Sahin, C., Kjær, L., Christensen, M. S., Nedergaard Pedersen, J., Christiansen, G., Pérez, A-M. W., Moller, I. M., Enghild, J., Pedersen, J. S., Larsen, K. & Otzen, D. E. (2018).
α-synucleins from animal species show low fibrillation propensities and weak oligomer membrane disruption.
Biochemistry,
57(34), 5145-5158.
https://doi.org/10.1021/acs.biochem.8b00627
Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016).
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology.
Journal of Neuroinflammation,
13, [74].
https://doi.org/10.1186/s12974-016-0532-8
Wang, H., Andersen, K. K., Sehgal, P., Hagedorn, J., Westh, P., Borch, K.
& Otzen, D. E. (2013).
pH regulation of the kinetic stability of the lipase from Thermomyces lanuginosus.
Biochemistry,
52(1), 264-276.
https://doi.org/10.1021/bi301258e
Song, Y. J. C.
, Lundvig, D. M. S., Huang, Y., Wei, P. G., Blumbergs, P. C., Højrup, P.
, Otzen, D., Halliday, G. M.
& Jensen, P. H. (2007).
p25α relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.
American Journal of Pathology,
171(4), 1291-1303.
https://doi.org/10.2353/ajpath.2007.070201
Song, Y. J. C.
, Lundvig, D. M. S., Huang, Y., Gai, W. P., Blumbergs, P. C., Højrup, P.
, Otzen, D., Halliday, G. M. & Jensen, P. H. (2007).
p25a Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy.
Am. J. Path., (171), 1291-1303.
Nielsen, S. B., Franzmann, M.
, Basaiawmoit, R. V., Wimmer, R., Mikkelsen, J. D.
& Otzen, D. E. (2010).
beta-Sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles.
Biopolymers,
93(8), 678-89.
https://doi.org/10.1002/bip.21434
Nielsen, S. B., Macchi, F., Raccosta, S., Langkilde, A. E.
, Giehm, L., Kyrsting, A.
, Svane, A. S. P., Manno, M.
, Christiansen, G., Nielsen, N. C., Oddershede, L., Vestergaard, B.
& Otzen, D. (2013).
Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures.
P L o S One,
8(7), [e67713].
https://doi.org/10.1371/journal.pone.0067713
Jensen, P. L., Dueholm, M. S., Larsen, P.
, Petersen, S. V., Enghild, J. J., Christiansen, G., Højrup, P., Nielsen, P. H.
& Otzen, D. (2009).
Widespread abundance of Functional Bacterial Amyloid in Mycolata and other Gram positive Bacteria.
Applied and Environmental Microbiology,
75, 4101-4110.
Madsen, J. K., Kaspersen, J. D., Andersen, K. K., Pedersen, J. S. & Otzen, D. E. (2016).
When Enzymes and Green Surfactants Meet.
Biophysical Journal,
110(3), 211A.
https://doi.org/10.1016/j.bpj.2015.11.1171
Andersen, K. K., Vad, B. S., Roelants, S., van Bogaert, I. N. A.
& Otzen, D. E. (2016).
Weak and Saturable Protein-Surfactant Interactions in the Denaturation of Apo-α-Lactalbumin by Acidic and Lactonic Sophorolipid.
Frontiers in Microbiology,
7, [1711].
https://doi.org/10.3389/fmicb.2016.01711
Wang, H., Hagedorn, J., Svendsen, A., Borch, K.
& Otzen, D. (2013).
Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: a candidate for enzyme replacement therapy.
Biophysical Chemistry,
172, 43-52.
https://doi.org/10.1016/j.bpc.2012.12.003
Nielsen, J. T., Bjerring, M., Jeppesen, M., Pedersen, R. O.
, Pedersen, J. M., Hein, K. L., Vosegaard, T., Skrydstrup, T., Otzen, D. & Nielsen, N. C. (2009).
Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy.
Angewandte Chemie International Edition,
48, 2118-2121.
Nielsen, J. T., Bjerring, M., Jeppesen, M., Pedersen, R. O., Pedersen, J. M., Hein, K. L., Vosegaard, T., Skrydstrup, T., Otzen, D. & Nielsen, N. C. (2009).
Unique Identification of Supramolecular Structures in Amyloid Fibrils by Solid-State NMR. Poster session presented at 50th Experimental NMR Conference (ENC), Asilomar, CA, United States.
Meisl, G., Xu, C. K., Taylor, J. D., Michaels, T. C. T., Levin, A.
, Otzen, D., Klenerman, D., Matthews, S., Linse, S.
, Andreasen, M. & Knowles, T. P. J. (2022).
Uncovering the universality of self-replication in protein aggregation and its link to disease.
Science Advances,
8(32), [eabn6831].
https://doi.org/10.1126/sciadv.abn6831
van Diggelen, F., Hrle, D., Apetri, M.
, Christiansen, G., Rammes, G., Tepper, A.
& Otzen, D. E. (2019).
Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.
PLOS ONE,
14(3), [0213663].
https://doi.org/10.1371/journal.pone.0213663
Melo, E. P., Chen, L. Y., Cabral, J. M. S., Fojan, P.
, Petersen, S. B. & Otzen, D. E. (2003).
Trehalose favors a cutinase compact intermediate off-folding pathway.
Biochemistry,
42(24), 7611-7617.
https://doi.org/10.1021/bi034267x
Schafer, N., Truong, H. H.
, Otzen, D., Lindorff-Larsen, K. & Wolynes, P. G. (2016).
Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease.
Proceedings of the National Academy of Sciences of the United States of America,
113(8), 2098-2103.
https://doi.org/10.1073/pnas.1524027113
Baptista, R. P., Pedersen, S. H., Cabrita, G. J. M.
, Otzen, D., Cabral, J. M. & Melo, E. P. (2008).
Thermodynamics and mechanism of cutinase stabilization by trehalose.
Biopolymers,
89, 538-547.
Agerschou, E. D., Christiansen, G., Schafer, N. P., Madsen, D. J., Brodersen, D. E., Semsey, S.
& Otzen, D. E. (2016).
The transcriptional regulator GalR self-assembles to form highly regular tubular structures.
Scientific Reports,
6, [27672].
https://doi.org/10.1038/srep27672
Marvian, A. T.
, Aliakbari, F., Mohammad-Beigi, H., Ahmadi, Z. A., Mehrpouyan, S., Lermyte, F., Nasouti, M., Collingwood, J. F.
, Otzen, D. E. & Morshedi, D. (2020).
The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization.
International Journal of Biological Macromolecules,
155, 543-550.
https://doi.org/10.1016/j.ijbiomac.2020.03.238
Cavallin, A., Arozenius, H., Kristensson, K., Antonsson, P.
, Otzen, D. E., Björk, P. & Forsberg, G. (2000).
The spectral and thermodynamic properties of staphylococcal enterotoxin A, E, and variants suggest that structural modifications are important to control their function.
Journal of Biological Chemistry,
275(3), 1665-1672.
https://doi.org/10.1074/jbc.275.3.1665
Lorenzen, N., Nielsen, S. B., Buell, A. K.
, Kaspersen, J. D., Arosio, P.
, Vad, B. S., Paslawski, W., Christiansen, G., Valnickova Hansen, Z., Andreasen, M., Enghild, J. J., Pedersen, J. S., Dobson, C. M., Knowles, T. P. J.
& Otzen, D. (2014).
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
Journal of the American Chemical Society,
136(10), 3859-3868.
https://doi.org/10.1021/ja411577t
Andersen, K., Oliveira, C. L. P. D., Larsen, K. L., Poulsen, F., Callisen, T., Westh, P.
, Pedersen, J. S. & Otzen, D. (2009).
The role of decorated SDS micelles in sub-cmc protein denaturation and association.
Journal of Molecular Biology,
391, 207-226.
Christiansen, S. H., Zhang, X., Juul-Madsen, K., Hvam, M. L., Vad, B. S., Behrens, M. A., Thygesen, I. L., Jalilian, B., Pedersen, J. S., Howard, K., Otzen, D. E. & Vorup-Jensen, T. (2017).
The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage.
B B A - Biomembranes,
1859(3), 425-437.
https://doi.org/10.1016/j.bbamem.2017.01.001
Aliakbari, F., Mohammad-Beigi, H., Rezaei-Ghaleh, N., Becker, S., Dehghani Esmatabad, F., Eslampanah Seyedi, H. A., Bardania, H., Tayaranian Marvian, A., Collingwood, J. F.
, Christiansen, G., Zweckstetter, M.
, Otzen, D. E. & Morshedi, D. (2018).
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease.
Nanoscale,
10(19), 9174-9185.
https://doi.org/10.1039/c8nr00632f
Helwig, M., Hoshino, A., Berridge, C., Lee, S-N.
, Lorenzen, N., Otzen, D., Eriksen, J. & Lindberg, I. (2013).
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.
Journal of Biological Chemistry,
288(2), 1114.
Jarvela, T. S., Lam, H. A., Helwig, M.
, Lorenzen, N., Otzen, D. E., McLean, P. J., Maidment, N. T. & Lindberg, I. (2016).
The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America,
113(32).
https://doi.org/10.1073/pnas.1601091113
Frahm, H., Hansen, S. K., Vad, B. S., Nielsen, E. H., Nielsen, J. T., Vosegaard, T., Skrydstrup, T. & Otzen, D. E. (2015).
The natural, peptaibolic peptide SPF-5506-A4 adopts a β-bend spiral structure, shows low hemolytic activity and targets membranes through formation of large pores.
B B A - Proteins and Proteomics,
1854(8), 882-889.
https://doi.org/10.1016/j.bbapap.2015.03.003
Mogensen, J. E., Wimmer, R., Larsen, J. N., Spangfort, M. D.
& Otzen, D. E. (2002).
The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands.
Journal of Biological Chemistry,
277(26), 23684-23692.
https://doi.org/10.1074/jbc.M202065200
Michaels, T. C. T., Yde, P., Willis, J. C. W., Jensen, M. H.
, Otzen, D., Dobson, C. M., Buell, A. K. & Knowles, T. P. J. (2015).
The length distribution of frangible biofilaments.
Journal of Chemical Physics,
143(16), 1-15. [164901].
https://doi.org/10.1063/1.4933230
van Diggelen, F., Frank, S. A., Somavarapu, A. K., Scavenius, C., Apetri, M. M.
, Nielsen, J., Tepper, A. W. J. W.
, Enghild, J. J. & Otzen, D. E. (2020).
The interactome of stabilized α-synuclein oligomers and neuronal proteins.
The FEBS Journal,
287(10), 2037-2054.
https://doi.org/10.1111/febs.15124
Nielsen, S. B., Wilhelm, K.
, Vad, B., Schleucher, J., Morozova-Roche, L. A.
& Otzen, D. (2010).
The interaction of equine lysozyme:oleic acid complexes with lipid membranes suggests a cargo off-loading mechanism.
Journal of Molecular Biology,
398(2), 351-61.
https://doi.org/10.1016/j.jmb.2010.03.012