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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


PhD Alexander Sandahl, together with Professor Kurt Gothelf, Professor Troels Skrydstrup and a number of students in the groups, has developed a method for efficient and automated production of ingredients for DNA synthesis. (Illustration: Colourbox)
Schematic overview of strategy for synthesis of phosphoramidites in a flow-based setup. (Illustration: Nature Commun 12, Artikel nr. 2760 (2021))

2021.05.10 | iNano

New method for producing synthetic DNA

Chemically synthesized short DNA sequences are extremely important ingredients with countless uses in research laboratories, hospitals and in industry, like in the method for identifying COVID-19. Phosporamidites are necessary building blocks in the production of DNA sequences, but they are unstable, and break quickly. PhD Alexander Sandahl…

2021.05.10 | iNano

65.5 million DKK from DFF for research at Natural Sciences

The Independent Research Fund Denmark grants DKK 65.5 million for 20 research projects at Natural Sciences. Jeppe Vang Lauritsen, Duncan Sutherland, Jan Skov Pedersen, Mogens Christensen, and Martin Bremholm receive DKK 17 million in total.

Manish Debnath receives DKK 2.4m from the Lundbeck Foundation and will start as a post doc at iNANO, AU. Illustration: Colourbox

2021.05.07 | iNano

DKK 2.4m for developing a method to testing for disease-specific biomarkers

The Lundbeck Foundation has granted Manish Debnath DKK 2.4m, who will come to iNANO in order to work on developing chemically modified aptamers for rapid detection of disease-specific biomarkers. This could help SARS COV-2 testing.

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