Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I. (2010).
Treatment of radiation-induced fibrosis. (Patent No.
WO2010085959A1).
Dinesen, A., Winther, A., Wall, A.
, Märcher, A., Palmfeldt, J., Chudasama, V., Wengel, J.
, Gothelf, K. V., Baker, J. R.
& Howard, K. (2022).
An Albumin Biomolecular Drug Design Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Assembly. Poster session presented at Controlled Release Society 2022 Annual Meeting, Montreal, Quebec, Canada.
Nygaard, J. V., Andersen, M. Ø., Howard, K., Sasov, A.
, Kjems, J. & Besenbacher, F. (2004).
Analysis of Nanoparticles in Scaffolds for Tissue Engineering by use of X-Ray Nano Tomography. Poster session presented at iNANO 4
th annual meeting, Aarhus, Denmark.
Ebbesen, M. F., Bienk, K., Deleuran, B. W. & Howard, K. (2014).
Extended circulation and accumulation of p(HPMA-co-AzMA) and accumulation in arthritic joints. Poster session presented at 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014 Chicago, USA , Chicago, United States.
Østergaard, R. H., Yan, Y., Venø, M. T.
, Dinesen, A., Kjaer-Sorensen, K., Oxvig, C., Rasmussen, J. T., Howard, K., Kjems, J., van Niel, G., Verweij, F.
& Hayashi, Y. (2022).
Extracellular Vesicle Biology Meets Zebrafish: Real-Time Visualization and RNA Profiling of Physiological Exosomes in the Bloodstream. Poster session presented at The Danish Society for Extracellular Vesicles (DSEV) 3rd Annual Symposium 2022, Roskilde, Denmark.
Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., Boysen, A., Howard, K., Christensen, E. I., Morth, P., Bui, K. H., Theodorescu, D.
, Jensen, J. B., Borre, M., Dyrskjøt, L. & Ørntoft, T. F. (2013).
Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells.
Whitehead, B. J., Hvam, M. L., Bienk, K., Ostenfeld, M. S. & Howard, K. (2014).
The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.
Hartmann, H., Lakner, U.
, Andersen, M. Ø., Kjems, J., Howard, K. A. & Schloßhauer, B. (2009).
Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. Tissue Engineering. Part A. Tissue Engineering, (3), 718.
Larsen, E. K. U., Nielsen, T., Wittenborn, T., Rydtoft, L. M., Lokanathan, A. R., Hansen, L., Østergaard, L., Kingshott, P., Howard, K. A., Besenbacher, F., Nielsen, N. C. & Kjems, J. (2012).
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
Nanoscale,
4(7), 2352-2361 .
https://doi.org/10.1039/C2NR11554A
Cai, Y., López-Ruiz , E., Wengel, J., Creemers, L.
& Howard, K. (2017).
A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.
Journal of Controlled Release,
253(May), 153-159.
https://doi.org/10.1016/j.jconrel.2017.03.004
Caspersen , M. B.
, Kuhlmann, M., Nicholls , K., Saxton , M. J., Andersen , B., Bunting , K., Cameron, J.
& Howard, K. (2017).
Albumin-based drug delivery using cysteine 34 chemical conjugates; important considerations and requirements.
Therapeutic Delivery,
8(7), 511-519.
https://doi.org/10.4155/tde-2017-0038
Dinesen, A., Winther, A., Wall, A.
, Märcher, A., Palmfeldt, J., Chudasama, V., Wengel, J.
, Gothelf, K. V., Baker, J. R.
& Howard, K. A. (2022).
Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly.
Bioconjugate Chemistry,
33(2), 333-342.
https://doi.org/10.1021/acs.bioconjchem.1c00561
Elkhashab, M., Dilek, Y.
, Foss, M., Creemers, L. B.
& Howard, K. A. (2024).
A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics: Molecular Pharmaceutics.
Molecular Pharmaceutics,
21(2), 491-500.
https://doi.org/10.1021/acs.molpharmaceut.3c00561
Fuchs, E., Rudnik-Jansen, I., Dinesen, A., Selnihhin, D., Mandrup, O. A., Thiam, K.
, Kjems, J., Pedersen, F. S. & Howard, K. A. (2022).
An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Acta Biomaterialia,
153, 411-418.
https://doi.org/10.1016/j.actbio.2022.09.048
Dinesen, A., Andersen, V. L., Elkhashab, M., Pilati, D., Bech, P., Fuchs, E., Samuelsen, T. R., Winther, A., Cai, Y., Märcher, A., Wall, A.
, Omer, M., Nielsen, J. S., Chudasama, V., Baker, J. R.
, Gothelf, K. V., Wengel, J.
, Kjems, J. & Howard, K. A. (2024).
An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.
Bioconjugate Chemistry,
35(2), 214-222.
https://doi.org/10.1021/acs.bioconjchem.3c00491
Bienk, K., Hvam, M. L., Pakula, M. M., Dagnæs-Hansen, F., Wengel, J., Malle, B. M.
, Kragh-Hansen, U., Cameron, J., Bukrinski, J. T.
& Howard, K. (2016).
An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.
Journal of Controlled Release,
232, 143-151.
https://doi.org/10.1016/j.jconrel.2016.04.013
Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J., Sohn, E., Bienk, K., Schaffert, D. H., Sørensen, E. S., Wengel, J.
, Dupont, D. M. & Howard, K. (2017).
An albumin-oligonucleotide assembly for potential combinatorial drug delivery and half-life extension applications.
Molecular Therapy - Nucleic Acids,
9, 284-293.
https://doi.org/10.1016/j.omtn.2017.10.004
Schelde, K. K., Nicholls , K.
, Dagnæs-Hansen, F., Bunting , K., Rawsthorne, H., Andersen, B., Finnis, C., Williamson, M., Cameron, J.
& Howard, K. (2019).
A new class of recombinant human albumin with multiple surface thiols exhibit stable conjugation, and enhanced FcRn binding and blood circulation.
Journal of Biological Chemistry,
294(10), 3735-3743.
https://doi.org/10.1074/jbc.RA118.005870
de Paz, L.
, Resin, A., Howard, K., Sutherland, D. S. & Wejse, P. (2011).
Antimicrobial effect of chitosan nanoparticles on streptococcus mutans biofilms.
Applied and Environmental Microbiology,
77(11), 3892-3895.
Rahbek, U. L., Nielsen, A. F., Dong, M., You, Y., Chauchereau, A., Oupicky, D.
, Besenbacher, F., Kjems, J. & Howard, K. A. (2010).
Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
Journal of Drug Targeting,
18(10), 812-20.
https://doi.org/10.3109/1061186X.2010.527982
Yang, H. Y., Vonk, L. A., Licht, R., Van Boxtel, A. M. G., Bekkers, J. E. J., Kragten, A. H. M.
, Hein, S., Varghese, O. P.
, Howard, K., Cumhur Öner, F., Dhert, W. J. A. & Creemers, L. B. (2014).
Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.
European Journal of Pharmaceutical Sciences,
53(1), 35-44.
https://doi.org/10.1016/j.ejps.2013.12.006
Larsen, M. T., Rawsthorne, H.
, Schelde, K. K., Dagnæs-Hansen, F., Cameron, J.
& Howard, K. (2018).
Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement.
Journal of Controlled Release,
287, 132-141.
https://doi.org/10.1016/j.jconrel.2018.07.023
Gaglianone, N., Hvam, M. L., Aslan, H., Dong, M., Howard, K. & Ho, Y.-P. (2016).
Chip-Free Microscale-Incubator-Based Synthesis of Chitosan-Based Gene Silencing Nanoparticles.
Particle & Particle Systems Characterization,
33(5), 279-285.
https://doi.org/10.1002/ppsc.201500225
Howard, K. A., Paludan, S. R., Behlke, M. A.
, Besenbacher, F., Deleuran, B. W. & Kjems, J. (2008).
Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.
Molecular Therapy,
17(1), 162-168.
https://doi.org/10.1038/mt.2008.220
Mittnacht, U., Hartmann, H.
, Hein, S., Oliveira, H.
, Dong, M., Pêgo, A. P.
, Kjems, J., Howard, K. A. & Schlosshauer, B. (2010).
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth.
Nano Letters,
10(10), 3933-9.
https://doi.org/10.1021/nl1016909
Chen, M., Gao, S., Dong, M., Song, J., Yang, C., Howard, K. A., Kjems, J. & Besenbacher, F. (2012).
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
A C S Nano,
6(6), 4835-4844.
https://doi.org/10.1021/nn300106t
Jeppesen, D. K., Hvam, M. L., Primdahl-Bengtson, B.
, Boysen, A. T., Whitehead, B., Dyrskjøt, L., Orntoft, T. F., Howard, K. & Ostenfeld, M. S. (2014).
Comparative analysis of discrete exosome fractions obtained by differential centrifugation.
Journal of Extracellular Vesicles,
3, 1-16. Article 25011.
https://doi.org/10.3402/jev.v3.25011
Andersen, M. Ø., Howard, K. A., Paludan, S. R., Besenbacher, F. & Kjems, J. (2008).
Delivery of siRNA from lyophilized polymeric surfaces.
Biomaterials,
29(4), 506-512.
https://doi.org/10.1016/j.biomaterials.2007.10.003
Schmidt, E. G. W.
, Hvam, M. L., Antunes, F., Cameron, J., Viuff, D., Andersen, B., Kristensen, N. N.
& Howard, K. A. (2017).
Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
Journal of Biological Chemistry,
292(32), 13312-13322.
https://doi.org/10.1074/jbc.M117.794248
Xu, S., Dong, M., Liu, X., Howard, K. A., Kjems, J. & Besenbacher, F. (2007).
Direct force measurements between siRNA and chitosan molecules using force spectroscopy.
Biophysical Journal,
93(3), 952-9.
https://doi.org/10.1529/biophysj.106.093229
Mistry, A.
, Glud, S. Z., Kjems, J., Nyengaard, J. R., Howard, K. A., Stolnik, S. & Illum, L. (2009).
Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium.
Journal of Drug Evaluation,
17(7), 543-552.
https://doi.org/10.1080/10611860903055470