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, Kragh-Hansen, U., Cameron, J., Bukrinski, J. T.
& Howard, K. (2016).
An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.
Journal of Controlled Release,
232, 143-151.
https://doi.org/10.1016/j.jconrel.2016.04.013
Whitehead, B. J., Wu, L.
, Hvam, M. L., Aslan, H., Dong, M., Dyrskjøt, L., Ostenfeld, M. S., Moein Moghimi, S.
& Howard, K. (2015).
Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness.
Journal of Extracellular Vesicles,
4, Article 29685.
https://doi.org/10.3402/jev.v4.29685
Ostenfeld, M. S., Jeppesen, D. K., Bramsen, J. B., Laurberg, J. R., Howard, K., Dyrskjøt, L. & Ørntoft, T. F. (2015).
Selective cellular removal of miR23b by Rab27a/b-dependent exosome release is linked to acquisition of a metastatic property in bladder cancer. Cancer Research.
Ebbesen, M. F., Olesen, M. T. J., Gjelstrup, M. C., Pakula, M. M., Larsen, E. K., Hansen, I. M., Hansen, P. L., Mollenhauer, J., Malle, B. M.
& Howard, K. (2015).
Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells.
Pharmaceutical Research,
32(4), 1462-1474.
https://doi.org/10.1007/s11095-014-1552-7
Whitehead, B. J., Hvam, M. L., Bienk, K., Ostenfeld, M. S. & Howard, K. (2014).
The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.
Ebbesen, M. F., Bienk, K., Deleuran, B. W. & Howard, K. (2014).
Extended circulation and accumulation of p(HPMA-co-AzMA) and accumulation in arthritic joints. Poster session presented at 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014 Chicago, USA , Chicago, United States.
Yang, H. Y., Vonk, L. A., Licht, R., Van Boxtel, A. M. G., Bekkers, J. E. J., Kragten, A. H. M.
, Hein, S., Varghese, O. P.
, Howard, K., Cumhur Öner, F., Dhert, W. J. A. & Creemers, L. B. (2014).
Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.
European Journal of Pharmaceutical Sciences,
53(1), 35-44.
https://doi.org/10.1016/j.ejps.2013.12.006
Rubert, M., Fang-Li, Y.
, Aslan, H., Yu, Y.
, Howard, K. A., Dong, MD., Besenbacher, F. & Chen, M. (2014).
Inflammatory response of RAW 264.7 cells to ultraporous interweaving PCL-PEO electrospun microfibers.
Journal of Tissue Engineering and Regenerative Medicine,
8, 249-249.
Miclaus, T., Bochenkov, V., Ogaki, R., Howard, K. & Sutherland, D. S. (2014).
Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes.
Nano Letters,
14(4), 2086-2093.
https://doi.org/10.1021/nl500277c
Li, Y. Y., Femenias, M. R., Aslan, H. H., Yu, Y. Y.
, Howard, K., Dong, MD., Besenbacher, F. F. & Chen, M. M. (2014).
Ultraporous interweaving electrospun microfibers from PCL-PEO binary blends and their inflammatory responses.
Nanoscale,
6(6), 3392-3402.
https://doi.org/10.1039/c3nr06197c
Jeppesen, D. K., Hvam, M. L., Primdahl-Bengtson, B.
, Boysen, A. T., Whitehead, B., Dyrskjøt, L., Orntoft, T. F., Howard, K. & Ostenfeld, M. S. (2014).
Comparative analysis of discrete exosome fractions obtained by differential centrifugation.
Journal of Extracellular Vesicles,
3, 1-16. Article 25011.
https://doi.org/10.3402/jev.v3.25011
Jeppesen, D. K., Nawrocki, A.
, Jensen, S. G., Thorsen, K., Whitehead, B., Howard, K., Andersen, L. D., Orntoft, T. F., Larsen, M. R.
& Ostenfeld, M. S. (2014).
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics,
14(6), 699-712.
https://doi.org/10.1002/pmic.201300452
Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., Boysen, A., Howard, K., Christensen, E. I., Morth, P., Bui, K. H., Theodorescu, D.
, Jensen, J. B., Borre, M., Dyrskjøt, L. & Ørntoft, T. F. (2013).
Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells.
Nawroth, I., Alsner, J., Deleuran, B. W., Dagnæs-Hansen, F., Yang, C., Horsman, M. R., Overgaard, J., Howard, K., Kjems, J. & Gao, S. (2013).
Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model.
Acta Oncologica,
52(8), 1730-1738.
https://doi.org/10.3109/0284186X.2012.726373
Gonzalez, B. B., Dagnæs-Hansen, F., Fenton, R. A., Gao, S., Hein, S., Dong, M., Kjems, J. & Howard, K. A. (2013).
Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles.
Molecular Therapy - Nucleic Acids,
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https://doi.org/10.1038/mtna.2013.2
Ebbesen, M. F., Whitehead, B. J., Gonzalez, B. B., Kingshott, P.
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Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors.
Pharmaceutical Research,
30(7), 1758-1767.
https://doi.org/10.1007/s11095-013-1018-3
Ebbesen, M. F., Schaffert, D. H., Crowley, M. L., Oupický, D.
& Howard, K. (2013).
Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications.
Journal of Polymer Science. Part A, Polymer Chemistry,
51(23), 5091-5099.
https://doi.org/10.1002/pola.26941
Larsen, E. K. U., Nielsen, T., Wittenborn, T., Rydtoft, L. M., Lokanathan, A. R., Hansen, L., Østergaard, L., Kingshott, P., Howard, K. A., Besenbacher, F., Nielsen, N. C. & Kjems, J. (2012).
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
Nanoscale,
4(7), 2352-2361 .
https://doi.org/10.1039/C2NR11554A
Chen, M., Gao, S., Dong, M., Song, J., Yang, C., Howard, K. A., Kjems, J. & Besenbacher, F. (2012).
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
A C S Nano,
6(6), 4835-4844.
https://doi.org/10.1021/nn300106t
de Paz, L.
, Resin, A., Howard, K., Sutherland, D. S. & Wejse, P. (2011).
Antimicrobial effect of chitosan nanoparticles on streptococcus mutans biofilms.
Applied and Environmental Microbiology,
77(11), 3892-3895.
Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I. (2010).
Treatment of radiation-induced fibrosis. (Patent No.
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Rahbek, U. L., Nielsen, A. F., Dong, M., You, Y., Chauchereau, A., Oupicky, D.
, Besenbacher, F., Kjems, J. & Howard, K. A. (2010).
Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
Journal of Drug Targeting,
18(10), 812-20.
https://doi.org/10.3109/1061186X.2010.527982
Nielsen, E. J. B., Nielsen, J. M., Becker, D., Karlas, A., Prakash, H.
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, Kjems, J. & Howard, K. A. (2010).
Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.
Pharmaceutical Research,
27(12), 2520-7.
https://doi.org/10.1007/s11095-010-0255-y
Nawroth, I., Alsner, J., Behlke, M. A.
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Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis.
Radiotherapy & Oncology,
97(1), 143-8.
https://doi.org/10.1016/j.radonc.2010.09.010
Mittnacht, U., Hartmann, H.
, Hein, S., Oliveira, H.
, Dong, M., Pêgo, A. P.
, Kjems, J., Howard, K. A. & Schlosshauer, B. (2010).
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth.
Nano Letters,
10(10), 3933-9.
https://doi.org/10.1021/nl1016909
Andersen, M. Ø., Nygaard, J. V., Burns, J. S.
, Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J. (2010).
siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.
Molecular Therapy,
18(11), 2018-2027.
https://doi.org/10.1038/mt.2010.166
Hartmann, H., Lakner, U.
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Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. Tissue Engineering. Part A. Tissue Engineering, (3), 718.
Mistry, A.
, Glud, S. Z., Kjems, J., Nyengaard, J. R., Howard, K. A., Stolnik, S. & Illum, L. (2009).
Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium.
Journal of Drug Evaluation,
17(7), 543-552.
https://doi.org/10.1080/10611860903055470
Larsen, E. K. U., Nielsen, T., Wittenborn, T., Birkedal, H., Vorup-Jensen, T., Jakobsen, M. H.
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Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
A C S Nano,
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https://doi.org/10.1021/nn900330m
Glud, S. Z., Bramsen, J. B., Dagnaes-Hansen, F., Wengel, J.
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Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.
Oligonucleotides,
19(2), 163-8.
https://doi.org/10.1089/oli.2008.0175
Gao, S., Dagnæs-Hansen, F., Nielsen, E. J. B., Wengel, J.
, Besenbacher, F., Howard, K. A. & Kjems, J. (2009).
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular Therapy,
17(7), 1225-1233.
https://doi.org/10.1038/mt.2009.91
Rahbek, U. L., Howard, K. A., Oupicky, D., Manickam, D. S.
, Dong, M., Nielsen, A. F., Hansen, T. B., Besenbacher, F. & Kjems, J. (2008).
Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides.
Journal of Gene Medicine,
10(1), 81-93.
https://doi.org/10.1002/jgm.1120
Nygaard, J. V., Andersen, M. Ø., Howard, K. A., Foss, M., Bünger, C., Kjems, J. & Besenbacher, F. (2008).
Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnology and Bioengineering (Print),
100(4), 820-9.
https://doi.org/10.1002/bit.21796
Howard, K. A., Paludan, S. R., Behlke, M. A.
, Besenbacher, F., Deleuran, B. W. & Kjems, J. (2008).
Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.
Molecular Therapy,
17(1), 162-168.
https://doi.org/10.1038/mt.2008.220
Andersen, M. Ø., Howard, K. A., Paludan, S. R., Besenbacher, F. & Kjems, J. (2008).
Delivery of siRNA from lyophilized polymeric surfaces.
Biomaterials,
29(4), 506-512.
https://doi.org/10.1016/j.biomaterials.2007.10.003