Santos, J., Cuellar, J., Pallarès, I., Byrd, E. J., Lends, A., Moro, F., Abdul-Shukkoor, M. B., Pujols, J., Velasco-Carneros, L., Sobott, F.
, Otzen, D. E., Calabrese, A. N., Muga, A.
, Pedersen, J. S., Loquet, A., Valpuesta, J. M., Radford, S. E. & Ventura, S. (2024).
A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion.
Journal of the American Chemical Society,
146(18), 12702-12711.
https://doi.org/10.1021/jacs.4c02262
Pirhaghi, M., Mamashli, F., Moosavi-Movahedi, F., Arghavani, P., Amiri, A., Davaeil, B., Mohammad-Zaheri, M., Mousavi-Jarrahi, Z., Sharma, D., Langel, Ü.
, Otzen, D. E. & Saboury, A. A. (2024).
Cell-Penetrating Peptides: Promising Therapeutics and Drug-Delivery Systems for Neurodegenerative Diseases.
Molecular Pharmaceutics,
21(5), 2097-2117.
https://doi.org/10.1021/acs.molpharmaceut.3c01167
Olsen, W. P., Courtade, G.
, Peña-Díaz, S., Nagaraj, M., Sønderby, T. V., Mulder, F. A. A., Malle, M. G. & Otzen, D. E. (2024).
CsgA gatekeeper residues control nucleation but not stability of functional amyloid.
Protein Science,
33(10), Article e5178.
https://doi.org/10.1002/pro.5178
Minero, G. A. S., Møllebjerg, A., Thiesen, C., Johansen, M. I., Jørgensen, N. P., Birkedal, V., Otzen, D. E. & Meyer, R. L. (2024).
Extracellular G-quadruplexes and Z-DNA protect biofilms from DNase I, and G-quadruplexes form a DNAzyme with peroxidase activity.
Nucleic Acids Research,
52(4), 1575-1590.
https://doi.org/10.1093/nar/gkae034
Dilamian, M., Montazer, M., Yousefi, H.
, Otzen, D. E. & Morshedi, D. (2024).
Functional porous protein nanofibrils/polysaccharides aerogel beads for efficient dyes removal from water.
Materials Advances,
5(18), 7199-7221.
https://doi.org/10.1039/d4ma00380b
Knudsen, L. J., Nielsen, S. D.-H., Dekker, P.
, Otzen, D. E., Rauh, V.
& Larsen, L. B. (2024).
Impact of hydrolysis method and lactase preparation on proteolysis and glycation in long-term stored lactose-hydrolysed UHT milk.
International Dairy Journal,
154, Article 105946.
https://doi.org/10.1016/j.idairyj.2024.105946
Knudsen, L. J., Rauh, V., Pedersen, J. N., Dekker, P.
, Otzen, D. E., Larsen, L. B. & Nielsen, S. D.-H. (2024).
Insight into protein cross-linking and casein polymerization in pre- and post-hydrolyzed lactose-free UHT milk during long-term storage.
Journal of Dairy Science. Advance online publication.
https://doi.org/10.3168/jds.2024-25103
Nielsen, J., Lauritsen, J., Pedersen, J. N., Nowak, J. S., Bendtsen, M. K., Kleijwegt, G., Lusser, K.
, Pitarch, L. C., Moreno, J. V., Schneider, M. M., Krainer, G., Goksøyr, L., Khalifé, P., Kaalund, S. S., Aznar, S.
, Kjærgaard, M., Sereikaité, V., Strømgaard, K., Knowles, T. P. J.
... Otzen, D. E. (2024).
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers.
npj Parkinson's Disease ,
10(1), Article 139.
https://doi.org/10.1038/s41531-024-00747-6
Adam, L., Kumar, R., Arroyo-Garcia, L. E., Molenkamp, W. H.
, Nowak, J. S., Klute, H., Farzadfard, A., Alkenayeh, R.
, Nielsen, J., Biverstål, H.
, Otzen, D. E., Johansson, J. & Abelein, A. (2024).
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS.
Protein Science,
33(8), Article e5091.
https://doi.org/10.1002/pro.5091
Žvirblis, M., Sakalauskas, A., Janvand, S. H. A., Dudutienė, V., Žiaunys, M., Sniečkutė, R.
, Otzen, D. E., Smirnovas, V. & Matulis, D. (2024).
Structure-Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid-β Aggregation.
Chemistry - A European Journal,
30(58), Article e202402330.
https://doi.org/10.1002/chem.202402330
Aliakbari, F., Marzookian, K., Parsafar, S., Hourfar, H., Nayeri, Z., Fattahi, A., Raeiji, M., Boroujeni, N. N.
, Otzen, D. E. & Morshedi, D. (2024).
The impact of hUC MSC-derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity.
Science Advances,
10(14), eadl3406. Article eadl3406.
https://doi.org/10.1126/sciadv.adl3406
Monti, M., Milanetti, E., Frans, M. T., Miotto, M., Di Rienzo, L., Baranov, M. V., Gosti, G.
, Somavarapu, A. K., Nagaraj, M., Golbek, T. W., Rossing, E., Moons, S. J., Boltje, T. J., van den Bogaart, G.
, Weidner, T., Otzen, D. E., Tartaglia, G. G., Ruocco, G.
& Roeters, S. J. (2024).
Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain.
The journal of physical chemistry. B,
128(2), 451-464.
https://doi.org/10.1021/acs.jpcb.3c06258
Andersen, C. B., Lausdahl, A. K.
, Nielsen, J., Clausen, M. P.
, Mulder, F. A. A., Otzen, D. E. & Arnspang, E. C. (2023).
4-Oxo-2-nonenal-Induced α-Synuclein Oligomers Interact with Membranes in the Cell, Leading to Mitochondrial Fragmentation.
Biochemistry,
62(16), 2417-2425.
https://doi.org/10.1021/acs.biochem.3c00114
Ali, S. A., Chung, K. H. K., Forgham, H., Olsen, W. P., Kakinen, A., Balaji, A.
, Otzen, D. E., Davis, T. P. & Javed, I. (2023).
Alzheimer's Progenitor Amyloid-β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function.
Advanced Science,
10(29), Article e2301423.
https://doi.org/10.1002/advs.202301423
Somavarapu, A. K., Kleijwegt, G.
, Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E. (2023).
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions.
Chemical Science,
14(11), 3030-3047.
https://doi.org/10.1039/d2sc05534a
Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T. (2023).
Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces.
Nature Communications,
14(1), Article 5731.
https://doi.org/10.1038/s41467-023-39843-1
Rasmussen, H. Ø., Kumar, A., Shin, B., Stylianou, F., Sewell, L., Xu, Y.
, Otzen, D. E., Pedersen, J. S. & Matthews, S. J. (2023).
FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC.
Journal of Molecular Biology,
435(2), Article 167878.
https://doi.org/10.1016/j.jmb.2022.167878
Evans, D. C. S., Khamas, A. B., Marcussen, L., Rasmussen, K. S., Klitgaard, J. K., Kallipolitis, B. H.
, Nielsen, J., Otzen, D. E., Leake, M. C.
& Meyer, R. L. (2023).
GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureusreveal surface-associated coagulase in biofilms.
Microbial Cell,
10(7), 145-156.
https://doi.org/10.15698/mic2023.07.800
Alijanvand, S. H., Ladefoged, L. K., Zubrienė, A., Sakalauskas, A., Christiansen, G., Dudutiene, V.
, Schiøtt, B., Matulis, D., Smirnovas, V.
& Otzen, D. E. (2023).
Inhibitory effects of fluorinated benzenesulfonamides on insulin fibrillation.
International Journal of Biological Macromolecules,
227, 590-600.
https://doi.org/10.1016/j.ijbiomac.2022.12.105
Singh, Y., Trautwein, C., Romani, J., Salker, M. S., Neckel, P. H., Fraccaroli, I., Abeditashi, M., Woerner, N., Admard, J., Dhariwal, A., Dueholm, M. K. D., Schäfer, K. H., Lang, F.
, Otzen, D. E., Lashuel, H. A., Riess, O. & Casadei, N. (2023).
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.
Molecular Neurodegeneration,
18(1), Article 44.
https://doi.org/10.1186/s13024-023-00628-1
Rusbjerg-Weberskov, C. E., Johansen, M. L., Nowak, J. S., Otzen, D., Pedersen, J. S., Enghild, J. J. & Nielsen, N. S. (2023).
Periostin C-Terminal Is Intrinsically Disordered and Interacts with 143 Proteins in an In Vitro Epidermal Model of Atopic Dermatitis.
Biochemistry,
62(19), 2803-2815.
https://doi.org/10.1021/acs.biochem.3c00176
Sønderby, T. V., Louros, N. N., Khodaparast, L., Khodaparast, L.
, Madsen, D. J., Olsen, W. P., Moonen, N.
, Nagaraj, M., Sereikaite, V.
, Strømgaard, K., Rousseau, F., Schymkowitz, J.
& Otzen, D. E. (2023).
Sequence-targeted Peptides Divert Functional Bacterial Amyloid Towards Destabilized Aggregates and Reduce Biofilm Formation.
Journal of Molecular Biology,
435(11), 168039. Article 168039.
https://doi.org/10.1016/j.jmb.2023.168039
Rasmussen, H. Ø., Nielsen, J., de Poli, A., Otzen, D. E. & Pedersen, J. S. (2023).
Tau Fibrillation Induced by Heparin or a Lysophospholipid Show Different Initial Oligomer Formation.
Journal of Molecular Biology,
435(17), Article 168194.
https://doi.org/10.1016/j.jmb.2023.168194
Pirhaghi, M., Najarzadeh, Z., Moosavi-Movahedi, F., Shafizadeh, M., Mamashli, F., Atarod, D., Ghasemi, A., Morshedi, D., Meratan, A. A.
, Otzen, D. E. & Saboury, A. A. (2023).
The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity.
Biochimica et Biophysica Acta - Proteins and Proteomics,
1871(2), Article 140883.
https://doi.org/10.1016/j.bbapap.2022.140883
Hourfar, H., Aliakbari, F., Aqdam, S. R., Nayeri, Z., Bardania, H.
, Otzen, D. E. & Morshedi, D. (2023).
The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells.
International Journal of Biological Macromolecules,
229, 305-320.
https://doi.org/10.1016/j.ijbiomac.2022.12.134
He, J., Steffen, J. H., Thulstrup, P. W.
, Pedersen, J. N., Sauerland, M. B.
, Otzen, D. E., Hawkins, C. L., Gourdon, P., Davies, M. J. & Hägglund, P. (2022).
Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells.
Scientific Reports,
12(1), Article 22051.
https://doi.org/10.1038/s41598-022-26359-9
Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaite, V., Gupta, A., Strømgaard, K.
, Andreasen, M., Sharma, D., Saboury, A. A.
& Otzen, D. E. (2022).
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers.
Journal of Biological Chemistry,
298(12), Article 102688.
https://doi.org/10.1016/j.jbc.2022.102688
Mohammad-Beigi, H., Zanganeh, M.
, Scavenius, C., Eskandari, H., Farzadfard, A., Shojaosadati, S. A.
, Enghild, J. J., Otzen, D. E., Buell, A. K.
& Sutherland, D. S. (2022).
A Protein Corona Modulates Interactions of α-Synuclein with Nanoparticles and Alters the Rates of the Microscopic Steps of Amyloid Formation.
ACS Nano,
16(1), 1102-1118.
https://doi.org/10.1021/acsnano.1c08825
Kjærgaard, M., Rasmussen, L. S., Vinther, J. N., Andersen, K. R., Andersen, E. S., Lorentzen, E., Thirup, S. S., Otzen, D. & Brodersen, D. E. (2022).
A Semester-Long Learning Path Teaching Computational Skills via Molecular Graphics in PyMOL.
The Biophysicist,
3(2), 106–114.
https://doi.org/10.35459/tbp.2022.000219
Christensen, N. R., Pedersen, C. P., Sereikaite, V.
, Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T.
, Otzen, D., Teilum, K., Madsen, K. L. & Strømgaard, K. (2022).
Bidirectional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners.
iScience,
25(2), Article 103808.
https://doi.org/10.1016/j.isci.2022.103808
Nagaraj, M., Najarzadeh, Z., Pansieri, J., Biverstål, H., Musteikyte, G., Smirnovas, V., Matthews, S., Emanuelsson, C., Johansson, J., Buxbaum, J. N., Morozova-Roche, L.
& Otzen, D. E. (2022).
Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation.
Chemical Science,
13(2), 536-553.
https://doi.org/10.1039/d1sc05790a
Nayeri, Z., Aliakbari, F., Afzali, F., Parsafar, S., Gharib, E.
, Otzen, D. E. & Morshedi, D. (2022).
Characterization of exogenous αSN response genes and their relation to Parkinson's disease using network analyses.
Frontiers in Pharmacology,
13, Article 966760.
https://doi.org/10.3389/fphar.2022.966760
Sønderby, T. V., Rasmussen, H. Ø., Frank, S. A., Skov Pedersen, J. & Otzen, D. E. (2022).
Folding steps in the fibrillation of functional amyloid: denaturant sensitivity reveals common features in nucleation and elongation.
Journal of Molecular Biology,
434(2), Article 167337.
https://doi.org/10.1016/j.jmb.2021.167337
Farzadfard, A., König, A.
, Petersen, S. V., Nielsen, J., Vasili, E., Dominguez-Meijide, A., Buell, A. K., Outeiro, T. F.
& Otzen, D. E. (2022).
Glycation modulates alpha-synuclein fibrillization kinetics: a sweet spot for inhibition.
The Journal of Biological Chemistry,
298(5), Article 101848.
https://doi.org/10.1016/j.jbc.2022.101848
Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G.
, Pedersen, J. S., Nielsen, J. & Otzen, D. E. (2022).
Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation. BBA advances,
2, Article 100055.
https://doi.org/10.1016/j.bbadva.2022.100055