Christoffersen, H. F.
, Andreasen, M., Zhang, S., Nielsen, E. H., Christiansen, G., Dong, M., Skrydstrup, T. & Otzen, D. E. (2015).
Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment.
Biochimica et Biophysica Acta - Proteins and Proteomics,
1854(12), 1890-1897.
https://doi.org/10.1016/j.bbapap.2015.08.005Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016).
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.
Journal of Neuroinflammation,
13(1), Article 74.
https://doi.org/10.1186/s12974-016-0532-8
Christiansen, S. H., Zhang, X., Juul-Madsen, K., Hvam, M. L., Vad, B. S., Behrens, M. A., Thygesen, I. L., Jalilian, B., Pedersen, J. S., Howard, K., Otzen, D. E. & Vorup-Jensen, T. (2017).
The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.
Biochimica et biophysica acta - Biomembranes,
1859(3), 425-437.
https://doi.org/10.1016/j.bbamem.2017.01.001
Christensen, L. F. B., Hansen, L. M.
, Finster, K., Christiansen, G., Nielsen, P. H.
, Otzen, D. E. & Dueholm, M. S. (2018).
The Sheaths of Methanospirillum Are Made of a New Type of Amyloid Protein.
Frontiers in Microbiology,
9(NOV), Article 2729.
https://doi.org/10.3389/fmicb.2018.02729,
https://doi.org/10.3389/fmicb.2018.02729
Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G. & Otzen, D. E. (2019).
Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation.
ACS Omega,
4(2), 4029-4039.
https://doi.org/10.1021/acsomega.8b03590
Christensen, L. F. B., Schafer, N., Wolf-Perez, A., Madsen, D. J. & Otzen, D. E. (2019).
Bacterial Amyloids: Biogenesis and Biomaterials. In S. Perrett, A. K. Buell & T. P. J. Knowles (Eds.),
Advances in Experimental Medicine and Biology (pp. 113-159). Springer.
https://doi.org/10.1007/978-981-13-9791-2_4
Christensen, L. F. B., Nowak, J. S., Sønderby, T. V., Frank, S. A. & Otzen, D. E. (2020).
Quantitating denaturation by formic acid: Imperfect repeats are essential to the stability of the functional amyloid protein FapC.
Journal of Biological Chemistry,
295(37), 13036-13041.
https://doi.org/10.1074/jbc.ra120.013396
Christensen, L. F. B., Alijanvand, S. H., Burdukiewicz, M., Herbst, F.-A., Kjeldal, H.
, Dueholm, M. S. & Otzen, D. E. (2021).
Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats.
Protein Science,
30(9), 1854-1870.
https://doi.org/10.1002/pro.4137
Christensen, N. R., Pedersen, C. P., Sereikaite, V.
, Pedersen, J. N., Vistrup-Parry, M., Sørensen, A. T.
, Otzen, D., Teilum, K., Madsen, K. L. & Strømgaard, K. (2022).
Bidirectional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners.
iScience,
25(2), Article 103808.
https://doi.org/10.1016/j.isci.2022.103808Chrenková, A., Nashier, P.
, Madsen, C. L., Singh, M., Nielsen, J., Otzen, D. E., Enghild, J. J., Macek, B.
, Skjerning, R. B. & Brodersen, D. E. (2025).
Homologous HipA-like kinases are controlled by internal translational initiation and genetic organisation.
FEBS Letters. Advance online publication.
https://doi.org/10.1002/1873-3468.70234
Choong, F. X., Huzell, S., Rosenberg, M., Eckert, J. A.
, Nagaraj, M., Zhang, T., Melican, K.
, Otzen, D. E. & Richter-Dahlfors, A. (2021).
A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces.
Biofilm,
3, Article 100060.
https://doi.org/10.1016/j.bioflm.2021.100060Cavallin, A., Arozenius, H., Kristensson, K., Antonsson, P.
, Otzen, D. E., Björk, P. & Forsberg, G. (2000).
The spectral and thermodynamic properties of staphylococcal enterotoxin A, E, and variants suggest that structural modifications are important to control their function.
Journal of Biological Chemistry,
275(3), 1665-1672.
https://doi.org/10.1074/jbc.275.3.1665Calcutta, A., Jessen, C. M., Behrens, M. A., Oliveira, C. L. P., Renart, M. L., González-Ros, J. M.
, Otzen, D., Pedersen, J. S., Malmendal, A. & Nielsen, N. C. (2012).
Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant.
Biochimica et biophysica acta - Biomembranes,
1818(9), 2290-301.
https://doi.org/10.1016/j.bbamem.2012.04.005
Cabré, E.
, Malmström, J., Sutherland, D., Perez-Gil, J.
& Otzen, D. (2009).
Surfactant protein SP-B strongly modifies surface collapse of phospholipid vesicles: Insights from a quartz crystal microbalance with dissipation.
Biophysical Journal,
97(3), 768-76.
https://doi.org/10.1016/j.bpj.2009.04.057Bro̷chner, B. V., Zhang, X., Nielsen, J., Kjems, J., Otzen, D. E. & Malle, M. G. (2025).
Single-vesicle Tracking of α-Synuclein Oligomers Reveals Pore Formation by a Three-Stage Model.
ACS Nano,
19(36), 32108-32122.
https://doi.org/10.1021/acsnano.5c04005
Bleem, A.
, Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, K., Bryers, J. D., Daggett, V.
, Meyer, R. L. & Otzen, D. E. (2018).
Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms.
Journal of Molecular Biology,
430(20), 3751-3763.
https://doi.org/10.1016/j.jmb.2018.06.043Bisiak, F., Chrenková, A., Zhang, S. D.
, Pedersen, J. N., Otzen, D. E., Zhang, Y. E.
& Brodersen, D. E. (2022).
Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
Journal of Biological Chemistry,
298(7), Article 102142.
https://doi.org/10.1016/j.jbc.2022.102142
Beyschau Andersen, C., Yagi, H., Manno, M., Martorana, V., Ban, T.
, Christiansen, G., Otzen, D., Goto, Y. & Rischel, C. (2009).
Branching in amyloid fibril growth.
Biophysical Journal,
96(4), 1529-36.
https://doi.org/10.1016/j.bpj.2008.11.024Bertelsen, K., Vad, B., Nielsen, E. H. T., Hansen, S. K., Skrydstrup, T., Otzen, D., Vosegaard, T. & Nielsen, N. C. (2011).
Long-term-stable ether-lipid vs conventional ester-lipid bicelles in oriented solid-state NMR: altered structural information in studies of antimicrobial peptides.
Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical,
115(8), 1767-1774.
https://doi.org/10.1021/jp110866g
Bendtsen, M. K., Nowak, J. S., Paiva, P.
, López Hernández, M., Ferreira, P.
, Pedersen, J. S., Bekker, N. S., Viezzi, E.
, Bisiak, F., Brodersen, D. E., Pedersen, L. H.
, Zervas, A., Fernandes, P. A., Ramos, M. J.
, Stougaard, P., Thøgersen, M. S. & Otzen, D. E. (2025).
Cold-Active Starch-Degrading Enzymes from a Cold and Alkaline Greenland Environment: Role of Ca2+ Ions and Conformational Dynamics in Psychrophilicity.
Biomolecules,
15(3), Article 415.
https://doi.org/10.3390/biom15030415
Basaiawmoit, R. V., Oliveira, C. L. P. D., Runager, K., Kristensen, T., Enghild, J. J., Pedersen, J. S.
& Otzen, D. (2009).
First Low Resolution Structural Evidence of Full-length TGFBIp and Its Implications in TGFBI-linked Corneal Dystrophy. Abstract from ARVO 2009 Annual Meeting, nr. 2009, Fort Lauderdale, USA, 3. maj - 7. maj 2009, Investigative Ophthalmology & Visual Science. 2009. E-Abstract 4311. Association for Research in Vision and Ophthalmology..
Basaiawmoit, R. V., Deva, T., Runager, K., Kristensen, T., Enghild, J. J. & Otzen, D. (2009).
The Underlying Mechanisms of TGFBIp-mediated Corneal Dystrophies. Abstract from Asia ARVO, International Meeting on Research in Vision and Ophthalmology, Hyderabad International Convention Center. Abstract number: PAP05.01, Hyderabad, India.
Basaiawmoit, R. V., Oliveira, C. L. P., Runager, K., Sørensen, C. S., Behrens, M. A., Jonsson, B.-H., Kristensen, T., Klintworth, G. K.
, Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2011).
SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation.
Journal of Molecular Biology,
408(3), 503-513.
https://doi.org/10.1016/j.jmb.2011.02.052
Barciszewski, J.
, Rattan, S., Siboska, G., Otzen, D. & Clark, B. F. C. (1993).
Reduction in the amount of 8-hydroxy-2´-deoxyguanosine in the DNA of SV40-transformed human fibroblasts as compared with normal cells in culture. FEBS Letters,
318, 186-188.
Baptista, R. P., Pedersen, S. H., Cabrita, G. J. M.
, Otzen, D., Cabral, J. M. & Melo, E. P. (2008).
Thermodynamics and mechanism of cutinase stabilization by trehalose.
Biopolymers,
89, 538-547.
Baldry, M., Bojer, M. S.
, Najarzadeh, Z., Vestergaard, M.
, Meyer, R. L., Otzen, D. E. & Ingmer, H. (2020).
Phenol-Soluble Modulins Modulate Persister Cell Formation in Staphylococcus aureus.
Frontiers in Microbiology,
11, Article 573253.
https://doi.org/10.3389/fmicb.2020.573253Andreasen, M., Nielsen, S. B., Mittag, T., Bjerring, M., Nielsen, J. T., Zhang, S., Nielsen, E. H., Jeppesen, M., Christiansen, G., Besenbacher, F., Dong, M., Nielsen, N. C., Skrydstrup, T. & Otzen, D. E. (2012).
Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone.
Biochimica et Biophysica Acta - Proteins and Proteomics,
1824(2), 274-85.
https://doi.org/10.1016/j.bbapap.2011.10.014
Andreasen, M., Nielsen, S. B., Runager, K., Christiansen, G., Nielsen, N. C., Enghild, J. J. & Otzen, D. (2012).
Polymorphic Fibrillation of the Destabilized Fourth Fasciclin-1 Domain Mutant A546T of the Transforming Growth Factor-β-induced Protein (TGFBIp) Occurs through Multiple Pathways with Different Oligomeric Intermediates.
Journal of Biological Chemistry,
287(41), 34730-34742.
https://doi.org/10.1074/jbc.M112.379552
Andreasen, M., Skeby, K. K., Zhang, S., Nielsen, E. H., Klausen, L. H., Frahm, H., Christiansen, G., Skrydstrup, T., Dong, M., Schiøtt, B. & Otzen, D. (2014).
The Importance of Being Capped: Terminal Capping of an Amyloidogenic Peptide Affects Fibrillation Propensity and Fibril Morphology.
Biochemistry,
53(44), 6968-6980.
https://doi.org/10.1021/bi500674u
Andreasen, M., Meisl, G., Taylor, J. D., Michaels, T. C. T., Levin, A.
, Otzen, D. E., Chapman, M. R., Dobson, C. M., Matthews, S. J. & Knowles, T. P. J. (2019).
Physical Determinants of Amyloid Assembly in Biofilm Formation.
mBio,
10(1), Article e02279-18.
https://doi.org/10.1128/mBio.02279-18
Andersen, K., Oliveira, C. L. P. D., Larsen, K. L., Poulsen, F., Callisen, T., Westh, P.
, Pedersen, J. S. & Otzen, D. (2009).
The role of decorated SDS micelles in sub-cmc protein denaturation and association.
Journal of Molecular Biology,
391, 207-226.
Andersen, C. B., Hicks, M. R., Vetri, V., Vandahl, B., Rahbek-Nielsen, H., Thøgersen, H.
, Thøgersen, I., Enghild, J. J., Serpell, L. C., Rischel, C.
& Otzen, D. E. (2010).
Glucagon fibril polymorphism reflects differences in protofilament backbone structure.
Journal of Molecular Biology,
397(4), 932-46.
https://doi.org/10.1016/j.jmb.2010.02.012Andersen, K. K., Vad, B. S., Roelants, S., van Bogaert, I. N. A.
& Otzen, D. E. (2016).
Weak and Saturable Protein-Surfactant Interactions in the Denaturation of Apo-α-Lactalbumin by Acidic and Lactonic Sophorolipid.
Frontiers in Microbiology,
7(NOV), Article 1711.
https://doi.org/10.3389/fmicb.2016.01711
Andersen, K. K., Vad, B. S., Scavenius, C., Enghild, J. J. & Otzen, D. E. (2017).
Human lysozyme peptidase resistance is perturbed by the anionic glycolipid biosurfactant rhamnolipid produced by the opportunistic pathogen Pseudomonas aeruginosa.
Biochemistry,
56(1), 260–270.
https://doi.org/10.1021/acs.biochem.6b01009
Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, T.
, Christiansen, G. & Otzen, D. E. (2018).
Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation.
FEBS Letters,
592(9), 1484-1496.
https://doi.org/10.1002/1873-3468.13038
