Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Pasquini, J, Pavese, N, Ceravolo, R, Helmich, RC & Deuschl, G 2026, 'Contralateral Spread of Asymmetrical Tremor in Parkinson's Disease', Movement Disorders Clinical Practice, vol. 13, no. 3, pp. 702-710. https://doi.org/10.1002/mdc3.70353

Gossmann, A, Runnel, K, Bahram, M & Ranius, T 2026, 'Contrasting diversity patterns of brown: and white-rot wood saprotrophs in response to climate and dispersal vectors', FEMS Microbiology Ecology, vol. 102, no. 1, fiaf116. https://doi.org/10.1093/femsec/fiaf116

Yu, J, Xue, Y, Chen, H, Jin, L, Shi, W, Xiao, P, Jeppesen, E & Yang, J 2026, 'Contrasting latitudinal patterns of reservoir methane-cycling microbial communities in water and sediment', Environmental Technology and Innovation, vol. 41, 104786. https://doi.org/10.1016/j.eti.2026.104786

Zhou, J, Liu, S, Jan van Groenigen, K, Mueller, CW, Ochoa-Hueso, R, Fanin, N, Ren, Z, Zhang, Y, Ma, Y, Sun, S, Hu, J, Zhang, Y, Yahdjian, L, Wanek, W, Olesen, JE, Kuzyakov, Y, Liu, J & Chen, J 2026, 'Contrasting responses of particulate and mineral-associated organic carbon stocks to grazing exclusion in an alpine meadow', Agriculture, Ecosystems and Environment, vol. 400, 110227. https://doi.org/10.1016/j.agee.2026.110227

Ge, F , Wang, Y , Agerbo, E , Köhler-Forsberg, O, Bulik, CM, Petersen, LV & Vilhjálmsson, BJ 2026, 'Contrasting Risk Profiles for Suicide Attempt and Suicide Using Danish Registers and Genetic Data', JAMA Psychiatry, vol. 83, no. 1, pp. 32-42. https://doi.org/10.1001/jamapsychiatry.2025.3444

Jaeger, SR, Chheang, SL, Hedderley, DI, Roigard, CM & Harker, FR 2026, 'Controlled atmosphere storage of apples: An online study of consumer attitudes and willingness to eat', Food Research International, vol. 225, 118099. https://doi.org/10.1016/j.foodres.2025.118099

Li, L, Li, F, Cui, M, Liu, L, Zhen, X, Wei, J, Cui, J, Dong, J, Long, J, Dong, M & Wang, X 2026, 'Controlling Cleavage of C_α–C_βBonds in Lignin Induced by Photo-Driven Iron Salt at Simulated Natural Environment Conditions', ACS Catalysis, vol. 16, no. 5, pp. 4712-4728. https://doi.org/10.1021/acscatal.5c08182

Makareviciute, A 2026, 'Control of crystallization kinetics in Germanium Telluride via thermal annealing and role of β-relaxations', PhD, Aarhus University.

Jabed, A, Goto, F, Frimpong, B, Armanno, D, Longa, A, Michiardi, M, Damascelli, A, Hofmann, P, Jargot, G, Ibrahim, H, Légaré, F, Gauthier, N, Beaulieu, S & Boschini, F 2026, 'Control of intervalley scattering in Bi₂Te₃ via temperature-dependent band renormalization', npj Quantum Materials, vol. 11, no. 1, 12. https://doi.org/10.1038/s41535-025-00842-8

Gázquez-Gutiérrez, A, Chin, P, Peris, G, Gordon, K, Marchante, PG, Witteveldt, J, Tristán-Ramos, P, Rouvière, JO, Knol, LI, Ivens, A, López-Onieva, L, Estévez, AM, Garland, W , Jensen, TH, Heras, SR & Macias, S 2026, 'Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8', Nucleic Acids Research, vol. 54, no. 5, gkag190. https://doi.org/10.1093/nar/gkag190

Garrett, C, Brown, KGM, Solomon, MJ, Sutton, PA, Koh, CE, Aguiar, S, Bezerra, TS, Clouston, HW, Desouza, AL, Dozois, EJ, Ersryd, AL, Frizelle, FA, Funder, JA, Garcia-Aguilar, J, Garfinkle, R, Glyn, T, Heriot, A, Kanemitsu, Y, Kong, CY, Kristensen, H, Malakorn, S, Mens, DM, Nilsson, PJ, Palmer, GJ, Pappou, E, Quinn, MM, Quyn, AJ, Sahakitrungruang, C, Saklani, A, Solbakken, AM, Tiernan, JP, Verhoef, C & Steffens, D 2026, 'Conventional Versus High-Complexity Total Pelvic Exenteration for Locally Advanced and Locally Recurrent Rectal Cancer: An International Multicenter Study', Diseases of the Colon & Rectum, vol. 69, no. 1, pp. 34-41. https://doi.org/10.1097/DCR.0000000000003986

Bourban, M, Lenzi , D, Sørensen, MP , Fishberg, R, Mehlich, J, Fischbach, F, Molina, JL, Poague, KIHM, Csábi, A, Heffernan, R, Hastings, R & Rességuier, A 2026, 'Convergences and Gaps between Environmental Ethics, Climate Ethics, and Research Ethics: A Scoping Review', Science and Engineering Ethics, vol. 32, no. 1, 11. https://doi.org/10.1007/s11948-025-00575-8

Nielsen, YA , Fusaroli, R , Trecca, F , Bleses, D, Fein, D, Højen, A, Naigles, L, Templeton, E & Christiansen, MH 2026, 'Conversational alignment as an individual difference', Proceedings of the Royal Society B: Biological Sciences, vol. 293, no. 2067, 20252205. https://doi.org/10.1098/rspb.2025.2205

Thomsen, MK & Jakobsen, M 2026, 'Coproduction Encouragement Can Backfire: Evidence from Randomized Controlled Trials', International Public Management Journal.

Mogensen, BH, Nielsen, TH, Pedersen, MØ, Gjerdrum, LMR, El-Galaly, TC & Pedersen, LM 2026, 'Core Needle Biopsies in Patients With Lymphoproliferative Malignancies: An Observational Single-Center Cohort Study', European Journal of Haematology, vol. 116, no. 1, pp. 85-92. https://doi.org/10.1111/ejh.70045

Wurtz, A & Bennedsen, M 2026, Cornerstones in Quantitative Empirical Methods: Volume 1: Foundations. vol. 1, 1 edn, Chapman & Hall/CRC Press . https://doi.org/10.1201/9781003591191

Yang, S, Nam, C-W, Nørgaard, BL, Ko, B, Leipsic, J, Matsuo, H, Kubo, T, Kawasaki, T, Narula, J & Koo, B-K 2026, 'Coronary Plaque and Physiological Characteristics in ACS Risk Assessment According to Lesion Count', JACC. Cardiovascular interventions, vol. 19, no. 5, pp. 651-653. https://doi.org/10.1016/j.jcin.2025.11.002

Aabo, T, Garbers, ND, Holgersen, LA & Jørgensen, JG 2026, 'Corporate climate risk: Do female CEOs matter?', Finance Research Letters, vol. 2026, no. 109849, 109849, pp. 1. https://doi.org/10.1016/j.frl.2026.109849

Frandsen, F & Johansen, W 2026, Corporate Image, Reputation and Identity. in R Tench & S Waddington (eds), Exploring Public Relations and Management Communication. 6th edition edn, Harlow, UK.

de Jager, M, Buitendijk, NH, Baveco, JM, Hornman, M, Kruckenberg, H, Kölzsch, A, Madsen, J, Moonen, S, Schreven, KHT & Nolet, BA 2026, 'Correction: A multi-species model for goose management: Competition and facilitation drive space use of foraging geese (Ambio, (2026), 55, 2, (450-464), 10.1007/s13280-025-02206-9)', AMBIO, vol. 55, no. 2, pp. 465-466. https://doi.org/10.1007/s13280-025-02279-6

Visser, R, Lambers, K, Aitchison, K, Jutte, A, Rocks-Macqueen, D, van der Knaap, L, Romanowska, I , Brughmans, T, Linssen, J & Pažout, A 2026, 'Correction: Lessons Learned: Creating Tutorials to Teach Agent-Based Modelling to Archaeologists', Journal of Computer Applications in Archaeology, vol. 9, no. 1, pp. 105-106. https://doi.org/10.5334/jcaa.270

Russell, DJ, Naudts, E, Soudzilovskaia, NA, Briones, MJI, Çakır, M, Conti, E, Cortet, J, Fiera, C, Kutuzovic, DH, Hedde, M, Hohberg, K, Indjic, D, Krogh, PH, Lehmitz, R, Lesch, S, Marjanović, Mulder, C, Mumladze, L, Murvanidze, M, Rick, S, Roß-Nickoll, M, Schlaghamerský, J, Schmidt, O, Shelef, O, Suhadolc, M, Tsiafouli, M, Winding, A, Zaytsev, A & Potapov, A 2026, 'Corrigendum to “Edaphobase 2.0: Advanced international data warehouse for collating and using soil biodiversity datasets” (Applied Soil Ecology, (2024), 204, C, (105710), (S0929139324004414), 10.1016/j.apsoil.2024.105710)', Applied Soil Ecology, vol. 217, 106603. https://doi.org/10.1016/j.apsoil.2025.106603

Ma, X, Räisänen, SE, Wang, K, Amelchanka, S, Giller, K, Islam, MZZ, Li, Y, Peng, R, Reichenbach, M, Serviento, AM, Sun, X & Niu, M 2026, 'Corrigendum to “Evaluating GreenFeed and respiration chambers for daily and intraday measurements of enteric gaseous exchange in dairy cows housed in tiestalls” (J. Dairy Sci. 107:10913–10931) (Journal of Dairy Science (2024) 107(12) (10913–10931), (S0022030224011664), (10.3168/jds.2024-25246))', Journal of Dairy Science, vol. 109, no. 1, pp. 870-874. https://doi.org/10.3168/jds.2026-109-1-870

Laursen, DRT, Broager, MI, Damkjær, MW, Eiset, AH, Elkjær, M, Faltinsen, E, MacLean-Nyegaard, IR, Nejstgaard, CH, Paludan-Müller, AS, Petersen, LAB, Vestergaard, SV & Hróbjartsson, A 2026, 'Corrigendum to "Impact of active placebo controls on estimated drug effects in randomized trials: a meta-epidemiological study" [Journal of Clinical Epidemiology 188 (2025) 111998]', Journal of Clinical Epidemiology, vol. 191, 112091. https://doi.org/10.1016/j.jclinepi.2025.112091

Marzookian, K, Aliakbari, F, Hourfar, H, Sabouni, F, Otzen, DE & Morshedi, D 2026, 'Corrigendum to “The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier” [Int. J. Biol. Macromol. Volume 290 (2025), 140387] (S0141813025009365), (10.1016/j.ijbiomac.2025.140387)', International Journal of Biological Macromolecules, vol. 337, 149909. https://doi.org/10.1016/j.ijbiomac.2025.149909

Liebermann, R 2026, 'Corrine Carvalho, ed. The Oxford Handbook of Ezekiel. Oxford Handbooks. Oxford University Press, 2023. Pp. xii + 543. Hardcover. $175.00. ISBN 9780190634513.', Review of Biblical Literature , vol. 02/2026.

Johansson, D 2026, 'Corrosion detection by identification of a nonlinear Robin boundary condition', Annales Fennici Mathematici, vol. 51, no. 1, pp. 197-221. https://doi.org/10.54330/afm.180808

Skøtt, MV , Melnikova, E , Gutiérrez, E , Matchkov, V , Østergaard, L & Postnov, DD 2026, 'Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia', Advanced Science, vol. 13, no. 4, e19324. https://doi.org/10.1002/advs.202519324

Dilnessa, AA , Elofsson, K , Taghizadeh-Toosi, A & Jansson, T 2026, 'Cost-effective Carbon Sequestration in Agricultural Soils in the EU From 2020 to 2050', Environmental Modeling & Assessment. https://doi.org/10.1007/s10666-025-10092-4

Ehlers, LH, Levin, MD, van der Klift, M, Jensen, MB, Tran, HTT, Kater, A & Niemann, CU 2026, 'Cost-Effectiveness of Venetoclax-Based Treatment in Treatment-Naïve Fit Patients With CLL Without TP53 Aberrations', European Journal of Haematology. https://doi.org/10.1111/ejh.70143

Risør, BW , Tayyari, N, Sopina, L, Juul, T , Laurberg, S , Thaysen, HV & Hovdenak, I 2026, 'Cost-Utility analysis of Patient-Led Follow-Up after Rectal Cancer Compared to Standard Follow-Up: A three-year follow-up of the FURCA Randomised Controlled Trial', Journal of Cancer Survivorship. https://doi.org/10.1007/s11764-026-01976-9

Kildahl, SS , Kaussler, C , Ebenbauer, R , Bech, TB, Giovanelli, R, Henriksen, ML , Mithani, M , Uysal-Unalan, I , Juhl, DW , Nielsen, NC & Skrydstrup, T 2026, 'CO₂ capture with post-modified nitrile and styrene-butadiene-styrene rubbers', Chem. https://doi.org/10.1016/j.chempr.2025.102918

Hoffmann, SV , Jones, NC & Rodger, A 2026, Couette Flow Linear Dichroism Spectroscopy. in V Arluison & F Wien (eds), Methods in Molecular Biology. 2 edn, vol. 3004, Springer, Methods in Molecular Biology, vol. 3004, pp. 105-121. https://doi.org/10.1007/978-1-0716-5084-4_7

Gundersen, LB & Kallestrup, J 2026, 'Counterfactuals, Irrelevant Semifactuals and the § 1.000.000 bet', Inquiry, vol. 69, no. 2, pp. 1122-1138. https://doi.org/10.1080/0020174X.2023.2249510

Mørck, LL 2026, 'Counter-hegemonic Co-research as Learning from the Margins', Qualitative Studies.

Beck, SN & Christensen, TK 2026, Countering pseudolinguistic claims: The ethical challenges facing forensic linguists. in The Routledge Handbook of Ethics in Forensic Linguistics. Routledge, pp. 105-117. https://doi.org/10.4324/9781003391074-10

Pristed, BB 2026, 'Counter-Narratives in Train-Themed Russian and Ukrainian Children’s Books, 2019–2022', International Research in Children's Literature, vol. 20, no. 1.

Pettigrew, LM, Akl, S, Bharmal, AV, Exley, J, Allen, LN, Petersen, I, Cromwell, DA & Mays, N 2026, 'Counting general practitioners: a comparative repeat cross-sectional analysis of GPs in NHS general practice in England', British Journal of General Practice, vol. 76, no. 764, pp. e175-e182. https://doi.org/10.3399/BJGP.2024.0833

Meng, Z, Li, H, Wu, Y, Reich, PB, Eisenhauer, N, Abalos, D, Revillini, D, Liu, S, Yan, W, Chen, J, Voinov, A, Yang, Z, Wang, Y-P, Zhao, F, Qiu, L, Xiao, J, An, S, Liang, G & Delgado-Baquerizo, M 2026, 'Coupled Above- and Belowground Ecosystem Stability Worldwide', Advanced Science, pp. e17411. https://doi.org/10.1002/advs.202517411

Akhtar, Z, Islam, MA, Aleem, MA, Shuvo, TA, Hassan, MZ, Asadullah, Rahman, M, Rahman, MZ, Hossain, ME, Shirin, T, Rahman, M, Khan Jony, MH, Monalisa, Sarker, FR, Alam, AN, Rubaid Anwar, SNM, Rahman, M, Jiamsakul, A, Moa, AM, Tan, TC, Fröbert, O, Chowdhury, F & MacIntyre, CR 2026, 'COVID-19 vaccination and mortality among coronary care patients with severe acute respiratory infection in Bangladesh: a prospective study (2021–2024)', The Lancet Regional Health - Southeast Asia, vol. 46, 100745. https://doi.org/10.1016/j.lansea.2026.100745

Hund, J, Cuenca, N & Andriollo, T 2026, 'Crack detection by holomorphic neural networks and transfer-learning-enhanced genetic optimization', Engineering Fracture Mechanics, vol. 338, 112050. https://doi.org/10.1016/j.engfracmech.2026.112050

Ebsen, M 2026, Crafting Co-ops in Denmark: Reworking Craftmanship, construction and capitalism in a cooperative realm. Berghahn Books.

Eriksson, B & Sørensen, TLH 2026, Crafting Participation at the Art Museum: Affect, Agency and Community . Palgrave Macmillan Cham.

Christiansen, CE 2026, 'Creativity as messy interface: Fish and water tropes in writers’ descriptions of their practice', Language, Culture and Society.

Søgaard, TF, Andell, P, Coomber, R, Chomczyński , P, Bowden , M, Gundhus, HOI, Frąckowiak , P, Szykut , M, Tollin, K, Windle , J, Löfstrand , CH & Seal, M 2026, 'Criminal exploitation and vulnerability in drug markets: A six-nation comparison of its recognition in international policy discourses and criminal justice systems', European Journal of Criminology, pp. 1-22. https://doi.org/10.1177/14773708261427649

Buij, R, Moonen, S, Müskens, G, van der Horst, Y, Kruckenberg, H, Liljebäck, N, Månsson, J, Koffijberg, K, van der Jeugd, H, Nolet, BA, Baveco , H & Madsen, J 2026, 'Crippling rates of waterfowl by gunshot in Northwestern Europe: interspecific and geographic differences give clues to possible management challenges and options', European Journal of Wildlife Research, vol. 72, no. 2, 35. https://doi.org/10.1007/s10344-026-02070-2

Fogt, MM 2026, 'Crisis and War as a Challenge to Harmonisation of Private International Law', Scandinavian Studies in Law, vol. 72, no. The Politicization of Private International Law.

Misceo, D, Terkelsen, T, Bøen, SM, Bjørnstad, PM, Strand, ME, Orszagh, VC, Jensen, UB & Frengen, E 2026, 'CRISPR Activation Reveals the Spliceogenicity of an Intronic NEB Variant in Fetuses With Arthrogryposis Multiplex Congenita 6', Clinical Genetics, vol. 109, no. 4, pp. 772-777. https://doi.org/10.1111/cge.70097

Khider, MLK, Irla, M, López, MG, Gispert, A, Konjetzko, T, Meliawati, M, Schmid, J, Brautaset, T & Brito, LF 2026, 'CRISPR-Cas9-driven genome editing in Bacillus methanolicus MGA3', Frontiers in Microbiology, vol. 16, 1728984. https://doi.org/10.3389/fmicb.2025.1728984

Yuriditsky, E, Lyhne, MD, Horowitz, JM & Dudzinski, DM 2026, 'Critical Care Management of Acute Pulmonary Embolism', Journal of Intensive Care Medicine, vol. 41, no. 3, pp. 200-213. https://doi.org/10.1177/08850666241311512

Displaying results 751 to 800 out of 389648

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen