Juul-Madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B.
, Howard, K., Dehesa-Etxebeste, M.
, Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-Ramos, M. & Vorup-Jensen, T. (2020).
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.
Journal of Immunology,
204(5), 1345-1361.
https://doi.org/10.4049/jimmunol.1900494
van Gils, J. H. M., van Dijk, E., Peduzzo, A., Hofmann, A., Vettore, N., Schützmann, M. P., Groth, G., Mouhib, H.
, Otzen, D. E., Buell, A. K. & Abeln, S. (2020).
The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth.
PLOS Computational Biology,
16(5), Article e1007767.
https://doi.org/10.1371/journal.pcbi.1007767
van Diggelen, F., Frank, S. A., Somavarapu, A. K., Scavenius, C., Apetri, M. M.
, Nielsen, J., Tepper, A. W. J. W.
, Enghild, J. J. & Otzen, D. E. (2020).
The interactome of stabilized α-synuclein oligomers and neuronal proteins.
FEBS journal,
287(10), 2037-2054.
https://doi.org/10.1111/febs.15124
Marvian, A. T.
, Aliakbari, F., Mohammad-Beigi, H., Ahmadi, Z. A., Mehrpouyan, S., Lermyte, F., Nasouti, M., Collingwood, J. F.
, Otzen, D. E. & Morshedi, D. (2020).
The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization.
International Journal of Biological Macromolecules,
155, 543-550.
https://doi.org/10.1016/j.ijbiomac.2020.03.238
Nissen, S. K., Shrivastava, K., Schulte, C.
, Otzen, D. E., Goldeck, D., Berg, D.
, Møller, H. J., Maetzler, W.
& Romero-Ramos, M. (2019).
Alterations in Blood Monocyte Functions in Parkinson's Disease.
Movement Disorders,
34(11), 1711-1721.
https://doi.org/10.1002/mds.27815
Mohammad-Beigi, H., Kjær, L., Eskandari, H., Aliakbari, F., Christiansen, G., Ruvo, G., L. Ward, J.
& Otzen, D. (2019).
A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants.
Frontiers in Plant Science,
10(148), Article 148.
https://doi.org/10.3389/fpls.2019.00148
Najarzadeh, Z., Pedersen, J. N., Christiansen, G., Shojaosadati, S. A.
, Pedersen, J. S. & Otzen, D. E. (2019).
Bacterial amphiphiles as amyloid inducers: Effect of Rhamnolipid and Lipopolysaccharide on FapC fibrillation.
B B A - Proteins and Proteomics,
1867(11), Article 140263.
https://doi.org/10.1016/j.bbapap.2019.140263
Christensen, L. F. B., Schafer, N., Wolf-Perez, A., Madsen, D. J. & Otzen, D. E. (2019).
Bacterial Amyloids: Biogenesis and Biomaterials. In S. Perrett, A. K. Buell & T. P. J. Knowles (Eds.),
Advances in Experimental Medicine and Biology (pp. 113-159). Springer.
https://doi.org/10.1007/978-981-13-9791-2_4
Juhl, D. W., Risør, M. W., Scavenius, C., Rasmussen, C. B., Otzen, D., Nielsen, N. C. & Enghild, J. J. (2019).
Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures.
Scientific Reports,
9(1), Article 3863.
https://doi.org/10.1038/s41598-019-40483-z
Rasmussen, C. B., Christiansen, G., Vad, B. S., Lynggaard, C., Enghild, J. J., Andreasen, M. & Otzen, D. (2019).
Imperfect repeats in the functional amyloid protein FapC reduce the tendency to fragment during fibrillation.
Protein Science,
28(3), 633-642.
https://doi.org/10.1002/pro.3566
Knudsen, L. J., Nielsen, S. D.-H., Rauh, V.
, Otzen, D., Dekker, P. J. T.
& Larsen, L. B. (2019).
Interrelations between chemical changes in lactose-free UHT milk. Abstract from 16th Symposium on Milk Genomics and Human Health, Aarhus, Denmark.
Knudsen, L. J., Nielsen, S. D., Rauh, V.
, Otzen, D., Dekker, P. J. T.
& Larsen, L. B. (2019).
Interrelations between chemical changes in lactose-free UHT milk. Abstract from Sandbjerg Seminar 2019, Sønderborg, Denmark.
Wolf Pérez, A.-M., Sormanni, P., Andersen, J. S., Sakhnini, L. I., Rodriguez-Leon, I., Bjelke, J. R., Gajhede, A. J., De Maria, L.
, Otzen, D. E., Vendruscolo, M. & Lorenzen, N. (2019).
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
mAbs,
11(2), 388-400.
https://doi.org/10.1080/19420862.2018.1556082
Pedersen, J. N., Jiang, Z.
, Christiansen, G., Lee, J. C.
, Pedersen, J. S. & Otzen, D. E. (2019).
Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures.
Biochimica et Biophysica Acta - Proteins and Proteomics,
1867(5), 519-528.
https://doi.org/10.1016/j.bbapap.2018.11.007
Mohammad-Beigi, H., Hosseini, A., Adeli, M., Ejtehadi, M. R.
, Christiansen, G., Sahin, C., Tu, Z., Tavakol, M., Dilmaghani-Marand, A., Nabipour, I., Farzadfar, F.
, Otzen, D. E., Mahmoudi, M. & Hajipour, M. J. (2019).
Mechanistic Understanding of the Interactions between Nano-Objects with Different Surface Properties and α-Synuclein.
ACS Nano,
13(3), 3243-3256.
https://doi.org/10.1021/acsnano.8b08983
Poghosyan, A. H.
, Schafer, N., Lyngsø, J., Shahinyan, A. A.
, Pedersen, J. S. & Otzen, D. (2019).
Molecular dynamics study of ACBP denaturation in alkyl sulfates demonstrates possible pathways of unfolding through fused surfactant clusters.
Protein Engineering, Design and Selection,
32(4), 175-190. Article gzz037.
https://doi.org/10.1093/protein/gzz037
Knudsen, L. J., Nielsen, S. D.-H., Rauh, V.
, Otzen, D. & Larsen, L. B. (2019).
New Lactase Enzymes. Abstract from Sandbjerg Seminar 2019, Sønderborg, Denmark.
Mohammad-Beigi, H., Aliakbari, F., Sahin, C., Lomax, C., Tawfike, A.
, P. Schafer, N., Amiri-Nowdijeh, A.
, Eskandari, H., Møller, I. M., Hosseini-Mazinani, M.
, Christiansen, G., Ward, J. L., Morshedi, D.
& Otzen, D. (2019).
Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity.
Journal of Biological Chemistry,
294(11), 4215-4232.
https://doi.org/10.1074/jbc.RA118.005723
Andreasen, M., Meisl, G., Taylor, J. D., Michaels, T. C. T., Levin, A.
, Otzen, D. E., Chapman, M. R., Dobson, C. M., Matthews, S. J. & Knowles, T. P. J. (2019).
Physical Determinants of Amyloid Assembly in Biofilm Formation.
mBio,
10(1), Article e02279-18.
https://doi.org/10.1128/mBio.02279-18
Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Sønderby, T. V., Shojaosadati, S. A., Morshedi, D., Strømgaard, K., Meisl, G.
, Sutherland, D., Pedersen, J. S. & Otzen, D. (2019).
Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers.
Biomolecules,
9(11), Article 659.
https://doi.org/10.3390/biom9110659
Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G. & Otzen, D. E. (2019).
Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation.
ACS Omega,
4(2), 4029-4039.
https://doi.org/10.1021/acsomega.8b03590
van Diggelen, F., Hrle, D., Apetri, M.
, Christiansen, G., Rammes, G., Tepper, A.
& Otzen, D. E. (2019).
Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.
PLOS ONE,
14(3), Article 0213663.
https://doi.org/10.1371/journal.pone.0213663
Højgaard, C.
, Sørensen, H. V., Pedersen, J. S., Winther, J. R.
& Otzen, D. E. (2018).
Can a Charged Surfactant Unfold an Uncharged Protein? Biophysical Journal,
115(11), 2081-2086.
https://doi.org/10.1016/j.bpj.2018.10.022
Stenvang, M., Schafer, N. P., Malmos, K. G., Pérez, A.-M. W., Niembro, O., Sormanni, P.
, Basaiawmoit, R. V., Christiansen, G., Andreasen, M. & Otzen, D. E. (2018).
Corneal dystrophy mutations drive pathogenesis by targeting TGFBIp stability and solubility in a latent amyloid-forming domain.
Journal of Molecular Biology,
430(8), 1116-1140.
https://doi.org/10.1016/j.jmb.2018.03.001
Tiwari, M. K., Leinisch, F.
, Sahin, C., Møller, I. M., Otzen, D., Davies, M. J.
& Bjerrum, M. J. (2018).
Early events in copper-ion catalyzed oxidation of α-synuclein.
Free Radical Biology & Medicine,
121, 38-50.
https://doi.org/10.1016/j.freeradbiomed.2018.04.559
Aliakbari, F., Shabani, A. A., Bardania, H.
, Mohammad-Beigi, H., Tayaranian Marvian, A., Dehghani Esmatabad, F., Vafaei, A. A., Shojaosadati, S. A., Saboury, A. A.
, Christiansen, G., Otzen, D. E. & Morshedi, D. (2018).
Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome.
Colloids and surfaces. B, Biointerfaces,
161, 578-587.
https://doi.org/10.1016/j.colsurfb.2017.11.023
Kurnik, M., Sahin, C., Andersen, C. B., Lorenzen, N., Giehm, L., Mohammad-Beigi, H., Jessen, C. M., Pedersen, J. S., Christiansen, G., Petersen, S. V., Staal, R., Krishnamurthy, G., Pitts, K., Reinhart, P. H.
, Mulder, F. A. A., Mente, S., Hirst, W. D.
& Otzen, D. E. (2018).
Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.
Cell Chemical Biology,
25(11), 1389-1402.
https://doi.org/10.1016/j.chembiol.2018.08.005
Bleem, A.
, Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, K., Bryers, J. D., Daggett, V.
, Meyer, R. L. & Otzen, D. E. (2018).
Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms.
Journal of Molecular Biology,
430(20), 3751-3763.
https://doi.org/10.1016/j.jmb.2018.06.043
Andersen, K. K., Vad, B. S., Kjaer, L., Tolker-Nielsen, T.
, Christiansen, G. & Otzen, D. E. (2018).
Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation.
FEBS Letters,
592(9), 1484-1496.
https://doi.org/10.1002/1873-3468.13038
Nedergaard Pedersen, J., Wilhelmus Johannes Maria Frederix, P.
, Skov Pedersen, J., Marrink, S. J.
& Otzen, D. (2018).
Role of charge and hydrophobicity in liprotide formation: a molecular dynamics study with experimental constraints.
ChemBioChem,
19(3), 263–271.
https://doi.org/10.1002/cbic.201700496
Aliakbari, F., Mohammad-Beigi, H., Rezaei-Ghaleh, N., Becker, S., Dehghani Esmatabad, F., Eslampanah Seyedi, H. A., Bardania, H., Tayaranian Marvian, A., Collingwood, J. F.
, Christiansen, G., Zweckstetter, M.
, Otzen, D. E. & Morshedi, D. (2018).
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.
Nanoscale,
10(19), 9174-9185.
https://doi.org/10.1039/c8nr00632f
Christensen, L. F. B., Hansen, L. M.
, Finster, K., Christiansen, G., Nielsen, P. H.
, Otzen, D. E. & Dueholm, M. S. (2018).
The Sheaths of Methanospirillum Are Made of a New Type of Amyloid Protein.
Frontiers in Microbiology,
9(NOV), Article 2729.
https://doi.org/10.3389/fmicb.2018.02729,
https://doi.org/10.3389/fmicb.2018.02729
Sahin, C., Kjær, L., Christensen, M. S., Nedergaard Pedersen, J., Christiansen, G., Pérez, A.-M. W., Moller, I. M., Enghild, J., Pedersen, J. S., Larsen, K. & Otzen, D. E. (2018).
α-synucleins from animal species show low fibrillation propensities and weak oligomer membrane disruption.
Biochemistry,
57(34), 5145-5158.
https://doi.org/10.1021/acs.biochem.8b00627
Rouse, S. L., Hawthorne, W. J., Berry, J.-L., Chorev, D. S., Ionescu, S. A., Lambert, S., Stylianou, F., Ewert, W., Mackie, U., Morgan, R. M. L.
, Otzen, D., Herbst, F.-A., Nielsen, P. H.
, Dueholm, M., Bayley, H., Robinson, C. V., Hare, S. & Matthews, S. (2017).
A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis.
Nature Communications,
8(1), Article 263.
https://doi.org/10.1038/s41467-017-00361-6
Sahin, C., Lorenzen, N., Lemminger, L., Christiansen, G., Møller, I. M., Vesterager, L. B., Pedersen, L. Ø., Fog, K., Kallunki, P.
& Otzen, D. E. (2017).
Antibodies against the C-terminus of α-synuclein modulate its fibrillation.
Biophysical Chemistry,
220, 34-41.
https://doi.org/10.1016/j.bpc.2016.11.002
Malmos, K. G., Bjerring, M., Jessen, C. M., Nielsen, E. H. T., Poulsen, E. T., Christiansen, G., Vosegaard, T., Skrydstrup, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2017).
Correction to: How glycosaminoglycans promote fibrillation of salmon calcitonin.
Journal of Biological Chemistry,
292(38), 15992.
https://doi.org/10.1074/jbc.A116.715466
Risør, M. W., Juhl, D. W., Bjerring, M., Mathiesen, J.
, Enghild, J. J., Nielsen, N. C. & Otzen, D. E. (2017).
Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils.
Biophysical Journal,
113(3), 580-596.
https://doi.org/10.1016/j.bpj.2017.06.030
Madsen, J. K., Kaspersen, J. D., Andersen, C. B., Nedergaard Pedersen, J., Andersen, K. K., Pedersen, J. S. & Otzen, D. E. (2017).
Glycolipid Biosurfactants Activate, Dimerize, and Stabilize Thermomyces lanuginosus Lipase in a pH-Dependent Fashion.
Biochemistry,
56(32), 4256-4268.
https://doi.org/10.1021/acs.biochem.7b00420