areskoug Josefsson, K 2026, 'Confronting decisions related to the termination or continuation of doctoral supervision: a supervisor perspective', Studies in Graduate and Postdoctoral Education, vol. 17, no. 1, pp. 1-15. https://doi.org/10.1108/SGPE-07-2023-0062

Gheorghiade, P, Lorenzon, M, Reinikainen, S, Smith, SL, Tarboush, M, Miettunen, P, Kouki, P & Lahelma, A 2026, 'Connecting and Disconnecting Zones of Interaction in Northern Jordan: Tall al-Assara and Regional Connectivity in the Iron Age IIB–IIC', Bulletin of the American Society of Overseas Research. https://doi.org/10.1086/740319

Schow-Madsen, M, Jensen, K, Márquez-Toribio, M, Schøn, ML, Schou, TM, Nørgaard, JV & Overgaard, J 2026, 'Consequences of dietary amino acid imbalance for growth and gas exchange in black soldier fly (Hermetia illucens) larvae', Journal of Insects as Food and Feed, pp. 1-14. https://doi.org/10.1163/23524588-bja10368

Schuurmans, IK, Mulder, RH, Baltramonaityte, V, Lahtinen, A, Qiuyu, F, Rothmann, LM, Staginnus, M, Tuulari, JJ, Burt, SA, Buss, C, Craig, JM, Donald, KA, Eriksson, JG, Felix, JF, Freeman, TP, Grassi-Oliveira, R, Huels, A, Hyde, LW, Jones, SA, Karlsson, H, Karlsson, L, Koen, N, Lawn, W, Mitchell, C, Monk, CS, Mooney, MA, Muetzel, R, Nigg, JT, Belangero, SIN, Notterman, D, Ong, YY, O’Connor, T, O’Donnell, KJ, Pan, PM, Paunio, T, Ryabinin, P, Saffery, R, Salum, GA, Seal, M, Silk, TJ, Stein, DJ, Tan, AP, Teh, AL, Wang, D, Zar, H, Walton, E & Cecil, CAM 2026, 'Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium', Molecular Psychiatry, vol. 31, no. 2, pp. 1177-1189. https://doi.org/10.1038/s41380-025-03203-w

Chen, L, Li, H, Teng, J, Wang, Z, Qu, X, Chen, Z, Cai, X, Zeng, H, Bai, Z, Li, J, Pan, X, Yan, L, Wang, F , Lin, L , Luo, Y , Sahana, G , Lund, MS, Ballester, M, Crespo-Piazuelo, D, Karlskov-Mortensen, P, Fredholm, M, Clop, A, Amills, M, Loving, C, Tuggle, CK, Madsen, O, Li, J, Zhang, Z, Liu, GE, Jiang, J, Fang, L & Yi, G 2026, 'Construction of a Multitissue Cell Atlas Reveals Cell-Type-Specific Regulation of Molecular and Complex Phenotypes in Pigs', Advanced Science, vol. 13, no. 8, e04961. https://doi.org/10.1002/advs.202504961

Daugaard, LM, Peskova, RE, Thomsen, MRK & Bade, S 2026, 'Construction of second language subjects: A comparative analysis of the national curriculum in Denmark and Iceland across educational levels', The Nordic Educational Research Association (NERA) Conference 2026 , Aarhus, Denmark, 04/03/2026 - 06/03/2026.

Frank, D-A, Folwarczny, M & Otterbring, T 2026, 'Consumer Acceptance of High-Autonomy AI Assistants is Driven by Perceived Benefits in Online Shopping Settings Characterized by Scarcity', Psychology & Marketing, vol. 43, no. 3, pp. 538-555. https://doi.org/10.1002/mar.70074

Zhang, T, Grunert, KG & Guo, Y 2026, 'Consumer minimalism in local food consumption: The impact of pro-environmental self-identity and locavorism', Food Quality and Preference, vol. 135, 105711. https://doi.org/10.1016/j.foodqual.2025.105711

Grønhøj, A , Pedersen, S & Kümpel Nørgaard, M 2026, Consumer research with adolescents. in G Ares & P Varela (eds), Methods in Consumer Research. vol. 2, Elsevier.

Banovic, M 2026, Consumers still cutting meat intake: What is a reductarian? By Augustus Bambridge-Sutton. <https://www.foodnavigator.com/Article/2026/01/23/meat-consumption-reduced-reductarians-explained/>

Mathiasen Stopa, SE 2026, Consuming the Word of God. The Divine Word as Material Reality in Luther’s Theology and in 18th century Danish Catechetical Literature. in Moving Objects. Trans- and Interconfessional Perspectives on Early Modern Material Culture. Vandenhoeck & Ruprecht.

Lim, DBN, Bryce, J, Ali, SR, Tseretopoulou, X, Birkebaek, NH, Hannema, SE, Campos-Martorell, A, Clemente, M, Neumann, U, Flück, CE, Metzger, S, Krone, RE, German, A, Baronio, F, Barat, P, Delagrange, M, Vautier, V, Vieites, A, Rey, R, Elsedfy, H, Atapattu, N, Seneviratne, SN, Cools, M, Guran, T, Yavas Abali, Z, Fu, A, Janus, D, Shenoy, S, Wasniewska, M, Coco, R, Russo, G, Stancampiano, MR, Bonfig, W, Salerno, M, Claahsen-Van der Grinten, HL, Adriaansen, BPH, Mozzato, C, Guazzarotti, L, Niedziela, M, Banaszak-Ziemska, M, Van Eck, J, Bachega, T, Miranda, MC, Marginean, O, Munarin, J, De Sanctis, L, Probst-Scheidegger, U, Lenherr-Taube, N, Konrad, D, O’Connell, M, Gawlik-Starzyk, A, Sandberg, DE, Shnorhavorian, M, Krone, N, Ahmed, SF & Davies, JH 2026, 'Contemporary global management of 21-hydroxylase deficiency congenital adrenal hyperplasia in early infancy: a multi-national registry study', European Journal of Endocrinology, vol. 194, no. 2, pp. 123-135. https://doi.org/10.1093/ejendo/lvag004

Displaying results 701 to 750 out of 389671

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen