Christophersen, C.
, Otzen, D. E., Norman, B. E., Christensen, S. & Schäfer, T. (1998).
Enzymatic characterisation of novamyl®, a thermostable α-amylase.
Starch/Staerke,
50(1), 39-45.
https://doi.org/10.1002/(SICI)1521-379X(199801)50:1<39::AID-STAR39>3.0.CO;2-S
Bendtsen, M. K., Møllebjerg, A., Peña-Díaz, S., Graham, R., Petersen, N. C., Isaksen, B. N., Carstensen, M., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Chuma, I. K.
, Ryberg, C., Wittenborn, T. R., Gichuru, V., Wang, H.
, Scavenius, C., Sandahl, A.
& Otzen, D. E. (2026).
Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation.
Angewandte Chemie International Edition,
65(35), Article e6159643.
https://doi.org/10.1002/anie.6159643
Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T. (2023).
Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces.
Nature Communications,
14(1), Article 5731.
https://doi.org/10.1038/s41467-023-39843-1
Nielsen, J. E., Beier, L.
, Otzen, D., Borchert, T. V., Frantzen, H. B.
, Andersen, K. V. & Svendsen, A. (1999).
Electrostatics in the active site of an α-amylase.
European Journal of Biochemistry,
264(3), 816-824.
https://doi.org/10.1046/j.1432-1327.1999.00664.x
Lopes, P., Dyrnesli, H.
, Lorenzen, N., Otzen, D. & Ferapontova, E. (2014).
Electrochemical Analysis of the Fibrillation of Parkinson's Disease α-synuclein.
Analyst,
139(4), 749-756.
https://doi.org/10.1039/C3AN01616A
Lopes, P., Dyrnesli, H.
, Lorenzen, N., Otzen, D. & Ferapontova, E. (2013).
Electroanalysis of Amyloid Formation of Parkinson's Disease alpha-Synuclein. Abstract from 6th International Workshop on Surface Modification for Chemical and Biochemical Sensing, Warsaw, Poland.
Knudsen, S. K., Westergaard, U. B., Frantzmann, M., Stensballe, A.
& Otzen, D. (2008).
Effect of glycosylation on biphysical and flocculative properties of the extracellular domain of Ag43.
Biochemical Journal, (412), 563-577.
Svane, A. S. P., Jahn, K., Deva, T., Malmendal, A., Otzen, D., Dittmer, J. & Nielsen, N. C. (2008).
Early Stages of Amyloid Fibril Formation Studied by Liquid-State NMR: The Peptide Hormone Glucagon.
Biophysical Journal,
95(1), 366 – 377.
https://doi.org/10.1529/biophysj.107.122895
Tiwari, M. K., Leinisch, F.
, Sahin, C., Møller, I. M., Otzen, D., Davies, M. J.
& Bjerrum, M. J. (2018).
Early events in copper-ion catalyzed oxidation of α-synuclein.
Free Radical Biology & Medicine,
121, 38-50.
https://doi.org/10.1016/j.freeradbiomed.2018.04.559
Zhang, T., Bär, J., Risberg, L., Gómez Mejia, A., Hammar, H., Löffler, S.
, Otzen, D. E., Andreasen, M., Meyer, R. L., Melican, K., Zinkernagel, A. S. & Richter-Dahlfors, A. (2025).
Dynamic visualization of extracellular matrix components in S. aureus colony biofilms reveals functional amyloids leading to the formation of cap-like structures.
Biofilm,
10, Article 100318.
https://doi.org/10.1016/j.bioflm.2025.100318
Somavarapu, A. K., Kleijwegt, G.
, Nagaraj, M., Alam, P., Nielsen, J. & Otzen, D. E. (2023).
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions.
Chemical Science,
14(11), 3030-3047.
https://doi.org/10.1039/d2sc05534a
Harazin, A., Reinert, L. S., Alam, P., Hoy, L., Marnow, A. B., Nielsen, J., Lorentzen, A., Otzen, D. E., Paludan, S. R. & Nielsen, M. S. (2026).
Double-Stranded DNA Sensing cGAS-STING Immune Signaling in a Rat Co-Culture Model of the Blood-Brain Barrier.
Cell Biochemistry and Function,
44(6), e70240. Article e70240.
https://doi.org/10.1002/cbf.70240
Vad, B. S., Thomsen, L. A. H.
, Bertelsen, K., Franzmann, M.
, Pedersen, J. M., Nielsen, S. B., Vosegaard, T., Valnickova, Z., Skrydstrup, T., Enghild, J. J., Wimmer, R.
, Nielsen, N. C. & Otzen, D. (2010).
Divorcing folding from function: how acylation affects the membrane-perturbing properties of an antimicrobial peptide.
Biochimica et Biophysica Acta - Proteins and Proteomics,
1804(4), 806-20.
https://doi.org/10.1016/j.bbapap.2009.12.006
López Hernández, M., Scavenius, C., Otzen, D. E. & Pedersen, J. S. (2026).
Divergent effects of anionic surfactants on laundry enzymes: Structural stability, activity modulation, and self-cleavage mechanisms.
International Journal of Biological Macromolecules,
335(1), Article 149069.
https://doi.org/10.1016/j.ijbiomac.2025.149069
Nybo, T., Gamon, L. F., Fuentes-Lemus, E.
, Otzen, D. E., Davies, M. J. & Hägglund, P. (2025).
Dimethyl labeling of N-terminal amines allows unambiguous identification of protein crosslinks.
Free Radical Biology & Medicine,
227, 629-637.
https://doi.org/10.1016/j.freeradbiomed.2024.12.002
Adão, R., Cruz, P. F., Vaz, D. C., Fonseca, F.
, Pedersen, J. N., Ferreira-da-Silva, F., Brito, R. M. M., Ramos, C. H. I.
, Otzen, D., Keller, S. & Bastos, M. (2020).
DIBMA nanodiscs keep α-synuclein folded.
Biochimica et Biophysica Acta - Biomembranes,
1862(9), Article 183314.
https://doi.org/10.1016/j.bbamem.2020.183314
Jordal, P. L.
, Dyrlund, T. F., Winge, K.
, Larsen, M. R., Danielsen, E. H., Wells, J. A.
, Otzen, D. E. & Enghild, J. J. (2016).
Detection of proteolytic signatures for Parkinson's disease.
Future Neurology,
11(1), 15-32.
https://doi.org/10.2217/fnl.16.3
Kim, J.-Y., Sahu, S., Yau, Y.-H., Wang, X., Shochat, S. G., Nielsen, P. H., Dueholm, M. S.
, Otzen, D. E., Lee, J., Delos Santos, M. M. S., Yam, J. K. H., Kang, N.-Y., Park, S.-J., Kwon, H., Seviour, T. W., Yang, L., Givskov, M. & Chang, Y.-T. (2016).
Detection of pathogenic biofilms with bacterial amyloid targeting fluorescent probe, CDy11.
Journal of the American Chemical Society,
138(1), 402-407.
https://doi.org/10.1021/jacs.5b11357
Giehm, L., Christensen, C., Boas, U., Heegaard, P. M. H.
& Otzen, D. (2008).
Dendrimers destabilize proteins in a generation-dependent manner involving eletrostatic interactions.
Biopolymers,
89, 522-529.
Otzen, D. E., Pedersen, J. N., Somavarapu, A. K., Clement, A., Ji, M., Petersen, E. H.
, Pedersen, J. S., Urban, S.
& Schafer, N. P. (2021).
Cys-labelling kinetics of membrane protein GlpG: a role for specific SDS binding and micelle changes? Biophysical Journal,
120(18), 4115-4128.
https://doi.org/10.1016/j.bpj.2021.08.001
Hjørringgaard, C. U., Vad, B. S., Matchkov, V., Nielsen, S. B., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2012).
Cyclodextrin-Scaffolded Alamethicin with Remarkably Efficient Membrane Permeabilizing Properties and Membrane Current Conductance.
Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical,
116(26), 7652-7659.
https://doi.org/10.1021/jp2098679
Hjørringgaard, C. U., Vad, B. S., Matchkov, V., Nielsen, S. B., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2010).
Cyclodextrin Scaffolded Alamethicin with Highly Efficient Channel-forming Properties. Poster session presented at 31st European Peptide Symposium, 31EPS, Copenhagen, Denmark.
Hjørringgaard, C. U., Vad, B., Nielsen, S. B., Matchkov, V., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2010).
Cyclodextrin scaffolded alamethicin with highly efficient channel-forming properties.
Journal of Peptide Science,
16, 148.
Amodeo, G. F., Lee, B. Y., Krilyuk, N., Filice, C. T., Valyuk, D.
, Otzen, D. E., Noskov, S., Leonenko, Z. & Pavlov, E. V. (2021).
C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition.
Scientific Reports,
11(1), Article 8744.
https://doi.org/10.1038/s41598-021-88157-z
Olsen, W. P., Courtade, G.
, Peña-Díaz, S., Nagaraj, M., Sønderby, T. V., Mulder, F. A. A., Malle, M. G. & Otzen, D. E. (2024).
CsgA gatekeeper residues control nucleation but not stability of functional amyloid.
Protein Science,
33(10), Article e5178.
https://doi.org/10.1002/pro.5178
Hein, K. L., Kragh-Hansen, U., Morth, J. P., Jeppesen, M., Otzen, D., Møller, J. V. & Nissen, P. (2010).
Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin.
Journal of Structural Biology,
171, 353-360.
Risør, M. W., Juhl, D. W., Bjerring, M., Mathiesen, J.
, Enghild, J. J., Nielsen, N. C. & Otzen, D. E. (2017).
Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils.
Biophysical Journal,
113(3), 580-596.
https://doi.org/10.1016/j.bpj.2017.06.030
Marzookian, K., Aliakbari, F., Hourfar, H., Sabouni, F.
, Otzen, D. E. & Morshedi, D. (2026).
Corrigendum to “The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier” [Int. J. Biol. Macromol. Volume 290 (2025), 140387] (S0141813025009365), (10.1016/j.ijbiomac.2025.140387).
International Journal of Biological Macromolecules,
337, Article 149909.
https://doi.org/10.1016/j.ijbiomac.2025.149909
Malmos, K. G., Bjerring, M., Jessen, C. M., Nielsen, E. H. T., Poulsen, E. T., Christiansen, G., Vosegaard, T., Skrydstrup, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2017).
Correction to: How glycosaminoglycans promote fibrillation of salmon calcitonin.
Journal of Biological Chemistry,
292(38), 15992.
https://doi.org/10.1074/jbc.A116.715466
Stenvang, M., Schafer, N. P., Malmos, K. G., Pérez, A.-M. W., Niembro, O., Sormanni, P.
, Basaiawmoit, R. V., Christiansen, G., Andreasen, M. & Otzen, D. E. (2018).
Corneal dystrophy mutations drive pathogenesis by targeting TGFBIp stability and solubility in a latent amyloid-forming domain.
Journal of Molecular Biology,
430(8), 1116-1140.
https://doi.org/10.1016/j.jmb.2018.03.001
Paslawski, W., Lillelund, O. K., Kristensen, J. V.
, Schafer, N. P., Baker, R. P., Urban, S.
& Otzen, D. E. (2015).
Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops.
Proceedings of the National Academy of Sciences (PNAS),
112(6), 7978-7983.
https://doi.org/10.1073/pnas.1424751112
Juhl, D. W., Risør, M. W., Scavenius, C., Rasmussen, C. B., Otzen, D., Nielsen, N. C. & Enghild, J. J. (2019).
Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures.
Scientific Reports,
9(1), Article 3863.
https://doi.org/10.1038/s41598-019-40483-z
De Prat Gay, G., Ruiz-Sanz, J., Neira, J. L., Corrales, F. J.
, Otzen, D. E., Ladurner, A. G. & Fersht, A. R. (1995).
Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminus in vitro. Parallels with the protein folding pathway.
Journal of Molecular Biology,
254(5), 968-979.
https://doi.org/10.1006/jmbi.1995.0669
Knudsen, A. D., Bennike, T., Kjeldal, H.
, Birkelund, S., Otzen, D. & Stensballe, A. (2014).
Condenser: A statistical aggregation tool for multi-sample quantitative proteomic data from Matrix Science Mascot Distiller™.
Journal of Proteomics,
103, 261-266.
https://doi.org/10.1016/j.jprot.2014.02.001