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Surface delivery of siRNA for implants.
European Cells & Materials,
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Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
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A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.
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Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly.
Bioconjugate Chemistry,
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A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics: Molecular Pharmaceutics.
Molecular Pharmaceutics,
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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Acta Biomaterialia,
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An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.
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An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.
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An albumin-oligonucleotide assembly for potential combinatorial drug delivery and half-life extension applications.
Molecular Therapy - Nucleic Acids,
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A new class of recombinant human albumin with multiple surface thiols exhibit stable conjugation, and enhanced FcRn binding and blood circulation.
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Antimicrobial effect of chitosan nanoparticles on streptococcus mutans biofilms.
Applied and Environmental Microbiology,
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Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
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Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.
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Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement.
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Chip-Free Microscale-Incubator-Based Synthesis of Chitosan-Based Gene Silencing Nanoparticles.
Particle & Particle Systems Characterization,
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Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.
Molecular Therapy,
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Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth.
Nano Letters,
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Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
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Comparative analysis of discrete exosome fractions obtained by differential centrifugation.
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Delivery of siRNA from lyophilized polymeric surfaces.
Biomaterials,
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Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
Journal of Biological Chemistry,
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Direct force measurements between siRNA and chitosan molecules using force spectroscopy.
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Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium.
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Fatty acid-modified gapmer antisense oligonucleotide and human serum albumin constructs for pharmacokinetic modulation.
Molecular Therapy,
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FcRn overexpression in human cancer drives albumin recycling and cell growth: a mechanistic basis for exploitation in targeted albumin-drug designs.
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Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis. Journal of Controlled Release,
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Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo.
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Generation of a Double Transgenic Humanised Neonatal Fc Receptor (FcRn)/Albumin Mouse to Study the Pharmacokinetics of Albumin-linked Drugs.
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Highly porous PEGylated Bi2S3 nano-urchins as a versatile platform for in vivo triple-modal imaging, photothermal therapy and drug delivery.
Nanoscale,
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Human serum albumin coated Prussian blue nanoparticles as pH-/thermo-triggered drug delivery vehicles for cancer thermo-chemotherapy.
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Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications.
Molecular Pharmaceutics,
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Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design.
British Journal of Cancer,
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Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model (uCaP) for Prostate Cancer in Cell-Free Urine.
Clinical Chemistry,
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Inflammatory response of RAW 264.7 cells to ultraporous interweaving PCL-PEO electrospun microfibers.
Journal of Tissue Engineering and Regenerative Medicine,
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Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling.
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Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides.
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Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis.
Radiotherapy & Oncology,
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Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnology and Bioengineering (Print),
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Martirosyan, A., Olesen, M. J., Fenton, R. A., Kjems, J. & Howard, K. A. (2016).
Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours.
Nanoscale,
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Li, Z., Hu, Y.
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Multifunctional bismuth selenide nanocomposites for anti-tumor thermo-chemotherapy and imaging.
A C S Nano,
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Multimodal Imaging-Guided Antitumor Photothermal Therapy and Drug Delivery Using Bismuth Selenide Spherical-Sponge.
A C S Nano,
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Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.
Oligonucleotides,
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