Neurodegenerative disease, diabetes and cancer are pressing health concerns in modern society, and in part are related to disruptions in the composition and asymmetric distribution of lipids within the biological membrane. Such changes are typically a result of dysfunction in lipid metabolism and/or impaired protein driven lipid transport. However, there is a major knowledge gap regarding the basic biology of lipid transport and their role in the aforementioned diseases. Our goal is to identify new pathways and strategies to address changes in lipid homeostasis in health and disease.
We apply a "bottom-up" approach by asking fundamental questions regarding protein driven lipid transport and metabolism and use biochemistry, biophysics and structural biology (cryo-electron microscopy and crystallisation) to identify and understand the molecular mechanisms at the atomic and cellular levels.
Our research is supported by the Lundbeck Foundation and the Aligning Science across Parkinson's (ASAP) Initiative.