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Ideas for Bachelor and Master's projects

Studying cell signalling using nanopatterning of receptor ligands on self-assembled DNA origami structures

In the context of the Danish National Research Foundation Centre of Excellence, CellPAT, we run a number of projects that use specifically designed DNA origami structures to position ligands in a predefined nanoscale pattern, allowing us to study how pattern recognition and avidity contribute to cell signalling and activation. The current projects are focused on the immune system and skin stem cells but we plan to expand to other biological systems in the future.

Contact person: Assistant professor Jesper Sejrup Nielsen, Postdocs Rasmus Schøler Sørensen and Veronica Liv Andersen, PhD students Marjan Omer and Laura Teodori

Selection and characterization of aptamers for complex biological mixtures

Aptamers are oligonucleotides that fold into specific 3D structures that allow them to exert numerous functions, including specific binding to various biomolecules such as proteins, lipids or metabolites. We conduct large-scale screens for aptamer sequence that can characterise complex biological samples (e.g. body fluids) and combine this with multiomics analysis and mass spectrometry to identify new biomarkers.

Contact person: Assistant professors Daniel Dupont and Julian Valero, Postdocs Søren Fjelstrup and Rasmus Thomsen, PhD student Asger Givskov Jørgensen

Biosynthesis and function of circular RNA

CircRNAs are covalently joined RNA molecules that show tissue- and age-dependent expression in metazoans. We combine high-throughput sequencing, biochemical analysis and cell biology to understand how circRNAs are formed, how they regulate gene expression and how they function in development.

Contact person: 

Assistant professor Karim Rahimi, PhD students Maria Schertz Andersen and Sabine Seeler