Exosomes

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types in vitro. Cells continuously secrete a large number of microvesicles, exosomes and small molecules into the extracellular space. Exosomes have been shown to contain mRNA and miRNA and they are able to mediate communication between cells, by transport of RNA and proteins which can be functionalized in the recipient cell. The ability to transport bioactive cargoes, gives exosomes innate therapeutic potential as a natural drug carrier. Efficient techniques for loading drugs into exosomes to utilize the natural carrier capabilities of these vesicles remains to be elucidated.

Applications of Exosomes

The presence exosomes in blood, saliva, and urine paves the way for the possible application of exosomes as a diagnostic marker for diseases. Many diseases are difficult to detect by the methods and equipment available today and there is a growing demand for development of new non‐invasive methods to detect diseases in early stages. The use of exosomes as markers of disease is being investigated to cement their potential as a non-invasive diagnostic tool for early detection of many diseases, in particular cancers. This, however, relies on thorough characterisation of exosomes in both healthy and diseased states

An important factor to understanding the roles of exosomes is knowledge of their biodistribution. Currently, the number of publications describing the biodistribution of exosomes is limited. The main reason being the lack of a robust fluorescent label that can be visualised in vivo. Mapping the specific cell type derived exosomes can increase our knowledge on the roles of exosomes in the organism, as well as help to identify natural targeting systems.

Isolation, Characterisation and Fluorescent Labelling

The most common isolation protocol uses a differential centrifugation to fractionate cells, microvesicles, and exosomes, which are pelleted by ultracentrifugation. After vesicles are secreted from cells into the extracellular environment, it difficult to separate the different subpopulations of vesicles to obtain a pure sample. We have developed methods to optimise isolation and thorough characterisation procedures to obtain pure and well-characterised exosomes. Furthermore, we have developed a simple method for labelling of exosomes with a robust fluorescent label that can be visualised in vivo, allowing investigation of the biodistribution of different cell derived exosomes.

Collaborators:

Department of Clinical Medicine, Aarhus University Hospital, Denmark

Dan Peer, Department of Cell Research & Immunology, Tel Aviv University, Israel

Moein Moghimi, school of Medicine, Pharmacy and Health, Durham University, UK

Recent Publications

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Aagaard, A & Andersen, MD 2026, 'Business model innovation under institutionalized ESG regulation: Ontological limits of dominant frameworks', Business Strategy and the Environment.

Hillingsø, R, Kjaergaard, AD, Larsen, MK, Mandrup-Poulsen, T, Poulsen, HE, Mottelson, M, Petersen, JB, Nordestgaard, BG, Hasselbalch, HC, Bojesen, SE, Helby, J, Glenthøj, A & Ellervik, C 2026, 'C282Y Homozygosity Increases Erythrocyte Turnover and Decreases HbA1c-A Population-Based Study', International Journal of Molecular Sciences , vol. 27, no. 5. https://doi.org/10.3390/ijms27052410

Beach, D , Senninger, R & Fenger, J 2026, 'Campaigns do matter: The impact of campaigns in reducing framing effects', European Journal of Political Research, vol. 65, no. 1, pp. 198-219. https://doi.org/10.1017/S147567652510011X

Thomsen, PT 2026, 'Canadisk bedrift satser på avlsdyr i topklasse', Bovi : Til fremtidens mælkeproducent, vol. Marts 2026, pp. 34-35. <https://www.maskinbladet.dk/artikel/129620_canadisk-bedrift-satser-paa-avlsdyr-i-topklasse>

Alcalay, I, Weissman, A, Ganer Herman, H, Tsafrir, A, Friedman, M, Weiner, E, Orvieto, R, Polyzos, NP, Dahan, MH, Polyakov, A, Fischer, R, Esteves, SC, Ata, B, Franasiak, JM & Mizrachi, Y 2026, 'Can artificial intelligence models provide reliable medical counselling to fertility patients?', Reproductive BioMedicine Online, vol. 52, no. 2, 105237. https://doi.org/10.1016/j.rbmo.2025.105237

Blanke, ML , Salachan, PV , Georgsen, JB , Fredsøe, J , Ulhøi, B , Borre, M & Sørensen, KD 2026, 'Cancer-associated fibroblast subtypes in the tumor microenvironment of prostate cancer and associations to patient outcomes', Journal of Pathology, vol. 268, no. 4, pp. 413-427. https://doi.org/10.1002/path.70023

Grooss, K 2026, 'Cancer recurrence detection in general practice', PhD, Aarhus University.

Højsager, FD, Borch, L, Castelein, R, Christensen, SB & Simony, A 2026, 'Cancer risk among women with scoliosis: a nationwide danish register-based study', Spine Deformity. https://doi.org/10.1007/s43390-026-01301-5

Kothari, SF , Odgaard, L & Kothari, M 2026, Candidiasis in Adults with Swallowing Disorders. in L Cummings (ed.), Communication and Swallowing Disorders in Infectious Diseases. Routledge.

Frølunde, AS, Valentin, JB, Kristensen, L, Schachsen, PK, Thomsen, JL & Vestergaard, C 2026, 'Can Foot Dermatophyte Infections Signal Future Diabetes Risk? Findings from a Register-based Study', Acta Dermato-Venereologica, vol. 106. https://doi.org/10.2340/actadv.v106.adv-2025-0125

Carballo Santiago, F & Gupta, ND 2026, 'Can preschool reduce school dropout in developing countries? Evidence based on Young Lives data from Andhra Pradesh, India', Education Economics. https://doi.org/10.1080/09645292.2026.2618827

Poncin, W, Kothari, SF, Magara, J, Inoue, M, Castrillon, E & Kothari, M 2026, 'Can Recordings of Tongue Motor-Evoked Potentials Be Improved? Comparison of Two Electrode Types and Their Reliability', Journal of Oral Rehabilitation, vol. 53, no. 2, pp. 439-447. https://doi.org/10.1111/joor.70098

Ahrensberg, NV 2026, 'Can selective acculturation foster integration? A systematic literature review', Ethnicities. https://doi.org/10.1177/14687968261430350

Hou Søhoel, JE, Gehrt, TB, Bohnstedt-Pedersen, NH, Dalgaard, AK, Vaeggemose, U & Gude, MF 2026, 'Can Video Reduce Conflict Between Dispatcher and Caller During Emergency Medical Calls? A Randomized Substudy of the CAM-VISION Trial', Journal of Telemedicine and Telecare. https://doi.org/10.1177/1357633X261435246

Boonkaew, S & Ferapontova, EE 2026, 'Capacitive Lateral Flow Test for Sub-fM Analysis of Serum HER-2/neu Using a Magnetic Cellulase-Linked Aptamer Sandwich Strategy', Analytical Chemistry, vol. 98, no. 2, pp. 1370-1379. https://doi.org/10.1021/acs.analchem.5c05265

Bubandt, N 2026, Carbon Entanglements: Bodies After Anthropocentrism. in A Masquelier & A McDowell (eds), The Cambridge Handbook of the Anthropology of the Body. Cambridge University Press.

Zhartybayeva, A , Christensen, BT , Eriksen, J, Don, A & Jensen, JL 2026, 'Carbon in above- and belowground harvest residues of silage maize under contrasting nutrient regimes', Agriculture, Ecosystems & Environment, vol. 400, 110243, pp. 1-8. https://doi.org/10.1016/j.agee.2026.110243

Wu, D, Ding, H, Cheng, Y, Li, HJ, Wang, W & Sun, Q 2026, 'Carbon tax, renewable portfolio Standards, or both? Evaluating policy effectiveness in promoting renewable energy and reducing emissions', Environment, Development and Sustainability. https://doi.org/10.1007/s10668-025-07203-2

Carter-Storch, R, Terkelsen, CJ, Nissen, H, Pedersen, ALD, Andersen, KJ, Frederiksen, CA, Haujir, A, Ulrikkaholm, E, Vase, H , Thim, T, Freeman, P, Uttenthal, F, Christiansen, U, Christiansen, EH & Dahl, JS 2026, 'Cardiac damage and outcome in transcatheter aortic valve replacement patients: a COMPARE-TAVI 1 trial sub-study', European Heart Journal Cardiovascular Imaging, vol. 27, no. 2, pp. 293–301. https://doi.org/10.1093/ehjci/jeaf300

Desdentado, L, Allen, MG, Schultze, J, Banellis, L, Navarro-Siurana, J, Nikolova, N, Baños, RM & Pollatos, O 2026, 'Cardiac interoception in action: Modulation after a stress induction with a speech task', Biological Psychology, vol. 205, 109228. https://doi.org/10.1016/j.biopsycho.2026.109228

Jensen, RJ , Skøtt, MV & Postnov, DD 2026, 'Cardiac pulse transfer along the cerebral microvascular network captured by laser speckle contrast imaging', Biomedical Optics Express, vol. 17, no. 1, pp. 227-241. https://doi.org/10.1364/BOE.578846

Schaarup, JR , Bjerg, L, Hansen, CS, Andersen, ST, van Greevenbroek, MM, Schram, MT, De Galan, BE, Stehouwer, C & Witte, DR 2026, 'Cardiovascular autonomic dysfunction is linked with arterial stiffness across glucose metabolism: the Maastricht study', BMJ Open Diabetes Research & Care, vol. 14, no. 2. https://doi.org/10.1136/bmjdrc-2025-004995

Pedersen, AAU 2026, 'Cardiovascular Magnetic Resonance Imaging for Coronary Atherosclerotic Plaque Visualization and Transcatheter Aortic Valve Performance Assessment', PhD, Aarhus University.

Bolla, E, Semb, AG, Petri, M, Sfikakis, PP, Artim-Esen, B, Hernandez-Molina, G, Hachulla, E, Direskeneli, H, Karpouzas, GA, Zucchi, D, Goyal, M, Costedoat-Chalumeau, N, Tincani, A, Yazici, A, Lerang, K, Troldborg, A, Ajeganova, S, Popkova, TV, Svenungsson, E, Pantazis, N, Tektonidou, MG, Dehimat, S, Sevik, G, Mosca, M, Nalli, C & Yilmaz, E 2026, 'Cardiovascular risk factor control in antiphospholipid syndrome, and differences between primary and systemic lupus erythematosus-related antiphospholipid syndrome (SURF-SLE and APS project): a cross-sectional study of 1003 individuals from 11 countries', The Lancet Rheumatology, vol. 8, no. 3, pp. e192-e203. https://doi.org/10.1016/S2665-9913(25)00257-7

Bilon-Piórko, AD, Lucas-Casanova, M, Toiviainen, S, Thomsen, R & Olsen, A 2026, 'Career guidance practitioners’ understandings of social justice in four European', British Journal of Guidance and Counselling. https://doi.org/10.1080/03069885.2026.2613213

Stoksted, KT 2026, 'Career perspectives in the HE curriculum: – A system theoretical approach to a curriculum study', Paper presented at The Nordic Educational Research Association (NERA) Conference 2026 , Aarhus, Denmark, 04/03/2026 - 06/03/2026.

Corredig, M, Ortega, J, Coskun, O, Raak, N & Wiking, L 2026, 'Caseins in focus: Filtration techniques can change the ingredient landscape – from raw material to functional ingredient', Maelkeritidende, vol. 2026, no. 1, pp. 14-15. <https://mejerimedier.dk/forskningsartikler/caseins-in-focus/#1>

Vilches-Freixas, G, Unipan, M, Velders, M, Weessies, M, Kneepkens, E, Rinaldi, I, Taasti, VT, Öllers, M, Wubbels, M, Sadowska, A, van Teeffelen, S & Peeters, S 2026, 'Case Report: Proton Therapy of a Pregnant Patient With Small-Cell Lung Cancer in the Third Trimester Using Synthetic Computed Tomographies for Tumor Monitoring', Advances in Radiation Oncology, vol. 11, no. 4, 101972. https://doi.org/10.1016/j.adro.2025.101972

Bogers, MLAM, Alizad Poursaeidi, S, Mahdad, M & Norn, M-T 2026, 'Catalyzing Regional Innovation Ecosystems to Address Global Challenges: Toward the Fourth-Generation University?', Research Technology Management, vol. 69, no. 2, pp. 14-22. https://doi.org/10.1080/08956308.2026.2618461

Fusaroli, M, Mitchell, J, Rudolph, A, Rocca, E & Fusaroli, R 2026, 'Causal Inference Tools for Pharmacovigilance: Using Causal Graphs to Identify and Address Biases in Disproportionality Analysis', Drug Safety, vol. 49, no. 4, pp. 449-469. https://doi.org/10.1007/s40264-025-01628-4

Garset-Zamani, M, Mikkelsen, R & Todsen, T 2026, 'Caution Comparing Transoral Ultrasonography With Postbiopsy Magnetic Resonance Imaging-Reply', JAMA Otolaryngology - Head and Neck Surgery, vol. 152, no. 1, pp. 102. https://doi.org/10.1001/jamaoto.2025.3785

Mitra, T 2026, 'Cavity optomechanics with suspended resonant mirrors', PhD, Aarhus University.

Skytthe, M, Graversen, JH & Moestrup, SK 2026, 'CD163 Expression Protects Against Early Hepatic Steatosis in Western Diet-Fed Male Mice', Gastro Hep Advances, vol. 5, no. 1, 100809. https://doi.org/10.1016/j.gastha.2025.100809

Kiani, Z, Urbach, JM, Wisner, H, Olatotse, MJ, Chang, DY, Acklin, JA, Piechocka-Trocha, A, Bonheur, N, Khatri, A, Lichterfeld, M, Gunst, JD, Søgaard, OS, Caskey, M, Nussenzweig, MC, Walker, BD & Collins, DR 2026, 'CD8⁺ T cell stemness precedes post-intervention control of HIV viraemia', Nature, vol. 650, no. 8100, pp. 196-204. https://doi.org/10.1038/s41586-025-09932-w

Thomsen, AK, Steffensen, MA, Gotfredsen, K, Vorum, H, Honoré, B, Nissen, MH & Sørensen, TL 2026, 'CD8+ T cell aging is associated with macular neovascularization area change in neovascular age-related macular degeneration: a prospective cohort study', BMC Ophthalmology, vol. 26, no. 1, 66. https://doi.org/10.1186/s12886-025-04570-2

Nielsen, MBD , Mikkelsen, MKD , Rasmussen, HC , Hvistendahl, MA , Lützhøft, CH , Slater, J, Crocoll, C, Poborsky, M, Jørgensen, NP, Soriano, A, Stilling, M & Bue, M 2026, 'Cefepime/enmetazobactam for Gram-negative periprosthetic joint infections? A randomized porcine study on target tissue pharmacokinetics', Journal of Antimicrobial Chemotherapy, vol. 81, no. 2, dkaf487. https://doi.org/10.1093/jac/dkaf487

Hansen, JR , Hillerup, S , Greibe, E , Gade, S , Pikelis, A , Hanberg, P & Klug, TE 2026, 'Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study', Journal of Antimicrobial Chemotherapy, vol. 81, no. 4, dkag085. https://doi.org/10.1093/jac/dkag085

Christensen, AH, Fabricius Hansen, M, Svenningsen, J & Tarp, L (eds) 2026, Celebrations at Court: Ephemeral Objects, Materials, and Machinery in the Early Modern Period. Aarhus Universitetsforlag, Aarhus.

Kirbis, IS, Kholova, I, Huhtala, H, Flezar, MS, Roque, RR, Mäkinen, HH, Litmanen, M, Vrdoljak-Mozetič, D, Harabajsa, S, Hewer, E, Bresaola, E, Van Zuylen-Manders, L, Schubert, P, Praça, M, Rossi, ED, Bode, PK, Lacoste-Collin, L, Barizzi, J, Fiorentino, V, Hedegaard, T, van der Meulen, S, Engel, U, Timmer, I, Turkmenoglu, TT, Vidak, J, Vigliar, E, Manso, SA, Musayev, J, Barkan, GA, Lozano, MD, Ivkovski, L, van Hemel, B, Carsana, L, Di Tonno, C, Weynand, B, Labiano, T & Cochand-Priollet, B 2026, 'Cellularity of Routinely Prepared Cell Blocks: Insights From an International Study', Cytopathology. https://doi.org/10.1111/cyt.70065

Yan, K, Stanley, M, Raimi, O, Ferenbach, AT, Dorfmueller, HC & van Aalten, DMF 2026, 'Cell wall target fragment discovery using a low-cost, minimal fragment library', FEBS Letters. https://doi.org/10.1002/1873-3468.70281

De Grado, A, Fanella, G, Howells, J, Khan, BYA , Jacobsen, AB, Cengiz, B, Samusyte, G, Otto, M, Lanteri, P, Stefani, A & Tankisi, H 2026, 'Central and peripheral excitability in restless limbs syndrome', Brain Communications, vol. 8, no. 1, fcaf506. https://doi.org/10.1093/braincomms/fcaf506

Mørk, SR, Gregers, E, Kragholm, K, Kjaergaard, J, Folke, F, Torp-Pedersen, C, Køber, L, Soja, AMB, Gerds, T, Michalik, F, Møller, JE, Henriksen, FL, Lippert, F, Terkelsen, CJ, Hassager, C & Søholm, H 2026, 'Centralization of post-resuscitation care after out-of-hospital cardiac arrest at cardiac arrest centres: a Danish nationwide follow-up study', Critical Care. https://doi.org/10.1186/s13054-026-05875-4

Tiger, A, Molero, Y, Brikell, I, Chang, Z, Lichtenstein, P, Larsson, H, D’Onofrio, BM, Hellner, C, Lagerberg, T, Jayaram-Lindström, N & Kuja-Halkola, R 2026, 'Central nervous system acting medication used by young adults with borderline personality disorder in Sweden 2006–2019', Journal of Psychopharmacology. https://doi.org/10.1177/02698811251413479

Geller, F, Wu, X, Lammi, V, Abner, E, Valliere, JT, Nastou, K, Burns, A, Rasmussen, M, Andersson, NW, Quinn, L, Aagaard, B, Banasik, K, Bliddal, S, Boding, L, Brunak, S, Brøns, N, Bybjerg-Grauholm, J, Christoffersen, LAN, Didriksen, M, Dinh, KM , Erikstrup, C, Feldt-Rasmussen, U, Grønbæk, K, Kaspersen, KA, Mikkelsen, C, Nielsen, CH, Nielsen, HS, Nielsen, SD, Nissen, J, Sequeros, CB, Tommerup, N, Ullum, H, Spiliopoulos, L, Bager, P, Hviid, A, Sørensen, E, Pedersen, OB, Lane, JM, Lassaunière, R, Ollila, HM, Ostrowski, SR, Feenstra, B, DBDS Genomic Consortium, Estonian Biobank Research Team & FinnGen 2026, 'Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants', Nature Genetics, vol. 58, no. 2, pp. 299-306. https://doi.org/10.1038/s41588-025-02484-9

Pedersen, MV , Lindhard, MS, Moster, D, Lie, RT & Henriksen, TB 2026, 'Cerebral Palsy Risk by Combined Apgar Score and Umbilical Cord Blood pH Levels', JAMA network open, vol. 9, no. 2, e2559359. https://doi.org/10.1001/jamanetworkopen.2025.59359

Damsbo, AG , Blauenfeldt, RA , Vestergaard, SB , Pedersen, NL , Ørskov, KM , Hindsholm, MF, Bilgin-Freiert, A, Simonsen, CZ, Johnsen, SP, Dalby, RB , Andersen, G & Mortensen, JK 2026, 'Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke and the Role of Physical Activity: Cross-Sectional Study', Brain and Behavior, vol. 16, no. 1, e71165. https://doi.org/10.1002/brb3.71165

Kristensen, L, Jeppesen, HSF, Brink, O & Høy, K 2026, 'Cervical spine fracture patterns associated with blunt cerebrovascular injuries: A literature review and meta-analysis', European Spine Journal. https://doi.org/10.1007/s00586-026-09857-6

Bugenings, LA, Ostmann, P, Kamari, A & Rong, L 2026, 'CFD model validation and mesh resolution reduction strategies for complex louvred openings', Building and Environment, vol. 291, 114207. https://doi.org/10.1016/j.buildenv.2026.114207

Berg, P , Rousing, AQ , Jensen-Fangel, S , Jeppesen, M , Sørensen, MV & Leipziger, J 2026, 'CFTR knock-out mice exhibit impaired renal compensation to dietary NaCl depletion', Journal of Cystic Fibrosis. https://doi.org/10.1016/j.jcf.2026.03.004

Olesen, LK, Handberg, C, Missel, M, Schierakow, L & Werlauff, U 2026, 'Challenges and rehabilitation needs among adults with myasthenia gravis - a Danish cross-sectional questionnaire study', Disability and Rehabilitation, vol. 48, no. 3, pp. 701-709. https://doi.org/10.1080/09638288.2025.2512408

Displaying results 551 to 600 out of 389656

Revised 08.12.2025

Lise Refstrup Linnebjerg Pedersen