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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Poul Nissen (right) and his colleagues will establish an Infrastructure for Cryo-Electron Tomography (ICE-T) which will be embedded in the Danish National Cryo-EM Facility – EMBION – where cryo-CLEM and high-end cryo-TEMs are available. From the left: Thomas Boesen and Gregers Rom Andersen. Photo: Lisbeth Heilesen

2020.10.09 | iNano

The cryoEM facility EMBION receives DKK 13,3 million from the Novo Nordisk Foundation for large equipment

With the grant from the Novo Nordisk Foundation, main applicant Poul Nissen and colleagues from the Department of Molecular Biology and Genetics and iNANO as well as partners at the Department of Biomedicine and the Department of Engineering will be able to establish an infrastructure for Cryo-Electron Tomography (ICE-T), which will also be made…

Professor Liv Hornekær has been elected as member of The Royal Danish Academy of Sciences and Letters. (Photo: Lars Kruse, AU Photo)

2020.10.08 | iNano

Liv Hornekær elected as member of The Royal Danish Academy of Sciences and Letters

Congratulations to Professor Liv Hornekær and all the other 15 outstanding scientists who have been elected as new members of The Royal Danish Academy of Sciences and Letters. They will enter into a year-long tradition, and follow in the footsteps of famous former members such as Niels Bohr and H.C. Ørsted, Marie Curie, Albert Einstein and Charles…

Extracts from rose and olives can prevent parkinson’s. Paper by AU researchers in ACS Chemical Neuroscience. (Photo: Colourbox)

2020.10.07 | iNano

Extracts from rose and olives can prevent parkinson’s

Parkinson’s disease is caused by an imbalance in the brain resulting from alpha-synuclein, a small unstable protein that misfolds and accumulates in clusters and clumps that destroy the brain cells of people with the disease. Researchers from Aarhus University have now discovered that extracts from Damask roses and Koroneiki olives can prevent…

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