The Bio-SPM group investigates the physical and chemical properties of biomolecules and novel materials based on nano objects. To explore mechanical properties of molecules, we use harmonic AFM techniques. Another area of focus is understanding and controlling the self-assembly of nano structures. For all these studies we have developed state-of-the-art SPM techniques.
Our research focuses on identifying the functional properties of materials in air and liquid using a number of different SPMs. We have developed a novel atomic force microscope (AFM) platform for quantitative nanomechanical imaging methods, including microsecond force spectroscopy and microsecond single-molecule recognition spectroscopy. In another study, we have developed a new mode for the scanning ion conductance microscope (SICM) capable of quantifying the density of surface charges in solution. The advanced AFM techniques provide sub-molecular resolution and high-scanning speeds and have been applied to study dynamic and physical properties of biological systems, such as the abnormal conformational transitions of proteins associated with amyloid-related diseases. The new SICM mode was used to quantify the surface charge of different lipid bilayers and can provide valuable information about the membrane systems, which could prove useful for drug delivery.
The combination of structure and functional properties provides new insight into events occurring at the nanoscale.
Many projects involve collaborations with international leading companies such as Lundbeck A/S, Novo Nordisk A/S, DuPont Danisco, Danish Technological Institute, Carlsberg A/S, Park Systems and Bruker USA. These industry collaborations enable us to extend our established fundamental academic platform to applied technology.
For more information about the research, research opportunities and collaborations, please contact dong@inano.au.dk
The group works with development and application of advanced scanning probe methods (SPM) for the characterization of micro- and nanoscale materials:
