Interdisciplinary Nanoscience Center

Aarhus University Seal
 iNANO Research Senior scientists K-N Lyons, Joseph

Lyons, Joseph

Keywords

  • Cryogenic electron microscopy
  • Crystallography
  • Structural Biology
  • Membrane Proteins
  • Lipid transport
  • Protein-lipid interactions

Laboratory of Lipid Transport and Metabolism

Tenure Track Assistant Professor Joseph Lyons
Lundbeck Foundation Fellow

Laboratory of Lipid Transport and Metabolism

Neurodegenerative disease, diabetes and cancer are pressing health concerns in modern society, and in part are related to disruptions in the composition and asymmetric distribution of lipids within the biological membrane. Such changes are typically a result of dysfunction in lipid metabolism and/or impaired protein driven lipid transport. However, there is a major knowledge gap regarding the basic biology of lipid transport and their role in the aforementioned diseases. Our goal is to identify new pathways and strategies to address changes in lipid homeostasis in health and disease.

We apply a "bottom-up" approach by asking fundamental questions regarding protein driven lipid transport and metabolism and use biochemistry, biophysics and structural biology (cryo-electron microscopy and crystallisation) to identify and understand the molecular mechanisms at the atomic and cellular levels.

Our research is supported by the Lundbeck Foundation and the Aligning Science across Parkinson's (ASAP) Initiative. 

Recent publications

Sort by: Date | Author | Title

Lyons, J. A. & Nissen, P. (2015). Digesting New Elements in Peptide Transport. Structure, 23(10), 1779-80. https://doi.org/10.1016/j.str.2015.09.006
Fowler, P. W., Orwick-Rydmark, M., Radestock, S., Solcan, N., Dijkman, P. M., Lyons, J. A., Kwok, J., Caffrey, M., Watts, A., Forrest, L. R. & Newstead, S. (2015). Gating topology of the proton-coupled oligopeptide symporters. Structure, 23(2), 290-301. https://doi.org/10.1016/j.str.2014.12.012
McGovern, R. E., Snarr, B. D., Lyons, J. A., McFarlane, J., Whiting, A. L., Paci, I., Hof, F. & Crowley, P. B. (2015). Structural study of a small molecule receptor bound to dimethyllysine in lysozyme. Chemical Science, 6(1), 442-449. https://doi.org/10.1039/c4sc02383h
Li, D., Stansfeld, P. J., Sansom, M. S. P., Keogh, A., Vogeley, L., Howe, N., Lyons, J. A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N. A., Cherezov, V., Liu, W., Bandaru, S. ... Caffrey, M. (2015). Ternary structure reveals mechanism of a membrane diacylglycerol kinase. Nature Communications, 6, Article 10140. https://doi.org/10.1038/ncomms10140
Malinauskaite, L., Quick, M., Reinhard, L., Lyons, J. A., Yano, H., Javitch, J. A. & Nissen, P. (2014). A mechanism for intracellular release of Na(+) by neurotransmitter/sodium symporters. Nature Structural and Molecular Biology, 21(11), 1006-1012. https://doi.org/10.1038/nsmb.2894

Displaying results 21 to 25 out of 26

Previous

1

2

3

4

5

6

Next

Revised 08.12.2025