Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I. (2010).
Treatment of radiation-induced fibrosis. (Patent No.
WO2010085959A1).
Whitehead, B. J., Hvam, M. L., Bienk, K., Ostenfeld, M. S.
& Howard, K. (2014).
The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.
Østergaard, R. H., Yan, Y., Venø, M. T.
, Dinesen, A., Kjaer-Sorensen, K., Oxvig, C., Rasmussen, J. T., Howard, K., Kjems, J., van Niel, G., Verweij, F.
& Hayashi, Y. (2022).
Extracellular Vesicle Biology Meets Zebrafish: Real-Time Visualization and RNA Profiling of Physiological Exosomes in the Bloodstream. Poster session presented at The Danish Society for Extracellular Vesicles (DSEV) 3rd Annual Symposium 2022, Roskilde, Denmark.
Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R.
, Boysen, A., Howard, K., Christensen, E. I., Morth, P., Bui, K. H., Theodorescu, D.
, Jensen, J. B., Borre, M., Dyrskjøt, L. & Ørntoft, T. F. (2013).
Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells.
Nygaard, J. V., Andersen, M. Ø.
, Howard, K., Sasov, A.
, Kjems, J. & Besenbacher, F. (2004).
Analysis of Nanoparticles in Scaffolds for Tissue Engineering by use of X-Ray Nano Tomography. Poster session presented at iNANO 4
th annual meeting, Aarhus, Denmark.
Ebbesen, M. F., Bienk, K.
, Deleuran, B. W. & Howard, K. (2014).
Extended circulation and accumulation of p(HPMA-co-AzMA) and accumulation in arthritic joints. Poster session presented at 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014 Chicago, USA , Chicago, United States.
Dinesen, A., Winther, A., Wall, A., Märcher, A.
, Palmfeldt, J., Chudasama, V., Wengel, J.
, Gothelf, K. V., Baker, J. R.
& Howard, K. (2022).
An Albumin Biomolecular Drug Design Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Assembly. Poster session presented at Controlled Release Society 2022 Annual Meeting, Montreal, Quebec, Canada.
Hartmann, H., Lakner, U., Andersen, M. Ø.
, Kjems, J., Howard, K. A. & Schloßhauer, B. (2009).
Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. Tissue Engineering. Part A. Tissue Engineering, (3), 718.
Yang, H. Y., Vonk, L. A., Licht, R., Van Boxtel, A. M. G., Bekkers, J. E. J., Kragten, A. H. M., Hein, S., Varghese, O. P.
, Howard, K., Cumhur Öner, F., Dhert, W. J. A. & Creemers, L. B. (2014).
Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.
European Journal of Pharmaceutical Sciences,
53(1), 35-44.
https://doi.org/10.1016/j.ejps.2013.12.006
Xu, S.
, Dong, M., Liu, X.
, Howard, K. A., Kjems, J. & Besenbacher, F. (2007).
Direct force measurements between siRNA and chitosan molecules using force spectroscopy.
Biophysical Journal,
93(3), 952-9.
https://doi.org/10.1529/biophysj.106.093229
Whitehead, B. J., Wu, L., Hvam, M. L., Aslan, H.
, Dong, M., Dyrskjøt, L., Ostenfeld, M. S., Moein Moghimi, S.
& Howard, K. (2015).
Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness.
Journal of Extracellular Vesicles,
4, Article 29685.
https://doi.org/10.3402/jev.v4.29685
Walther, R., Monge, P.
, Pedersen, A., Benderoth, A., Pedersen, J., Farzadfard, A.
, Mandrup, O., Howard, K., Otzen, D. & Zelikin, A. N. (2021).
Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity.
ChemBioChem,
22(14), 2478-2485.
https://doi.org/10.1002/cbic.202100228
Viuff, D., Antunes, F., Evans, L., Cameron, J., Dyrnesli, H., Ravn, B. T.
, Stougaard, M., Thiam, K., Andersen, B., Kjærulff, S.
& Howard, K. (2016).
Generation of a Double Transgenic Humanised Neonatal Fc Receptor (FcRn)/Albumin Mouse to Study the Pharmacokinetics of Albumin-linked Drugs.
Journal of Controlled Release,
223, 22-30.
https://doi.org/10.1016/j.jconrel.2015.12.019
Symons, R. A., Colella, F., Collins, F. L., Rafipay, A. J., Kania, K., McClure, J. J., White, N., Cunningham, I., Ashraf, S., Hay, E., Mackenzie, K. S.
, Howard, K. A., Riemen, A. H. K., Manzo, A., Clark, S. M., Roelofs, A. J. & De Bari, C. (2022).
Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.
Annals of the Rheumatic Diseases,
81(2), 214-224.
https://doi.org/10.1136/annrheumdis-2021-220875
Schmøkel, J., Voldum, A., Tsakiridou, G., Kuhlmann, M., Cameron, J.
, Sørensen, E. S., Wengel, J.
& Howard, K. (2017).
Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding.
Nanotechnology,
28(20), Article 204004 .
https://doi.org/10.1088/1361-6528/aa6a9b
Schmidt, E. G. W., Hvam, M. L., Antunes, F., Cameron, J., Viuff, D., Andersen, B., Kristensen, N. N.
& Howard, K. A. (2017).
Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
Journal of Biological Chemistry,
292(32), 13312-13322.
https://doi.org/10.1074/jbc.M117.794248
Schelde, K. K., Nicholls , K., Dagnæs-Hansen, F., Bunting , K., Rawsthorne, H., Andersen, B., Finnis, C., Williamson, M., Cameron, J.
& Howard, K. (2019).
A new class of recombinant human albumin with multiple surface thiols exhibit stable conjugation, and enhanced FcRn binding and blood circulation.
Journal of Biological Chemistry,
294(10), 3735-3743.
https://doi.org/10.1074/jbc.RA118.005870
Rubert, M., Fang-Li, Y., Aslan, H., Yu, Y.
, Howard, K. A., Dong, MD., Besenbacher, F. & Chen, M. (2014).
Inflammatory response of RAW 264.7 cells to ultraporous interweaving PCL-PEO electrospun microfibers.
Journal of Tissue Engineering and Regenerative Medicine,
8, 249-249.
Rahbek, U. L.
, Nielsen, A. F., Dong, M., You, Y., Chauchereau, A., Oupicky, D.
, Besenbacher, F., Kjems, J. & Howard, K. A. (2010).
Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
Journal of Drug Targeting,
18(10), 812-20.
https://doi.org/10.3109/1061186X.2010.527982
Rahbek, U. L.
, Howard, K. A., Oupicky, D., Manickam, D. S.
, Dong, M., Nielsen, A. F., Hansen, T. B.
, Besenbacher, F. & Kjems, J. (2008).
Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides.
Journal of Gene Medicine,
10(1), 81-93.
https://doi.org/10.1002/jgm.1120
Petersen, S., Kläning, E., Andersen, B., Cameron, J.
, Sørensen, E. S. & Howard, K. (2016).
Neonatal Fc Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants.
Molecular Pharmaceutics,
13(2), 677–682.
https://doi.org/10.1021/acs.molpharmaceut.5b00605
Ostenfeld, M. S., Jeppesen, D. K.
, Bramsen, J. B., Laurberg, J. R.
, Howard, K., Dyrskjøt, L. & Ørntoft, T. F. (2015).
Selective cellular removal of miR23b by Rab27a/b-dependent exosome release is linked to acquisition of a metastatic property in bladder cancer. Cancer Research.
Nygaard, J. V., Andersen, M. Ø.
, Howard, K. A., Foss, M., Bünger, C.
, Kjems, J. & Besenbacher, F. (2008).
Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnology and Bioengineering (Print),
100(4), 820-9.
https://doi.org/10.1002/bit.21796
Nielsen, E. J. B., Nielsen, J. M., Becker, D., Karlas, A., Prakash, H.
, Glud, S. Z., Merrison, J., Besenbacher, F., Meyer, T. F.
, Kjems, J. & Howard, K. A. (2010).
Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.
Pharmaceutical Research,
27(12), 2520-7.
https://doi.org/10.1007/s11095-010-0255-y
Nawroth, I.
, Alsner, J., Behlke, M. A.
, Besenbacher, F., Overgaard, J., Howard, K. A. & Kjems, J. (2010).
Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis.
Radiotherapy & Oncology,
97(1), 143-8.
https://doi.org/10.1016/j.radonc.2010.09.010
Nawroth, I.
, Alsner, J., Deleuran, B. W., Dagnæs-Hansen, F., Yang, C.
, Horsman, M. R., Overgaard, J., Howard, K., Kjems, J. & Gao, S. (2013).
Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model.
Acta Oncologica,
52(8), 1730-1738.
https://doi.org/10.3109/0284186X.2012.726373
Nandakumar, R., Tschismarov, R., Meissner, F.
, Prabakaran, T., Krissanaprasit, A.
, Farahani, E., Zhang, B. C., Assil, S., Martin, A., Bertrams, W.
, Holm, C. K., Ablasser, A., Klause, T.
, Thomsen, M. K., Schmeck, B.
, Howard, K. A., Henry, T.
, Gothelf, K. V., Decker, T.
& Paludan, S. R. (2019).
Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling.
Nature Microbiology,
4, 701-713.
https://doi.org/10.1038/s41564-019-0367-z
Mittnacht, U., Hartmann, H., Hein, S., Oliveira, H.
, Dong, M., Pêgo, A. P.
, Kjems, J., Howard, K. A. & Schlosshauer, B. (2010).
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth.
Nano Letters,
10(10), 3933-9.
https://doi.org/10.1021/nl1016909
Mistry, A.
, Glud, S. Z., Kjems, J., Nyengaard, J. R., Howard, K. A., Stolnik, S. & Illum, L. (2009).
Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium.
Journal of Drug Evaluation,
17(7), 543-552.
https://doi.org/10.1080/10611860903055470
Miclaus, T., Bochenkov, V., Ogaki, R.
, Howard, K. & Sutherland, D. S. (2014).
Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes.
Nano Letters,
14(4), 2086-2093.
https://doi.org/10.1021/nl500277c
Martirosyan, A.
, Olesen, M. J., Fenton, R. A., Kjems, J. & Howard, K. A. (2016).
Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours.
Nanoscale,
8(25), 12599-12607.
https://doi.org/10.1039/c5nr07206a
Märcher, A., Kumar, V., Andersen, V. L., El-Chami, K., Nguyen, T. J. D.
, Skaanning, M. K., Rudnik-Jansen, I., Nielsen, J. S.
, Howard, K. A., Kjems, J. & Gothelf, K. V. (2022).
Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo.
Angewandte Chemie - International Edition,
61(24), Article 202115275.
https://doi.org/10.1002/anie.202115275
Mandrup, O. A., Ong, S. C., Lykkemark, S.
, Dinesen, A., Rudnik-Jansen, I., Dagnæs-Hansen, N. F., Andersen, J. T., Alvarez-Vallina, L.
& Howard, K. A. (2021).
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.
Communications Biology,
4(1), Article 310.
https://doi.org/10.1038/s42003-021-01790-2