Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

Sort by: Date | Author | Title

Søby, JH , Mortensen, J , Rasmussen, LD , Tolbod, LP , Winther, S & Böttcher, M 2026, 'Systematic differences in myocardial blood flow and flow reserve quantification using Rubidium-82 and [ ¹⁵O]H ₂O positron emission tomography: Implications for Prognostic Cut-Offs', Journal of Nuclear Cardiology, vol. 55, 102533, pp. 102533. https://doi.org/10.1016/j.nuclcard.2025.102533

Callesen, LB & Spindler, KLG 2026, 'Systematic review and meta-analysis of studies assessing circulating tumor DNA kinetics in metastatic colorectal cancer', ESMO Gastrointestinal Oncology, vol. 11, 100314. https://doi.org/10.1016/j.esmogo.2026.100314

Rudolfsen, JH, Vukmirica, J, Johansen, P, Lundgren, KL & Mortensen, MB 2026, 'Systemic inflammation is associated with increased risk of death in population with atherosclerotic cardiovascular disease and chronic kidney disease-a Danish national register study', Frontiers in Cardiovascular Medicine, vol. 13, 1749835. https://doi.org/10.3389/fcvm.2026.1749835

Dige, M 2026, 'Syv paradokser i krigens etik', Paradoks: Tidsskrift for Filosofi og Teori.

Christiansen, AV & Hjørngaard, MW 2026, Tacit Pacts and Podium Placings: Cooperation, Altruism, and Corruption in Competitive Cycling. in D Collins, M Kostera, M Polec & T Vine (eds), THE ROUTLEDGE COMPANION TO ORGANIZATIONAL CULTURE. Routledge.

Jensen, VV , Johansson Jørgensen, M , Jensen, RH , Lange, J , Wolff, J & Hoybye, MT 2026, 'Tailored AI Ethics: Enacting Geriatric Care with AI-Based Patient Monitoring', Social Science & Medicine, vol. 397, 119135. https://doi.org/10.1016/j.socscimed.2026.119135

Amsinck, BL , Benhammouche, I , Chrenková, A , Snow, AJD & Pedersen, BP 2026, 'Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters', Plant Journal, vol. 125, no. 5, e70762. https://doi.org/10.1111/tpj.70762

Mamedipaka, R, Yadav, AK, Sinhmar, S, Yıldırım, HC & Thapliyal, S 2026, 'Tailoring microstructure and performance of thick-walled SS316L through overlap control in wire arc directed energy deposition', Materials Characterization, vol. 231, 115899. https://doi.org/10.1016/j.matchar.2025.115899

Fulco, S, Budzik, MK & Turner, K 2026, 'Tailoring toughness and adhesion through architected interfaces', npj Metamaterials, vol. 2, 5, pp. 1-10. https://doi.org/10.1038/s44455-025-00014-5

Ejsing, MA , Johansen, W & Frandsen, F 2026, 'Taking stock of what we know about internal crisis communication - How far have we come?', Corporate Communications: an international journal.

Terkelsen, O 2026, 'Taksationskendelser: Kommentarer til kendelser fra taksaktionskommissioner og overtaksationskommissioner.', Kendelser om fast ejendom, vol. 50 (2024), no. 8, pp. 1269–1363.

Larsen, SN 2026, Tankekraft: Om væren, tænkning, dannelse – og den uhyre anstrengelse det er at blive gjort dum. Samfundslitteratur.

Ardyna, M, Nicolaus, M, Houssais, M-N, Raut, J-C, Angot, H, Bisson, K, Brown, KA, Flores, JM, Galand, PE, Ghiglione, J-F, Law, KS, Ravetta, F, Schmale, J, Sonke, JE, Babin, M, Geoffroy, M, Heimbürger-Boavida, L-E, Lovejoy, C, Rysgaard, S, Schuback, N, Vancoppenolle, M, Tremblay, J-E, Bowler, C, Karp-Boss, L & Troublé, R 2026 'Tara Polaris expeditions: Sustained decadal observations of the coupled Arctic system in rapid transition'.

Anderson, S, Karlstaedt, A, Young, M, Karatzia, L, Cullen, F, Chen, J, O’Riordan, CE, Barnes, MR, Štaka, Z, Albee, LJ, Garrod-Ketchley, C, Dambure, S, Prag, HA, Cvetko, F, Miller, JJJJ, Thiemermann, C, Lewis, AJM, Murphy, MP, Smith, DM, Henson, SM, Tyler, DJ & Aksentijevic, D 2026, 'Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy', Nature Cardiovascular Research, vol. 5, no. 2, pp. 138-154. https://doi.org/10.1038/s44161-025-00769-0

Vinther, SC, Resag, A, Le, KTT, Zelle-Rieser, CC, Strandt, H, Malle, MG , Christiansen, SH, Del Frari, B, Stigger, T, Schilling, B, Wohlfarth, J, Thiel, S, Valero, J, Stoitzner, P & Kjems, J 2026, 'Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform', Journal of Controlled Release, vol. 392, pp. 114741. https://doi.org/10.1016/j.jconrel.2026.114741

Rasmussen, AN, Mcdermott, I & Spooner, S 2026, 'Taskification in general practice: A solution to, or an aggravator of, the workforce crisis?', Journal of Health Services Research and Policy, vol. 31, no. 2, pp. 120-124. https://doi.org/10.1177/13558196251400266

Chevalier, D, Geissmann, Q & Carrillo, J 2026, 'Taxonomic effects of white and amber LED artificial light at night on arthropods', Biological Conservation, vol. 317, 111798. https://doi.org/10.1016/j.biocon.2026.111798

Bondonno, NP, Pokharel, P, Parmenter, BH, Thompson, AS, Jennings, A, Murray, K, Meteran, H, Hodgson, J, Kühn, T & Cassidy, A 2026, 'Tea and coffee intakes, COPD, adult asthma, and lung function in the UK Biobank', Food and Function, vol. 17, no. 2, pp. 673-686. https://doi.org/10.1039/d5fo01943e

Jensen, TW & Albrechtsen, C 2026, 'Teacher and Teacher Union Perspectives on GenAI's Impact on Professional Identity and Practice in Nordic Education', NERA (The Nordic Educational Research Association) Conference 2026, Aarhus, Denmark, 04/03/2026 - 06/03/2026. <https://virtual.oxfordabstracts.com/event/75373/submission/879>

Musaeus, P , Prilop, CN, Dikilitas, K, Sundset, MA, Svensen, C, Ershova, T, Boud, D, Lindberg, AB , Bjælde, OE, Gray, RM, Istencioglu, T, Kvernenes, M, Lassesen, B & Raaheim, A 2026, 'Teacher feedback literacy in higher education: Navigating enablers and constraints', Assessment & Evaluation in Higher Education, vol. 51, no. 2, pp. 315-331. https://doi.org/10.1080/02602938.2025.2591556

Maurer, MM, Hiltunen, V, Aunola, K & Silinskas, G 2026, 'Teachers' and parents' beliefs about children's competence: Longitudinal and interactive associations with children's interest and self-concept of ability in literacy and math', Learning and Individual Differences, vol. 128.

Jensen, AV, Surrow, IM, Shokeen, E , Liu, Y-Y , Connelly, L , Dindler, C , Hjorth, M , Petersen, MG & Iversen, OS 2026, Teachers Bridging Technical and Reflective Stances in K-9 AI Education. in Proceedings of the International Society of the Learning Sciences (ISLS) Annual Meeting. International Society of the Learning Sciences (ISLS).

Liu, Y-Y , Jensen, AV , Shokeen, E , Dindler, C & Iversen, OS 2026, 'Teachers’ formative assessment practices for Computational Empowerment in K–12 education', International Journal of Child-Computer Interaction, vol. 48, 100805. https://doi.org/10.1016/j.ijcci.2026.100805

Sigurdsson, L. (Redaktør), Breidlid, H. (Redaktør), Sigurdsson, L., Breidlid, H., Emerson, L., Christodoulou, E., Daou, A. M., Lindhardt, E., Kornholt, B., Kopp, A. O., Henriksen, G. F., Paaske, N., Aukland, K., Myrbøe, T., Richardson, N., Gallagher, T., Fahed, Z., Al Hindy, E. & Zembylas, M. 2026, Teaching contested narratives and controversial issues: Contextualised approaches from Cyprus, Denmark, Lebanon, Northern Ireland and Denmark.

Hillebrand, E 2026, Teaching Mathematics for Economists. in E Hillebrand & W Griffiths (eds), Teaching econometrics: A tribute to R. Carter Hill. Springer, Advanced Studies in Theoretical and Applied Econometrics, vol. 56, pp. 365-399. https://doi.org/10.1007/978-3-031-97942-2_20

Refskou, AS 2026, Teaching Shakespeare's Emotions. Cambridge University Press.

Krøgholt, I , Høeg, MO , Christoffersen, EE & Thygesen, M 2026, 'TEATERPRODUKTION', Peripeti, vol. Årg 23, no. 41, pp. 7-17. <https://tidsskrift.dk/peripeti>

Arioti, M, Moroni, A, Mashayekhi, K, Werner, GS, Agostoni, P, Gorgulu, S, Ayoub, M, Avran, A, Kalay, N, Goktekin, O, Ladwiniec, A, Zaczkiewicz, M, Wojcik, J, Arenz, J, Rathore, S, Atmowihardjo, I, Dalibor, J, Christiansen, EH, Chico, L-G, Gasparini, GL, Galassi, AR, Vadalà, G, Gagnor, A, Diletti, R, Behnes, M, Pyxaras, SA, Di Mario, C, Boudou, N & Garbo, R 2026, 'Technical use of intravascular ultrasound in chronic total occlusion percutaneous coronary interventions: insights from the Euro-CTO registry', Clinical Research in Cardiology, vol. 115, no. 1, pp. 145-158. https://doi.org/10.1007/s00392-025-02788-0

Khan, AS & Laustsen, C 2026, 'Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI', Journal of Magnetic Resonance Imaging, vol. 63, no. 2, pp. 310-327. https://doi.org/10.1002/jmri.70084

Karpavice, J & Tambo, T 2026, Technology Roadmapping Revisited: Assessing Its Contemporary Relevance and Analytical Maturity. in Proceedings of IAMOT 2026. Springer, pp. 12.

Bregnballe, T & Holm, TE 2026, Tejst, overvågning af ynglefugle. DCE, Teknisk anvisning fra Fagdatacenter for Biodiversitet og Terrestrisk Natur, no. A184, vers. 3, Aarhus University, DCE - Danish Centre for Environment and Energy. <https://ecos.au.dk/fileadmin/ecos/Fagdatacentre/Biodiversitet/TAA184_Tejst_v3.pdf>

Nielsen, JV 2026, telefonaflytning. in Den store danske. <https://lex.dk/telefonaflytning>

Nielsen, JV 2026, telefonhemmeligheden. in Den store danske. <https://lex.dk/telefonhemmeligheden>

Nielsen, JV 2026, telegramhemmeligheden. in Den store danske. <https://lex.dk/telegramhemmeligheden>

Bergholdt Jul Christiansen, I, Zoch-Lesniak, B, Lindberg, B, Björkman, A, Ramerman, L, Payne, R, Herrmann, T, Homar, V & Huibers, L 2026, 'Telephone triage in urgent unscheduled primary care in 16 European countries: a cross-national questionnaire-based expert study', Scandinavian Journal of Primary Health Care, vol. 44, no. 1, pp. 2600632. https://doi.org/10.1080/02813432.2025.2600632

Skytte, MMB & Jensen, PM 2026, Television and children. in Routledge Resources Online.

Karlsson, A 2026, 'Telling through doing: Men’s illness narratives emerging in acts of paying it forward'.

Nielsen, FE, Abdullah, OB, Chafranska, L, Schmidt, TA & Søresnen, RH 2026, 'Temperature at admission and mortality in older adults with infection: Limited prognostic value in non-sepsis cases', American Journal of Emergency Medicine, vol. 103, pp. 1-8. https://doi.org/10.1016/j.ajem.2026.01.045

Gao, J, Dai, A, Wu, M, Kang, Y, Liao, M, Liu, Z & Jeppesen, E 2026, 'Temperature mediates grazer effects on filamentous green algae proliferation: evidence from a macrophyte mesocosm experiment', Hydrobiologia. https://doi.org/10.1007/s10750-026-06153-8

Schmidt, BM & Plotnikof, M 2026, Temporal Governance Through Rhythmic Organizing: Exploring Polyrhythms of Fixed and Fluid Times in a Case of School Inclusion. in R Laursen & M Madsen (eds), Education and the Politics of Time: Temporal Governance in Teaching and Learning. Springer Science+Business Media, Educational Governance Research, vol. 26, pp. 117-137. https://doi.org/10.1007/978-3-032-09590-9_7

Burta, O, Akbarian, F, Rossi, C, Vidaurre, D, D'hooghe, MB, D'Haeseleer, M, Nagels, G & Van Schependom, J 2026, 'Temporally Defined Brain Network Activation Associated With Slowed Information Processing Speed in Multiple Sclerosis', Human Brain Mapping, vol. 47, no. 3, e70478. https://doi.org/10.1002/hbm.70478

Vinter, N , Johnsen, SP, Lip, GYH, Trinquart, L, Frost, L & Benjamin, EJ 2026, 'Temporal trends in associations between social drivers and life-years lost in newly diagnosed atrial fibrillation in Denmark, 2000-22: a nationwide cohort study', The Lancet. Public health, vol. 11, no. 1, pp. e17-e25. https://doi.org/10.1016/S2468-2667(25)00260-9

Tong, B, Farmer, JR, Rosner, J, Noonan, VK, Cragg, JJ, Griesdale, D, Shuster, C & Kramer, JLK 2026, 'Temporal trends in gabapentinoid use for the acute management of spinal cord injury: a retrospective cohort study', Spinal Cord. https://doi.org/10.1038/s41393-026-01172-7

Gundersen, TW, Knorr, S, Ringholm, L, Moeller Jensen, D, Damm, P, Kragelund Nielsen, K, Backman, H, Lauenborg, J, Mathiesen, ER, Petersen, AH , Skipper, N, Kofoed-Enevoldsen, A & Clausen, TD 2026, 'Temporal Trends in Pregnancy Outcomes Among Parents With Type 1 Diabetes: A Nationwide Register-Based Study', BJOG: An International Journal of Obstetrics and Gynaecology. https://doi.org/10.1111/1471-0528.70174

Halbig, JM, Stoustrup, P , Kristensen, KD, Frid, P, Rypdal, V, Songstad, NT, Augdal, TA, Fischer, J, Gil, EG, Cetrelli, L, Lundestad, A, Angenete, O, Aukland, SM, Tylleskär, K, Rosen, A, Skeie, MS, Rygg, M, Rosendahl, K, Jönsson, B & Nordal, E 2026, 'Temporomandibular disorder in children with juvenile idiopathic arthritis with and without temporomandibular joint involvement compared to controls: a two-year prospective multicenter cohort study', BMC Oral Health, vol. 26, no. 1, 334. https://doi.org/10.1186/s12903-026-07738-4

Bennett-Tennenhaus, R, Goodbody, I, Letz, JC & Shah, A 2026, 'Tensor extriangulated categories', Journal of Algebra, vol. 685, pp. 361-405. https://doi.org/10.1016/j.jalgebra.2025.07.041

Gaml-Sørensen, A , Ernst, A , Brix, N , Lunddorf, LLH , Thomsen, AH & Ramlau-Hansen, CH 2026, 'Ten-year findings from the Puberty Cohort: a sub-cohort within the Danish National Birth Cohort', International Journal of Epidemiology, vol. 55, no. 1, dyaf209. https://doi.org/10.1093/ije/dyaf209

Agkathidis, A, Hudert, M & Medel-Vera, C 2026, Terminology and Definitions. in SpringerBriefs in Architectural Design and Technology. Springer, SpringerBriefs in Architectural Design and Technology, vol. Part F1429, pp. 15-19. https://doi.org/10.1007/978-981-95-0760-3_2

van Emde Boas, E 2026, ‘Terrifying and Full of Power’: Agency and Affect in Homer's Ballistics. in A Novokhatko & J Devereaux (eds), Embodied Natural and Artificial Intelligence in Classics and Philosophy. De Gruyter.

Krieger, J & Parks Pieper, L 2026, 'Testing Boundaries: Claiming Authority of Sex in Sport', International Journal of the History of Sport, pp. 1-16. https://doi.org/10.1080/09523367.2026.2627484

Displaying results 3351 to 3400 out of 389736

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen